IT1255207B - Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatrice - Google Patents
Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatriceInfo
- Publication number
- IT1255207B IT1255207B ITMI921629A ITMI921629A IT1255207B IT 1255207 B IT1255207 B IT 1255207B IT MI921629 A ITMI921629 A IT MI921629A IT MI921629 A ITMI921629 A IT MI921629A IT 1255207 B IT1255207 B IT 1255207B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- aggregating
- pharmaceutical compositions
- phenyl
- vasodilating activity
- Prior art date
Links
- 230000002744 anti-aggregatory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000000304 vasodilatating effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Si descrivono composti di formula I (FORMULA I) in cui R1, è alchile C1-C4; alcossile C1-C4; fenile a sua volta eventualmente sostituito da un gruppo OH, C1- C4 alchile, C1 -C4 alcossile, alogeno o fenile; un gruppo -S(O)nR2 in cui R2 è alchile o fenile eventualmente sostituito da OH, C1-C4 alchile, C1-C4 alcossile o da un alogeno;R è alchile C1-C4 o fenile a sua volta eventualmente sostituito da OH, C1-C4 alchile, C1-C4 alcossile, da un alogeno o da fenile; n= 0, 1 oppure 2; m = 0 oppure 1, come agenti cardiovascolari.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921629A IT1255207B (it) | 1992-07-03 | 1992-07-03 | Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatrice |
| AU44192/93A AU4419293A (en) | 1992-07-03 | 1993-06-18 | Pharmaceutical compositions having antiaggregant and vasodilating activities |
| PCT/EP1993/001559 WO1994001422A1 (en) | 1992-07-03 | 1993-06-18 | Pharmaceutical compositions having antiaggregant and vasodilating activities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921629A IT1255207B (it) | 1992-07-03 | 1992-07-03 | Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatrice |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI921629A0 ITMI921629A0 (it) | 1992-07-03 |
| ITMI921629A1 ITMI921629A1 (it) | 1994-01-03 |
| IT1255207B true IT1255207B (it) | 1995-10-20 |
Family
ID=11363616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI921629A IT1255207B (it) | 1992-07-03 | 1992-07-03 | Composizioni farmaceutuche ad attivita' antiaggregante e vasodilatatrice |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU4419293A (it) |
| IT (1) | IT1255207B (it) |
| WO (1) | WO1994001422A1 (it) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4220264A1 (de) * | 1992-06-20 | 1993-12-23 | Cassella Ag | Phenyl-1,2,5-oxadiazol-carbonamid-2-oxide |
| DE4417705A1 (de) * | 1994-05-20 | 1995-11-23 | Cassella Ag | Substituierte Furoxane |
| DE19624990A1 (de) * | 1996-06-22 | 1998-01-08 | Gluesenkamp Karl Heinz Dr | Verfahren zur chemischen kontrollierten Modifizierung von Oberflächen sowie von Acyl- und/oder Hydroxyl-Gruppen tragenden Polymeren |
| US8394840B2 (en) | 2005-06-15 | 2013-03-12 | Hydra Biosciences, Inc. | Modulators of sperm hypermotility and uses thereof |
| US20090018091A1 (en) | 2005-08-02 | 2009-01-15 | Nitromed, Inc. | Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use |
| WO2007126609A1 (en) | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
| US10053435B2 (en) | 2015-01-14 | 2018-08-21 | National University Corporation Kobe University | Furoxan compound, and manufacturing method for same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3012862A1 (de) * | 1980-04-02 | 1981-10-08 | Cassella Ag, 6000 Frankfurt | Substituierte 1,2,5-oxdiazol-2-oxide als pharmazeutische wirkstoffe, ihre verwendung und sie enthaltende arzneimittel |
-
1992
- 1992-07-03 IT ITMI921629A patent/IT1255207B/it active IP Right Grant
-
1993
- 1993-06-18 WO PCT/EP1993/001559 patent/WO1994001422A1/en active Application Filing
- 1993-06-18 AU AU44192/93A patent/AU4419293A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1994001422A1 (en) | 1994-01-20 |
| ITMI921629A0 (it) | 1992-07-03 |
| AU4419293A (en) | 1994-01-31 |
| ITMI921629A1 (it) | 1994-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |