HRP970063B1 - Triazole derivatives useful in therapy - Google Patents

Triazole derivatives useful in therapy

Info

Publication number
HRP970063B1
HRP970063B1 HR970063A HRP970063A HRP970063B1 HR P970063 B1 HRP970063 B1 HR P970063B1 HR 970063 A HR970063 A HR 970063A HR P970063 A HRP970063 A HR P970063A HR P970063 B1 HRP970063 B1 HR P970063B1
Authority
HR
Croatia
Prior art keywords
therapy
triazole derivatives
derivatives useful
useful
triazole
Prior art date
Application number
HR970063A
Other languages
English (en)
Inventor
Stuart Green
Peter T Stephenson
Charles W Murtiashaw
Original Assignee
Pfizer Res And Dev Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res And Dev Company filed Critical Pfizer Res And Dev Company
Publication of HRP970063A2 publication Critical patent/HRP970063A2/xx
Publication of HRP970063B1 publication Critical patent/HRP970063B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR970063A 1996-02-02 1997-01-31 Triazole derivatives useful in therapy HRP970063B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9602080.5A GB9602080D0 (en) 1996-02-02 1996-02-02 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
HRP970063A2 HRP970063A2 (en) 1998-06-30
HRP970063B1 true HRP970063B1 (en) 2001-12-31

Family

ID=10787975

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970063A HRP970063B1 (en) 1996-02-02 1997-01-31 Triazole derivatives useful in therapy

Country Status (43)

Country Link
US (4) US6790957B2 (xx)
EP (1) EP0880533B1 (xx)
JP (1) JP2959846B2 (xx)
KR (1) KR100283546B1 (xx)
CN (1) CN1085213C (xx)
AP (1) AP678A (xx)
AT (1) ATE219089T1 (xx)
AU (1) AU709781B2 (xx)
BG (1) BG63946B1 (xx)
BR (1) BR9707257A (xx)
CA (1) CA2240777C (xx)
CO (1) CO4761066A1 (xx)
CZ (1) CZ291431B6 (xx)
DE (1) DE69713284T2 (xx)
DK (1) DK0880533T3 (xx)
DZ (1) DZ2172A1 (xx)
ES (1) ES2175336T3 (xx)
GB (1) GB9602080D0 (xx)
GT (1) GT199700016A (xx)
HK (1) HK1018217A1 (xx)
HN (1) HN1997000012A (xx)
HR (1) HRP970063B1 (xx)
HU (1) HU226133B1 (xx)
ID (1) ID15858A (xx)
IL (3) IL124865A (xx)
IS (1) IS1995B (xx)
MY (1) MY116849A (xx)
NO (1) NO323771B1 (xx)
NZ (1) NZ330654A (xx)
OA (1) OA10711A (xx)
PL (1) PL187237B1 (xx)
PT (1) PT880533E (xx)
RS (1) RS49526B (xx)
RU (1) RU2176244C2 (xx)
SA (1) SA97170578B1 (xx)
SI (1) SI0880533T1 (xx)
SK (1) SK283136B6 (xx)
TN (1) TNSN97023A1 (xx)
TR (1) TR199801440T2 (xx)
TW (1) TW434247B (xx)
UA (1) UA46828C2 (xx)
WO (1) WO1997028169A1 (xx)
ZA (1) ZA97826B (xx)

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US6265584B1 (en) 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
AU1915500A (en) 1998-11-20 2000-06-13 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6235728B1 (en) 1999-02-19 2001-05-22 Bristol-Myers Squibb Company Water-soluble prodrugs of azole compounds
KR20010050557A (ko) * 1999-09-29 2001-06-15 타이도 나오카타 아졸 유도체 또는 그의 염
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) * 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
US7540402B2 (en) * 2001-06-29 2009-06-02 Kva, Inc. Method for controlling weld metal microstructure using localized controlled cooling of seam-welded joints
US7323572B2 (en) 2002-07-16 2008-01-29 Pfizer Inc Process for controlling the hydrate mix of a compound
WO2005006860A2 (en) * 2003-07-18 2005-01-27 The Board Of Governors For Higher Education State Of Rhode Island And Providence Plantations Azole derivatives and methods for making the same
BRPI0509085A (pt) * 2004-03-24 2007-08-21 Fasgen Llc processo de neuroproteção através da inibição farmacológica da proteìna quinase ativada por amp
CN1303073C (zh) * 2005-05-31 2007-03-07 中国人民解放军第二军医大学 取代三唑酮苄胺三唑醇类抗真菌化合物及其制备方法
AU2006328455B2 (en) * 2005-12-20 2012-02-09 Eisai R & D Management Co., Ltd. Process for production of water-soluble azole prodrug
BRPI0620715A2 (pt) 2005-12-27 2011-11-22 Otsuka Pharma Co Ltd composto da benzoazepina solúvel em água e a sua composição farmacêutica
JP5058150B2 (ja) * 2006-02-22 2012-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定化医薬組成物
EP2285351A2 (en) * 2008-04-15 2011-02-23 Schering Corporation Oral pharmaceutical compositions in a solid dispersion comprising preferably posaconazole and hpmcas
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
WO2011064558A2 (en) 2009-11-30 2011-06-03 Cipla Limited Pharmaceutical composition
CN103857440B (zh) 2011-06-22 2018-09-25 维奥姆生物科学有限公司 基于缀合物的抗真菌和抗细菌前药
EP2561863A1 (en) 2011-08-22 2013-02-27 Farmaprojects, S.A.U. Pharmaceutical compositions comprising voriconazole
KR102061137B1 (ko) 2012-01-20 2019-12-31 마이코비아 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
SI3677252T1 (sl) * 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
CN103864844B (zh) * 2012-12-09 2016-10-05 正大天晴药业集团股份有限公司 一种福司氟康唑的制备方法
CN103304600B (zh) * 2013-03-04 2018-05-25 陕西合成药业股份有限公司 一种伏立康唑磷酸酯三水合物及其制备方法和用途
RU2719579C2 (ru) * 2013-03-14 2020-04-21 Сидара Терапьютикс, Инк. Режимы дозирования для соединений класса эхинокандинов
CA2904670A1 (en) 2013-03-14 2014-09-13 Fresenius Kabi Usa, Llc Voriconazole formulations
EP3003031A1 (en) 2013-06-04 2016-04-13 Vyome Biosciences Pvt Ltd Coated particles and compositions comprising same
CN103524560A (zh) * 2013-09-28 2014-01-22 陕西合成药业有限公司 伏立康磷酸酯钠水合物及其多晶型
CN104650140B (zh) * 2013-11-18 2017-11-10 正大天晴药业集团股份有限公司 一种高纯度福司氟康唑的制备方法
AU2015212312A1 (en) 2014-01-29 2016-08-18 Vyome Therapeutics Limited Treatments for resistant acne
CN104860992A (zh) * 2014-02-25 2015-08-26 陕西合成药业股份有限公司 一种高纯度福司氟康唑制备方法
CN105985377A (zh) * 2015-02-09 2016-10-05 陕西合成药业股份有限公司 一种福司氟康唑盐水合物及其制备方法
CN106279280A (zh) * 2015-05-25 2017-01-04 西藏卫信康医药股份有限公司 一种化合物及其制备方法和应用
CN106518922A (zh) * 2015-09-12 2017-03-22 陕西合成药业股份有限公司 一种三唑类化合物及其制备方法和用途
CN106546668A (zh) * 2015-09-22 2017-03-29 陕西合成药业股份有限公司 一种分离福司氟康唑或其药用盐有关物质的hplc方法
CN105237569B (zh) * 2015-10-21 2017-07-25 西南科技大学 一种制备2，4‑二氟‑α，α‑二（1氢‑1，2，4‑三唑‑1‑基甲基）苯甲醇磷酸二苄酯的合成方法
CN105753902B (zh) * 2016-04-11 2017-08-25 浙江诚意药业股份有限公司 一种福司氟康唑的制备方法
CN108676031A (zh) * 2018-05-29 2018-10-19 重庆威鹏药业有限公司 水溶性三唑类抗真菌膦酸化合物及其制备方法和应用
CN111171075B (zh) * 2020-04-03 2022-07-12 北京四环生物制药有限公司 一种福司氟康唑的制备方法

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US4528284A (en) * 1982-10-15 1985-07-09 Ciba-Geigy Corporation Fungicidal 2-(azolylmethyl-1'-yl)-2-aryl-2-(cyano, alkoxycarbonyl, alkylthiocarbonyl and aminocarbonyl)-2-phosphorus acid esters
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
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US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
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NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
EP0746318A1 (en) * 1994-02-25 1996-12-11 Takeda Chemical Industries, Ltd. Injectable emulsions containing antifungal triazole derivatives
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Also Published As

Publication number Publication date
AP9700923A0 (en) 1997-01-31
KR100283546B1 (ko) 2001-04-02
KR19990082233A (ko) 1999-11-25
HRP970063A2 (en) 1998-06-30
HUP9900949A3 (en) 2001-08-28
GT199700016A (es) 1998-07-24
NO323771B1 (no) 2007-07-02
TW434247B (en) 2001-05-16
IL133135A (en) 2003-07-06
CA2240777A1 (en) 1997-08-07
ATE219089T1 (de) 2002-06-15
JP2959846B2 (ja) 1999-10-06
ES2175336T3 (es) 2002-11-16
US6977302B2 (en) 2005-12-20
ID15858A (id) 1997-08-14
CZ291431B6 (cs) 2003-03-12
BG63946B1 (bg) 2003-07-31
RS49526B (sr) 2006-12-15
PT880533E (pt) 2002-09-30
SK283136B6 (sk) 2003-03-04
US20070027115A1 (en) 2007-02-01
US20030144250A1 (en) 2003-07-31
PL328436A1 (en) 1999-02-01
CA2240777C (en) 2002-06-11
IL124865A (en) 2002-03-10
IL133135A0 (en) 2001-03-19
IS1995B (is) 2005-03-15
US20050130940A1 (en) 2005-06-16
ZA97826B (en) 1998-07-31
DE69713284D1 (de) 2002-07-18
TR199801440T2 (xx) 1998-10-21
AU709781B2 (en) 1999-09-09
CN1085213C (zh) 2002-05-22
IS4785A (is) 1998-06-26
UA46828C2 (uk) 2002-06-17
SI0880533T1 (en) 2002-08-31
DE69713284T2 (de) 2003-03-27
HN1997000012A (es) 1997-06-26
CO4761066A1 (es) 1999-04-27
BG102603A (en) 1999-03-31
DZ2172A1 (fr) 2002-12-01
AP678A (en) 1998-09-28
BR9707257A (pt) 1999-04-06
RU2176244C2 (ru) 2001-11-27
DK0880533T3 (da) 2002-07-15
IL124865A0 (en) 1999-01-26
NO983560L (no) 1998-08-03
US20040236105A1 (en) 2004-11-25
EP0880533A1 (en) 1998-12-02
EP0880533B1 (en) 2002-06-12
CN1210540A (zh) 1999-03-10
NZ330654A (en) 1999-08-30
AU1598597A (en) 1997-08-22
NO983560D0 (no) 1998-08-03
JPH10512599A (ja) 1998-12-02
SK102298A3 (en) 1999-08-06
GB9602080D0 (en) 1996-04-03
SA97170578B1 (ar) 2006-01-28
OA10711A (en) 2001-06-04
WO1997028169A1 (en) 1997-08-07
MY116849A (en) 2004-04-30
PL187237B1 (pl) 2004-06-30
TNSN97023A1 (fr) 2005-03-15
US6790957B2 (en) 2004-09-14
HU226133B1 (en) 2008-05-28
CZ242098A3 (cs) 1999-05-12
YU2997A (sh) 2000-10-30
HUP9900949A2 (hu) 2001-05-28
HK1018217A1 (en) 1999-12-17

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