RO113529B1 - Procedeu de preparare a cristalelor de analog de insulina umana - Google Patents

Procedeu de preparare a cristalelor de analog de insulina umana Download PDF

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Publication number
RO113529B1
RO113529B1 RO95-01139A RO9501139A RO113529B1 RO 113529 B1 RO113529 B1 RO 113529B1 RO 9501139 A RO9501139 A RO 9501139A RO 113529 B1 RO113529 B1 RO 113529B1
Authority
RO
Romania
Prior art keywords
insulin
human
solution
crystals
zinc
Prior art date
Application number
RO95-01139A
Other languages
English (en)
Romanian (ro)
Inventor
Jeffrey Clayton Baker
Nancy Delores Carter
Bruce Hill Frank
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22990041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO113529(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of RO113529B1 publication Critical patent/RO113529B1/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RO95-01139A 1994-06-16 1995-06-14 Procedeu de preparare a cristalelor de analog de insulina umana RO113529B1 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,647 US5504188A (en) 1994-06-16 1994-06-16 Preparation of stable zinc insulin analog crystals

Publications (1)

Publication Number Publication Date
RO113529B1 true RO113529B1 (ro) 1998-08-28

Family

ID=22990041

Family Applications (1)

Application Number Title Priority Date Filing Date
RO95-01139A RO113529B1 (ro) 1994-06-16 1995-06-14 Procedeu de preparare a cristalelor de analog de insulina umana

Country Status (29)

Country Link
US (1) US5504188A (OSRAM)
EP (1) EP0692489B1 (OSRAM)
JP (1) JP3595607B2 (OSRAM)
KR (1) KR100369951B1 (OSRAM)
CN (1) CN1184234C (OSRAM)
AT (1) ATE233278T1 (OSRAM)
AU (1) AU697794B2 (OSRAM)
BR (1) BR9502798A (OSRAM)
CA (1) CA2151563C (OSRAM)
CO (1) CO4410205A1 (OSRAM)
CZ (1) CZ286066B6 (OSRAM)
DE (1) DE69529708T2 (OSRAM)
DK (1) DK0692489T3 (OSRAM)
ES (1) ES2188637T3 (OSRAM)
FI (1) FI952930L (OSRAM)
HU (1) HUT73495A (OSRAM)
IL (1) IL114152A (OSRAM)
IN (1) IN178919B (OSRAM)
MY (1) MY130551A (OSRAM)
NO (1) NO952334L (OSRAM)
NZ (1) NZ272358A (OSRAM)
PE (1) PE21896A1 (OSRAM)
PL (1) PL180968B1 (OSRAM)
RO (1) RO113529B1 (OSRAM)
RU (1) RU2156257C2 (OSRAM)
SI (1) SI0692489T1 (OSRAM)
TW (1) TW379228B (OSRAM)
YU (1) YU39595A (OSRAM)
ZA (1) ZA954942B (OSRAM)

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* Cited by examiner, † Cited by third party
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RU2205188C2 (ru) 1998-06-30 2003-05-27 Ново Нордиск А/С Затравочные кристаллы для получения пептидов или протеинов
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6635617B1 (en) 1998-10-16 2003-10-21 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
CN1210058C (zh) * 1998-10-16 2005-07-13 诺沃挪第克公司 用于肺送递的稳定的浓缩胰岛素制剂
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
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US20040214747A1 (en) * 1999-01-06 2004-10-28 Dimarchi Richard Dennis Method for administering monomeric insulin
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US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
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US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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MX2008011123A (es) 2006-03-28 2008-09-30 High Point Pharmaceuticals Llc Benzotiazoles que tienen actividad de receptor h3 de histamina.
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CN106117345B (zh) * 2015-05-05 2020-11-24 宜昌东阳光长江药业股份有限公司 一种制备甘精胰岛素结晶的方法
CN104892749B (zh) * 2015-06-16 2019-02-05 珠海联邦制药股份有限公司 一种德谷胰岛素结晶的制备方法及应用
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JP2023520049A (ja) 2020-03-31 2023-05-15 プロトマー・テクノロジーズ・インコーポレイテッド 隣接ジオールに対する選択的応答性のためのコンジュゲート
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Also Published As

Publication number Publication date
CZ154195A3 (en) 1996-02-14
CN1184234C (zh) 2005-01-12
PL309099A1 (en) 1995-12-27
AU2168195A (en) 1996-01-04
BR9502798A (pt) 1996-06-04
CA2151563A1 (en) 1995-12-17
RU95110107A (ru) 1997-05-10
NZ272358A (en) 1996-12-20
FI952930A0 (fi) 1995-06-14
DE69529708T2 (de) 2003-10-16
AU697794B2 (en) 1998-10-15
FI952930A7 (fi) 1995-12-17
CZ286066B6 (cs) 2000-01-12
MY130551A (en) 2007-06-29
IL114152A0 (en) 1995-10-31
CO4410205A1 (es) 1997-01-09
KR960000922A (ko) 1996-01-25
TW379228B (en) 2000-01-11
ZA954942B (en) 1996-12-17
IN178919B (OSRAM) 1997-07-19
EP0692489A1 (en) 1996-01-17
JP3595607B2 (ja) 2004-12-02
DK0692489T3 (da) 2003-03-31
EP0692489B1 (en) 2003-02-26
CN1128271A (zh) 1996-08-07
KR100369951B1 (ko) 2003-03-28
DE69529708D1 (de) 2003-04-03
ATE233278T1 (de) 2003-03-15
CA2151563C (en) 2007-08-07
NO952334D0 (no) 1995-06-13
JPH08169899A (ja) 1996-07-02
YU39595A (sh) 1997-08-22
SI0692489T1 (en) 2003-06-30
HU9501715D0 (en) 1995-08-28
IL114152A (en) 1999-12-31
FI952930L (fi) 1995-12-17
PE21896A1 (es) 1996-06-15
ES2188637T3 (es) 2003-07-01
HUT73495A (en) 1996-08-28
PL180968B1 (pl) 2001-05-31
NO952334L (no) 1995-12-18
RU2156257C2 (ru) 2000-09-20
US5504188A (en) 1996-04-02

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