AT340605B - Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saureadditionssalze - Google Patents

Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saureadditionssalze

Info

Publication number
AT340605B
AT340605B AT267974A AT267974A AT340605B AT 340605 B AT340605 B AT 340605B AT 267974 A AT267974 A AT 267974A AT 267974 A AT267974 A AT 267974A AT 340605 B AT340605 B AT 340605B
Authority
AT
Austria
Prior art keywords
leurocristin
leurosidine
vinblastin
amide derivatives
preparing new
Prior art date
Application number
AT267974A
Other languages
English (en)
Other versions
ATA267974A (de
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to AT980175A priority Critical patent/AT345996B/de
Publication of ATA267974A publication Critical patent/ATA267974A/de
Application granted granted Critical
Publication of AT340605B publication Critical patent/AT340605B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT267974A 1973-04-02 1974-04-01 Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saureadditionssalze AT340605B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT980175A AT345996B (de) 1973-04-02 1974-04-01 Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saeureadditionssalze

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (2)

Publication Number Publication Date
ATA267974A ATA267974A (de) 1977-04-15
AT340605B true AT340605B (de) 1977-12-27

Family

ID=23363051

Family Applications (1)

Application Number Title Priority Date Filing Date
AT267974A AT340605B (de) 1973-04-02 1974-04-01 Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saureadditionssalze

Country Status (28)

Country Link
JP (2) JPS5919117B2 (de)
AR (2) AR204004A1 (de)
AT (1) AT340605B (de)
BE (1) BE813168A (de)
BG (3) BG21235A3 (de)
CA (1) CA1042428A (de)
CH (1) CH603669A5 (de)
CS (1) CS185223B2 (de)
CY (1) CY1044A (de)
DD (1) DD113538A5 (de)
DE (1) DE2415980A1 (de)
DK (1) DK141511B (de)
ES (2) ES424882A1 (de)
FR (1) FR2223044B1 (de)
GB (1) GB1463575A (de)
HK (1) HK20180A (de)
HU (1) HU171572B (de)
IE (1) IE39071B1 (de)
IL (1) IL44415A (de)
KE (1) KE3028A (de)
MY (1) MY8100025A (de)
NL (1) NL181079C (de)
PH (1) PH13623A (de)
RO (2) RO73524B (de)
SE (1) SE416206B (de)
SU (4) SU731900A3 (de)
YU (3) YU39719B (de)
ZA (1) ZA741674B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (de) * 1976-09-08 1982-07-07 Lilly Co Eli
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
FR2623504B1 (fr) * 1987-11-25 1990-03-09 Adir Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CA2662517A1 (en) 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
AU2014253584B2 (en) * 2013-04-19 2017-02-02 Jinan University Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof
CN113456797B (zh) * 2021-06-18 2024-03-08 暨南大学 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
HK20180A (en) 1980-04-25
RO73524A (ro) 1984-10-31
ZA741674B (en) 1975-10-29
IL44415A (en) 1978-08-31
IE39071B1 (en) 1978-08-02
FR2223044B1 (de) 1978-06-30
ES424882A1 (es) 1976-12-16
YU39876B (en) 1985-04-30
DE2415980A1 (de) 1974-10-10
MY8100025A (en) 1981-12-31
NL181079C (nl) 1987-06-16
DK141511B (da) 1980-04-08
HU171572B (hu) 1978-02-28
CH603669A5 (de) 1978-08-31
ES446571A1 (es) 1977-06-16
JPS6033837B2 (ja) 1985-08-05
RO77533A (ro) 1982-02-01
FR2223044A1 (de) 1974-10-25
KE3028A (en) 1980-03-28
NL181079B (nl) 1987-01-16
BG21235A3 (bg) 1976-03-20
AR203882A1 (es) 1975-10-31
BG22831A3 (bg) 1977-04-20
SU623522A3 (ru) 1978-09-05
YU113980A (en) 1982-05-31
YU39719B (en) 1985-04-30
BG21612A3 (bg) 1976-07-20
BE813168A (fr) 1974-10-02
IL44415A0 (en) 1974-06-30
RO73524B (ro) 1984-11-30
SU652896A3 (ru) 1979-03-15
SE416206B (sv) 1980-12-08
CS185223B2 (en) 1978-09-15
YU81774A (en) 1982-05-31
JPS59193895A (ja) 1984-11-02
GB1463575A (en) 1977-02-02
IE39071L (en) 1974-10-02
DK141511C (de) 1980-09-29
SU731900A3 (ru) 1980-04-30
DD113538A5 (de) 1975-06-12
SU784783A3 (ru) 1980-11-30
AR204004A1 (es) 1975-11-12
NL7404423A (de) 1974-10-04
PH13623A (en) 1980-08-07
YU39875B (en) 1985-04-30
YU113880A (en) 1982-05-31
DE2415980C2 (de) 1989-11-09
ATA267974A (de) 1977-04-15
CY1044A (en) 1980-08-01
CA1042428A (en) 1978-11-14
JPS49128000A (de) 1974-12-07
AU6671974A (en) 1975-09-18
JPS5919117B2 (ja) 1984-05-02

Similar Documents

Publication Publication Date Title
AT340605B (de) Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saureadditionssalze
AT330776B (de) Verfahren zur herstellung von neuen indolderivaten und von deren saureadditionssalzen
AT336202B (de) Verfahren zur herstellung neuer n- (methoxymethyl-furyl-methyl) -6,7- benzomorphane und -morphinane und deren saureadditionssalze
AT340920B (de) Verfahren zur herstellung neuer substituierter alfa-aminooxycarbonsaurehydrazidderivate und ihrer saureadditionssalze
AT336030B (de) Verfahren zur herstellung von neuen naphthyridinderivaten und von deren saureadditionssalzen
AT339307B (de) Verfahren zur herstellung von neuen derivaten des 1-phenoxy-3-amino-propan-2-ols und deren saureadditionssalzen
AT333724B (de) Verfahren zur herstellung von neuen n-substituierten phenoxyalkylaminen und deren saureadditionssalzen
ATA980175A (de) Verfahren zur herstellung neuer amidderivate von vinblastin, leurosidin und leurocristin und ihrer saureadditionssalze
AT337692B (de) Verfahren zur herstellung neuer nitroimidazolderivate und ihrer salze
AT339892B (de) Verfahren zur herstellung von neuen pyrazol -4- essigsaurederivaten und deren salzen
AT330737B (de) Verfahren zur herstellung von n-cyclohexyl-n-methyl-2-amino-3,5-dibrombenzylamin und dessen saureadditionssalzen
AT338784B (de) Verfahren zur herstellung von neuen derivaten des 1-phenoxy-3-amino-propan-2-ols und deren saureadditionssalzen
AT340422B (de) Verfahren zur herstellung von neuen dibenzyl-glykolsaurederivaten und deren salzen
AT332365B (de) Verfahren zur herstellung von acetondicarbonsaure und deren saurederivaten
AT338789B (de) Verfahren zur herstellung von neuen chinolin-derivaten und deren salzen
ATA629476A (de) Verfahren zur herstellung neuer substituierter alfa-aminooxycarbonsaurehydrazidderivate und ihrer salze
AT342604B (de) Verfahren zur herstellung von neuen thienotriazolodiazepin-derivaten und deren saureadditionssalzen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
ELJ Ceased due to non-payment of the annual fee
EWE Authorization for restitution
ELA Expired due to lapse of time