DK1737438T3 - Alfa-aminoamidderivater til behandling af syndromet restless legs - Google Patents

Alfa-aminoamidderivater til behandling af syndromet restless legs

Info

Publication number
DK1737438T3
DK1737438T3 DK05736365T DK05736365T DK1737438T3 DK 1737438 T3 DK1737438 T3 DK 1737438T3 DK 05736365 T DK05736365 T DK 05736365T DK 05736365 T DK05736365 T DK 05736365T DK 1737438 T3 DK1737438 T3 DK 1737438T3
Authority
DK
Denmark
Prior art keywords
treatment
alpha
restless legs
legs syndrome
aminoamide derivatives
Prior art date
Application number
DK05736365T
Other languages
Danish (da)
English (en)
Inventor
Claudia Besana
Elena Barbanti
Florian Thaler
Ruggero Fariello
Patricia Salvati
Luca Benatti
Emanuela Izzo
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Application granted granted Critical
Publication of DK1737438T3 publication Critical patent/DK1737438T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK05736365T 2004-04-22 2005-04-19 Alfa-aminoamidderivater til behandling af syndromet restless legs DK1737438T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04009532A EP1588704A1 (en) 2004-04-22 2004-04-22 Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
PCT/EP2005/004166 WO2005102300A1 (en) 2004-04-22 2005-04-19 α-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF RESTLESS LEGS SYNDROME AND ADDICTIVE DISORDERS

Publications (1)

Publication Number Publication Date
DK1737438T3 true DK1737438T3 (da) 2008-12-08

Family

ID=34924693

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05736365T DK1737438T3 (da) 2004-04-22 2005-04-19 Alfa-aminoamidderivater til behandling af syndromet restless legs
DK07022078.5T DK1900362T3 (da) 2004-04-22 2005-04-19 Alfa-aminoamidderivater anvendelige ved behandlingen af addiktive forstyrrelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK07022078.5T DK1900362T3 (da) 2004-04-22 2005-04-19 Alfa-aminoamidderivater anvendelige ved behandlingen af addiktive forstyrrelser

Country Status (26)

Country Link
US (2) US8445513B2 (hr)
EP (3) EP1588704A1 (hr)
JP (1) JP5020069B2 (hr)
KR (2) KR101195819B1 (hr)
CN (1) CN1942179B (hr)
AT (2) ATE405256T1 (hr)
AU (1) AU2005235428B2 (hr)
BR (2) BR122020004541B1 (hr)
CA (1) CA2563674C (hr)
CY (2) CY1108494T1 (hr)
DE (2) DE602005009162D1 (hr)
DK (2) DK1737438T3 (hr)
ES (2) ES2313330T3 (hr)
HK (1) HK1099216A1 (hr)
HR (2) HRP20080593T3 (hr)
IL (1) IL178732A (hr)
ME (2) ME01219B (hr)
MX (1) MXPA06012163A (hr)
NO (2) NO337900B1 (hr)
NZ (1) NZ550664A (hr)
PL (2) PL1900362T3 (hr)
PT (2) PT1737438E (hr)
RS (2) RS50667B (hr)
RU (1) RU2403030C2 (hr)
SI (2) SI1737438T1 (hr)
WO (1) WO2005102300A1 (hr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
DK1423168T3 (da) * 2001-09-03 2006-05-15 Newron Pharm Spa Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
WO2005018627A1 (en) * 2003-08-25 2005-03-03 Newron Pharmaceuticals, Spa Alpha-aminoamide derivatives useful as anti-inflammatory agents
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
ES2347581T3 (es) * 2004-09-10 2010-11-02 Newron Pharmaceuticals S.P.A. Uso de (r)-(halobenciloxi)bencilamino-propanamidas como moduladores selectivos del canal de sodio y/o calcio.
JP2008519811A (ja) * 2004-11-10 2008-06-12 オリオン コーポレーション 下肢静止不能症候群の治療
BRPI0620239B8 (pt) 2005-12-22 2021-05-25 Newron Pharm Spa derivados de 2-feniletilamino.
AU2007235517B2 (en) * 2006-04-03 2013-01-31 Teva Pharmaceutical Industries, Ltd. Use of rasagiline for the treatment of Restless Legs Syndrome
EP1870097A1 (en) 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
BRPI0712936B8 (pt) * 2006-06-19 2021-05-25 Newron Pharm Spa processo para a produção de 2-[4-(3- e 2-fluorbenziloxi)benzila-mino]propanamidas
GB0706630D0 (en) * 2007-04-04 2007-05-16 Glaxo Group Ltd Novel compounds
AU2008261325B2 (en) 2007-06-15 2012-12-06 Newron Pharmaceuticals S.P.A. Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
AU2008334778B2 (en) * 2007-12-11 2013-05-23 Newron Pharmaceuticals S.P.A. Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree
BRPI0821026A2 (pt) * 2007-12-19 2015-06-16 Newron Pharmaceutical S P A Derivados de alfa-minoamidas úteis no tratamento de transtornos psiquiátricos
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
WO2011134763A1 (en) 2010-04-27 2011-11-03 Newron Pharmaceuticals S.P.A. Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers
US11278651B2 (en) * 2018-10-17 2022-03-22 Gambro Lundia Ab Membrane and device for treating restless leg syndrome
CN114667963B (zh) * 2020-12-24 2024-04-26 中国科学院脑科学与智能技术卓越创新中心 一种非人灵长类动物药物成瘾性评估的装置

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GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4935429A (en) * 1985-10-25 1990-06-19 Dackis Charles A Method of treating psychostimulant addiction
CA1336169C (en) * 1988-03-01 1995-07-04 Walther Birkmayer Agent for treatment of parkinson's disease
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5221536A (en) * 1990-05-07 1993-06-22 Alza Corporation Dosage form indicated for the management of abnormal posture, tremor and involuntary movement
EP0520325A1 (de) * 1991-06-28 1992-12-30 F.Hoffmann-La Roche & Co. Aktiengesellschaft Verwendung von Monoaminoxidase-B-Hemmern zur Verhütung und Behandlung von Entzugserscheinungen nach Alkohol- und Drogenmissbrauch
GB9306886D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
IL111240A (en) * 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
JPH11505828A (ja) * 1995-05-26 1999-05-25 ファイザー・インコーポレーテッド パーキンソン症候群の治療用の選択的ｎｍｄａアンタゴニスト含有組合せ
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JP2005060370A (ja) * 2003-07-25 2005-03-10 Kyowa Hakko Kogyo Co Ltd 医薬組成物
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EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Also Published As

Publication number Publication date
ES2313330T3 (es) 2009-03-01
EP1900362A3 (en) 2009-04-01
EP1900362A2 (en) 2008-03-19
KR20120028399A (ko) 2012-03-22
DE602005025941D1 (de) 2011-02-24
IL178732A0 (en) 2007-05-15
MXPA06012163A (es) 2007-01-17
RU2006137079A (ru) 2008-04-27
BR122020004541B1 (pt) 2021-11-09
SI1900362T1 (sl) 2011-03-31
ATE494890T1 (de) 2011-01-15
AU2005235428A1 (en) 2005-11-03
CA2563674A1 (en) 2005-11-03
RU2403030C2 (ru) 2010-11-10
PT1900362E (pt) 2011-03-09
US8697738B2 (en) 2014-04-15
ME02324B (me) 2016-06-20
RS50667B (sr) 2010-06-30
BRPI0509976A (pt) 2007-10-16
PL1900362T3 (pl) 2011-06-30
WO2005102300A1 (en) 2005-11-03
NO337900B1 (no) 2016-07-04
HK1099216A1 (en) 2007-08-10
NZ550664A (en) 2010-08-27
JP5020069B2 (ja) 2012-09-05
ATE405256T1 (de) 2008-09-15
CY1108494T1 (el) 2014-04-09
US20130217747A1 (en) 2013-08-22
CA2563674C (en) 2012-12-18
BRPI0509976B1 (pt) 2020-10-06
EP1588704A1 (en) 2005-10-26
EP1737438B1 (en) 2008-08-20
RS51791B (en) 2011-12-31
ES2357559T3 (es) 2011-04-27
AU2005235428B2 (en) 2010-03-18
PT1737438E (pt) 2008-12-22
KR20070042914A (ko) 2007-04-24
NO338870B1 (no) 2016-10-31
CN1942179B (zh) 2010-08-11
US8445513B2 (en) 2013-05-21
DE602005009162D1 (de) 2008-10-02
EP1737438A1 (en) 2007-01-03
IL178732A (en) 2013-01-31
SI1737438T1 (sl) 2008-12-31
US20070203182A1 (en) 2007-08-30
NO20150971L (no) 2006-11-22
BRPI0509976B8 (pt) 2021-05-25
CY1111656T1 (el) 2015-10-07
NO20064732L (no) 2006-11-22
PL1737438T3 (pl) 2009-01-30
KR101238377B1 (ko) 2013-03-04
EP1900362B1 (en) 2011-01-12
DK1900362T3 (da) 2011-05-09
JP2007533691A (ja) 2007-11-22
HRP20110230T1 (hr) 2011-04-30
KR101195819B1 (ko) 2012-11-05
HRP20080593T3 (hr) 2008-12-31
ME01219B (me) 2013-06-20
CN1942179A (zh) 2007-04-04

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