HRP20110230T1 - Derivati alfa-aminoamida korisni u tretmanu poremećaja uzrokovanih ovisnošću - Google Patents
Derivati alfa-aminoamida korisni u tretmanu poremećaja uzrokovanih ovisnošću Download PDFInfo
- Publication number
- HRP20110230T1 HRP20110230T1 HR20110230T HRP20110230T HRP20110230T1 HR P20110230 T1 HRP20110230 T1 HR P20110230T1 HR 20110230 T HR20110230 T HR 20110230T HR P20110230 T HRP20110230 T HR P20110230T HR P20110230 T1 HRP20110230 T1 HR P20110230T1
- Authority
- HR
- Croatia
- Prior art keywords
- benzylamino
- propanamide
- fluorobenzyloxy
- methyl
- acetamide
- Prior art date
Links
- -1 3-fluorobenzyloxy Chemical group 0.000 claims abstract 19
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 claims abstract 11
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- AHMWTDOZNQOCAI-UHFFFAOYSA-N 2-(2-fluorophenyl)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]acetamide Chemical compound C=1C=CC=C(F)C=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC=C1F AHMWTDOZNQOCAI-UHFFFAOYSA-N 0.000 claims abstract 2
- SUAPKJRANCSCBZ-UHFFFAOYSA-N 2-(2-fluorophenyl)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]acetamide Chemical compound C=1C=CC=C(F)C=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 SUAPKJRANCSCBZ-UHFFFAOYSA-N 0.000 claims abstract 2
- UZUNVRHFYYUUJH-UHFFFAOYSA-N 2-(3-fluorophenyl)-2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]acetamide Chemical compound C=1C=CC(F)=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC=C1F UZUNVRHFYYUUJH-UHFFFAOYSA-N 0.000 claims abstract 2
- RBPLIQLNWOKJFW-UHFFFAOYSA-N 2-(3-fluorophenyl)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]acetamide Chemical compound C=1C=CC(F)=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 RBPLIQLNWOKJFW-UHFFFAOYSA-N 0.000 claims abstract 2
- JCIZOFILWMNHSB-UHFFFAOYSA-N 2-[[4-[(2-chlorophenyl)methoxy]phenyl]methylamino]-3-hydroxy-n-methylpropanamide Chemical compound C1=CC(CNC(CO)C(=O)NC)=CC=C1OCC1=CC=CC=C1Cl JCIZOFILWMNHSB-UHFFFAOYSA-N 0.000 claims abstract 2
- JYXHMCQBDXKJFB-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methyl-methylamino]-2-phenylacetamide Chemical compound C=1C=CC=CC=1C(C(N)=O)N(C)CC(C=C1)=CC=C1OCC1=CC=CC=C1F JYXHMCQBDXKJFB-UHFFFAOYSA-N 0.000 claims abstract 2
- KWMDBCXQGPZBCB-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]-2-phenylacetamide Chemical compound C=1C=CC=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC=C1F KWMDBCXQGPZBCB-UHFFFAOYSA-N 0.000 claims abstract 2
- ALWXTQNAGVDEMX-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]-3-hydroxy-n-methylpropanamide Chemical compound C1=CC(CNC(CO)C(=O)NC)=CC=C1OCC1=CC=CC=C1F ALWXTQNAGVDEMX-UHFFFAOYSA-N 0.000 claims abstract 2
- MODFUWXCNUBNKW-UHFFFAOYSA-N 2-[[4-[(3-chlorophenyl)methoxy]phenyl]methylamino]-2-(3-fluorophenyl)acetamide Chemical compound C=1C=CC(F)=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(Cl)=C1 MODFUWXCNUBNKW-UHFFFAOYSA-N 0.000 claims abstract 2
- UGAZPYAMTAVKDF-UHFFFAOYSA-N 2-[[4-[(3-chlorophenyl)methoxy]phenyl]methylamino]-2-phenylacetamide Chemical compound C=1C=CC=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(Cl)=C1 UGAZPYAMTAVKDF-UHFFFAOYSA-N 0.000 claims abstract 2
- XWCJJIVVFMWOQA-UHFFFAOYSA-N 2-[[4-[(3-cyanophenyl)methoxy]phenyl]methylamino]-3-hydroxy-n,2-dimethylpropanamide Chemical compound C1=CC(CNC(C)(CO)C(=O)NC)=CC=C1OCC1=CC=CC(C#N)=C1 XWCJJIVVFMWOQA-UHFFFAOYSA-N 0.000 claims abstract 2
- QNGQPQCXSOZZQG-UHFFFAOYSA-N 2-[[4-[(3-cyanophenyl)methoxy]phenyl]methylamino]-3-hydroxy-n-methylpropanamide Chemical compound C1=CC(CNC(CO)C(=O)NC)=CC=C1OCC1=CC=CC(C#N)=C1 QNGQPQCXSOZZQG-UHFFFAOYSA-N 0.000 claims abstract 2
- CYZUAXYGTDLCAW-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl-methylamino]-2-phenylacetamide Chemical compound C=1C=CC=CC=1C(C(N)=O)N(C)CC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 CYZUAXYGTDLCAW-UHFFFAOYSA-N 0.000 claims abstract 2
- HCSMEIBTXUDXFF-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]-2-phenylacetamide Chemical compound C=1C=CC=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 HCSMEIBTXUDXFF-UHFFFAOYSA-N 0.000 claims abstract 2
- HAQWBSZODRWECB-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]-3-hydroxy-n-methylpropanamide Chemical compound C1=CC(CNC(CO)C(=O)NC)=CC=C1OCC1=CC=CC(F)=C1 HAQWBSZODRWECB-UHFFFAOYSA-N 0.000 claims abstract 2
- AROJRYZKACVPEC-UHFFFAOYSA-N 2-phenyl-2-[(4-phenylmethoxyphenyl)methylamino]acetamide Chemical compound C=1C=CC=CC=1C(C(=O)N)NCC(C=C1)=CC=C1OCC1=CC=CC=C1 AROJRYZKACVPEC-UHFFFAOYSA-N 0.000 claims abstract 2
- PPNQCSNKEHUNCF-UHFFFAOYSA-N 3-hydroxy-n-methyl-2-[(4-phenylmethoxyphenyl)methylamino]propanamide Chemical compound C1=CC(CNC(CO)C(=O)NC)=CC=C1OCC1=CC=CC=C1 PPNQCSNKEHUNCF-UHFFFAOYSA-N 0.000 claims abstract 2
- HXJYSYZXIYIPLJ-UHFFFAOYSA-N n,3-dimethyl-2-[(4-phenylmethoxyphenyl)methylamino]butanamide Chemical compound C1=CC(CNC(C(=O)NC)C(C)C)=CC=C1OCC1=CC=CC=C1 HXJYSYZXIYIPLJ-UHFFFAOYSA-N 0.000 claims abstract 2
- 230000003287 optical effect Effects 0.000 claims abstract 2
- JEARPZLCKWXTFT-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]-2-methylpropanamide Chemical compound C1=CC(CNC(C)(C)C(N)=O)=CC=C1OCC1=CC=CC(F)=C1 JEARPZLCKWXTFT-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- BHJIBOFHEFDSAU-LBPRGKRZSA-N ralfinamide Chemical compound C1=CC(CN[C@@H](C)C(N)=O)=CC=C1OCC1=CC=CC=C1F BHJIBOFHEFDSAU-LBPRGKRZSA-N 0.000 claims 2
- NEMGRZFTLSKBAP-LBPRGKRZSA-N safinamide Chemical compound C1=CC(CN[C@@H](C)C(N)=O)=CC=C1OCC1=CC=CC(F)=C1 NEMGRZFTLSKBAP-LBPRGKRZSA-N 0.000 claims 2
- FVPIWKJMLINOHB-UHFFFAOYSA-N 2-[(4-benzylsulfanylphenyl)methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1SCC1=CC=CC=C1 FVPIWKJMLINOHB-UHFFFAOYSA-N 0.000 claims 1
- IEHDKRBHKAGVKZ-UHFFFAOYSA-N 2-[(4-phenylmethoxyphenyl)methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCC1=CC=CC=C1 IEHDKRBHKAGVKZ-UHFFFAOYSA-N 0.000 claims 1
- FAMQOOVSHKPIHZ-UHFFFAOYSA-N 2-[(4-thiophen-2-yloxyphenyl)methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OC1=CC=CS1 FAMQOOVSHKPIHZ-UHFFFAOYSA-N 0.000 claims 1
- BMPOJUVVLQGTSW-UHFFFAOYSA-N 2-[2-[4-[(3-chlorophenyl)methoxy]phenyl]ethylamino]propanamide Chemical compound C1=CC(CCNC(C)C(N)=O)=CC=C1OCC1=CC=CC(Cl)=C1 BMPOJUVVLQGTSW-UHFFFAOYSA-N 0.000 claims 1
- KYGCCDPEFAOIFA-UHFFFAOYSA-N 2-[[4-(3-phenylpropoxy)phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCCCC1=CC=CC=C1 KYGCCDPEFAOIFA-UHFFFAOYSA-N 0.000 claims 1
- DWHVPAYXTBJTSK-UHFFFAOYSA-N 2-[[4-(4-phenylbutoxy)phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCCCCC1=CC=CC=C1 DWHVPAYXTBJTSK-UHFFFAOYSA-N 0.000 claims 1
- OOTDSHVAUGIWQG-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]-1-pyrrolidin-1-ylpropan-1-one Chemical compound C1CCCN1C(=O)C(C)NCC(C=C1)=CC=C1OCC1=CC=CC=C1F OOTDSHVAUGIWQG-UHFFFAOYSA-N 0.000 claims 1
- ARKJBLYSUDCWBM-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]-2-methylpropanamide Chemical compound C1=CC(CNC(C)(C)C(N)=O)=CC=C1OCC1=CC=CC=C1F ARKJBLYSUDCWBM-UHFFFAOYSA-N 0.000 claims 1
- HYRAJPATCBQKCF-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]-3-hydroxypropanamide Chemical compound C1=CC(CNC(CO)C(=O)N)=CC=C1OCC1=CC=CC=C1F HYRAJPATCBQKCF-UHFFFAOYSA-N 0.000 claims 1
- WGXNRJBCPJAUOL-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]-n-methylpropanamide Chemical compound C1=CC(CNC(C)C(=O)NC)=CC=C1OCC1=CC=CC=C1F WGXNRJBCPJAUOL-UHFFFAOYSA-N 0.000 claims 1
- BHJIBOFHEFDSAU-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methoxy]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCC1=CC=CC=C1F BHJIBOFHEFDSAU-UHFFFAOYSA-N 0.000 claims 1
- CXWAISQTEMSTKD-UHFFFAOYSA-N 2-[[4-[(2-fluorophenyl)methylsulfanyl]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1SCC1=CC=CC=C1F CXWAISQTEMSTKD-UHFFFAOYSA-N 0.000 claims 1
- OBIIMYCBFFXWQB-UHFFFAOYSA-N 2-[[4-[(2-methoxyphenyl)methoxy]phenyl]methylamino]propanamide Chemical compound COC1=CC=CC=C1COC1=CC=C(CNC(C)C(N)=O)C=C1 OBIIMYCBFFXWQB-UHFFFAOYSA-N 0.000 claims 1
- JFADNUHMEURSIM-UHFFFAOYSA-N 2-[[4-[(3-chlorophenyl)methoxy]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCC1=CC=CC(Cl)=C1 JFADNUHMEURSIM-UHFFFAOYSA-N 0.000 claims 1
- BBMKDZGTJLFKTA-UHFFFAOYSA-N 2-[[4-[(3-cyanophenyl)methoxy]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCC1=CC=CC(C#N)=C1 BBMKDZGTJLFKTA-UHFFFAOYSA-N 0.000 claims 1
- MQLXKWISZJYEOW-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]-1-pyrrolidin-1-ylpropan-1-one Chemical compound C1CCCN1C(=O)C(C)NCC(C=C1)=CC=C1OCC1=CC=CC(F)=C1 MQLXKWISZJYEOW-UHFFFAOYSA-N 0.000 claims 1
- UTIKAYGNKRMHTP-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]-3-hydroxypropanamide Chemical compound C1=CC(CNC(CO)C(=O)N)=CC=C1OCC1=CC=CC(F)=C1 UTIKAYGNKRMHTP-UHFFFAOYSA-N 0.000 claims 1
- RLHPBZNGBNCVBL-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]-n-methylpropanamide Chemical compound C1=CC(CNC(C)C(=O)NC)=CC=C1OCC1=CC=CC(F)=C1 RLHPBZNGBNCVBL-UHFFFAOYSA-N 0.000 claims 1
- NEMGRZFTLSKBAP-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCC1=CC=CC(F)=C1 NEMGRZFTLSKBAP-UHFFFAOYSA-N 0.000 claims 1
- FZSPWFMNPPFIJE-UHFFFAOYSA-N 2-[[4-[(3-fluorophenyl)methylsulfanyl]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1SCC1=CC=CC(F)=C1 FZSPWFMNPPFIJE-UHFFFAOYSA-N 0.000 claims 1
- KAWCXZXQTSSDOQ-UHFFFAOYSA-N 2-[[4-[(4-fluorophenyl)methoxy]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCC1=CC=C(F)C=C1 KAWCXZXQTSSDOQ-UHFFFAOYSA-N 0.000 claims 1
- MBABTXVDELKRJL-UHFFFAOYSA-N 2-[[4-[2-(3-fluorophenyl)ethoxy]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1OCCC1=CC=CC(F)=C1 MBABTXVDELKRJL-UHFFFAOYSA-N 0.000 claims 1
- FMVVWKBPYPEPAF-UHFFFAOYSA-N 2-[[4-[2-(3-fluorophenyl)ethyl]phenyl]methylamino]propanamide Chemical compound C1=CC(CNC(C)C(N)=O)=CC=C1CCC1=CC=CC(F)=C1 FMVVWKBPYPEPAF-UHFFFAOYSA-N 0.000 claims 1
- DABZEFFZGNRXOC-UHFFFAOYSA-N 2-[methyl-[(4-phenylmethoxyphenyl)methyl]amino]propanamide Chemical compound C1=CC(CN(C)C(C)C(N)=O)=CC=C1OCC1=CC=CC=C1 DABZEFFZGNRXOC-UHFFFAOYSA-N 0.000 claims 1
- JMIJOQDPXHRPOI-UHFFFAOYSA-N 3-hydroxy-2-[(4-phenylmethoxyphenyl)methylamino]propanamide Chemical compound C1=CC(CNC(CO)C(=O)N)=CC=C1OCC1=CC=CC=C1 JMIJOQDPXHRPOI-UHFFFAOYSA-N 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims 1
- 229960000911 benserazide Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 229960004205 carbidopa Drugs 0.000 claims 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 claims 1
- 229960004502 levodopa Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 abstract 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Upotreba spojeva, naznačena time da su odabrani od sljedećih: 2-(4-benziloksibenzilamino)propanamid, 2-[4-(2-metoksibenziloksi)-benzilamino]propanamid, 2-[4-(2-fluorbenziloksi)-benzilamino]propanamid, (S)-(+)-2-[4-(2-fluorbenziloksi)-benzilamino]propanamid, (S)-(+)-2-[4-(3-fluorbenziloksi)-benzilamino]propanamid, 2-[4-(2-fluorbenziloksi)-benzilamino]-2-metil-propanamid, 2-[4-(2-fluorbenziloksi)-benzilamino]-N-metil-propanamid, N-{2-[4-(2-fluorbenziloksi)-benzilamino]}propionil-pirolidin, 2-[4-(3-metoksibenziloksi)-benzilamino] propanamid, 2-[4-(3-cijanobenziloksi)-benzilamino]propanamid, 2-[4-(3-fluorbenziloksi)-benzilamino]propanamid, 2-[4-(3-fluorbenziloksi)-benzilamino]-2- metil-propanamid, 2-[4-(3-fluorbenziloksi)-benzilamino]-N- metil-propanamid, N-{2-[4-(3-fluorbenziloksi)-benzilamino]}propionil-pirolidin, 2-[4-(4-fluorbenziloksi)-benzilamino]propanamid, 2-[4-(3-fluorbenziloksi)-benzilamino]- 2- metilpropanamid, 2-[4-(2-klorbenziloksi)-benzilamino] propanamid, 2-[4-(3-klorbenziloksi)-benzilamino]propanamid, 2-(4-benziloksibenzilamino)-3-hidroksi-propanamid, 2-[4-(2-fluorbenziloksi)-benzilamino]-3-hidroksi-propanamid, 2-[4-(3-fluorbenziloksi)-benzilamino]-3-hidroksi-propanamid, 2-(4-benziloksibenzilamino)-3-hidroksi-N-metil-propanamid, 2-[4-(2-fluorbenziloksi)-benzilamino]-3-hidroksi-N-metil-propanamid, 2-[4-(3-fluorbenziloksi)-benzilamino]-3-hidroksi-N-metil-propanamid, 2-[4-(2-klorbenziloksi)-benzilamino]-3- hidroksi-N-metil-propanamid, 2-[4-(3-cijanobenziloksi)-benzilamino]-3-hidroksi-N-metil-propanamid, 2-[4-(3-cijanobenziloksi)-benzilamino]-2-metil-3-hidroksi-N-metil-propanamid, 2-[4-(3-klorbenziloksi)-feniletilamino]propanamid, 2-{4-[2-(3-fluorfenil)-etiloksi] benzilamino}propanamid, 2-{4-[2-(3-fluorfenil)-etil] benzilamino}propanamid, 2-[N-(4-benziloksibenzil)-N-metilamino]propanamid, 2-{4-[(3-klorbenziloksi)-feniletil]-amino}propanamid, 2-[4-benziltiobenzilamino]propanamid, 2-[4-(2-fluorbenziltio)-benzilamino]propanamid, 2-[4-(3-fluorbenziltio)-benzilamino]propanamid, 2-[4-(3-fenilpropiloksi)-benzilamino]propanamid, 2-[4-(4-fenilbutiloksi)-benzilamino]propanamid, 2-[4-(5-fenilpentiloksi)-benzilamino]propanamid2-(4-benziloksibenzilamino)-3-fenil-N-metil-propanamid, 2-(4-benziloksibenzilamino)-3-metil-N-metil-butanamid, 2-(4-benziloksibenzilamino)-2-fenil-acetamid, 2-[4-(2-fluorbenziloksi)-benzilamino]-2-fenil-acetamid, 2-[4-(3-fluorbenziloksi)-benzilamino]-2-fenil-acetamid, 2-[4-(2-fluorbenziloksi)-benzil-N-metilamino]-2-fenil-acetamid, 2-[4-(3-fluorbenziloksi)-benzil-N-metilamino]-2-fenil-acetamid, 2-[4-(3-klorbenziloksi)-benzilamino]-2-fenil-acetamid, 2-[4-(2-fluorbenziloksi)-benzilamino]- 2-(2-fluorfenil)-acetamid, 2-[4-(2-fluorbenziloksi)-benzilamino]- 2-(3-fluorfenil)-acetamid, 2-[4-(3-fluorbenziloksi)-benzilamino]- 2-(2-fluorfenil)-acetamid, 2-[4-(3-fluorbenziloksi)-benzilamino]- 2-(3-fluorfenil)-acetamid, 2-[4-(3-klorbenziloksi)-benzilamino]- 2-(3-fluorfenil)-acetamid, 2-(4-(2-tieniloksi)-benzilamino)propanamid, ili optički izo
Claims (5)
1. Upotreba spojeva, naznačena time da su odabrani od sljedećih:
2-(4-benziloksibenzilamino)propanamid,
2-[4-(2-metoksibenziloksi)-benzilamino]propanamid,
2-[4-(2-fluorbenziloksi)-benzilamino]propanamid,
(S)-(+)-2-[4-(2-fluorbenziloksi)-benzilamino]propanamid,
(S)-(+)-2-[4-(3-fluorbenziloksi)-benzilamino]propanamid,
2-[4-(2-fluorbenziloksi)-benzilamino]-2-metil-propanamid,
2-[4-(2-fluorbenziloksi)-benzilamino]-N-metil-propanamid,
N-{2-[4-(2-fluorbenziloksi)-benzilamino]}propionil-pirolidin,
2-[4-(3-metoksibenziloksi)-benzilamino] propanamid,
2-[4-(3-cijanobenziloksi)-benzilamino]propanamid,
2-[4-(3-fluorbenziloksi)-benzilamino]propanamid,
2-[4-(3-fluorbenziloksi)-benzilamino]-2- metil-propanamid,
2-[4-(3-fluorbenziloksi)-benzilamino]-N- metil-propanamid,
N-{2-[4-(3-fluorbenziloksi)-benzilamino]}propionil-pirolidin,
2-[4-(4-fluorbenziloksi)-benzilamino]propanamid,
2-[4-(3-fluorbenziloksi)-benzilamino]- 2- metilpropanamid,
2-[4-(2-klorbenziloksi)-benzilamino] propanamid,
2-[4-(3-klorbenziloksi)-benzilamino]propanamid,
2-(4-benziloksibenzilamino)-3-hidroksi-propanamid,
2-[4-(2-fluorbenziloksi)-benzilamino]-3-hidroksi-propanamid,
2-[4-(3-fluorbenziloksi)-benzilamino]-3-hidroksi-propanamid,
2-(4-benziloksibenzilamino)-3-hidroksi-N-metil-propanamid,
2-[4-(2-fluorbenziloksi)-benzilamino]-3-hidroksi-N-metil-propanamid,
2-[4-(3-fluorbenziloksi)-benzilamino]-3-hidroksi-N-metil-propanamid,
2-[4-(2-klorbenziloksi)-benzilamino]-3- hidroksi-N-metil-propanamid,
2-[4-(3-cijanobenziloksi)-benzilamino]-3-hidroksi-N-metil-propanamid,
2-[4-(3-cijanobenziloksi)-benzilamino]-2-metil-3-hidroksi-N-metil-propanamid,
2-[4-(3-klorbenziloksi)-feniletilamino]propanamid,
2-{4-[2-(3-fluorfenil)-etiloksi] benzilamino}propanamid,
2-{4-[2-(3-fluorfenil)-etil] benzilamino}propanamid,
2-[N-(4-benziloksibenzil)-N-metilamino]propanamid,
2-{4-[(3-klorbenziloksi)-feniletil]-amino}propanamid,
2-[4-benziltiobenzilamino]propanamid,
2-[4-(2-fluorbenziltio)-benzilamino]propanamid,
2-[4-(3-fluorbenziltio)-benzilamino]propanamid,
2-[4-(3-fenilpropiloksi)-benzilamino]propanamid,
2-[4-(4-fenilbutiloksi)-benzilamino]propanamid,
2-[4-(5-fenilpentiloksi)-benzilamino]propanamid
2-(4-benziloksibenzilamino)-3-fenil-N-metil-propanamid,
2-(4-benziloksibenzilamino)-3-metil-N-metil-butanamid,
2-(4-benziloksibenzilamino)-2-fenil-acetamid,
2-[4-(2-fluorbenziloksi)-benzilamino]-2-fenil-acetamid,
2-[4-(3-fluorbenziloksi)-benzilamino]-2-fenil-acetamid,
2-[4-(2-fluorbenziloksi)-benzil-N-metilamino]-2-fenil-acetamid,
2-[4-(3-fluorbenziloksi)-benzil-N-metilamino]-2-fenil-acetamid,
2-[4-(3-klorbenziloksi)-benzilamino]-2-fenil-acetamid,
2-[4-(2-fluorbenziloksi)-benzilamino]- 2-(2-fluorfenil)-acetamid,
2-[4-(2-fluorbenziloksi)-benzilamino]- 2-(3-fluorfenil)-acetamid,
2-[4-(3-fluorbenziloksi)-benzilamino]- 2-(2-fluorfenil)-acetamid,
2-[4-(3-fluorbenziloksi)-benzilamino]- 2-(3-fluorfenil)-acetamid,
2-[4-(3-klorbenziloksi)-benzilamino]- 2-(3-fluorfenil)-acetamid,
2-(4-(2-tieniloksi)-benzilamino)propanamid,
ili optički izomeri, smjese i odgovarajuće farmaceutski prihvatljive soli, a za pripravu lijeka za tretman poremećaja uzrokovanih ovisnošću.
2. Upotreba spoja kao što je definirano u patentnom zahtjevu 1, naznačena time da spoj jest (S)-(+)-2-[4-(2-fluorbenziloksi)-benzilamino]propanamid.
3. Upotreba spoja kao što je definirano u patentnom zahtjevu 1, naznačena time da spoj jest (S)-(+)-2-[4-(3-fluorbenziloksi)-benzilamino]propanamid.
4. Upotreba spojeva kao što je definirano u bilo kojem od patentnih zahtjeva 1 do 3, naznačena time da je u kombinaciji s agonistom dopamina i/ili sa sljedećim: levodopa, karbidopa, benserazidd te njihova kombinacija.
5. Upotreba spojeva kao što je definirano u bilo kojem od patentnih zahtjeva 1 do 3, naznačena time da se rečeni lijek daje u dozi koja je u rasponu od oko 0.3 do oko 100 mg/kg tjelesne mase po danu.
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EP04009532A EP1588704A1 (en) | 2004-04-22 | 2004-04-22 | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
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HR20080593T HRP20080593T3 (hr) | 2004-04-22 | 2008-11-18 | Derivati alfa-aminoamida koji su korisni u tretmanu sindroma nemirnih nogu |
HR20110230T HRP20110230T1 (hr) | 2004-04-22 | 2011-03-30 | Derivati alfa-aminoamida korisni u tretmanu poremećaja uzrokovanih ovisnošću |
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Country Status (26)
Country | Link |
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US (2) | US8445513B2 (hr) |
EP (3) | EP1588704A1 (hr) |
JP (1) | JP5020069B2 (hr) |
KR (2) | KR101195819B1 (hr) |
CN (1) | CN1942179B (hr) |
AT (2) | ATE494890T1 (hr) |
AU (1) | AU2005235428B2 (hr) |
BR (2) | BRPI0509976B8 (hr) |
CA (1) | CA2563674C (hr) |
CY (2) | CY1108494T1 (hr) |
DE (2) | DE602005009162D1 (hr) |
DK (2) | DK1737438T3 (hr) |
ES (2) | ES2357559T3 (hr) |
HK (1) | HK1099216A1 (hr) |
HR (2) | HRP20080593T3 (hr) |
IL (1) | IL178732A (hr) |
ME (2) | ME02324B (hr) |
MX (1) | MXPA06012163A (hr) |
NO (2) | NO337900B1 (hr) |
NZ (1) | NZ550664A (hr) |
PL (2) | PL1900362T3 (hr) |
PT (2) | PT1737438E (hr) |
RS (2) | RS51791B (hr) |
RU (1) | RU2403030C2 (hr) |
SI (2) | SI1737438T1 (hr) |
WO (1) | WO2005102300A1 (hr) |
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2004
- 2004-04-22 EP EP04009532A patent/EP1588704A1/en not_active Withdrawn
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2005
- 2005-04-19 PL PL07022078T patent/PL1900362T3/pl unknown
- 2005-04-19 EP EP07022078A patent/EP1900362B1/en active Active
- 2005-04-19 DE DE602005009162T patent/DE602005009162D1/de active Active
- 2005-04-19 ME MEP-2016-18A patent/ME02324B/me unknown
- 2005-04-19 EP EP05736365A patent/EP1737438B1/en active Active
- 2005-04-19 DE DE602005025941T patent/DE602005025941D1/de active Active
- 2005-04-19 DK DK05736365T patent/DK1737438T3/da active
- 2005-04-19 BR BRPI0509976A patent/BRPI0509976B8/pt active IP Right Grant
- 2005-04-19 RU RU2006137079/15A patent/RU2403030C2/ru active
- 2005-04-19 WO PCT/EP2005/004166 patent/WO2005102300A1/en active Application Filing
- 2005-04-19 PL PL05736365T patent/PL1737438T3/pl unknown
- 2005-04-19 ES ES07022078T patent/ES2357559T3/es active Active
- 2005-04-19 SI SI200530430T patent/SI1737438T1/sl unknown
- 2005-04-19 AT AT07022078T patent/ATE494890T1/de active
- 2005-04-19 BR BR122020004541-8A patent/BR122020004541B1/pt active IP Right Grant
- 2005-04-19 NZ NZ550664A patent/NZ550664A/en unknown
- 2005-04-19 US US11/578,988 patent/US8445513B2/en active Active
- 2005-04-19 AU AU2005235428A patent/AU2005235428B2/en active Active
- 2005-04-19 JP JP2007508825A patent/JP5020069B2/ja active Active
- 2005-04-19 KR KR1020067021748A patent/KR101195819B1/ko active IP Right Grant
- 2005-04-19 AT AT05736365T patent/ATE405256T1/de active
- 2005-04-19 PT PT05736365T patent/PT1737438E/pt unknown
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- 2005-04-19 KR KR1020127003440A patent/KR101238377B1/ko active IP Right Grant
- 2005-04-19 CA CA2563674A patent/CA2563674C/en active Active
- 2005-04-19 SI SI200531224T patent/SI1900362T1/sl unknown
- 2005-04-19 MX MXPA06012163A patent/MXPA06012163A/es active IP Right Grant
- 2005-04-19 ES ES05736365T patent/ES2313330T3/es active Active
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- 2005-04-19 DK DK07022078.5T patent/DK1900362T3/da active
- 2005-04-19 CN CN2005800118905A patent/CN1942179B/zh active Active
- 2005-04-19 RS RSP-2008/0531A patent/RS50667B/sr unknown
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2006
- 2006-10-19 NO NO20064732A patent/NO337900B1/no unknown
- 2006-10-19 IL IL178732A patent/IL178732A/en active IP Right Grant
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2007
- 2007-06-13 HK HK07106351.3A patent/HK1099216A1/xx unknown
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2008
- 2008-11-10 CY CY20081101279T patent/CY1108494T1/el unknown
- 2008-11-18 HR HR20080593T patent/HRP20080593T3/hr unknown
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2011
- 2011-03-04 CY CY20111100255T patent/CY1111656T1/el unknown
- 2011-03-30 HR HR20110230T patent/HRP20110230T1/hr unknown
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2013
- 2013-03-15 US US13/835,445 patent/US8697738B2/en active Active
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2015
- 2015-07-27 NO NO20150971A patent/NO338870B1/no unknown
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