RS50835B - Hemostatički aktivni preparat koji sadrži vwf i postupak njegovog pripremanja - Google Patents
Hemostatički aktivni preparat koji sadrži vwf i postupak njegovog pripremanjaInfo
- Publication number
- RS50835B RS50835B YUP-784/02A YUP78402A RS50835B RS 50835 B RS50835 B RS 50835B YU P78402 A YUP78402 A YU P78402A RS 50835 B RS50835 B RS 50835B
- Authority
- RS
- Serbia
- Prior art keywords
- vwf
- preparation containing
- containing vwf
- fraction
- production
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 108010047303 von Willebrand Factor Proteins 0.000 abstract 5
- 102100036537 von Willebrand factor Human genes 0.000 abstract 5
- 229960001134 von willebrand factor Drugs 0.000 abstract 5
- 238000005349 anion exchange Methods 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 229920000578 graft copolymer Polymers 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Postupak za pripremanje hemostatički aktivnog preparata koji sadrži von Willebrand-ov faktor (vWF) iz frakcije humane plazme, naznačen time, što se obavlja putemI. hromatografskog prečišćavanja plazma frakcije koja sadrži vWF na anjon-izmenjivačkom materijalu koji ima anjon-izmenjivačke grupe na kalemljenim polimernim strukturama (tentakularni materijal), sakupljajući frakciju koja sadrži vWF, praćenoII. prečišćavanjem pomenute frakcije korišćenjem hromatografije na molekularnim sitima za pripremu prečišćenog termalno stabilnog preparata koji sadrži vWF; iIII. preparat se u liofiliziranom stanju zagreje do temperature veće od 80°C radi inaktiviranja virusa.Prijava sadrži još 1 nazavisan i 12 zavisnih patentnih zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00108430A EP1148063A1 (de) | 2000-04-18 | 2000-04-18 | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
YU78402A YU78402A (sh) | 2006-08-17 |
RS50835B true RS50835B (sr) | 2010-08-31 |
Family
ID=8168496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-784/02A RS50835B (sr) | 2000-04-18 | 2001-04-04 | Hemostatički aktivni preparat koji sadrži vwf i postupak njegovog pripremanja |
Country Status (24)
Country | Link |
---|---|
US (2) | US7166709B2 (sr) |
EP (2) | EP1148063A1 (sr) |
JP (1) | JP4976634B2 (sr) |
KR (1) | KR100685448B1 (sr) |
CN (1) | CN100448888C (sr) |
AT (1) | ATE306494T1 (sr) |
AU (2) | AU6383501A (sr) |
BR (1) | BR0110193A (sr) |
CA (1) | CA2406626C (sr) |
CZ (1) | CZ303932B6 (sr) |
DE (1) | DE50107689D1 (sr) |
DK (1) | DK1274721T3 (sr) |
EA (1) | EA006209B1 (sr) |
EE (1) | EE200200595A (sr) |
ES (1) | ES2247117T3 (sr) |
HU (1) | HU225992B1 (sr) |
IL (2) | IL152173A0 (sr) |
MX (1) | MXPA02010017A (sr) |
NO (1) | NO324773B1 (sr) |
RS (1) | RS50835B (sr) |
SI (1) | SI1274721T1 (sr) |
UA (1) | UA76714C2 (sr) |
WO (1) | WO2001079260A1 (sr) |
ZA (1) | ZA200208396B (sr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
ITLU20070007A1 (it) * | 2007-05-07 | 2008-11-08 | Kedrion Spa | Processo cromatografico per l'ottenimento di un complesso fviii/vwf con differenti rapporti tra le due proteine da utilizzare nella terapia della emofilia a e nella malattia di von willebrand. |
FR2920429B1 (fr) * | 2007-08-30 | 2012-10-05 | Lfb Biotechnologies | Procede de purification du facteur viii et du facteur von willebrand |
US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
BRPI0821474B8 (pt) | 2007-12-28 | 2021-05-25 | Baxalta GmbH | formulação farmacêutica líquida estável |
KR101507718B1 (ko) | 2008-06-24 | 2015-04-10 | 체에스엘 베링 게엠베하 | 연장된 생체내 반감기를 갖는 인자 viii, 폰 빌레브란트 인자 또는 이들의 복합체 |
TWI508735B (zh) | 2008-10-21 | 2015-11-21 | 巴克斯特國際公司 | 凍乾的重組vwf調配物 |
IT1396528B1 (it) * | 2009-01-19 | 2012-12-14 | Kedrion Spa | Nuovo processo di purificazione altamente selettivo di due proteine plasmatiche: von willebrand factor (vwf) e fibronectina (fn). |
CA2801116C (en) * | 2010-06-01 | 2019-02-12 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9371355B2 (en) | 2010-09-20 | 2016-06-21 | Octapharma Ag | Process for production of fibrinogen |
US9488625B2 (en) | 2010-12-15 | 2016-11-08 | Baxalta GmbH | Purification of factor VIII using a conductivity gradient |
US10064406B2 (en) * | 2011-01-06 | 2018-09-04 | Cytosorbents Corporation | Polymeric sorbent for removal of impurities from whole blood and blood products |
CN104321340B (zh) | 2012-03-13 | 2018-11-09 | 欧克塔医药公司 | 用于生产纤维蛋白原的改进工艺及其生产的纤维蛋白原 |
CN104411716B (zh) | 2012-04-24 | 2018-09-07 | 诺和诺德股份有限公司 | 适用于治疗血友病的化合物 |
EP2796145B1 (en) | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT389815B (de) * | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
ES2053684T3 (es) | 1988-11-05 | 1994-08-01 | Octapharma Ag | Procedimiento para preparar un factor antihemofilico, altamente puro, no infeccioso, mediante cromatografia. |
FR2673632A1 (fr) * | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
FR2681867B1 (fr) * | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
DE4204694C3 (de) * | 1992-02-01 | 1995-10-12 | Octapharma Ag | Verfahren zur Gewinnung von hochreinem, virusinaktiviertem Faktor VIII mittels Anionenaustauscher-Chromatographie |
JP3133338B2 (ja) * | 1992-12-16 | 2001-02-05 | イムノ・アクチエンゲゼルシャフト | ウイルス的に安全な生物学的組成物の調製方法 |
DE4435392B4 (de) * | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
DE4437544A1 (de) * | 1994-10-20 | 1996-04-25 | Behringwerke Ag | Einsatz von vWF-enthaltenden Konzentraten als Kombinationstherapie bei Therapie mit Antithrombotika und Fibrinolytika |
US6005077A (en) * | 1995-11-10 | 1999-12-21 | Immuno Aktiengesellschaft | Use of von willebrand factor and pharmaceutical formulation |
AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
AT404358B (de) * | 1997-02-04 | 1998-11-25 | Immuno Ag | Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial |
US6531577B1 (en) * | 1997-12-15 | 2003-03-11 | Hemasure Denmark A/S | von Willebrand factor (vWF)-containing preparation, process for preparing vWF-containing preparations, and use of such preparations |
EP1148063A1 (de) * | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
-
2000
- 2000-04-18 EP EP00108430A patent/EP1148063A1/de not_active Withdrawn
-
2001
- 2001-04-04 IL IL15217301A patent/IL152173A0/xx active IP Right Grant
- 2001-04-04 SI SI200130460T patent/SI1274721T1/sl unknown
- 2001-04-04 MX MXPA02010017A patent/MXPA02010017A/es active IP Right Grant
- 2001-04-04 KR KR1020027013892A patent/KR100685448B1/ko not_active IP Right Cessation
- 2001-04-04 RS YUP-784/02A patent/RS50835B/sr unknown
- 2001-04-04 AU AU6383501A patent/AU6383501A/xx active Pending
- 2001-04-04 EP EP01938084A patent/EP1274721B1/de not_active Expired - Lifetime
- 2001-04-04 US US10/257,375 patent/US7166709B2/en not_active Expired - Fee Related
- 2001-04-04 EA EA200201104A patent/EA006209B1/ru not_active IP Right Cessation
- 2001-04-04 JP JP2001576857A patent/JP4976634B2/ja not_active Expired - Fee Related
- 2001-04-04 CZ CZ20023454A patent/CZ303932B6/cs not_active IP Right Cessation
- 2001-04-04 DK DK01938084T patent/DK1274721T3/da active
- 2001-04-04 CA CA2406626A patent/CA2406626C/en not_active Expired - Fee Related
- 2001-04-04 AT AT01938084T patent/ATE306494T1/de active
- 2001-04-04 EE EEP200200595A patent/EE200200595A/xx unknown
- 2001-04-04 WO PCT/EP2001/003819 patent/WO2001079260A1/de active IP Right Grant
- 2001-04-04 DE DE50107689T patent/DE50107689D1/de not_active Expired - Lifetime
- 2001-04-04 BR BR0110193-5A patent/BR0110193A/pt not_active Application Discontinuation
- 2001-04-04 HU HU0301211A patent/HU225992B1/hu not_active IP Right Cessation
- 2001-04-04 UA UA2002108257A patent/UA76714C2/uk unknown
- 2001-04-04 ES ES01938084T patent/ES2247117T3/es not_active Expired - Lifetime
- 2001-04-04 CN CNB018082297A patent/CN100448888C/zh not_active Expired - Fee Related
- 2001-04-04 AU AU2001263835A patent/AU2001263835B2/en not_active Ceased
-
2002
- 2002-10-08 IL IL152173A patent/IL152173A/en not_active IP Right Cessation
- 2002-10-17 NO NO20025007A patent/NO324773B1/no not_active IP Right Cessation
- 2002-10-17 ZA ZA200208396A patent/ZA200208396B/en unknown
-
2007
- 2007-01-04 US US11/649,357 patent/US7985846B2/en not_active Expired - Fee Related
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