WO2008056377A3 - Polymorphic forms of rimonabant - Google Patents

Polymorphic forms of rimonabant Download PDF

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Publication number
WO2008056377A3
WO2008056377A3 PCT/IN2007/000522 IN2007000522W WO2008056377A3 WO 2008056377 A3 WO2008056377 A3 WO 2008056377A3 IN 2007000522 W IN2007000522 W IN 2007000522W WO 2008056377 A3 WO2008056377 A3 WO 2008056377A3
Authority
WO
WIPO (PCT)
Prior art keywords
rimonabant
polymorphic forms
hydratcd
preparation
disclosed
Prior art date
Application number
PCT/IN2007/000522
Other languages
French (fr)
Other versions
WO2008056377A2 (en
Inventor
Parind Narendra Dholakia
Mayank Ghanshyambhai Dave
Bipin Pandey
Pankaj Ramanbhai Patel
Original Assignee
Cadila Healthcare Ltd
Parind Narendra Dholakia
Mayank Ghanshyambhai Dave
Bipin Pandey
Pankaj Ramanbhai Patel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd, Parind Narendra Dholakia, Mayank Ghanshyambhai Dave, Bipin Pandey, Pankaj Ramanbhai Patel filed Critical Cadila Healthcare Ltd
Publication of WO2008056377A2 publication Critical patent/WO2008056377A2/en
Publication of WO2008056377A3 publication Critical patent/WO2008056377A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed herein are the novel amorphous hydratcd and crystalline forms of Rimonabant, process(s) for their preparation and pharmaceutical compositions containing it.
PCT/IN2007/000522 2006-11-06 2007-11-05 Polymorphic forms of rimonabant WO2008056377A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1839/MUM/2006 2006-11-06
IN1839MU2006 2006-11-06
IN1846/MUM/2006 2006-11-07
IN1846MU2006 2006-11-07

Publications (2)

Publication Number Publication Date
WO2008056377A2 WO2008056377A2 (en) 2008-05-15
WO2008056377A3 true WO2008056377A3 (en) 2008-10-30

Family

ID=39322618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000522 WO2008056377A2 (en) 2006-11-06 2007-11-05 Polymorphic forms of rimonabant

Country Status (1)

Country Link
WO (1) WO2008056377A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
WO2024092205A1 (en) * 2022-10-27 2024-05-02 The Trustees Of Indiana University Inhibition of ship1 as a therapeutic strategy for the treatment of alzheimer's disease

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656354A1 (en) * 1993-12-02 1995-06-07 Sanofi Substituted N-piperidino 3-pyrazolecarboxamide
WO2003040105A1 (en) * 2001-11-08 2003-05-15 Sanofi-Synthelabo Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
EP1816125A1 (en) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Novel crystalline forms of an antagonist of CB1 cannabinoid receptor and preparation method thereof
WO2007090949A1 (en) * 2006-02-08 2007-08-16 Sanofi-Aventis Rimonabant monohydrate, process for the preparation thereof and pharmaceutical compositions containing same
WO2007103711A2 (en) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Polymorphic forms of rimonabant
WO2008026219A2 (en) * 2006-09-01 2008-03-06 Hetero Drugs Limited Novel polymorphs of rimonabant
WO2008035023A1 (en) * 2006-09-19 2008-03-27 Cipla Limited Polymorphs of rimonabant
WO2008064615A2 (en) * 2006-12-01 2008-06-05 Zentiva, A.S. Crystalline and amorphous forms of rimonabant and processes for obtaining them

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656354A1 (en) * 1993-12-02 1995-06-07 Sanofi Substituted N-piperidino 3-pyrazolecarboxamide
WO2003040105A1 (en) * 2001-11-08 2003-05-15 Sanofi-Synthelabo Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
EP1816125A1 (en) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Novel crystalline forms of an antagonist of CB1 cannabinoid receptor and preparation method thereof
WO2007090949A1 (en) * 2006-02-08 2007-08-16 Sanofi-Aventis Rimonabant monohydrate, process for the preparation thereof and pharmaceutical compositions containing same
WO2007103711A2 (en) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Polymorphic forms of rimonabant
WO2008026219A2 (en) * 2006-09-01 2008-03-06 Hetero Drugs Limited Novel polymorphs of rimonabant
WO2008035023A1 (en) * 2006-09-19 2008-03-27 Cipla Limited Polymorphs of rimonabant
WO2008064615A2 (en) * 2006-12-01 2008-06-05 Zentiva, A.S. Crystalline and amorphous forms of rimonabant and processes for obtaining them

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COLTMAN, S.C.W. ET AL, SYNTHESIS, 1984, pages 150 - 152, XP002491304 *
HANCOCK B C ET AL: "What is the true solubility advantage for amorphous pharmaceuticals?", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 17, no. 4, 1 April 2000 (2000-04-01), pages 397 - 404, XP009086748, ISSN: 0724-8741 *
KOTAGIRI V.K. ET AL, ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 11, 2007, pages 910 - 912, XP002491303 *

Also Published As

Publication number Publication date
WO2008056377A2 (en) 2008-05-15

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