RS50667B - Alfa-aminoamidni derivati delotvorni u tretmanu sindroma nemirnih nogu - Google Patents

Alfa-aminoamidni derivati delotvorni u tretmanu sindroma nemirnih nogu

Info

Publication number
RS50667B
RS50667B RSP-2008/0531A RSP20080531A RS50667B RS 50667 B RS50667 B RS 50667B RS P20080531 A RSP20080531 A RS P20080531A RS 50667 B RS50667 B RS 50667B
Authority
RS
Serbia
Prior art keywords
benzylamino
propanamide
fluorobenzyloxy
methyl
acetamide
Prior art date
Application number
RSP-2008/0531A
Other languages
English (en)
Inventor
Claudia Besana
Elena Barbanti
Emanuela Izzo
Florian Thaler
Ruggero Fariello
Patricia Salvati
Luca Benatti
Original Assignee
Newron Pharmaceuticals S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharmaceuticals S.P.A. filed Critical Newron Pharmaceuticals S.P.A.
Publication of RS50667B publication Critical patent/RS50667B/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
RSP-2008/0531A 2004-04-22 2005-04-19 Alfa-aminoamidni derivati delotvorni u tretmanu sindroma nemirnih nogu RS50667B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04009532A EP1588704A1 (en) 2004-04-22 2004-04-22 Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
PCT/EP2005/004166 WO2005102300A1 (en) 2004-04-22 2005-04-19 α-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF RESTLESS LEGS SYNDROME AND ADDICTIVE DISORDERS

Publications (1)

Publication Number Publication Date
RS50667B true RS50667B (sr) 2010-06-30

Family

ID=34924693

Family Applications (2)

Application Number Title Priority Date Filing Date
RS20110128A RS51791B (sr) 2004-04-22 2005-04-19 Alfa-aminoamid derivati korisni u lečenju bolesti zavisnosti
RSP-2008/0531A RS50667B (sr) 2004-04-22 2005-04-19 Alfa-aminoamidni derivati delotvorni u tretmanu sindroma nemirnih nogu

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RS20110128A RS51791B (sr) 2004-04-22 2005-04-19 Alfa-aminoamid derivati korisni u lečenju bolesti zavisnosti

Country Status (26)

Country Link
US (2) US8445513B2 (sr)
EP (3) EP1588704A1 (sr)
JP (1) JP5020069B2 (sr)
KR (2) KR101238377B1 (sr)
CN (1) CN1942179B (sr)
AT (2) ATE494890T1 (sr)
AU (1) AU2005235428B2 (sr)
BR (2) BR122020004541B1 (sr)
CA (1) CA2563674C (sr)
CY (2) CY1108494T1 (sr)
DE (2) DE602005009162D1 (sr)
DK (2) DK1737438T3 (sr)
ES (2) ES2313330T3 (sr)
HK (1) HK1099216A1 (sr)
HR (2) HRP20080593T3 (sr)
IL (1) IL178732A (sr)
ME (2) ME01219B (sr)
MX (1) MXPA06012163A (sr)
NO (2) NO337900B1 (sr)
NZ (1) NZ550664A (sr)
PL (2) PL1900362T3 (sr)
PT (2) PT1900362E (sr)
RS (2) RS51791B (sr)
RU (1) RU2403030C2 (sr)
SI (2) SI1737438T1 (sr)
WO (1) WO2005102300A1 (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
PT1423168E (pt) * 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
ATE457724T1 (de) * 2003-08-25 2010-03-15 Newron Pharm Spa Alpha-aminoamid derivate zur verwendung als anti- inflammatorische wirkstoffe
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. (할로벤질옥시)벤질아미노-프로판아미드를 포함하는 선택적 나트륨 및/또는 칼슘 채널 조절제로서 유용한 약제학적 조성물
US20060173074A1 (en) * 2004-11-10 2006-08-03 Juha Ellmen Treatment of restless legs syndrome
CA2629065C (en) * 2005-12-22 2013-08-06 Newron Pharmaceuticals S.P.A. 2 -phenylethylamino derivatives as calcium and/or sodium channel modulators
CN101442997B (zh) * 2006-04-03 2012-11-14 泰华制药工业有限公司 雷沙吉兰用于治疗多动腿综合征
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
CN101472880B (zh) * 2006-06-19 2013-04-24 纽朗制药有限公司 生产2-[4-(3-和2-氟苄氧基)苄氨基]丙酰胺类的方法
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
MX2009013119A (es) 2007-06-15 2010-03-04 Newron Pharm Spa Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.
DK2229351T3 (en) * 2007-12-11 2018-01-22 Newron Pharm Spa PROCEDURE FOR THE PREPARATION OF 2- [4- (3- OR 2-FLUORBENZYLOXY) BENZYLAMINO] PROPANAMIDS WITH HIGH PURITY
BRPI0821026A2 (pt) * 2007-12-19 2015-06-16 Newron Pharmaceutical S P A Derivados de alfa-minoamidas úteis no tratamento de transtornos psiquiátricos
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
DK2563355T3 (en) 2010-04-27 2016-09-12 Newron Pharm Spa A process for the preparation of ralfinamide-methanesulphonate or R-enantiomers thereof.
US11278651B2 (en) 2018-10-17 2022-03-22 Gambro Lundia Ab Membrane and device for treating restless leg syndrome
CN114667963B (zh) * 2020-12-24 2024-04-26 中国科学院脑科学与智能技术卓越创新中心 一种非人灵长类动物药物成瘾性评估的装置

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4935429A (en) * 1985-10-25 1990-06-19 Dackis Charles A Method of treating psychostimulant addiction
DE58905201D1 (de) * 1988-03-01 1993-09-16 Birkmayer Walther Mittel zur behandlung des parkinson-syndroms.
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5221536A (en) * 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
EP0520325A1 (de) * 1991-06-28 1992-12-30 F.Hoffmann-La Roche & Co. Aktiengesellschaft Verwendung von Monoaminoxidase-B-Hemmern zur Verhütung und Behandlung von Entzugserscheinungen nach Alkohol- und Drogenmissbrauch
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
IL111240A (en) * 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
DK0828513T3 (da) * 1995-05-26 2004-04-13 Pfizer Kombinationspræparater til behandling af parkinsonisme, indeholdende selektive NMDA-antagonister
WO1997000511A1 (de) 1995-06-17 1997-01-03 Baumann Guenter Scheibenkörper
GB9515412D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9515411D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa N-(4-substituted-benzyl)-2-aminolactam derivatives
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
GB9727521D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
AU761457B2 (en) 1998-01-12 2003-06-05 Deborah Wenzel An additive composition also used as a fuel composition comprising water soluble alcohols
FI109453B (fi) * 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus
AU1359801A (en) * 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
AU2080201A (en) * 1999-12-10 2001-06-18 University Of Cincinnati, The Treatment of addiction disorders
US20020019421A1 (en) * 2000-07-05 2002-02-14 Roni Biberman Compositions and therapy for substance addiction
CA2450315A1 (en) * 2001-06-13 2002-12-19 The Regents Of The University Of Michigan Dopamine receptor ligands and therapeutic methods based thereon
PL212708B1 (pl) * 2002-05-29 2012-11-30 Hoffmann La Roche Pochodne N-acyloaminobenzenu, sposób ich wytwarzania, lek zawierajacy te pochodne i zastosowanie pochodnych N-acyloaminobenzenu
PL203763B1 (pl) 2002-06-24 2009-11-30 Rockwool Int Sposób i urządzenie do wytwarzania wełny mineralnej
US6900354B2 (en) * 2002-07-15 2005-05-31 Hoffman-La Roche Inc. 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
JP2005060370A (ja) * 2003-07-25 2005-03-10 Kyowa Hakko Kogyo Co Ltd 医薬組成物
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Also Published As

Publication number Publication date
ATE494890T1 (de) 2011-01-15
NZ550664A (en) 2010-08-27
NO20150971L (no) 2006-11-22
IL178732A (en) 2013-01-31
US20130217747A1 (en) 2013-08-22
PL1737438T3 (pl) 2009-01-30
EP1737438A1 (en) 2007-01-03
WO2005102300A1 (en) 2005-11-03
NO338870B1 (no) 2016-10-31
PT1900362E (pt) 2011-03-09
PL1900362T3 (pl) 2011-06-30
ES2313330T3 (es) 2009-03-01
ES2357559T3 (es) 2011-04-27
AU2005235428A1 (en) 2005-11-03
HRP20110230T1 (hr) 2011-04-30
JP5020069B2 (ja) 2012-09-05
KR101195819B1 (ko) 2012-11-05
HK1099216A1 (en) 2007-08-10
KR101238377B1 (ko) 2013-03-04
ME01219B (me) 2013-06-20
CY1111656T1 (el) 2015-10-07
PT1737438E (pt) 2008-12-22
EP1900362B1 (en) 2011-01-12
RS51791B (sr) 2011-12-31
RU2006137079A (ru) 2008-04-27
CY1108494T1 (el) 2014-04-09
BRPI0509976B1 (pt) 2020-10-06
RU2403030C2 (ru) 2010-11-10
DE602005025941D1 (de) 2011-02-24
BRPI0509976B8 (pt) 2021-05-25
DK1900362T3 (da) 2011-05-09
EP1737438B1 (en) 2008-08-20
SI1900362T1 (sl) 2011-03-31
KR20120028399A (ko) 2012-03-22
MXPA06012163A (es) 2007-01-17
NO20064732L (no) 2006-11-22
ME02324B (me) 2016-06-20
ATE405256T1 (de) 2008-09-15
CA2563674C (en) 2012-12-18
BRPI0509976A (pt) 2007-10-16
US8445513B2 (en) 2013-05-21
US20070203182A1 (en) 2007-08-30
SI1737438T1 (sl) 2008-12-31
EP1900362A2 (en) 2008-03-19
IL178732A0 (en) 2007-05-15
JP2007533691A (ja) 2007-11-22
CN1942179A (zh) 2007-04-04
BR122020004541B1 (pt) 2021-11-09
DK1737438T3 (da) 2008-12-08
EP1588704A1 (en) 2005-10-26
EP1900362A3 (en) 2009-04-01
DE602005009162D1 (de) 2008-10-02
NO337900B1 (no) 2016-07-04
AU2005235428B2 (en) 2010-03-18
CA2563674A1 (en) 2005-11-03
US8697738B2 (en) 2014-04-15
CN1942179B (zh) 2010-08-11
HRP20080593T3 (en) 2008-12-31
KR20070042914A (ko) 2007-04-24

Similar Documents

Publication Publication Date Title
RS50667B (sr) Alfa-aminoamidni derivati delotvorni u tretmanu sindroma nemirnih nogu
RU2006126346A (ru) L-аминоамидные производные, используемые для лечения расстройств нижних мочевыводящих путей
RU2008146755A (ru) Ингибиторы ионных task-1 и task-3 каналов
KR910004543A (ko) Acat 억제제
SI2182949T1 (sl) (2S,3R)-N-(2-((3-piridinil)metil)-1-azabiciklo(2.2.2)okt-3-il)benzofuran -2-karboksamid, nove oblike soli in postopki za njihovo uporabo
NO20050740D0 (no) Ny fremgangsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og anvendelse i syntesen av agomelatin
ATE295865T1 (de) Wässrige lösung oder dispersion eines polyetheraminsalzes
HRP20150136T1 (en) Process for the production of 2- [4 - ( 3- and 2-fluorobenzyloxy) benzylamino] propan amides
FR2881744B1 (fr) Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
FR2861074B1 (fr) Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2812875B1 (fr) Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
RS52982B (sr) Farmaceutski prihvatljivi kokristali n-[2-(7-metoksi-1-naftil]acetamida i postupci njihove izrade
NO20050738D0 (no) Ny fremgangsmate for syntesen av (7-metoksy-3,4-dihydro-1-naftalanyl)acetonitril og dens anvendelse i syntesen av agomelatin
EA200700574A3 (ru) Применение агомелатина в получении лекарственных средств, предназначенных для лечения генерализированного тревожного расстройства
BRPI0908675A2 (pt) "composto, composição farmacêutica, método de tratamento de um distúrbio relacionado à angiogênese e método de inibição da atividade do receptor do fator de crescimento epidérmico"
PT1240166E (pt) Inibidores n-[5-[[[5-alquil-2-oxazolil]tio}-2-tiazolil]-carboxamida de quinases dependentes de ciclina
JP2005514455A5 (sr)
KR890000416A (ko) N-(아릴-, 알릴옥시-, 아릴티오-아릴설피닐- 및 아릴설포닐- 알킬-n.n') v-(또는n',n')알킬아미노알킬 우레아 및 시아노구아니딘
JP2007503424A5 (sr)
FR2880023B1 (fr) Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
FR2806081B1 (fr) Procede d'hydrogenation de fonctions nitriles en fonctions amines
NO20042904L (no) Anvendelse av norepinefrin-reopptakinhibitorer for behandling av kognitiv svikt
RU2006105634A (ru) Производные-аминоамидов, применимые в качестве противовоспалительных агентов
NO20050739D0 (no) Ny fremgsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og dens anvendelse i syntesen av agomelatin
RU2002123337A (ru) Аминосульфонилбифенильные производные