RO73524B - Procedeu de preparare a unor derivati de alcaloizi - Google Patents

Procedeu de preparare a unor derivati de alcaloizi

Info

Publication number
RO73524B
RO73524B RO78274A RO7827474A RO73524B RO 73524 B RO73524 B RO 73524B RO 78274 A RO78274 A RO 78274A RO 7827474 A RO7827474 A RO 7827474A RO 73524 B RO73524 B RO 73524B
Authority
RO
Romania
Prior art keywords
acid
carbon atoms
general formula
preparation
nitric acid
Prior art date
Application number
RO78274A
Other languages
English (en)
Other versions
RO73524A (ro
Inventor
George Joseph Culliman
Koert Gerzon
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO73524A publication Critical patent/RO73524A/ro
Publication of RO73524B publication Critical patent/RO73524B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedeu pentru prepararea unor derivati de alcaloizi cu formula generala I: (vezi formula) în care R1 reprezinta -NH2; -NH-NH2, -NH-CH3; R2 reprezinta un radical alcanoil cu 1...3 atomi de carbon sau cloralcanoil cu 1...3 atomi de carbon; R3 reprezinta hidrogen, alchil inferior, formil sau alcanoil cu 1...3 atomi de carbon, iar unul din R4 si R5 este hidroxil si celalalt reprezinta etil, caracterizat prin aceea ca un compus cu formula generala I în care R1 reprezinta metoxi, iar R2 reprezinta hidrogen sau acetil, iar R3, R4 si R5 au semnificatiile aratate mai sus se trateaza cu amoniac, metilamina sau hidrazina în exces la temperatura de 50...100 degree C, apoi amestecul de reactie este prelucrat în mod cunoscut, în vederea reprezentarii produsului de reactie sub forma unei baze libere sau unor saruri acceptabile farmaceutic obtinute cu acid clorhidric, acid azotic, acid fosforic, acid sulfuric, acid bromhidric, acid iodhidric, acid azotic, acid azotat, acid fosforos, acid citric, acid lactic, acid benzoic, acid ftalic, si oxid tereftalic.
RO78274A 1973-04-02 1974-04-02 Procedeu de preparare a unor derivati de alcaloizi RO73524B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (2)

Publication Number Publication Date
RO73524A RO73524A (ro) 1984-10-31
RO73524B true RO73524B (ro) 1984-11-30

Family

ID=23363051

Family Applications (2)

Application Number Title Priority Date Filing Date
RO78274A RO73524B (ro) 1973-04-02 1974-04-02 Procedeu de preparare a unor derivati de alcaloizi
RO7498695A RO77533A (ro) 1973-04-02 1974-04-02 Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO7498695A RO77533A (ro) 1973-04-02 1974-04-02 Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina

Country Status (28)

Country Link
JP (2) JPS5919117B2 (ro)
AR (2) AR204004A1 (ro)
AT (1) AT340605B (ro)
BE (1) BE813168A (ro)
BG (3) BG21235A3 (ro)
CA (1) CA1042428A (ro)
CH (1) CH603669A5 (ro)
CS (1) CS185223B2 (ro)
CY (1) CY1044A (ro)
DD (1) DD113538A5 (ro)
DE (1) DE2415980A1 (ro)
DK (1) DK141511B (ro)
ES (2) ES424882A1 (ro)
FR (1) FR2223044B1 (ro)
GB (1) GB1463575A (ro)
HK (1) HK20180A (ro)
HU (1) HU171572B (ro)
IE (1) IE39071B1 (ro)
IL (1) IL44415A (ro)
KE (1) KE3028A (ro)
MY (1) MY8100025A (ro)
NL (1) NL181079C (ro)
PH (1) PH13623A (ro)
RO (2) RO73524B (ro)
SE (1) SE416206B (ro)
SU (4) SU731900A3 (ro)
YU (3) YU39719B (ro)
ZA (1) ZA741674B (ro)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (ro) * 1976-09-08 1982-07-07 Lilly Co Eli
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CA2662517A1 (en) 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
AU2014253584B2 (en) * 2013-04-19 2017-02-02 Jinan University Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
HK20180A (en) 1980-04-25
RO73524A (ro) 1984-10-31
ZA741674B (en) 1975-10-29
AT340605B (de) 1977-12-27
IL44415A (en) 1978-08-31
IE39071B1 (en) 1978-08-02
FR2223044B1 (ro) 1978-06-30
ES424882A1 (es) 1976-12-16
YU39876B (en) 1985-04-30
DE2415980A1 (de) 1974-10-10
MY8100025A (en) 1981-12-31
NL181079C (nl) 1987-06-16
DK141511B (da) 1980-04-08
HU171572B (hu) 1978-02-28
CH603669A5 (ro) 1978-08-31
ES446571A1 (es) 1977-06-16
JPS6033837B2 (ja) 1985-08-05
RO77533A (ro) 1982-02-01
FR2223044A1 (ro) 1974-10-25
KE3028A (en) 1980-03-28
NL181079B (nl) 1987-01-16
BG21235A3 (bg) 1976-03-20
AR203882A1 (es) 1975-10-31
BG22831A3 (bg) 1977-04-20
SU623522A3 (ru) 1978-09-05
YU113980A (en) 1982-05-31
YU39719B (en) 1985-04-30
BG21612A3 (bg) 1976-07-20
BE813168A (fr) 1974-10-02
IL44415A0 (en) 1974-06-30
SU652896A3 (ru) 1979-03-15
SE416206B (sv) 1980-12-08
CS185223B2 (en) 1978-09-15
YU81774A (en) 1982-05-31
JPS59193895A (ja) 1984-11-02
GB1463575A (en) 1977-02-02
IE39071L (en) 1974-10-02
DK141511C (ro) 1980-09-29
SU731900A3 (ru) 1980-04-30
DD113538A5 (ro) 1975-06-12
SU784783A3 (ru) 1980-11-30
AR204004A1 (es) 1975-11-12
NL7404423A (ro) 1974-10-04
PH13623A (en) 1980-08-07
YU39875B (en) 1985-04-30
YU113880A (en) 1982-05-31
DE2415980C2 (ro) 1989-11-09
ATA267974A (de) 1977-04-15
CY1044A (en) 1980-08-01
CA1042428A (en) 1978-11-14
JPS49128000A (ro) 1974-12-07
AU6671974A (en) 1975-09-18
JPS5919117B2 (ja) 1984-05-02

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