RO73524B - Procedeu de preparare a unor derivati de alcaloizi - Google Patents
Procedeu de preparare a unor derivati de alcaloiziInfo
- Publication number
- RO73524B RO73524B RO78274A RO7827474A RO73524B RO 73524 B RO73524 B RO 73524B RO 78274 A RO78274 A RO 78274A RO 7827474 A RO7827474 A RO 7827474A RO 73524 B RO73524 B RO 73524B
- Authority
- RO
- Romania
- Prior art keywords
- acid
- carbon atoms
- general formula
- preparation
- nitric acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fodder In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedeu pentru prepararea unor derivati de alcaloizi cu formula generala I: (vezi formula) în care R1 reprezinta -NH2; -NH-NH2, -NH-CH3; R2 reprezinta un radical alcanoil cu 1...3 atomi de carbon sau cloralcanoil cu 1...3 atomi de carbon; R3 reprezinta hidrogen, alchil inferior, formil sau alcanoil cu 1...3 atomi de carbon, iar unul din R4 si R5 este hidroxil si celalalt reprezinta etil, caracterizat prin aceea ca un compus cu formula generala I în care R1 reprezinta metoxi, iar R2 reprezinta hidrogen sau acetil, iar R3, R4 si R5 au semnificatiile aratate mai sus se trateaza cu amoniac, metilamina sau hidrazina în exces la temperatura de 50...100 degree C, apoi amestecul de reactie este prelucrat în mod cunoscut, în vederea reprezentarii produsului de reactie sub forma unei baze libere sau unor saruri acceptabile farmaceutic obtinute cu acid clorhidric, acid azotic, acid fosforic, acid sulfuric, acid bromhidric, acid iodhidric, acid azotic, acid azotat, acid fosforos, acid citric, acid lactic, acid benzoic, acid ftalic, si oxid tereftalic.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34727573A | 1973-04-02 | 1973-04-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO73524A RO73524A (ro) | 1984-10-31 |
RO73524B true RO73524B (ro) | 1984-11-30 |
Family
ID=23363051
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO78274A RO73524B (ro) | 1973-04-02 | 1974-04-02 | Procedeu de preparare a unor derivati de alcaloizi |
RO7498695A RO77533A (ro) | 1973-04-02 | 1974-04-02 | Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO7498695A RO77533A (ro) | 1973-04-02 | 1974-04-02 | Procedeu pentru prepararea unor derivati de vinblastina,leurozidina si leurocristina |
Country Status (28)
Country | Link |
---|---|
JP (2) | JPS5919117B2 (ro) |
AR (2) | AR204004A1 (ro) |
AT (1) | AT340605B (ro) |
BE (1) | BE813168A (ro) |
BG (3) | BG22831A3 (ro) |
CA (1) | CA1042428A (ro) |
CH (1) | CH603669A5 (ro) |
CS (1) | CS185223B2 (ro) |
CY (1) | CY1044A (ro) |
DD (1) | DD113538A5 (ro) |
DE (1) | DE2415980A1 (ro) |
DK (1) | DK141511B (ro) |
ES (2) | ES424882A1 (ro) |
FR (1) | FR2223044B1 (ro) |
GB (1) | GB1463575A (ro) |
HK (1) | HK20180A (ro) |
HU (1) | HU171572B (ro) |
IE (1) | IE39071B1 (ro) |
IL (1) | IL44415A (ro) |
KE (1) | KE3028A (ro) |
MY (1) | MY8100025A (ro) |
NL (1) | NL181079C (ro) |
PH (1) | PH13623A (ro) |
RO (2) | RO73524B (ro) |
SE (1) | SE416206B (ro) |
SU (4) | SU731900A3 (ro) |
YU (3) | YU39719B (ro) |
ZA (1) | ZA741674B (ro) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
GR69783B (ro) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
USRE30560E (en) * | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
US4096148A (en) * | 1976-12-06 | 1978-06-20 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
USRE30561E (en) | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Vinca alkaloid intermediates |
US4203898A (en) | 1977-08-29 | 1980-05-20 | Eli Lilly And Company | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids |
US4199504A (en) * | 1978-05-15 | 1980-04-22 | Eli Lilly And Company | Bridged cathranthus alkaloid dimers |
US4357334A (en) | 1980-03-20 | 1982-11-02 | Eli Lilly And Company | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
LU83822A1 (fr) * | 1981-12-08 | 1983-09-01 | Omnichem Sa | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
OA06421A (fr) * | 1980-06-10 | 1981-09-30 | Omnium Chimique Sa | Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. |
FR2623504B1 (fr) * | 1987-11-25 | 1990-03-09 | Adir | Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
HUT76925A (hu) * | 1995-04-04 | 1998-01-28 | MTA Enzimológiai Intézet | Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények |
US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6326402B1 (en) | 1998-08-12 | 2001-12-04 | Octamer, Inc. | Methods for treating viral infections using a compound capable of inhibiting microtubules |
AU2006207321B2 (en) | 2005-01-21 | 2012-09-06 | Astex Therapeutics Limited | Pharmaceutical compounds |
NZ587586A (en) | 2005-07-18 | 2012-04-27 | Bipar Sciences Inc | Treatment of cancer |
WO2008030891A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
CN101522609A (zh) | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
CN101917982B (zh) | 2007-11-12 | 2013-03-20 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌 |
CN105121447B (zh) * | 2013-04-19 | 2018-02-02 | 暨南大学 | 长春碱类衍生物及其制备方法和应用 |
CN113456797B (zh) * | 2021-06-18 | 2024-03-08 | 暨南大学 | 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
-
1974
- 1974-01-01 AR AR253105A patent/AR204004A1/es active
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/xx unknown
- 1974-03-13 IE IE532/74A patent/IE39071B1/xx unknown
- 1974-03-13 IL IL44415A patent/IL44415A/xx unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/xx unknown
- 1974-03-25 CY CY1044A patent/CY1044A/xx unknown
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-03-29 CH CH446374A patent/CH603669A5/xx active Protection Beyond IP Right Term
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-04-01 CS CS7400002335A patent/CS185223B2/cs unknown
- 1974-04-01 AT AT267974A patent/AT340605B/de not_active IP Right Cessation
- 1974-04-01 SU SU742013753A patent/SU731900A3/ru active
- 1974-04-01 DK DK178774AA patent/DK141511B/da not_active IP Right Cessation
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/xx not_active IP Right Cessation
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/hu unknown
- 1974-04-01 SE SE7404380A patent/SE416206B/xx not_active IP Right Cessation
- 1974-04-02 ES ES424882A patent/ES424882A1/es not_active Expired
- 1974-04-02 RO RO78274A patent/RO73524B/ro unknown
- 1974-04-02 BG BG26279A patent/BG22831A3/xx unknown
- 1974-04-02 BE BE1005847A patent/BE813168A/xx not_active IP Right Cessation
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 BG BG28514A patent/BG21235A3/xx unknown
- 1974-04-02 RO RO7498695A patent/RO77533A/ro unknown
- 1974-04-02 BG BG28513A patent/BG21612A3/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/ja not_active Expired
- 1974-04-02 DE DE2415980A patent/DE2415980A1/de active Granted
-
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/es active
- 1975-07-04 SU SU752151512A patent/SU784783A3/ru active
- 1975-07-09 SU SU752152020A patent/SU652896A3/ru active
-
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/es not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/ru active
-
1980
- 1980-02-27 KE KE3028A patent/KE3028A/xx unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/xx unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/xx unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/xx unknown
-
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/xx unknown
-
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/ja not_active Expired
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