DK1775346T3 - Disulfid-tværbundne glycoproteinhormonanaloger, deres fremstilling og anvendelse - Google Patents

Disulfid-tværbundne glycoproteinhormonanaloger, deres fremstilling og anvendelse

Info

Publication number
DK1775346T3
DK1775346T3 DK06015992T DK06015992T DK1775346T3 DK 1775346 T3 DK1775346 T3 DK 1775346T3 DK 06015992 T DK06015992 T DK 06015992T DK 06015992 T DK06015992 T DK 06015992T DK 1775346 T3 DK1775346 T3 DK 1775346T3
Authority
DK
Denmark
Prior art keywords
preparation
glycoprotein hormone
hormone analogues
disulfide crosslinked
crosslinked glycoprotein
Prior art date
Application number
DK06015992T
Other languages
English (en)
Inventor
William R Moyle
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21967404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1775346(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of DK1775346T3 publication Critical patent/DK1775346T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK06015992T 1997-06-25 1998-06-25 Disulfid-tværbundne glycoproteinhormonanaloger, deres fremstilling og anvendelse DK1775346T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5078497P 1997-06-25 1997-06-25
PCT/US1998/013070 WO1998058957A2 (en) 1997-06-25 1998-06-25 Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Publications (1)

Publication Number Publication Date
DK1775346T3 true DK1775346T3 (da) 2009-09-28

Family

ID=21967404

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06015992T DK1775346T3 (da) 1997-06-25 1998-06-25 Disulfid-tværbundne glycoproteinhormonanaloger, deres fremstilling og anvendelse
DK98930477T DK0996629T3 (da) 1997-06-25 1998-06-25 Disulfidtværbundne glycoproteinhormonanaloger, deres fremstilling og anvendelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98930477T DK0996629T3 (da) 1997-06-25 1998-06-25 Disulfidtværbundne glycoproteinhormonanaloger, deres fremstilling og anvendelse

Country Status (21)

Country Link
US (1) US8530190B1 (da)
EP (2) EP0996629B1 (da)
JP (3) JP3950484B2 (da)
KR (2) KR100560279B1 (da)
CN (3) CN1302010C (da)
AR (1) AR013139A1 (da)
AT (2) ATE439439T1 (da)
AU (1) AU747179B2 (da)
BR (1) BR9810478A (da)
CA (1) CA2293731C (da)
CY (2) CY1105763T1 (da)
DE (2) DE69835433T2 (da)
DK (2) DK1775346T3 (da)
ES (2) ES2332931T3 (da)
HK (1) HK1033149A1 (da)
HU (1) HU227908B1 (da)
IL (2) IL133686A0 (da)
PT (2) PT996629E (da)
SI (2) SI1775346T1 (da)
WO (1) WO1998058957A2 (da)
ZA (1) ZA985545B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716428B1 (en) * 1999-10-06 2004-04-06 The Ohio State University Research Foundation Antigenic modification of polypeptides
CN100480258C (zh) 2000-02-22 2009-04-22 雪兰诺实验室有限公司 纯化的黄体生成激素
AU2000280019A1 (en) * 2000-10-06 2002-04-22 Regeneron Pharmaceuticals, Inc. Polypeptides, methods of making, and uses thereof
CN1596304A (zh) * 2001-11-08 2005-03-16 威廉R·莫伊尔 蛋白质结节
KR20080043301A (ko) 2005-09-14 2008-05-16 아레스 트레이딩 에스.에이. 폴록사머의 정량 방법
EP1981908B1 (en) * 2006-01-17 2010-11-10 Merck Serono SA Novel fsh glycosylation variant d3n
CN101250531B (zh) * 2006-11-27 2013-04-24 株式会社Lg生命科学 一核苷酸序列、包含该序列的表达载体、该载体转化的动物细胞及利用该细胞生产人fsh的方法
UA99337C2 (ru) 2008-02-08 2012-08-10 Биодженерикс Аг Жидкая лекарственная форма фсг
CN101347613B (zh) * 2008-09-17 2011-10-26 上海天伟生物制药有限公司 几乎不含亚基的糖蛋白的组合物及其制备方法
ES2542202T3 (es) * 2009-01-22 2015-08-03 Novo Nordisk Health Care Ag Compuestos de hormonas de crecimiento estables
EA028065B1 (ru) 2009-04-01 2017-10-31 Рациофарм Гмбх Способ очистки рекомбинантного фсг
TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2325194A1 (en) 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
JP5875527B2 (ja) 2010-01-22 2016-03-02 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ｉｎ−ｖｉｖｏにおける効力が延長された成長ホルモン
AU2011208620B2 (en) 2010-01-22 2015-04-16 Novo Nordisk Health Care Ag Stable growth hormone compounds
CA3163525A1 (en) 2011-03-31 2012-10-04 Ferring Bv. Pharmaceutical preparation
PT3572515T (pt) * 2012-07-30 2021-10-22 Trophogen Inc Superagonistas de ação prolongada de hormonas glicoproteicas
JP6464145B2 (ja) 2013-04-05 2019-02-06 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー 成長ホルモン化合物製剤
JP2023544722A (ja) * 2020-09-30 2023-10-25 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 操作された安定な乳酸オキシドレダクターゼ、その組成物、デバイス、キットおよび使用
WO2022150878A1 (en) * 2021-01-13 2022-07-21 University Of Newcastle Compositions and methods of using targeting peptides and nanopharmaceuticals for the sterilization of cats and dogs
WO2024099445A1 (zh) * 2022-11-10 2024-05-16 康立泰生物医药(青岛)有限公司 聚乙二醇定点修饰异源聚体蛋白或多肽及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079230A (en) * 1988-09-12 1992-01-07 Pitman-Moore, Inc. Stable bioactive somatotropins
US5691455A (en) * 1995-10-24 1997-11-25 Akzo Nobel N.V. Gonadotropins with non-native disulfide bridges
US20090209453A1 (en) * 2005-04-13 2009-08-20 University Of Medicine And Dentistry Of New Jersey Glycoprotein Hormone Analogs

Also Published As

Publication number Publication date
AR013139A1 (es) 2000-12-13
JP4279768B2 (ja) 2009-06-17
CN1302010C (zh) 2007-02-28
KR20020006720A (ko) 2002-01-26
CY1105763T1 (el) 2011-02-02
WO1998058957A9 (en) 1999-06-03
EP1775346A1 (en) 2007-04-18
CN1548458A (zh) 2004-11-24
BR9810478A (pt) 2000-09-12
AU7986198A (en) 1999-01-04
JP2005162734A (ja) 2005-06-23
HUP0100681A1 (hu) 2001-06-28
ATE439439T1 (de) 2009-08-15
PT996629E (pt) 2006-12-29
EP0996629B1 (en) 2006-08-02
JP2007016040A (ja) 2007-01-25
DE69835433D1 (de) 2006-09-14
WO1998058957A3 (en) 1999-04-22
ATE335000T1 (de) 2006-08-15
KR20040039421A (ko) 2004-05-10
DK0996629T3 (da) 2006-12-04
CN100404551C (zh) 2008-07-23
HUP0100681A3 (en) 2004-03-01
EP1775346B1 (en) 2009-08-12
HK1033149A1 (en) 2001-08-17
EP0996629A2 (en) 2000-05-03
JP3950484B2 (ja) 2007-08-01
CN1197968C (zh) 2005-04-20
CA2293731A1 (en) 1998-12-30
HU227908B1 (en) 2012-05-29
DE69835433T2 (de) 2007-03-08
ES2268781T3 (es) 2007-03-16
KR100706469B1 (ko) 2007-04-10
ES2332931T3 (es) 2010-02-15
IL133686A0 (en) 2001-04-30
JP4278668B2 (ja) 2009-06-17
PT1775346E (pt) 2009-08-25
CA2293731C (en) 2010-01-12
SI1775346T1 (sl) 2009-10-31
US8530190B1 (en) 2013-09-10
IL133686A (en) 2007-07-24
AU747179B2 (en) 2002-05-09
SI0996629T1 (sl) 2006-12-31
CY1109439T1 (el) 2014-08-13
ZA985545B (en) 1999-04-01
CN1269833A (zh) 2000-10-11
CN1548459A (zh) 2004-11-24
DE69841063D1 (de) 2009-09-24
JP2001521402A (ja) 2001-11-06
KR100560279B1 (ko) 2006-03-10
WO1998058957A2 (en) 1998-12-30

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