|
DE19819023A1
(de)
|
1998-04-29 |
1999-11-04 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
US6331571B1
(en)
|
1998-08-24 |
2001-12-18 |
Sepracor, Inc. |
Methods of treating and preventing attention deficit disorders
|
|
US6974838B2
(en)
|
1998-08-24 |
2005-12-13 |
Sepracor Inc. |
Methods of treating or preventing pain using sibutramine metabolites
|
|
US6476078B2
(en)
|
1999-08-11 |
2002-11-05 |
Sepracor, Inc. |
Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
|
|
US6339106B1
(en)
|
1999-08-11 |
2002-01-15 |
Sepracor, Inc. |
Methods and compositions for the treatment and prevention of sexual dysfunction
|
|
CA2365578A1
(en)
|
1999-03-30 |
2000-10-12 |
Seiichi Uchida |
Thienopyrimidine compounds and salts thereof and process for the preparation of the same
|
|
US6399826B1
(en)
|
1999-08-11 |
2002-06-04 |
Sepracor Inc. |
Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
|
|
DE19950647A1
(de)
*
|
1999-10-21 |
2001-04-26 |
Merck Patent Gmbh |
Imidazolderivate als Phosphodiesterase VII-Hemmer
|
|
DE10031585A1
(de)
*
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
2-Aminoalkyl-thieno[2,3-d]pyrimidine
|
|
EP1329454A1
(en)
*
|
2000-09-29 |
2003-07-23 |
Nippon Soda Co., Ltd. |
Thienopyrimidine compounds and their salts and process for preparation of both
|
|
WO2002062343A2
(en)
*
|
2001-02-02 |
2002-08-15 |
Merck Patent Gmbh |
PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO[4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS
|
|
WO2002083631A1
(en)
|
2001-04-13 |
2002-10-24 |
Sepracor Inc. |
Methods of preparing didesmethylsibutramine and other sibutramine derivatives
|
|
JP2005503345A
(ja)
*
|
2001-04-30 |
2005-02-03 |
バイエル・コーポレーシヨン |
新規な4−アミノ−5,6−置換チオフェノ[2,3−d]ピリミジン
|
|
CN1261437C
(zh)
*
|
2001-09-04 |
2006-06-28 |
阿克佐诺贝尔公司 |
具有LH与FSH联合激动活性的甘氨酸-取代的噻吩并[2,3-d]嘧啶
|
|
JPWO2003035653A1
(ja)
*
|
2001-10-26 |
2005-02-10 |
日本曹達株式会社 |
ピリドチエノピリミジン化合物およびその塩
|
|
US7153412B2
(en)
|
2001-12-28 |
2006-12-26 |
Kabushiki Kaisha Toyota Chuo Kenkyusho |
Electrodes, electrochemical elements, gas sensors, and gas measurement methods
|
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
|
AR044743A1
(es)
*
|
2002-09-26 |
2005-10-05 |
Nihon Nohyaku Co Ltd |
Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos,
|
|
GB0320300D0
(en)
*
|
2003-08-29 |
2003-10-01 |
Cancer Rec Tech Ltd |
Pyrimidothiophene compounds
|
|
DE10351436A1
(de)
*
|
2003-11-04 |
2005-06-09 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
|
GB0420719D0
(en)
*
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
GB0420722D0
(en)
*
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
|
AR059898A1
(es)
*
|
2006-03-15 |
2008-05-07 |
Janssen Pharmaceutica Nv |
Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
|
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
|
TW200845978A
(en)
*
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
|
US9603848B2
(en)
|
2007-06-08 |
2017-03-28 |
Senomyx, Inc. |
Modulation of chemosensory receptors and ligands associated therewith
|
|
US8722894B2
(en)
*
|
2007-09-14 |
2014-05-13 |
Janssen Pharmaceuticals, Inc. |
1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
|
|
MX2010002536A
(es)
|
2007-09-14 |
2010-08-10 |
Ortho Mcneil Janssen Pharm |
4-fenil-3,4,5,6-tetrahidro-2h, 1'h-[1,4]bipiridinil-2'-onas 1',3'-disubstituidas.
|
|
CA2697399C
(en)
|
2007-09-14 |
2016-01-19 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
|
|
MX2010005110A
(es)
*
|
2007-11-14 |
2010-09-09 |
Ortho Mcneil Janssen Pharm |
Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2.
|
|
US20100227853A1
(en)
*
|
2008-04-18 |
2010-09-09 |
Trustees Of Boston College |
Inhibitors of cyclic amp phosphodiesterases
|
|
EP3085699B1
(en)
|
2008-07-31 |
2022-03-02 |
Firmenich Incorporated |
Processes for making sweet taste enhancers
|
|
BRPI0918055A2
(pt)
|
2008-09-02 |
2015-12-01 |
Addex Pharmaceuticals Sa |
derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato.
|
|
JP5656848B2
(ja)
|
2008-10-16 |
2015-01-21 |
ジャンセン ファーマシューティカルズ, インコーポレイテッド. |
代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
|
|
CA2744138C
(en)
|
2008-11-28 |
2015-08-11 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
|
|
ES2409006T3
(es)
|
2009-05-12 |
2013-06-24 |
Janssen Pharmaceuticals Inc. |
Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2
|
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
|
SG176021A1
(en)
|
2009-05-12 |
2011-12-29 |
Janssen Pharmaceuticals Inc |
1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
|
|
US9012448B2
(en)
|
2010-11-08 |
2015-04-21 |
Janssen Pharmaceuticals, Inc. |
1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
|
|
WO2012062759A1
(en)
|
2010-11-08 |
2012-05-18 |
Janssen Pharmaceuticals, Inc. |
1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
|
|
PL2649069T3
(pl)
|
2010-11-08 |
2016-01-29 |
Janssen Pharmaceuticals Inc |
Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
|
|
MX2014000648A
(es)
|
2011-07-19 |
2014-09-25 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y sus usos.
|
|
US20150119399A1
(en)
|
2012-01-10 |
2015-04-30 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
|
RU2018129982A
(ru)
|
2012-08-06 |
2019-03-15 |
Сеномикс, Инк. |
Модификатор сладкого вкуса и аромата
|
|
JO3155B1
(ar)
|
2013-02-19 |
2017-09-20 |
Senomyx Inc |
معدِّل نكهة حلوة
|
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
|
PT3096790T
(pt)
|
2014-01-21 |
2019-10-15 |
Janssen Pharmaceutica Nv |
Combinações compreendendo moduladores alostéricos positivos ou agonistas ortostéricos do recetor glutamatérgico metabotrópico do subtipo 2 e seu uso
|
|
EA202192105A3
(ru)
|
2014-02-04 |
2022-02-28 |
Янссен Фармацевтика Нв |
Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение
|
|
JP6687550B2
(ja)
|
2014-06-23 |
2020-04-22 |
セルジーン コーポレイション |
肝疾患又は肝機能異常を治療するためのアプレミラスト
|
|
SG11201804901WA
(en)
|
2015-12-22 |
2018-07-30 |
SHY Therapeutics LLC |
Compounds for the treatment of cancer and inflammatory disease
|
|
CA3066939A1
(en)
|
2017-06-21 |
2018-12-27 |
SHY Therapeutics LLC |
Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
MX2021001193A
(es)
|
2018-08-07 |
2021-04-28 |
Firmenich Incorporated |
2,2-dioxidos de 4-amino-1h-benzo[c][1,2,6]tiadiazina 5-sustituidos y formulaciones y usos de los mismos.
|
|
WO2020132071A1
(en)
|
2018-12-19 |
2020-06-25 |
Shy Therapeutics. Llc |
Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease
|
|
CN116178374B
(zh)
*
|
2023-01-13 |
2024-10-08 |
河北医科大学 |
小电导钙激活钾离子通道激动剂及其合成和应用
|