RO79132B - Procedeu pentru purificarea de proteine cu greutate moleculara mai mare de circa 12000 - Google Patents

Procedeu pentru purificarea de proteine cu greutate moleculara mai mare de circa 12000

Info

Publication number
RO79132B
RO79132B RO99322A RO9932279A RO79132B RO 79132 B RO79132 B RO 79132B RO 99322 A RO99322 A RO 99322A RO 9932279 A RO9932279 A RO 9932279A RO 79132 B RO79132 B RO 79132B
Authority
RO
Romania
Prior art keywords
proteins
purification
molecular weight
circa
procedure
Prior art date
Application number
RO99322A
Other languages
English (en)
Other versions
RO79132A (ro
Inventor
Sidney Pestka
Menachem Rubinstein
Original Assignee
F.Hoffmann-La Roche Et Co Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Et Co Aktiengesellschaft filed Critical F.Hoffmann-La Roche Et Co Aktiengesellschaft
Publication of RO79132A publication Critical patent/RO79132A/ro
Publication of RO79132B publication Critical patent/RO79132B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/811—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedeu pentru purificarea proteinelor cu o greutate moleculara mai mare de 12000, caracterizat prin aceea ca ca se supune cromatografiei în lichid la presiune înalta o solutie apoasa a proteinei impurificate pe bioxid de siliciu poros, modificat cu grupe cianpropil, ciclohexil, fenil, octil, octadecil sau gliceril si tamponat cu solutie tampon, proteina fiind mai întîi adsorbita si apoi eluata cu un gradient crescator sau descrescator al unui solvent miscibil cu apa si solutie tampon apoasa, astfel încît se obtine în forma mai pura în anumite fractiuni ale eluatului.
RO99322A 1978-11-24 1979-11-22 Procedeu pentru purificarea de proteine cu greutate moleculara mai mare de circa 12000 RO79132B (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96325778A 1978-11-24 1978-11-24
US6237479A 1979-07-31 1979-07-31
US7771079A 1979-09-21 1979-09-21

Publications (2)

Publication Number Publication Date
RO79132A RO79132A (ro) 1982-07-06
RO79132B true RO79132B (ro) 1983-05-30

Family

ID=27370266

Family Applications (1)

Application Number Title Priority Date Filing Date
RO99322A RO79132B (ro) 1978-11-24 1979-11-22 Procedeu pentru purificarea de proteine cu greutate moleculara mai mare de circa 12000

Country Status (34)

Country Link
US (1) US4289690A (ro)
JP (1) JPH07224098A (ro)
KR (1) KR830002616B1 (ro)
AR (1) AR222359A1 (ro)
AU (2) AU535936B2 (ro)
BE (1) BE880201A (ro)
CA (1) CA1129409A (ro)
CH (3) CH654843A5 (ro)
DE (1) DE2947134A1 (ro)
DK (1) DK161048C (ro)
DO (1) DOP1979002953A (ro)
ES (1) ES8100502A1 (ro)
FI (1) FI69476C (ro)
FR (1) FR2442054A1 (ro)
GB (1) GB2037296B (ro)
GR (1) GR72828B (ro)
HK (1) HK26684A (ro)
IE (1) IE48882B1 (ro)
IL (1) IL58759A (ro)
IN (1) IN150740B (ro)
IT (1) IT1127253B (ro)
KE (1) KE3347A (ro)
LU (2) LU81918A1 (ro)
MC (1) MC1300A1 (ro)
MY (1) MY8500222A (ro)
NL (1) NL193085C (ro)
NO (1) NO151157C (ro)
NZ (1) NZ192201A (ro)
PH (1) PH20763A (ro)
PT (1) PT70495A (ro)
RO (1) RO79132B (ro)
SE (1) SE454276B (ro)
SG (1) SG71183G (ro)
YU (1) YU286179A (ro)

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IL58759A0 (en) 1980-02-29
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ES486263A0 (es) 1980-11-01
CA1129409A (en) 1982-08-10
DOP1979002953A (es) 1992-11-10
DK161048C (da) 1991-11-04
FI793649A7 (fi) 1980-05-25
DE2947134C2 (ro) 1988-04-21
NO151157B (no) 1984-11-12
MY8500222A (en) 1985-12-31
CH653347A5 (de) 1985-12-31
FI69476B (fi) 1985-10-31
US4289690A (en) 1981-09-15
PH20763A (en) 1987-04-10
DE2947134A1 (de) 1980-06-12
RO79132A (ro) 1982-07-06
KR830002616B1 (ko) 1983-12-06
DK496779A (da) 1980-05-25
LU88314I2 (fr) 1994-05-04
MC1300A1 (fr) 1980-10-03
AU535936B2 (en) 1984-04-12
GR72828B (ro) 1983-12-06
YU286179A (en) 1983-10-31
AU5313679A (en) 1980-05-29
IN150740B (ro) 1982-12-04
SE7909721L (sv) 1980-06-16
HK26684A (en) 1984-03-30
FR2442054A1 (fr) 1980-06-20
IT7927524A0 (it) 1979-11-23
NL193085B (nl) 1998-06-02
AU1586683A (en) 1983-12-08
IE48882B1 (en) 1985-06-12
FI69476C (fi) 1986-02-10
GB2037296B (en) 1983-07-27
IE792247L (en) 1980-05-24
SE454276B (sv) 1988-04-18
AR222359A1 (es) 1981-05-15
KE3347A (en) 1983-12-16
BE880201A (fr) 1980-05-22
CH654843A5 (de) 1986-03-14
LU81918A1 (de) 1981-06-04
IT1127253B (it) 1986-05-21
GB2037296A (en) 1980-07-09
ES8100502A1 (es) 1980-11-01
AU561672B2 (en) 1987-05-14
NZ192201A (en) 1985-07-31
PT70495A (en) 1979-12-01
NL7908516A (nl) 1980-05-28
DK161048B (da) 1991-05-27
FR2442054B1 (ro) 1983-09-09
KR830000910A (ko) 1983-04-28
SG71183G (en) 1984-08-03
NO793819L (no) 1980-05-28
NL193085C (nl) 1998-10-05
CH658459A5 (de) 1986-11-14
NO151157C (no) 1985-02-20

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