YU113880A - Process for obtaining new derivatives of vinblastin, leurocrystin and leurosin - Google Patents

Process for obtaining new derivatives of vinblastin, leurocrystin and leurosin

Info

Publication number
YU113880A
YU113880A YU01138/80A YU113880A YU113880A YU 113880 A YU113880 A YU 113880A YU 01138/80 A YU01138/80 A YU 01138/80A YU 113880 A YU113880 A YU 113880A YU 113880 A YU113880 A YU 113880A
Authority
YU
Yugoslavia
Prior art keywords
leurocrystin
leurosin
vinblastin
obtaining new
new derivatives
Prior art date
Application number
YU01138/80A
Other versions
YU39875B (en
Inventor
G J Cullinan
K Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of YU113880A publication Critical patent/YU113880A/en
Publication of YU39875B publication Critical patent/YU39875B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
YU1138/80A 1973-04-02 1980-04-25 Process for obtaining new derivatives of vinblastine leurocristine and leurosidine YU39875B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (2)

Publication Number Publication Date
YU113880A true YU113880A (en) 1982-05-31
YU39875B YU39875B (en) 1985-04-30

Family

ID=23363051

Family Applications (3)

Application Number Title Priority Date Filing Date
YU817/74A YU39719B (en) 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine
YU1139/80A YU39876B (en) 1973-04-02 1980-04-25 Process for obtaining new vinblastine derivatives
YU1138/80A YU39875B (en) 1973-04-02 1980-04-25 Process for obtaining new derivatives of vinblastine leurocristine and leurosidine

Family Applications Before (2)

Application Number Title Priority Date Filing Date
YU817/74A YU39719B (en) 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine
YU1139/80A YU39876B (en) 1973-04-02 1980-04-25 Process for obtaining new vinblastine derivatives

Country Status (28)

Country Link
JP (2) JPS5919117B2 (en)
AR (2) AR204004A1 (en)
AT (1) AT340605B (en)
BE (1) BE813168A (en)
BG (3) BG21235A3 (en)
CA (1) CA1042428A (en)
CH (1) CH603669A5 (en)
CS (1) CS185223B2 (en)
CY (1) CY1044A (en)
DD (1) DD113538A5 (en)
DE (1) DE2415980A1 (en)
DK (1) DK141511B (en)
ES (2) ES424882A1 (en)
FR (1) FR2223044B1 (en)
GB (1) GB1463575A (en)
HK (1) HK20180A (en)
HU (1) HU171572B (en)
IE (1) IE39071B1 (en)
IL (1) IL44415A (en)
KE (1) KE3028A (en)
MY (1) MY8100025A (en)
NL (1) NL181079C (en)
PH (1) PH13623A (en)
RO (2) RO73524B (en)
SE (1) SE416206B (en)
SU (4) SU731900A3 (en)
YU (3) YU39719B (en)
ZA (1) ZA741674B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (en) * 1976-09-08 1982-07-07 Lilly Co Eli
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (en) * 1980-06-10 1981-09-30 Omnium Chimique Sa Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
LU83822A1 (en) * 1981-12-08 1983-09-01 Omnichem Sa N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2623504B1 (en) * 1987-11-25 1990-03-09 Adir NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
WO2006077424A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
SG164368A1 (en) 2005-07-18 2010-09-29 Bipar Sciences Inc Treatment of cancer
WO2008030891A2 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof
CA2662517A1 (en) 2006-09-05 2008-03-13 Jerome Moore Treatment of cancer
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
AU2014253584B2 (en) * 2013-04-19 2017-02-02 Jinan University Vinca Alkaloid Derivatives, Preparation Method therefor and Application thereof
CN113456797B (en) * 2021-06-18 2024-03-08 暨南大学 Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
HK20180A (en) 1980-04-25
RO73524A (en) 1984-10-31
ZA741674B (en) 1975-10-29
AT340605B (en) 1977-12-27
IL44415A (en) 1978-08-31
IE39071B1 (en) 1978-08-02
FR2223044B1 (en) 1978-06-30
ES424882A1 (en) 1976-12-16
YU39876B (en) 1985-04-30
DE2415980A1 (en) 1974-10-10
MY8100025A (en) 1981-12-31
NL181079C (en) 1987-06-16
DK141511B (en) 1980-04-08
HU171572B (en) 1978-02-28
CH603669A5 (en) 1978-08-31
ES446571A1 (en) 1977-06-16
JPS6033837B2 (en) 1985-08-05
RO77533A (en) 1982-02-01
FR2223044A1 (en) 1974-10-25
KE3028A (en) 1980-03-28
NL181079B (en) 1987-01-16
BG21235A3 (en) 1976-03-20
AR203882A1 (en) 1975-10-31
BG22831A3 (en) 1977-04-20
SU623522A3 (en) 1978-09-05
YU113980A (en) 1982-05-31
YU39719B (en) 1985-04-30
BG21612A3 (en) 1976-07-20
BE813168A (en) 1974-10-02
IL44415A0 (en) 1974-06-30
RO73524B (en) 1984-11-30
SU652896A3 (en) 1979-03-15
SE416206B (en) 1980-12-08
CS185223B2 (en) 1978-09-15
YU81774A (en) 1982-05-31
JPS59193895A (en) 1984-11-02
GB1463575A (en) 1977-02-02
IE39071L (en) 1974-10-02
DK141511C (en) 1980-09-29
SU731900A3 (en) 1980-04-30
DD113538A5 (en) 1975-06-12
SU784783A3 (en) 1980-11-30
AR204004A1 (en) 1975-11-12
NL7404423A (en) 1974-10-04
PH13623A (en) 1980-08-07
YU39875B (en) 1985-04-30
DE2415980C2 (en) 1989-11-09
ATA267974A (en) 1977-04-15
CY1044A (en) 1980-08-01
CA1042428A (en) 1978-11-14
JPS49128000A (en) 1974-12-07
AU6671974A (en) 1975-09-18
JPS5919117B2 (en) 1984-05-02

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