ES446571A1 - Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina. - Google Patents
Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina.Info
- Publication number
- ES446571A1 ES446571A1 ES446571A ES446571A ES446571A1 ES 446571 A1 ES446571 A1 ES 446571A1 ES 446571 A ES446571 A ES 446571A ES 446571 A ES446571 A ES 446571A ES 446571 A1 ES446571 A1 ES 446571A1
- Authority
- ES
- Spain
- Prior art keywords
- alq
- hydrogen
- formula
- alkyl
- cycloalq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940122803 Vinca alkaloid Drugs 0.000 title 1
- 150000003797 alkaloid derivatives Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001540 azides Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- JXLYSJRDGCGARV-PJXZDTQASA-N Leurosidine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-PJXZDTQASA-N 0.000 abstract 1
- JXLYSJRDGCGARV-KSNABSRWSA-N ac1l29ym Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-KSNABSRWSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- -1 cyano, phenyl Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 229960003048 vinblastine Drugs 0.000 abstract 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical class C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fodder In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34727573A | 1973-04-02 | 1973-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES446571A1 true ES446571A1 (es) | 1977-06-16 |
Family
ID=23363051
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES424882A Expired ES424882A1 (es) | 1973-04-02 | 1974-04-02 | Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina. |
| ES446571A Expired ES446571A1 (es) | 1973-04-02 | 1976-03-31 | Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES424882A Expired ES424882A1 (es) | 1973-04-02 | 1974-04-02 | Un procedimiento para la preparacion de derivados de vin- blastina, leurosidina y leurocristina. |
Country Status (28)
| Country | Link |
|---|---|
| JP (2) | JPS5919117B2 (es) |
| AR (2) | AR204004A1 (es) |
| AT (1) | AT340605B (es) |
| BE (1) | BE813168A (es) |
| BG (3) | BG22831A3 (es) |
| CA (1) | CA1042428A (es) |
| CH (1) | CH603669A5 (es) |
| CS (1) | CS185223B2 (es) |
| CY (1) | CY1044A (es) |
| DD (1) | DD113538A5 (es) |
| DE (1) | DE2415980A1 (es) |
| DK (1) | DK141511B (es) |
| ES (2) | ES424882A1 (es) |
| FR (1) | FR2223044B1 (es) |
| GB (1) | GB1463575A (es) |
| HK (1) | HK20180A (es) |
| HU (1) | HU171572B (es) |
| IE (1) | IE39071B1 (es) |
| IL (1) | IL44415A (es) |
| KE (1) | KE3028A (es) |
| MY (1) | MY8100025A (es) |
| NL (1) | NL181079C (es) |
| PH (1) | PH13623A (es) |
| RO (2) | RO73524B (es) |
| SE (1) | SE416206B (es) |
| SU (4) | SU731900A3 (es) |
| YU (3) | YU39719B (es) |
| ZA (1) | ZA741674B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL48685A (en) * | 1975-01-09 | 1980-03-31 | Lilly Co Eli | Amides of vincadioline and vinblastine |
| GR69783B (es) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
| USRE30561E (en) | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Vinca alkaloid intermediates |
| US4096148A (en) * | 1976-12-06 | 1978-06-20 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
| USRE30560E (en) * | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Oxazolidinedione derivatives of Vinca alkaloids |
| US4203898A (en) | 1977-08-29 | 1980-05-20 | Eli Lilly And Company | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids |
| US4199504A (en) * | 1978-05-15 | 1980-04-22 | Eli Lilly And Company | Bridged cathranthus alkaloid dimers |
| US4210584A (en) | 1979-01-15 | 1980-07-01 | Eli Lilly And Company | Vindesine synthesis |
| US4357334A (en) | 1980-03-20 | 1982-11-02 | Eli Lilly And Company | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
| OA06421A (fr) * | 1980-06-10 | 1981-09-30 | Omnium Chimique Sa | Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. |
| LU83822A1 (fr) * | 1981-12-08 | 1983-09-01 | Omnichem Sa | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
| FR2623504B1 (fr) * | 1987-11-25 | 1990-03-09 | Adir | Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| HUT76925A (hu) * | 1995-04-04 | 1998-01-28 | MTA Enzimológiai Intézet | Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények |
| US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6326402B1 (en) | 1998-08-12 | 2001-12-04 | Octamer, Inc. | Methods for treating viral infections using a compound capable of inhibiting microtubules |
| AU2006207321B2 (en) | 2005-01-21 | 2012-09-06 | Astex Therapeutics Limited | Pharmaceutical compounds |
| NZ565654A (en) | 2005-07-18 | 2010-10-29 | Bipar Sciences Inc | Use of iodonitrobenzamide compounds for the treatment of ovarian cancer |
| CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
| WO2008030883A2 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
| JP5528807B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| JP2011503111A (ja) | 2007-11-12 | 2011-01-27 | バイパー サイエンシズ，インコーポレイティド | Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療 |
| EP2987794B1 (en) * | 2013-04-19 | 2018-05-30 | Jinan University | Vinblastine derivatives, preparation method therefor and application thereof |
| CN113456797B (zh) * | 2021-06-18 | 2024-03-08 | 暨南大学 | 长春碱类衍生物在制备治疗骨肉瘤和/或软组织肉瘤药物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
-
1974
- 1974-01-01 AR AR253105A patent/AR204004A1/es active
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/xx unknown
- 1974-03-13 IL IL44415A patent/IL44415A/xx unknown
- 1974-03-13 IE IE532/74A patent/IE39071B1/xx unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-25 CY CY1044A patent/CY1044A/xx unknown
- 1974-03-25 YU YU817/74A patent/YU39719B/xx unknown
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/hu unknown
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/xx not_active IP Right Cessation
- 1974-04-01 SE SE7404380A patent/SE416206B/xx not_active IP Right Cessation
- 1974-04-01 SU SU742013753A patent/SU731900A3/ru active
- 1974-04-01 AT AT267974A patent/AT340605B/de not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/cs unknown
- 1974-04-01 DK DK178774AA patent/DK141511B/da not_active IP Right Cessation
- 1974-04-02 BG BG026279A patent/BG22831A3/xx unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/xx unknown
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/ja not_active Expired
- 1974-04-02 RO RO78274A patent/RO73524B/ro unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/es not_active Expired
- 1974-04-02 BE BE1005847A patent/BE813168A/xx not_active IP Right Cessation
- 1974-04-02 RO RO7498695A patent/RO77533A/ro unknown
- 1974-04-02 DE DE2415980A patent/DE2415980A1/de active Granted
- 1974-04-02 BG BG028514A patent/BG21235A3/xx unknown
-
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/es active
- 1975-07-04 SU SU752151512A patent/SU784783A3/ru active
- 1975-07-09 SU SU752152020A patent/SU652896A3/ru active
-
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/es not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/ru active
-
1980
- 1980-02-27 KE KE3028A patent/KE3028A/xx unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/xx unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/xx unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/xx unknown
-
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/xx unknown
-
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/ja not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES446571A1 (es) | Un procedimiento para la preparacion de derivados de vim- blastina, leurosidina y leurocristina. | |
| PH21545A (en) | Novel penicillins and pharmaceutically acceptable salts thereof which contain a mono- or di- oxo piperazino (thio)-carbonyl amino group in molecule | |
| IE41528L (en) | Furfuryl-benzomorphane derivatives. | |
| ES394370A1 (es) | Procedimiento para la preparacion de derivados de la inso-indolina. | |
| ES413639A1 (es) | Un procedimiento para la preparacion de un compuesto deri- vado de dopamina. | |
| ES393801A1 (es) | Un procedimiento para la preparacion de compuestos semisin-teticos utilizados en la produccion de cefalosporinas, peni-cilinas y compuestos antibioticos relacionados de beta-lac- tama. | |
| ES439909A1 (es) | Procedimiento para la preparacion de derivados s-2-tiol-4,5-difeniloxazol. | |
| SE7603951L (sv) | Forfarande for framstellning av 7-alfa-(4-hydroci-1,5-nafthydrin-3karbonamido)alfa-fenylacetamido-cefalosporinderivat | |
| ES479570A1 (es) | Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. | |
| ES404744A1 (es) | Un procedimiento para producir derivados de cefalosporina. | |
| ES423699A1 (es) | Procedimiento para la preparacion de acido amino-3-oxi-imi- nometil-3-cefem-4-carboxilico protegido en la posicion. | |
| SE7710059L (sv) | Forfarande for framstellning av amidderivat vinblastin, av leurosidin, leurokristin och beslektade dimera alkaloider | |
| ES395958A1 (es) | Un procedimiento para la produccion de un parahidroxifenil -alfa- aminoacido. | |
| ES438704A1 (es) | Procedimiento para preparar derivados de ergopectina. | |
| ES419142A1 (es) | Procedimiento para preparar derivados de tioseudourea. | |
| ES447615A1 (es) | Un procedimiento para obtener compuesto de cefalosporina. | |
| ES418841A1 (es) | Procedimiento para la obtencion de derivados del acido pi- ridin-3-acetico. | |
| ES393554A1 (es) | Un procedimiento para la preparacion de derivados de tia- zol. | |
| ES414340A1 (es) | Procedimiento de preparacion de derivados de la n-(m-tri- fluormetiltio-fenil-)-piperazina. | |
| ES444483A1 (es) | Un procedimiento de preparacion de nuevos derivados de acido2,3-alquilen (inferior) penam-3-carboxilico. | |
| ES441029A1 (es) | Procedimiento de preparacion de un nuevo derivado del acido acetilsalicilico. | |
| ES344072A1 (es) | Procedimiento para la obtencion de derivados de 2-imidazo- lidona. | |
| ES447375A1 (es) | Mejoras en la obtencion de composiciones para aumentar la produccion de legumbres. | |
| ES441151A1 (es) | Un metodo para preparar una composicion antialergica. | |
| GB1032377A (en) | Asymmetrical pyridoxolyl disulphides and their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970315 |