GB1492746A - Androstane derivatives and compositions containing them - Google Patents

Androstane derivatives and compositions containing them

Info

Publication number
GB1492746A
GB1492746A GB2211/74A GB221174A GB1492746A GB 1492746 A GB1492746 A GB 1492746A GB 2211/74 A GB2211/74 A GB 2211/74A GB 221174 A GB221174 A GB 221174A GB 1492746 A GB1492746 A GB 1492746A
Authority
GB
United Kingdom
Prior art keywords
isomer
androst
jan
pure
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2211/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Theramex SAM
Original Assignee
Laboratoire Theramex SAM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Priority to GB2211/74A priority Critical patent/GB1492746A/en
Priority to CH1734774A priority patent/CH606091A5/xx
Priority to BE151716A priority patent/BE823594A/en
Priority to DK690574AA priority patent/DK135538B/en
Priority to FR7443397A priority patent/FR2258185B1/fr
Priority to ES433677A priority patent/ES433677A1/en
Priority to DE19752501091 priority patent/DE2501091A1/en
Priority to ZA00750254A priority patent/ZA75254B/en
Priority to JP698075A priority patent/JPS576439B2/ja
Priority to AU77335/75A priority patent/AU521392B2/en
Priority to CA218,033A priority patent/CA1065851A/en
Priority to IT19319/75A priority patent/IT1044268B/en
Priority to PH16719A priority patent/PH15366A/en
Priority to LU71662A priority patent/LU71662A1/xx
Priority to SE7500479A priority patent/SE7500479L/xx
Priority to IE83/75A priority patent/IE40477B1/en
Priority to BR346/75A priority patent/BR7500346A/en
Priority to NLAANVRAGE7500608,A priority patent/NL183402C/en
Priority to AR257331A priority patent/AR203672A1/en
Publication of GB1492746A publication Critical patent/GB1492746A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Abstract

1492746 #<SP>2</SP>-Androstenes THERAMEX SA 17 Jan 1975 [17 Jan 1974] 02211/74 Heading C2U [Also in Division A5] The invention comprises 17α-ethynyl-5α- androst-2-en-17#-ol and its acetate free from their respective #<SP>3</SP>-isomers; and their preparation from the analogously pure corresponding 17-one by reaction with an alkali metal salt (simple or complex) of acetylene, followed when required by acetylation. 5α - Androst - 2 - en - 17 - one is freed from admixed #<SP>3</SP>-isomer thereof by treatment with Jones reagent and isolation of the pure #<SP>2</SP> compound from the resultant mixture, e.g. by crystallization or chromatography. (The #<SP>3</SP>- isomer is thought to be converted to a diacid or aldehyde while the #<SP>2</SP>-isomer remains unchanged). The inventive compounds are credited with pituitary gonadotrophin-stimulating, gonadinhibiting, antitumour, contraceptive, anti-parathyroid and anti-seborrhoeic activities, and may be made up with carriers into pharmaceutical compositions for oral, parenteral, topical and rectal administration.
GB2211/74A 1974-01-17 1974-01-17 Androstane derivatives and compositions containing them Expired GB1492746A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB2211/74A GB1492746A (en) 1974-01-17 1974-01-17 Androstane derivatives and compositions containing them
CH1734774A CH606091A5 (en) 1974-01-17 1974-12-18
BE151716A BE823594A (en) 1974-01-17 1974-12-19 PROCESS FOR OBTAINING THE COMPOUND 17 ALPHA-ETHINYL (5 ALPHA) 2-ANDROSTENE 17 BETA-OL IN THE PURE STATE AND THERAPEUTIC APPLICATIONS OF THE COMPOUND OBTAINED
DK690574AA DK135538B (en) 1974-01-17 1974-12-30 Process for the preparation of 17alpha-ethynyl- (5alpha) -2-androsten-17-beta-ol.
FR7443397A FR2258185B1 (en) 1974-01-17 1974-12-31
ES433677A ES433677A1 (en) 1974-01-17 1975-01-09 Androstane derivatives and compositions containing them
DE19752501091 DE2501091A1 (en) 1974-01-17 1975-01-13 17-ALPHA-AETHINYL- (5-ALPHA) -2-ANDROSTEN-17-BETA-OL AND ITS 17-BETA-ACETATE, METHOD FOR THEIR MANUFACTURING AND THERAPEUTIC USE
ZA00750254A ZA75254B (en) 1974-01-17 1975-01-14 17 alpha-ethynyl (5-alpha), 2-androsten, 17 beta-ol
JP698075A JPS576439B2 (en) 1974-01-17 1975-01-14
AU77335/75A AU521392B2 (en) 1974-01-17 1975-01-15 17-alpha-ethynyl-(5-alpha)-2-androsten-17-beta-ol and its beta-acetate
CA218,033A CA1065851A (en) 1974-01-17 1975-01-16 Process for the preparation of pure 17-alpha-ethinyl (5 alpha) 2-androstene 17 beta-ol and therapeutical application thereof
IT19319/75A IT1044268B (en) 1974-01-17 1975-01-16 PROCEDURE FOR THE PREPARATION OF THE COMPOUND 17 ALFA ETINIL 5 ALFA 2 ANDROSTENE 17 BETA OL AND ITS ACETATE 17 BETA IN THE PURE STATE ITS MIXTURE TO ITS DELTA 3 ISOMER AND THE THERAPEUTIC APPLICATIONS OF THE COMPOUND OBTAINED WITH THE PROCEDURE
PH16719A PH15366A (en) 1974-01-17 1975-01-16 17-alpha ethynyl,(5-alpha)-2-androsten,17-beta-ol and its beta agetate not mixed with its delta-3-isomers and the therapeutic applications of the compound
LU71662A LU71662A1 (en) 1974-01-17 1975-01-16
SE7500479A SE7500479L (en) 1974-01-17 1975-01-16
IE83/75A IE40477B1 (en) 1974-01-17 1975-01-17 Androstane derivatives and compositions containing them
BR346/75A BR7500346A (en) 1974-01-17 1975-01-17 PROCESS FOR OBTAINING COMPOUND 17-ALPHA-ETHINYL (5-ALPHA) -2-ANDROSTENE 17-BETA-OL AND ITS 17-BETA-ACETATE IN PURE STATE THE COMPOUND PRODUCED ITS MIXTURE WITH ITS DELTA-3 ISOMER AND THE APPLICATIONS OF COMPOUND OBTAINED BY THE PROCESS
NLAANVRAGE7500608,A NL183402C (en) 1974-01-17 1975-01-17 PROCESS FOR PREPARING 17-ALFA-ETHYNYL- (5-ALFA) -2-ANDROSTONE-17-BETA-OL, ITS ACETATE, METHOD FOR PREPARING A MEDICINAL PRODUCT, AND PREPARED PREPARED THEREOF.
AR257331A AR203672A1 (en) 1974-01-17 1975-01-17 PROCEDURE FOR OBTAINING IN THE COMPOSITE STATE 17ALPHA-ETHINYL (5ALPHA) -2-ANDROSTENE, 17BETA-OL, AND ITS 17BETA-ACETATE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2211/74A GB1492746A (en) 1974-01-17 1974-01-17 Androstane derivatives and compositions containing them

Publications (1)

Publication Number Publication Date
GB1492746A true GB1492746A (en) 1977-11-23

Family

ID=9735557

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2211/74A Expired GB1492746A (en) 1974-01-17 1974-01-17 Androstane derivatives and compositions containing them

Country Status (19)

Country Link
JP (1) JPS576439B2 (en)
AR (1) AR203672A1 (en)
AU (1) AU521392B2 (en)
BE (1) BE823594A (en)
BR (1) BR7500346A (en)
CA (1) CA1065851A (en)
CH (1) CH606091A5 (en)
DE (1) DE2501091A1 (en)
DK (1) DK135538B (en)
ES (1) ES433677A1 (en)
FR (1) FR2258185B1 (en)
GB (1) GB1492746A (en)
IE (1) IE40477B1 (en)
IT (1) IT1044268B (en)
LU (1) LU71662A1 (en)
NL (1) NL183402C (en)
PH (1) PH15366A (en)
SE (1) SE7500479L (en)
ZA (1) ZA75254B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0066001A1 (en) * 1981-06-02 1982-12-08 Laboratoire Théramex Pharmaceutical compositions containing androstenes
WO1986001208A1 (en) * 1984-08-17 1986-02-27 Sri International Stereoisometrically pure 17-alpha-ethynyl-estra-2-en-17beta-ol and esters thereof
FR2598083A1 (en) * 1986-05-05 1987-11-06 Theramex Laboratoire NOVEL PHARMACEUTICAL COMPOSITIONS WITH ANTIPROGESTERONIC ACTION AND PROCESS FOR OBTAINING THEM
US5116830A (en) * 1984-08-17 1992-05-26 Sri International Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60173248A (en) * 1984-02-16 1985-09-06 三晃金属工業株式会社 Inlaid outer enclosure
EP0200591B1 (en) * 1985-04-29 1989-01-18 Laboratoire Theramex Process for the preparation of pure androst-2-ene derivatives
RU2652702C2 (en) 2016-10-19 2018-04-28 Игорь Ву-Юнович Ван Sub-atmospheric system of heat and cold supply

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0066001A1 (en) * 1981-06-02 1982-12-08 Laboratoire Théramex Pharmaceutical compositions containing androstenes
WO1986001208A1 (en) * 1984-08-17 1986-02-27 Sri International Stereoisometrically pure 17-alpha-ethynyl-estra-2-en-17beta-ol and esters thereof
US5116830A (en) * 1984-08-17 1992-05-26 Sri International Stereoisomerically pure 17α-ethynyl-estra-2-en-17β-ol and the 17β esters thereof, methods of preparation and uses
FR2598083A1 (en) * 1986-05-05 1987-11-06 Theramex Laboratoire NOVEL PHARMACEUTICAL COMPOSITIONS WITH ANTIPROGESTERONIC ACTION AND PROCESS FOR OBTAINING THEM

Also Published As

Publication number Publication date
CA1065851A (en) 1979-11-06
AU521392B2 (en) 1982-04-01
PH15366A (en) 1982-12-10
FR2258185A1 (en) 1975-08-18
IT1044268B (en) 1980-03-20
SE7500479L (en) 1975-07-18
JPS576439B2 (en) 1982-02-04
AR203672A1 (en) 1975-09-30
CH606091A5 (en) 1978-10-13
DE2501091A1 (en) 1975-07-24
DK135538C (en) 1977-10-24
FR2258185B1 (en) 1978-07-28
NL7500608A (en) 1975-07-21
AU7733575A (en) 1976-07-15
DK690574A (en) 1975-09-29
IE40477B1 (en) 1979-06-06
ZA75254B (en) 1976-01-28
NL183402C (en) 1988-10-17
ES433677A1 (en) 1976-11-16
JPS50106952A (en) 1975-08-22
IE40477L (en) 1975-07-17
LU71662A1 (en) 1975-06-24
DK135538B (en) 1977-05-16
NL183402B (en) 1988-05-16
BR7500346A (en) 1975-11-04
BE823594A (en) 1975-04-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee