EP1497634A4 - Protein knobs - Google Patents

Protein knobs

Info

Publication number
EP1497634A4
EP1497634A4 EP02789525A EP02789525A EP1497634A4 EP 1497634 A4 EP1497634 A4 EP 1497634A4 EP 02789525 A EP02789525 A EP 02789525A EP 02789525 A EP02789525 A EP 02789525A EP 1497634 A4 EP1497634 A4 EP 1497634A4
Authority
EP
European Patent Office
Prior art keywords
knobs
protein
protein knobs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02789525A
Other languages
German (de)
French (fr)
Other versions
EP1497634A2 (en
Inventor
Yongna Xing
William R Moyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Publication of EP1497634A2 publication Critical patent/EP1497634A2/en
Publication of EP1497634A4 publication Critical patent/EP1497634A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP02789525A 2001-11-08 2002-11-08 Protein knobs Withdrawn EP1497634A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34528301P 2001-11-08 2001-11-08
US345283P 2001-11-08
PCT/US2002/035914 WO2003040695A2 (en) 2001-11-08 2002-11-08 Protein knobs

Publications (2)

Publication Number Publication Date
EP1497634A2 EP1497634A2 (en) 2005-01-19
EP1497634A4 true EP1497634A4 (en) 2007-02-07

Family

ID=23354368

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02789525A Withdrawn EP1497634A4 (en) 2001-11-08 2002-11-08 Protein knobs

Country Status (13)

Country Link
EP (1) EP1497634A4 (en)
JP (2) JP2005509652A (en)
KR (1) KR20040063928A (en)
CN (1) CN1596304A (en)
CA (1) CA2466595A1 (en)
EA (1) EA200400647A1 (en)
HR (1) HRP20040242A2 (en)
IL (1) IL161804A0 (en)
MX (1) MXPA04004289A (en)
NO (1) NO20042358L (en)
PL (1) PL373566A1 (en)
WO (1) WO2003040695A2 (en)
ZA (1) ZA200404373B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1769000B1 (en) * 2004-07-16 2014-12-24 Amgen Research (Munich) GmbH Expression-enhanced polypeptides
GB201403815D0 (en) * 2014-03-04 2014-04-16 Mologic Ltd Assay
CN112986571B (en) * 2019-12-12 2023-04-11 中国科学院大连化学物理研究所 Method for identifying Midkine spatiotemporal network interaction protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058957A2 (en) * 1997-06-25 1998-12-30 Applied Research Systems Ars Holding N.V. Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE190461T1 (en) * 1983-11-02 2000-04-15 Applied Research Systems PRODUCTS AND METHODS FOR PRODUCING A HETERODIMERIC HUMAN LH HAVING A MET42 VAL55 ALPHA SUBUNIT
EP0461200B1 (en) * 1989-02-21 1997-01-22 Washington University Modified forms of reproductive hormones
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
WO1997004080A1 (en) * 1995-07-14 1997-02-06 Fuji Yakuhin Kogyo Kabushiki Kaisha Novel protein and monoclonal antibody specific thereto
US6001354A (en) * 1995-11-17 1999-12-14 Washington University GRB2 associating polypeptides and nucleic acids encoding therefor
US5837837A (en) * 1997-02-27 1998-11-17 Millennium Pharmaceuticals, Inc. Nucleic acids molecules encoding Caspase-8h and Caspase-8i

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058957A2 (en) * 1997-06-25 1998-12-30 Applied Research Systems Ars Holding N.V. Disulfide cross-linked glycoprotein hormone analogs, their preparation and use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EINSTEIN MONICA ET AL: "Partial restoration of lutropin activity by an intersubunit disulfide bond: Implications for structure/function studies", EXPERIMENTAL BIOLOGY AND MEDICINE (MAYWOOD), vol. 226, no. 6, June 2001 (2001-06-01), pages 581 - 590, XP002412111, ISSN: 1535-3702 *
HEIKOOP J C ET AL: "STRUCTURE-BASED DESIGN AND PROTEIN ENGINEERING OF INTERSUBUNIT DISULFIDE BONDS IN GONADOTROPINS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 15, July 1997 (1997-07-01), pages 658 - 662, XP000619993, ISSN: 1087-0156 *
XING YONGNA ET AL: "Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 50, 14 December 2001 (2001-12-14), pages 46953 - 46960, XP002412112, ISSN: 0021-9258 *
XING YONGNA ET AL: "Use of protein knobs to characterize the position of conserved alpha-subunit regions in lutropin receptor complexes", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 43, 22 October 2004 (2004-10-22), pages 44427 - 44437, XP002412113, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
JP2008110973A (en) 2008-05-15
PL373566A1 (en) 2005-09-05
ZA200404373B (en) 2005-11-30
NO20042358L (en) 2004-08-09
MXPA04004289A (en) 2005-03-31
WO2003040695A3 (en) 2004-11-11
HRP20040242A2 (en) 2005-02-28
EP1497634A2 (en) 2005-01-19
CA2466595A1 (en) 2003-05-15
KR20040063928A (en) 2004-07-14
WO2003040695A2 (en) 2003-05-15
IL161804A0 (en) 2005-11-20
JP2005509652A (en) 2005-04-14
EA200400647A1 (en) 2004-10-28
CN1596304A (en) 2005-03-16

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20040602

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MOYLE, WILLIAM R.

Inventor name: XING, YONGNA

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/62 20060101ALI20061228BHEP

Ipc: C12N 15/52 20060101ALI20061228BHEP

Ipc: C12N 15/16 20060101ALI20061228BHEP

Ipc: C12N 15/12 20060101ALI20061228BHEP

Ipc: C12N 9/00 20060101ALI20061228BHEP

Ipc: C12N 5/06 20060101ALI20061228BHEP

Ipc: C07K 14/59 20060101AFI20061228BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20070110

17Q First examination report despatched

Effective date: 20090707

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20090603