JPS49128000A - - Google Patents

Info

Publication number
JPS49128000A
JPS49128000A JP49037765A JP3776574A JPS49128000A JP S49128000 A JPS49128000 A JP S49128000A JP 49037765 A JP49037765 A JP 49037765A JP 3776574 A JP3776574 A JP 3776574A JP S49128000 A JPS49128000 A JP S49128000A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP49037765A
Other languages
Japanese (ja)
Other versions
JPS5919117B2 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS49128000A publication Critical patent/JPS49128000A/ja
Publication of JPS5919117B2 publication Critical patent/JPS5919117B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP49037765A 1973-04-02 1974-04-02 Method for producing vinblastine leurocidin and leurocristine derivatives Expired JPS5919117B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02
US347275 1973-04-02

Publications (2)

Publication Number Publication Date
JPS49128000A true JPS49128000A (en) 1974-12-07
JPS5919117B2 JPS5919117B2 (en) 1984-05-02

Family

ID=23363051

Family Applications (2)

Application Number Title Priority Date Filing Date
JP49037765A Expired JPS5919117B2 (en) 1973-04-02 1974-04-02 Method for producing vinblastine leurocidin and leurocristine derivatives
JP58238722A Expired JPS6033837B2 (en) 1973-04-02 1983-12-16 Method for producing raw materials for producing vinblastine, leurocidine and leurocristine derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP58238722A Expired JPS6033837B2 (en) 1973-04-02 1983-12-16 Method for producing raw materials for producing vinblastine, leurocidine and leurocristine derivatives

Country Status (28)

Country Link
JP (2) JPS5919117B2 (en)
AR (2) AR204004A1 (en)
AT (1) AT340605B (en)
BE (1) BE813168A (en)
BG (3) BG21612A3 (en)
CA (1) CA1042428A (en)
CH (1) CH603669A5 (en)
CS (1) CS185223B2 (en)
CY (1) CY1044A (en)
DD (1) DD113538A5 (en)
DE (1) DE2415980A1 (en)
DK (1) DK141511B (en)
ES (2) ES424882A1 (en)
FR (1) FR2223044B1 (en)
GB (1) GB1463575A (en)
HK (1) HK20180A (en)
HU (1) HU171572B (en)
IE (1) IE39071B1 (en)
IL (1) IL44415A (en)
KE (1) KE3028A (en)
MY (1) MY8100025A (en)
NL (1) NL181079C (en)
PH (1) PH13623A (en)
RO (2) RO73524B (en)
SE (1) SE416206B (en)
SU (4) SU731900A3 (en)
YU (3) YU39719B (en)
ZA (1) ZA741674B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5195100A (en) * 1975-01-09 1976-08-20

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR69783B (en) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (en) * 1980-06-10 1981-09-30 Omnium Chimique Sa Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
LU83822A1 (en) * 1981-12-08 1983-09-01 Omnichem Sa N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2623504B1 (en) * 1987-11-25 1990-03-09 Adir NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
BRPI0606480A (en) 2005-01-21 2008-03-11 Astex Therapeutics Ltd pharmaceutical compounds
WO2007011962A2 (en) 2005-07-18 2007-01-25 Bipar Sciences, Inc. Treatment of cancer
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2217227B1 (en) 2007-11-12 2013-08-21 BiPar Sciences, Inc. Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
EP2987794B1 (en) * 2013-04-19 2018-05-30 Jinan University Vinblastine derivatives, preparation method therefor and application thereof
CN113456797B (en) * 2021-06-18 2024-03-08 暨南大学 Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5195100A (en) * 1975-01-09 1976-08-20

Also Published As

Publication number Publication date
YU113980A (en) 1982-05-31
FR2223044A1 (en) 1974-10-25
SU784783A3 (en) 1980-11-30
IL44415A (en) 1978-08-31
SE416206B (en) 1980-12-08
AR204004A1 (en) 1975-11-12
ES446571A1 (en) 1977-06-16
BG21235A3 (en) 1976-03-20
JPS5919117B2 (en) 1984-05-02
YU81774A (en) 1982-05-31
RO77533A (en) 1982-02-01
AU6671974A (en) 1975-09-18
IE39071B1 (en) 1978-08-02
MY8100025A (en) 1981-12-31
AT340605B (en) 1977-12-27
PH13623A (en) 1980-08-07
FR2223044B1 (en) 1978-06-30
JPS6033837B2 (en) 1985-08-05
BE813168A (en) 1974-10-02
HK20180A (en) 1980-04-25
GB1463575A (en) 1977-02-02
CH603669A5 (en) 1978-08-31
YU39719B (en) 1985-04-30
HU171572B (en) 1978-02-28
RO73524B (en) 1984-11-30
SU731900A3 (en) 1980-04-30
BG21612A3 (en) 1976-07-20
SU652896A3 (en) 1979-03-15
JPS59193895A (en) 1984-11-02
YU39876B (en) 1985-04-30
CA1042428A (en) 1978-11-14
YU113880A (en) 1982-05-31
KE3028A (en) 1980-03-28
DE2415980C2 (en) 1989-11-09
ES424882A1 (en) 1976-12-16
DK141511C (en) 1980-09-29
NL7404423A (en) 1974-10-04
YU39875B (en) 1985-04-30
CS185223B2 (en) 1978-09-15
NL181079C (en) 1987-06-16
IL44415A0 (en) 1974-06-30
DE2415980A1 (en) 1974-10-10
NL181079B (en) 1987-01-16
ATA267974A (en) 1977-04-15
AR203882A1 (en) 1975-10-31
RO73524A (en) 1984-10-31
IE39071L (en) 1974-10-02
DD113538A5 (en) 1975-06-12
SU623522A3 (en) 1978-09-05
BG22831A3 (en) 1977-04-20
ZA741674B (en) 1975-10-29
DK141511B (en) 1980-04-08
CY1044A (en) 1980-08-01

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