RU1779252C - Способ получени дигидрохлорида тригидрат 2-(1-пентил-3-гуанидино)-4-(2-метил-4-имидазолил)тиазола - Google Patents
Способ получени дигидрохлорида тригидрат 2-(1-пентил-3-гуанидино)-4-(2-метил-4-имидазолил)тиазолаInfo
- Publication number
- RU1779252C RU1779252C SU894613898A SU4613898A RU1779252C RU 1779252 C RU1779252 C RU 1779252C SU 894613898 A SU894613898 A SU 894613898A SU 4613898 A SU4613898 A SU 4613898A RU 1779252 C RU1779252 C RU 1779252C
- Authority
- RU
- Russia
- Prior art keywords
- pentyl
- methyl
- trihydrate
- dihydrochloride
- guanidino
- Prior art date
Links
- DBODNPMIIRVQGW-UHFFFAOYSA-N trihydrate;dihydrochloride Chemical compound O.O.O.Cl.Cl DBODNPMIIRVQGW-UHFFFAOYSA-N 0.000 title abstract description 3
- 238000004519 manufacturing process Methods 0.000 title description 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000002425 crystallisation Methods 0.000 claims abstract description 5
- 230000008025 crystallization Effects 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract 3
- 150000004684 trihydrates Chemical class 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- ZYVPOPWDOQZIQC-UHFFFAOYSA-N 1,3-thiazole;dihydrochloride Chemical compound Cl.Cl.C1=CSC=N1 ZYVPOPWDOQZIQC-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000704 physical effect Effects 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 238000001914 filtration Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- YMVTZNWDYURLQR-UHFFFAOYSA-N 2-[3-pentyl-5-(1,3-thiazol-2-yl)-2h-imidazol-1-yl]guanidine;trihydrate;dihydrochloride Chemical compound O.O.O.Cl.Cl.CCCCCN1CN(NC(N)=N)C(C=2SC=CN=2)=C1 YMVTZNWDYURLQR-UHFFFAOYSA-N 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
- C07C335/28—Y being a hetero atom, e.g. thiobiuret
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1986/002307 WO1988003140A1 (en) | 1986-10-29 | 1986-10-29 | Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU1779252C true RU1779252C (ru) | 1992-11-30 |
Family
ID=22195693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU894613898A RU1779252C (ru) | 1986-10-29 | 1989-04-24 | Способ получени дигидрохлорида тригидрат 2-(1-пентил-3-гуанидино)-4-(2-метил-4-имидазолил)тиазола |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4997949A (OSRAM) |
| JP (1) | JPS63122680A (OSRAM) |
| AU (1) | AU579775B2 (OSRAM) |
| CA (1) | CA1313378C (OSRAM) |
| DD (2) | DD272851A5 (OSRAM) |
| FI (1) | FI89918C (OSRAM) |
| NO (1) | NO170417C (OSRAM) |
| PH (1) | PH23922A (OSRAM) |
| RU (1) | RU1779252C (OSRAM) |
| WO (1) | WO1988003140A1 (OSRAM) |
| ZA (1) | ZA878083B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5387597A (en) * | 1991-02-25 | 1995-02-07 | Pfizer Inc. | Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole |
| NO329085B1 (no) * | 2008-01-31 | 2010-08-16 | Sorbwater Technology As | Fremgangsmate og apparat for separasjon av fluidfaser, samt anvendelser derav |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163170B (OSRAM) * | 1980-10-14 | 1988-08-20 | Pfizer | |
| US4560690A (en) * | 1984-04-30 | 1985-12-24 | Pfizer Inc. | 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents |
| US4632993A (en) * | 1984-10-11 | 1986-12-30 | Pfizer Inc. | Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide |
| JPS6191122A (ja) * | 1984-10-11 | 1986-05-09 | フアイザー・インコーポレーテツド | ２―グアニジノ―４―（２―メチル―４―イミダゾリル）チアゾール類からなる慢性関節リウマチ治療用組成物 |
-
1986
- 1986-10-29 WO PCT/US1986/002307 patent/WO1988003140A1/en not_active Ceased
- 1986-10-29 US US07/365,155 patent/US4997949A/en not_active Expired - Lifetime
-
1987
- 1987-10-27 DD DD87318777A patent/DD272851A5/de not_active IP Right Cessation
- 1987-10-27 PH PH35990A patent/PH23922A/en unknown
- 1987-10-27 DD DD87308315A patent/DD262659A5/de not_active IP Right Cessation
- 1987-10-27 CA CA000550298A patent/CA1313378C/en not_active Expired - Fee Related
- 1987-10-28 ZA ZA878083A patent/ZA878083B/xx unknown
- 1987-10-28 AU AU80428/87A patent/AU579775B2/en not_active Ceased
- 1987-10-29 JP JP62274631A patent/JPS63122680A/ja active Granted
-
1988
- 1988-06-28 NO NO88882861A patent/NO170417C/no unknown
-
1989
- 1989-04-24 RU SU894613898A patent/RU1779252C/ru active
- 1989-04-28 FI FI892034A patent/FI89918C/fi not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Патент US № 4560690. кл. 548/198, 1985. За вка ЕР ISfc 178123 кл С 07 D 417/04. 1986. * |
Also Published As
| Publication number | Publication date |
|---|---|
| PH23922A (en) | 1990-01-23 |
| FI892034L (fi) | 1989-04-28 |
| US4997949A (en) | 1991-03-05 |
| FI89918B (fi) | 1993-08-31 |
| ZA878083B (en) | 1989-06-28 |
| AU8042887A (en) | 1988-05-05 |
| DD272851A5 (de) | 1989-10-25 |
| WO1988003140A1 (en) | 1988-05-05 |
| CA1313378C (en) | 1993-02-02 |
| FI89918C (fi) | 1993-12-10 |
| FI892034A0 (fi) | 1989-04-28 |
| DD262659A5 (de) | 1988-12-07 |
| AU579775B2 (en) | 1988-12-08 |
| NO170417C (no) | 1992-10-14 |
| NO882861D0 (no) | 1988-06-28 |
| NO170417B (no) | 1992-07-06 |
| JPH0513952B2 (OSRAM) | 1993-02-23 |
| JPS63122680A (ja) | 1988-05-26 |
| NO882861L (no) | 1988-06-28 |
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