PT873405E - Elementos de sequencia que aumentam a expressao (ease) para sistemas de expressao eucarioticos - Google Patents
Elementos de sequencia que aumentam a expressao (ease) para sistemas de expressao eucarioticosInfo
- Publication number
- PT873405E PT873405E PT97902909T PT97902909T PT873405E PT 873405 E PT873405 E PT 873405E PT 97902909 T PT97902909 T PT 97902909T PT 97902909 T PT97902909 T PT 97902909T PT 873405 E PT873405 E PT 873405E
- Authority
- PT
- Portugal
- Prior art keywords
- expression
- eucariotic
- ease
- sequence
- elements
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Amplifiers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Control Of Indicators Other Than Cathode Ray Tubes (AREA)
- Error Detection And Correction (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58650996A | 1996-01-11 | 1996-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT873405E true PT873405E (pt) | 2005-01-31 |
Family
ID=24346030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97902909T PT873405E (pt) | 1996-01-11 | 1997-01-10 | Elementos de sequencia que aumentam a expressao (ease) para sistemas de expressao eucarioticos |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6027915A (pt) |
| EP (1) | EP0873405B1 (pt) |
| JP (1) | JP3495375B2 (pt) |
| KR (1) | KR19990077015A (pt) |
| AT (1) | ATE275628T1 (pt) |
| AU (1) | AU708981B2 (pt) |
| CA (1) | CA2241174C (pt) |
| DE (1) | DE69730592T2 (pt) |
| DK (1) | DK0873405T3 (pt) |
| ES (1) | ES2227669T3 (pt) |
| NO (1) | NO323277B1 (pt) |
| NZ (1) | NZ330926A (pt) |
| PT (1) | PT873405E (pt) |
| WO (1) | WO1997025420A1 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0873405T3 (da) * | 1996-01-11 | 2005-01-17 | Immunex Corp | Ekspressionsforøgende sekvenselementer (EASE) til eukaryote ekspressionssystemer |
| US6596514B2 (en) * | 1996-01-11 | 2003-07-22 | Immunex Corporation | Expression augmenting sequence elements (EASE) for eukaryotic expression systems |
| DE69740107D1 (de) | 1996-12-23 | 2011-03-10 | Immunex Corp | Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie |
| US6521419B1 (en) | 1998-09-22 | 2003-02-18 | Kanakaraju Koduri | Expression vectors containing hot spot for increased recombinant protein expression in transfected cells |
| US6800457B2 (en) | 1998-09-22 | 2004-10-05 | Bristol-Myers Squibb Company | Expression vectors containing hot spot for increased recombinant protein expression in transfected cells |
| DE60024659T2 (de) | 1999-10-13 | 2006-08-17 | Immunex Corp., Thousand Oaks | Vektoren und verfahren für rekombinante proteinexpression |
| DE60030769T2 (de) | 1999-12-23 | 2007-10-25 | Zymogenetics, Inc., Seattle | Verfahren zur behandlung von entzündungen |
| KR100450266B1 (ko) * | 2002-01-16 | 2004-09-30 | 주식회사 엘지생명과학 | 유전자 발현 동물세포 제조용 바이시스트로닉 벡터 및이를 포함하는 세포주 그리고 이를 이용한 항체단백질의생산방법 |
| AU2003228383A1 (en) * | 2002-04-09 | 2003-10-27 | Global Biotech Inc. | Human tissue urokinase type plasminogen activator production |
| AU2003278695A1 (en) * | 2002-05-28 | 2004-02-02 | Maxygen, Inc. | Nucleic acid vectors |
| JP2005031812A (ja) * | 2003-07-08 | 2005-02-03 | Toshiba Corp | 画像形成装置およびその制御方法 |
| KR100807312B1 (ko) | 2005-10-22 | 2008-02-28 | (주)리즈바이오텍 | 재조합 인간 인슐린 유사 성장 인자 결합 단백질-3의 생산정제 방법 |
| US20080124760A1 (en) * | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
| SG174804A1 (pt) | 2006-09-13 | 2011-10-28 | Abbott Lab | |
| EP2500415A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
| JP5432117B2 (ja) | 2007-03-30 | 2014-03-05 | アッヴィ・インコーポレイテッド | 宿主細胞中の組換えタンパク質の発現を増進するための組換え発現ベクター要素（ｒＥＶＥ） |
| EP2328908A4 (en) | 2008-08-28 | 2012-11-28 | Univ New York State Res Found | TREATMENT OF AMYLOIDOSES BASED ON MYELIN BASED PROTEIN AND FRAGMENTS THEREOF |
| JP4568378B2 (ja) * | 2008-08-29 | 2010-10-27 | 東洋紡績株式会社 | 遺伝子発現安定化エレメント |
| AU2009319772A1 (en) | 2008-11-26 | 2010-06-03 | Centocor Research & Development, Inc. | Compositions and methods for regulating collagen and smooth muscle actin expression by SERPINE2 |
| WO2010147464A1 (en) | 2009-06-15 | 2010-12-23 | Cellagenics B.V. | Use of a cysteine synthesizing enzyme as selectable marker |
| CN103038352B (zh) * | 2010-06-15 | 2015-12-16 | 萨拉基尼克有限公司 | 用于增强基因表达的新型基因间元件 |
| KR101599138B1 (ko) * | 2014-06-17 | 2016-03-03 | 한국생명공학연구원 | 재조합 단백질 발현 증진을 위한 유전자 절편을 포함하는 벡터 및 이의 용도 |
| WO2016003368A1 (en) * | 2014-07-01 | 2016-01-07 | Agency For Science, Technology And Research | Optimized vectors for the production of recombinant proteins |
| EP3856910A4 (en) * | 2018-09-24 | 2022-09-28 | Merck Sharp & Dohme Corp. | EXPRESSION VECTORS FOR EUKARYOT EXPRESSION SYSTEMS |
| KR20210101270A (ko) | 2018-12-10 | 2021-08-18 | 암젠 인크 | 돌연변이 피기백 트랜스포사제 |
| WO2020132382A1 (en) | 2018-12-21 | 2020-06-25 | Merck Sharp & Dohme Corp. | Expression vectors for eukaryotic expression systems |
| EP3980547A4 (en) * | 2019-06-07 | 2023-06-28 | Biocon Biologics Limited | Mammalian expression vectors |
| TW202233660A (zh) | 2020-10-30 | 2022-09-01 | 美商安進公司 | 過表現胰島素樣生長因子受體突變體以調節ｉｇｆ補充 |
| JP2024503239A (ja) | 2020-12-22 | 2024-01-25 | アムジェン インコーポレイテッド | 細胞培養法 |
| WO2022261299A1 (en) | 2021-06-10 | 2022-12-15 | Amgen Inc. | Engineered nrg-1 variants with improved selectivity toward erbb4 but not against erbb3 |
| TW202328442A (zh) | 2021-09-10 | 2023-07-16 | 美商安進公司 | 平臺宿主對ｉｇｆ—培養基之適應 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3730246A1 (de) * | 1987-09-09 | 1989-06-01 | Boehringer Mannheim Gmbh | Expressionsvektor und verfahren zur expression von heterologen proteinen in saeugerzellen |
| DK0873405T3 (da) * | 1996-01-11 | 2005-01-17 | Immunex Corp | Ekspressionsforøgende sekvenselementer (EASE) til eukaryote ekspressionssystemer |
-
1997
- 1997-01-10 DK DK97902909T patent/DK0873405T3/da active
- 1997-01-10 AT AT97902909T patent/ATE275628T1/de active
- 1997-01-10 KR KR1019980705146A patent/KR19990077015A/ko not_active Application Discontinuation
- 1997-01-10 NZ NZ330926A patent/NZ330926A/xx not_active IP Right Cessation
- 1997-01-10 ES ES97902909T patent/ES2227669T3/es not_active Expired - Lifetime
- 1997-01-10 EP EP97902909A patent/EP0873405B1/en not_active Expired - Lifetime
- 1997-01-10 CA CA002241174A patent/CA2241174C/en not_active Expired - Lifetime
- 1997-01-10 AU AU16973/97A patent/AU708981B2/en not_active Ceased
- 1997-01-10 PT PT97902909T patent/PT873405E/pt unknown
- 1997-01-10 JP JP52544497A patent/JP3495375B2/ja not_active Expired - Fee Related
- 1997-01-10 DE DE69730592T patent/DE69730592T2/de not_active Expired - Lifetime
- 1997-01-10 WO PCT/US1997/000483 patent/WO1997025420A1/en active IP Right Grant
- 1997-01-13 US US08/785,150 patent/US6027915A/en not_active Expired - Lifetime
-
1998
- 1998-07-03 NO NO19983102A patent/NO323277B1/no not_active IP Right Cessation
-
1999
- 1999-11-05 US US09/435,377 patent/US6312951B1/en not_active Expired - Lifetime
-
2000
- 2000-09-12 US US09/660,299 patent/US6309841B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0873405A1 (en) | 1998-10-28 |
| NO983102L (no) | 1998-09-08 |
| CA2241174C (en) | 2006-09-12 |
| DE69730592D1 (de) | 2004-10-14 |
| KR19990077015A (ko) | 1999-10-25 |
| US6309841B1 (en) | 2001-10-30 |
| US6027915A (en) | 2000-02-22 |
| EP0873405A4 (en) | 2001-10-17 |
| JP3495375B2 (ja) | 2004-02-09 |
| AU708981B2 (en) | 1999-08-19 |
| NO983102D0 (no) | 1998-07-03 |
| NZ330926A (en) | 1999-11-29 |
| EP0873405B1 (en) | 2004-09-08 |
| NO323277B1 (no) | 2007-02-26 |
| WO1997025420A1 (en) | 1997-07-17 |
| US6312951B1 (en) | 2001-11-06 |
| DE69730592T2 (de) | 2005-09-29 |
| DK0873405T3 (da) | 2005-01-17 |
| AU1697397A (en) | 1997-08-01 |
| JP2000503205A (ja) | 2000-03-21 |
| ATE275628T1 (de) | 2004-09-15 |
| CA2241174A1 (en) | 1997-07-17 |
| ES2227669T3 (es) | 2005-04-01 |
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