CY1109439T1 - Αναλογα γλυκοπρωτεϊνικων ορμονων δισουλφιδικης σταυρωτης συνδεσης, η παρασκευη και η χρηση τους - Google Patents

Αναλογα γλυκοπρωτεϊνικων ορμονων δισουλφιδικης σταυρωτης συνδεσης, η παρασκευη και η χρηση τους

Info

Publication number
CY1109439T1
CY1109439T1 CY20091100994T CY091100994T CY1109439T1 CY 1109439 T1 CY1109439 T1 CY 1109439T1 CY 20091100994 T CY20091100994 T CY 20091100994T CY 091100994 T CY091100994 T CY 091100994T CY 1109439 T1 CY1109439 T1 CY 1109439T1
Authority
CY
Cyprus
Prior art keywords
preparation
glycoprotein
hormones
analogues
disulfide crosslinked
Prior art date
Application number
CY20091100994T
Other languages
English (en)
Inventor
William R Moyle
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21967404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109439(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of CY1109439T1 publication Critical patent/CY1109439T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η εφεύρεση αφορά ανάλογα γλυκοπρωτεϊνικών ορμονών με δισουλφιδική σταυρωτή σύνδεση σε ενδο-υπομονάδα, καθώς και την παρασκευή και χρήση τους. Οι αντίστοιχες ακολουθίες DNA και τα κύτταρα-ξενιστές, καθώς και οι φαρμακευτικές συνθέσεις επίσης αποκαλύπτονται.
CY20091100994T 1997-06-25 2009-09-24 Αναλογα γλυκοπρωτεϊνικων ορμονων δισουλφιδικης σταυρωτης συνδεσης, η παρασκευη και η χρηση τους CY1109439T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5078497P 1997-06-25 1997-06-25
EP06015992A EP1775346B1 (en) 1997-06-25 1998-06-25 Disulfide crosslinked glycoprotein hormone analogs, their preparation and use

Publications (1)

Publication Number Publication Date
CY1109439T1 true CY1109439T1 (el) 2014-08-13

Family

ID=21967404

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20061101598T CY1105763T1 (el) 1997-06-25 2006-11-01 Αναλογα γλυκοπρωτεϊνικων ορμονων δισουλφιδικης σταυρωτης συνδεσης, η παρασκευη και η χρηση τους
CY20091100994T CY1109439T1 (el) 1997-06-25 2009-09-24 Αναλογα γλυκοπρωτεϊνικων ορμονων δισουλφιδικης σταυρωτης συνδεσης, η παρασκευη και η χρηση τους

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20061101598T CY1105763T1 (el) 1997-06-25 2006-11-01 Αναλογα γλυκοπρωτεϊνικων ορμονων δισουλφιδικης σταυρωτης συνδεσης, η παρασκευη και η χρηση τους

Country Status (21)

Country Link
US (1) US8530190B1 (el)
EP (2) EP1775346B1 (el)
JP (3) JP3950484B2 (el)
KR (2) KR100560279B1 (el)
CN (3) CN100404551C (el)
AR (1) AR013139A1 (el)
AT (2) ATE439439T1 (el)
AU (1) AU747179B2 (el)
BR (1) BR9810478A (el)
CA (1) CA2293731C (el)
CY (2) CY1105763T1 (el)
DE (2) DE69841063D1 (el)
DK (2) DK0996629T3 (el)
ES (2) ES2332931T3 (el)
HK (1) HK1033149A1 (el)
HU (1) HU227908B1 (el)
IL (2) IL133686A0 (el)
PT (2) PT1775346E (el)
SI (2) SI1775346T1 (el)
WO (1) WO1998058957A2 (el)
ZA (1) ZA985545B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716428B1 (en) * 1999-10-06 2004-04-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
KR100808149B1 (ko) 2000-02-22 2008-02-29 라보라토리스 세로노 에스.에이. 정제된 ｌｈ
WO2002030978A1 (en) * 2000-10-06 2002-04-18 Regeneron Pharmaceuticals, Inc. Polypeptides, methods of making, and uses thereof
EP1497634A4 (en) * 2001-11-08 2007-02-07 Applied Research Systems PROTEIN KNOT
WO2007031566A1 (en) 2005-09-14 2007-03-22 Ares Trading S.A. Method for the quantitative determination of poloxamers
CN101370825B (zh) * 2006-01-17 2012-10-10 默克雪兰诺有限公司 新颖的fsh糖基化突变体d3n
CN101250531B (zh) * 2006-11-27 2013-04-24 株式会社Lg生命科学 一核苷酸序列、包含该序列的表达载体、该载体转化的动物细胞及利用该细胞生产人fsh的方法
WO2009098318A1 (en) 2008-02-08 2009-08-13 Biogenerix Ag Liquid formulation of fsh
CN101347613B (zh) * 2008-09-17 2011-10-26 上海天伟生物制药有限公司 几乎不含亚基的糖蛋白的组合物及其制备方法
RU2539797C2 (ru) * 2009-01-22 2015-01-27 Ново Нордиск Хелс Кеа Аг Производное гормона роста человека с повышенной стабильностью к протеолитическому разрушению, способ получения такого производного, его применение, способ лечения и фармацевтическая композиция
JP5845170B2 (ja) 2009-04-01 2016-01-20 ラティオファーム ゲーエムベーハー 組換えｆｓｈを精製する方法
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
US9695226B2 (en) 2010-01-22 2017-07-04 Novo Nordisk Healthcare Ag Growth hormones with prolonged in-vivo efficacy
US9211342B2 (en) 2010-01-22 2015-12-15 Novo Nordisk Healthcare Ag Stable growth hormone compounds resistant to proteolytic degradation
JP6087338B2 (ja) 2011-03-31 2017-03-01 フェリング ベスローテン フェンノートシャップ 医薬製剤
EP3572515B1 (en) * 2012-07-30 2021-07-21 Trophogen Inc. Glycoprotein hormone long-acting superagonists
US11045523B2 (en) 2013-04-05 2021-06-29 Novo Nordisk Healthcare Ag Formulation of growth hormone albumin-binder conjugate
WO2022072677A1 (en) * 2020-09-30 2022-04-07 The University Of North Carolina At Chapel Hill Engineered stable lactate oxidoreductases, compositions, devices, kits and uses thereof
WO2022150878A1 (en) * 2021-01-13 2022-07-21 University Of Newcastle Compositions and methods of using targeting peptides and nanopharmaceuticals for the sterilization of cats and dogs
WO2024099445A1 (zh) * 2022-11-10 2024-05-16 康立泰生物医药(青岛)有限公司 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5691455A (en) * 1995-10-24 1997-11-25 Akzo Nobel N.V. Gonadotropins with non-native disulfide bridges
WO2006113452A2 (en) * 2005-04-13 2006-10-26 University Of Medicine And Dentistry Of New Jersey Glycoprotein hormone analogs

Also Published As

Publication number Publication date
EP0996629A2 (en) 2000-05-03
DK1775346T3 (da) 2009-09-28
HUP0100681A3 (en) 2004-03-01
JP4278668B2 (ja) 2009-06-17
WO1998058957A9 (en) 1999-06-03
CN1269833A (zh) 2000-10-11
AU747179B2 (en) 2002-05-09
SI1775346T1 (sl) 2009-10-31
CA2293731A1 (en) 1998-12-30
IL133686A (en) 2007-07-24
KR20040039421A (ko) 2004-05-10
ATE335000T1 (de) 2006-08-15
KR20020006720A (ko) 2002-01-26
KR100706469B1 (ko) 2007-04-10
CA2293731C (en) 2010-01-12
ZA985545B (en) 1999-04-01
CN1197968C (zh) 2005-04-20
DE69835433D1 (de) 2006-09-14
DE69841063D1 (de) 2009-09-24
EP0996629B1 (en) 2006-08-02
EP1775346B1 (en) 2009-08-12
US8530190B1 (en) 2013-09-10
CN1548458A (zh) 2004-11-24
PT996629E (pt) 2006-12-29
AR013139A1 (es) 2000-12-13
SI0996629T1 (sl) 2006-12-31
HU227908B1 (en) 2012-05-29
ATE439439T1 (de) 2009-08-15
ES2332931T3 (es) 2010-02-15
JP2005162734A (ja) 2005-06-23
CN1302010C (zh) 2007-02-28
DE69835433T2 (de) 2007-03-08
AU7986198A (en) 1999-01-04
ES2268781T3 (es) 2007-03-16
JP2001521402A (ja) 2001-11-06
CN1548459A (zh) 2004-11-24
CY1105763T1 (el) 2011-02-02
HUP0100681A1 (hu) 2001-06-28
KR100560279B1 (ko) 2006-03-10
IL133686A0 (en) 2001-04-30
DK0996629T3 (da) 2006-12-04
BR9810478A (pt) 2000-09-12
JP4279768B2 (ja) 2009-06-17
PT1775346E (pt) 2009-08-25
WO1998058957A3 (en) 1999-04-22
CN100404551C (zh) 2008-07-23
WO1998058957A2 (en) 1998-12-30
JP2007016040A (ja) 2007-01-25
HK1033149A1 (en) 2001-08-17
JP3950484B2 (ja) 2007-08-01
EP1775346A1 (en) 2007-04-18

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