RS49526B - Derivati triazola korisni u terapiji - Google Patents

Derivati triazola korisni u terapiji

Info

Publication number
RS49526B
RS49526B YU2997A YU2997A RS49526B RS 49526 B RS49526 B RS 49526B YU 2997 A YU2997 A YU 2997A YU 2997 A YU2997 A YU 2997A RS 49526 B RS49526 B RS 49526B
Authority
RS
Serbia
Prior art keywords
phenyl substituted
therapy
halogen
group
triazole derivatives
Prior art date
Application number
YU2997A
Other languages
English (en)
Inventor
Stuart Green
Peter T. Stephenson
Charles W. Murtiashaw
Original Assignee
Pfizer Research And Development Company N.V./S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Research And Development Company N.V./S.A. filed Critical Pfizer Research And Development Company N.V./S.A.
Publication of YU2997A publication Critical patent/YU2997A/sh
Publication of RS49526B publication Critical patent/RS49526B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Jedinjenje formule I: R1-OP(O)(OH)2 (I) gde R1 predstavlja ne-hidroksi deo antifungalnog jedinjenja triazola koje sadrži tercijarnu hidroksi grupu; ili njegova farmaceutski prihvatljiva so. 2. Jedinjenje prema zahevu 1, naznačeno time, što je R1 grupa formule Ia: gde R2 predstavlja fenil supstituisan jednim ili više halogenih atoma; R3 predstavlja H ili CH3; R3a predstavlja H, ili zajedno sa R3 može predstavljati =CH2 i R4 predstavlja 5- ili 6-člani heterociklični prsten koji sadrži azot, koji je po potrebi supstituisan jednom ili više grupa odabranih od halogena, =O, fenila supstituisanog jednom grupom odabranom od CN i (C6H4)-OCH2CF2CHF2 ili CH=CH-(C6H4)-OCH2CF2CHF2 ili fenil supstituisan jednom ili više grupa odabranih od halogena i metilpirazolila. Prijava sadrži još 5 zavisnih patentnih zahteva, 6 nezavisnih patentnih zahteva i 1 zavisan patentni zahtev.
YU2997A 1996-02-02 1997-01-28 Derivati triazola korisni u terapiji RS49526B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9602080.5A GB9602080D0 (en) 1996-02-02 1996-02-02 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
YU2997A YU2997A (sh) 2000-10-30
RS49526B true RS49526B (sr) 2006-12-15

Family

ID=10787975

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2997A RS49526B (sr) 1996-02-02 1997-01-28 Derivati triazola korisni u terapiji

Country Status (43)

Country Link
US (4) US6790957B2 (sr)
EP (1) EP0880533B1 (sr)
JP (1) JP2959846B2 (sr)
KR (1) KR100283546B1 (sr)
CN (1) CN1085213C (sr)
AP (1) AP678A (sr)
AT (1) ATE219089T1 (sr)
AU (1) AU709781B2 (sr)
BG (1) BG63946B1 (sr)
BR (1) BR9707257A (sr)
CA (1) CA2240777C (sr)
CO (1) CO4761066A1 (sr)
CZ (1) CZ291431B6 (sr)
DE (1) DE69713284T2 (sr)
DK (1) DK0880533T3 (sr)
DZ (1) DZ2172A1 (sr)
ES (1) ES2175336T3 (sr)
GB (1) GB9602080D0 (sr)
GT (1) GT199700016A (sr)
HK (1) HK1018217A1 (sr)
HN (1) HN1997000012A (sr)
HR (1) HRP970063B1 (sr)
HU (1) HU226133B1 (sr)
ID (1) ID15858A (sr)
IL (3) IL124865A (sr)
IS (1) IS1995B (sr)
MY (1) MY116849A (sr)
NO (1) NO323771B1 (sr)
NZ (1) NZ330654A (sr)
OA (1) OA10711A (sr)
PL (1) PL187237B1 (sr)
PT (1) PT880533E (sr)
RS (1) RS49526B (sr)
RU (1) RU2176244C2 (sr)
SA (1) SA97170578B1 (sr)
SI (1) SI0880533T1 (sr)
SK (1) SK283136B6 (sr)
TN (1) TNSN97023A1 (sr)
TR (1) TR199801440T2 (sr)
TW (1) TW434247B (sr)
UA (1) UA46828C2 (sr)
WO (1) WO1997028169A1 (sr)
ZA (1) ZA97826B (sr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
GB9713149D0 (en) 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
DE19751525C2 (de) 1997-11-20 2003-02-13 Bat Cigarettenfab Gmbh Verfahren und Vorrichtung zur Regelung der Ausgangsfeuchte von Tabak
US6265584B1 (en) 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
WO2000030655A1 (en) * 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6235728B1 (en) 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
KR20010050557A (ko) 1999-09-29 2001-06-15 타이도 나오카타 아졸 유도체 또는 그의 염
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) * 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
US7540402B2 (en) * 2001-06-29 2009-06-02 Kva, Inc. Method for controlling weld metal microstructure using localized controlled cooling of seam-welded joints
US7323572B2 (en) 2002-07-16 2008-01-29 Pfizer Inc Process for controlling the hydrate mix of a compound
EP1646284A4 (en) * 2003-07-18 2008-09-24 Rhode Island Education AZOL DERIVATIVES AND METHOD FOR THEIR PREPARATION
JP2008504228A (ja) * 2004-03-24 2008-02-14 ファスジェン・リミテッド・ライアビリティ・カンパニー Ａｍｐ活性化プロテインキナーゼの薬理学的阻害による新規神経保護方法
CN1303073C (zh) * 2005-05-31 2007-03-07 中国人民解放军第二军医大学 取代三唑酮苄胺三唑醇类抗真菌化合物及其制备方法
EP1964843B1 (en) * 2005-12-20 2013-08-28 Eisai R&D Management Co., Ltd. Process for production of water-soluble azole prodrug
CN101346390B (zh) 2005-12-27 2011-11-09 大塚制药株式会社 水溶性苯并氮杂*化合物及其药物组合物
DE602007009489D1 (de) 2006-02-22 2010-11-11 Eisai R&D Man Co Ltd Stabilisierte pharmazeutische zusammensetzung
KR20110004852A (ko) * 2008-04-15 2011-01-14 쉐링 코포레이션 포사코나졸 및 ｈｐｍｃａｓ를 바람직하게 포함하는 고체 분산액 중의 경구 약제학적 조성물
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
WO2011064558A2 (en) 2009-11-30 2011-06-03 Cipla Limited Pharmaceutical composition
EA032840B8 (ru) 2011-06-22 2020-06-18 Вайоми Терапеутикс Лимитед Пролекарства на основе конъюгатов противогрибковых агентов и их применение
EP2561863A1 (en) 2011-08-22 2013-02-27 Farmaprojects, S.A.U. Pharmaceutical compositions comprising voriconazole
IN2014DN06792A (sr) 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
CN104507309B (zh) * 2012-03-19 2017-05-03 奇达拉治疗公司 用于棘白菌素类化合物的给药方案
CN103864844B (zh) * 2012-12-09 2016-10-05 正大天晴药业集团股份有限公司 一种福司氟康唑的制备方法
CN103304600B (zh) * 2013-03-04 2018-05-25 陕西合成药业股份有限公司 一种伏立康唑磷酸酯三水合物及其制备方法和用途
CA2904670A1 (en) 2013-03-14 2014-09-13 Fresenius Kabi Usa, Llc Voriconazole formulations
RU2719579C2 (ru) * 2013-03-14 2020-04-21 Сидара Терапьютикс, Инк. Режимы дозирования для соединений класса эхинокандинов
KR101814895B1 (ko) 2013-06-04 2018-01-04 바이옴 바이오사이언스 피브이티. 엘티디. 코팅된 입자 및 이를 포함하는 조성물
CN103524560A (zh) * 2013-09-28 2014-01-22 陕西合成药业有限公司 伏立康磷酸酯钠水合物及其多晶型
CN104650140B (zh) * 2013-11-18 2017-11-10 正大天晴药业集团股份有限公司 一种高纯度福司氟康唑的制备方法
MX2016009898A (es) 2014-01-29 2017-01-23 Vyome Biosciences Pvt Ltd Tratamientos para acne resistente.
CN104860992A (zh) * 2014-02-25 2015-08-26 陕西合成药业股份有限公司 一种高纯度福司氟康唑制备方法
CN105985377A (zh) * 2015-02-09 2016-10-05 陕西合成药业股份有限公司 一种福司氟康唑盐水合物及其制备方法
CN106279280A (zh) * 2015-05-25 2017-01-04 西藏卫信康医药股份有限公司 一种化合物及其制备方法和应用
CN106518922A (zh) * 2015-09-12 2017-03-22 陕西合成药业股份有限公司 一种三唑类化合物及其制备方法和用途
CN106546668A (zh) * 2015-09-22 2017-03-29 陕西合成药业股份有限公司 一种分离福司氟康唑或其药用盐有关物质的hplc方法
CN105237569B (zh) * 2015-10-21 2017-07-25 西南科技大学 一种制备2，4‑二氟‑α，α‑二（1氢‑1，2，4‑三唑‑1‑基甲基）苯甲醇磷酸二苄酯的合成方法
CN105753902B (zh) * 2016-04-11 2017-08-25 浙江诚意药业股份有限公司 一种福司氟康唑的制备方法
CN108676031A (zh) * 2018-05-29 2018-10-19 重庆威鹏药业有限公司 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用
CN111171075B (zh) * 2020-04-03 2022-07-12 北京四环生物制药有限公司 一种福司氟康唑的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2099818A (en) * 1981-06-06 1982-12-15 Pfizer Ltd Triazoles
US4528284A (en) * 1982-10-15 1985-07-09 Ciba-Geigy Corporation Fungicidal 2-(azolylmethyl-1'-yl)-2-aryl-2-(cyano, alkoxycarbonyl, alkylthiocarbonyl and aminocarbonyl)-2-phosphorus acid esters
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5278175A (en) * 1990-02-02 1994-01-11 Pfizer Inc. Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
TW211006B (sr) * 1990-08-24 1993-08-11 Mochida Pharm Co Ltd
TW218017B (sr) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
PL181947B1 (en) * 1994-01-24 2001-10-31 Janssen Pharmaceutica Nv Water-soluble azole-type antimycotic agents
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
HUT74735A (en) * 1994-02-25 1997-02-28 Takeda Chemical Industries Ltd Injectable emulsion composition containing antifungal triazole derivatives and process for producing it
GB9512961D0 (en) * 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
FR2741061B1 (fr) * 1995-11-13 1998-03-20 Alcatel Fibres Optiques Procede de fabrication d'une fibre optique monomode et amplificateur optique utilisant une telle fibre
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US5767977A (en) * 1996-12-19 1998-06-16 Hewlett-Packard Co. Method and apparatus for a carriage latch and power cord lock-out system for an optical scanner

Also Published As

Publication number Publication date
NO983560L (no) 1998-08-03
HRP970063A2 (en) 1998-06-30
SK283136B6 (sk) 2003-03-04
US6790957B2 (en) 2004-09-14
NO323771B1 (no) 2007-07-02
OA10711A (en) 2001-06-04
IL124865A (en) 2002-03-10
AU1598597A (en) 1997-08-22
IS4785A (is) 1998-06-26
HUP9900949A2 (hu) 2001-05-28
UA46828C2 (uk) 2002-06-17
KR100283546B1 (ko) 2001-04-02
TR199801440T2 (xx) 1998-10-21
BG63946B1 (bg) 2003-07-31
CN1210540A (zh) 1999-03-10
HRP970063B1 (en) 2001-12-31
TW434247B (en) 2001-05-16
DZ2172A1 (fr) 2002-12-01
HN1997000012A (es) 1997-06-26
HUP9900949A3 (en) 2001-08-28
GT199700016A (es) 1998-07-24
IS1995B (is) 2005-03-15
MY116849A (en) 2004-04-30
YU2997A (sh) 2000-10-30
EP0880533B1 (en) 2002-06-12
BG102603A (en) 1999-03-31
DE69713284T2 (de) 2003-03-27
DE69713284D1 (de) 2002-07-18
US20070027115A1 (en) 2007-02-01
AU709781B2 (en) 1999-09-09
AP9700923A0 (en) 1997-01-31
GB9602080D0 (en) 1996-04-03
KR19990082233A (ko) 1999-11-25
CA2240777C (en) 2002-06-11
CN1085213C (zh) 2002-05-22
ES2175336T3 (es) 2002-11-16
IL133135A (en) 2003-07-06
JPH10512599A (ja) 1998-12-02
AP678A (en) 1998-09-28
TNSN97023A1 (fr) 2005-03-15
JP2959846B2 (ja) 1999-10-06
SI0880533T1 (en) 2002-08-31
SK102298A3 (en) 1999-08-06
CA2240777A1 (en) 1997-08-07
US20050130940A1 (en) 2005-06-16
HK1018217A1 (en) 1999-12-17
RU2176244C2 (ru) 2001-11-27
CZ291431B6 (cs) 2003-03-12
ID15858A (id) 1997-08-14
NZ330654A (en) 1999-08-30
US20040236105A1 (en) 2004-11-25
EP0880533A1 (en) 1998-12-02
IL124865A0 (en) 1999-01-26
WO1997028169A1 (en) 1997-08-07
US20030144250A1 (en) 2003-07-31
DK0880533T3 (da) 2002-07-15
US6977302B2 (en) 2005-12-20
SA97170578B1 (ar) 2006-01-28
BR9707257A (pt) 1999-04-06
PL328436A1 (en) 1999-02-01
ATE219089T1 (de) 2002-06-15
CZ242098A3 (cs) 1999-05-12
CO4761066A1 (es) 1999-04-27
PL187237B1 (pl) 2004-06-30
PT880533E (pt) 2002-09-30
NO983560D0 (no) 1998-08-03
HU226133B1 (en) 2008-05-28
IL133135A0 (en) 2001-03-19
ZA97826B (en) 1998-07-31

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