YU113980A - Process for obtaining new vinblastin derivatives - Google Patents

Process for obtaining new vinblastin derivatives

Info

Publication number
YU113980A
YU113980A YU01139/80A YU113980A YU113980A YU 113980 A YU113980 A YU 113980A YU 01139/80 A YU01139/80 A YU 01139/80A YU 113980 A YU113980 A YU 113980A YU 113980 A YU113980 A YU 113980A
Authority
YU
Yugoslavia
Prior art keywords
vinblastin
derivatives
obtaining new
obtaining
new
Prior art date
Application number
YU01139/80A
Other versions
YU39876B (en
Inventor
G J Cullinan
K Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of YU113980A publication Critical patent/YU113980A/en
Publication of YU39876B publication Critical patent/YU39876B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
YU1139/80A 1973-04-02 1980-04-25 Process for obtaining new vinblastine derivatives YU39876B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34727573A 1973-04-02 1973-04-02

Publications (2)

Publication Number Publication Date
YU113980A true YU113980A (en) 1982-05-31
YU39876B YU39876B (en) 1985-04-30

Family

ID=23363051

Family Applications (3)

Application Number Title Priority Date Filing Date
YU817/74A YU39719B (en) 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine
YU1139/80A YU39876B (en) 1973-04-02 1980-04-25 Process for obtaining new vinblastine derivatives
YU1138/80A YU39875B (en) 1973-04-02 1980-04-25 Process for obtaining new derivatives of vinblastine leurocristine and leurosidine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU817/74A YU39719B (en) 1973-04-02 1974-03-25 Process for obtaining new derivatives of vinbastine and leurocristine

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU1138/80A YU39875B (en) 1973-04-02 1980-04-25 Process for obtaining new derivatives of vinblastine leurocristine and leurosidine

Country Status (28)

Country Link
JP (2) JPS5919117B2 (en)
AR (2) AR204004A1 (en)
AT (1) AT340605B (en)
BE (1) BE813168A (en)
BG (3) BG21612A3 (en)
CA (1) CA1042428A (en)
CH (1) CH603669A5 (en)
CS (1) CS185223B2 (en)
CY (1) CY1044A (en)
DD (1) DD113538A5 (en)
DE (1) DE2415980A1 (en)
DK (1) DK141511B (en)
ES (2) ES424882A1 (en)
FR (1) FR2223044B1 (en)
GB (1) GB1463575A (en)
HK (1) HK20180A (en)
HU (1) HU171572B (en)
IE (1) IE39071B1 (en)
IL (1) IL44415A (en)
KE (1) KE3028A (en)
MY (1) MY8100025A (en)
NL (1) NL181079C (en)
PH (1) PH13623A (en)
RO (2) RO73524B (en)
SE (1) SE416206B (en)
SU (4) SU731900A3 (en)
YU (3) YU39719B (en)
ZA (1) ZA741674B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (en) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
USRE30560E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4096148A (en) * 1976-12-06 1978-06-20 Eli Lilly And Company Oxazolidinedione derivatives of Vinca alkaloids
US4203898A (en) 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (en) * 1980-06-10 1981-09-30 Omnium Chimique Sa Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
LU83822A1 (en) * 1981-12-08 1983-09-01 Omnichem Sa N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2623504B1 (en) * 1987-11-25 1990-03-09 Adir NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
BRPI0606480A (en) 2005-01-21 2008-03-11 Astex Therapeutics Ltd pharmaceutical compounds
WO2007011962A2 (en) 2005-07-18 2007-01-25 Bipar Sciences, Inc. Treatment of cancer
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
AU2007292306A1 (en) 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition of fatty acid synthesis by PARP inhibitors and methods of treatment thereof
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2217227B1 (en) 2007-11-12 2013-08-21 BiPar Sciences, Inc. Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents
EP2987794B1 (en) * 2013-04-19 2018-05-30 Jinan University Vinblastine derivatives, preparation method therefor and application thereof
CN113456797B (en) * 2021-06-18 2024-03-08 暨南大学 Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine

Also Published As

Publication number Publication date
FR2223044A1 (en) 1974-10-25
SU784783A3 (en) 1980-11-30
IL44415A (en) 1978-08-31
SE416206B (en) 1980-12-08
AR204004A1 (en) 1975-11-12
ES446571A1 (en) 1977-06-16
BG21235A3 (en) 1976-03-20
JPS5919117B2 (en) 1984-05-02
YU81774A (en) 1982-05-31
RO77533A (en) 1982-02-01
AU6671974A (en) 1975-09-18
IE39071B1 (en) 1978-08-02
MY8100025A (en) 1981-12-31
AT340605B (en) 1977-12-27
PH13623A (en) 1980-08-07
FR2223044B1 (en) 1978-06-30
JPS6033837B2 (en) 1985-08-05
BE813168A (en) 1974-10-02
HK20180A (en) 1980-04-25
GB1463575A (en) 1977-02-02
CH603669A5 (en) 1978-08-31
YU39719B (en) 1985-04-30
HU171572B (en) 1978-02-28
RO73524B (en) 1984-11-30
SU731900A3 (en) 1980-04-30
BG21612A3 (en) 1976-07-20
SU652896A3 (en) 1979-03-15
JPS59193895A (en) 1984-11-02
YU39876B (en) 1985-04-30
CA1042428A (en) 1978-11-14
YU113880A (en) 1982-05-31
KE3028A (en) 1980-03-28
DE2415980C2 (en) 1989-11-09
ES424882A1 (en) 1976-12-16
DK141511C (en) 1980-09-29
NL7404423A (en) 1974-10-04
YU39875B (en) 1985-04-30
CS185223B2 (en) 1978-09-15
NL181079C (en) 1987-06-16
IL44415A0 (en) 1974-06-30
DE2415980A1 (en) 1974-10-10
NL181079B (en) 1987-01-16
ATA267974A (en) 1977-04-15
AR203882A1 (en) 1975-10-31
RO73524A (en) 1984-10-31
IE39071L (en) 1974-10-02
DD113538A5 (en) 1975-06-12
SU623522A3 (en) 1978-09-05
BG22831A3 (en) 1977-04-20
ZA741674B (en) 1975-10-29
JPS49128000A (en) 1974-12-07
DK141511B (en) 1980-04-08
CY1044A (en) 1980-08-01

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