RS20070364A - New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal - Google Patents
New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinalInfo
- Publication number
- RS20070364A RS20070364A RSP-2007/0364A RSP20070364A RS20070364A RS 20070364 A RS20070364 A RS 20070364A RS P20070364 A RSP20070364 A RS P20070364A RS 20070364 A RS20070364 A RS 20070364A
- Authority
- RS
- Serbia
- Prior art keywords
- rifaximin
- production
- medicinal
- polymorphous forms
- processes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Cilj predmetnog pronalaska su kristalni polimorfni oblici antibiotika rifaksimina (INN), koji su označeni kao rifaksimin δ i rifaksimin ε, koji su korisni u proizvodnji medicinskih preparata koji sadrže rifaksimin za oralnu i topijsku primenu i dobijaju se postupkom kristalizacije, koja podrazumeva rastvaranje sirovog rifaksimina u vrućem etil alkoholu i izazivanje kristalizacije proizvoda dodavanjem vode na određenoj temp. i tokom određenog vremena, a nakon toga se sušenje izvodi pod kontrolisanim uslovima dok se ne postigne željeni sadržaj vode u krajnjem proizvodu.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05004695.2A EP1698630B1 (en) | 2005-03-03 | 2005-03-03 | New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
PCT/EP2006/001755 WO2006094662A1 (en) | 2005-03-03 | 2006-02-27 | New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal |
Publications (2)
Publication Number | Publication Date |
---|---|
RS20070364A true RS20070364A (en) | 2009-01-22 |
RS54570B1 RS54570B1 (sr) | 2016-06-30 |
Family
ID=34934045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20070364A RS54570B1 (sr) | 2005-03-03 | 2006-02-27 | Novi polimorfni oblici rifaksimina, postupak njihove proizvodnje i njihova upotreba u medicinskim preparatima |
Country Status (28)
Country | Link |
---|---|
US (9) | US8193196B2 (sr) |
EP (1) | EP1698630B1 (sr) |
JP (2) | JP5737825B2 (sr) |
KR (1) | KR100885755B1 (sr) |
CN (1) | CN1900077B (sr) |
AU (1) | AU2006222312B8 (sr) |
BR (1) | BRPI0608073A8 (sr) |
CA (1) | CA2594789C (sr) |
DK (1) | DK1698630T3 (sr) |
ES (1) | ES2522895T3 (sr) |
HK (1) | HK1096396A1 (sr) |
HR (1) | HRP20070433B1 (sr) |
IL (1) | IL184694A0 (sr) |
MA (1) | MA29345B1 (sr) |
MD (1) | MD4081G2 (sr) |
ME (1) | ME00272B (sr) |
MX (1) | MX2007010742A (sr) |
NO (1) | NO342197B1 (sr) |
NZ (1) | NZ556737A (sr) |
PL (1) | PL1698630T3 (sr) |
PT (1) | PT1698630E (sr) |
RS (1) | RS54570B1 (sr) |
RU (1) | RU2397985C2 (sr) |
SI (1) | SI1698630T1 (sr) |
TN (1) | TNSN07292A1 (sr) |
UA (1) | UA89809C2 (sr) |
WO (1) | WO2006094662A1 (sr) |
ZA (1) | ZA200707397B (sr) |
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