PT86226B - Processo para a preparacao de novos 1-ariloxi-3-amino-2-propanois e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos 1-ariloxi-3-amino-2-propanois e de composicoes farmaceuticas que os contem Download PDF

Info

Publication number
PT86226B
PT86226B PT86226A PT8622687A PT86226B PT 86226 B PT86226 B PT 86226B PT 86226 A PT86226 A PT 86226A PT 8622687 A PT8622687 A PT 8622687A PT 86226 B PT86226 B PT 86226B
Authority
PT
Portugal
Prior art keywords
radical
alkyl
carbon atoms
groups
substituted
Prior art date
Application number
PT86226A
Other languages
English (en)
Portuguese (pt)
Other versions
PT86226A (de
Inventor
Walter Kobinger
Christian Lillie
Herbert Koppe
Franz Esser
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of PT86226A publication Critical patent/PT86226A/pt
Publication of PT86226B publication Critical patent/PT86226B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
PT86226A 1986-11-28 1987-11-26 Processo para a preparacao de novos 1-ariloxi-3-amino-2-propanois e de composicoes farmaceuticas que os contem PT86226B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863640829 DE3640829A1 (de) 1986-11-28 1986-11-28 Neue 1-aryloxy-3-amino-2-propanole, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
PT86226A PT86226A (de) 1987-12-01
PT86226B true PT86226B (pt) 1990-11-07

Family

ID=6315091

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86226A PT86226B (pt) 1986-11-28 1987-11-26 Processo para a preparacao de novos 1-ariloxi-3-amino-2-propanois e de composicoes farmaceuticas que os contem

Country Status (20)

Country Link
US (1) US4948812A (ko)
EP (1) EP0269985A3 (ko)
JP (1) JPS63150253A (ko)
KR (1) KR880006164A (ko)
AU (1) AU594840B2 (ko)
CS (1) CS270576B2 (ko)
DD (1) DD275241A5 (ko)
DE (1) DE3640829A1 (ko)
DK (1) DK625287A (ko)
FI (1) FI875212A (ko)
HU (1) HU200319B (ko)
IL (1) IL84633A0 (ko)
NO (1) NO874958L (ko)
NZ (1) NZ222719A (ko)
PH (1) PH24745A (ko)
PL (1) PL269047A1 (ko)
PT (1) PT86226B (ko)
SU (1) SU1574169A3 (ko)
YU (1) YU213887A (ko)
ZA (1) ZA878917B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084463A (en) * 1989-12-11 1992-01-28 American Home Products Corporation N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
US4994459A (en) * 1989-12-11 1991-02-19 American Home Products Corporation Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity
US5250570A (en) * 1990-08-02 1993-10-05 Imperial Chemical Industries Plc Amidobenzene derivatives, compositions and use
US7351719B2 (en) * 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1199037A (en) * 1967-09-27 1970-07-15 Ici Ltd Alkanolamine Derivatives
GB1078852A (en) * 1964-09-30 1967-08-09 Ici Ltd Alkanolamine derivatives
US3864398A (en) * 1972-05-01 1975-02-04 Teikoku Hormone Mfg Co Ltd Process for the preparation of acylamino alkanol derivatives
DE2611601A1 (de) * 1976-03-19 1977-09-22 Basf Ag Nicotinsaeureanilide
JPS5988467A (ja) * 1982-11-09 1984-05-22 Yoshitomi Pharmaceut Ind Ltd フエノキシアミノプロパノ−ル誘導体

Also Published As

Publication number Publication date
KR880006164A (ko) 1988-07-21
HU200319B (en) 1990-05-28
PT86226A (de) 1987-12-01
SU1574169A3 (ru) 1990-06-23
DK625287D0 (da) 1987-11-27
AU594840B2 (en) 1990-03-15
DD275241A5 (de) 1990-01-17
AU8187487A (en) 1988-06-02
NO874958L (no) 1988-05-30
JPS63150253A (ja) 1988-06-22
PH24745A (en) 1990-10-01
DE3640829A1 (de) 1988-06-09
EP0269985A2 (de) 1988-06-08
EP0269985A3 (de) 1990-07-04
HUT49112A (en) 1989-08-28
NZ222719A (en) 1990-05-28
FI875212A (fi) 1988-05-29
CS270576B2 (en) 1990-07-12
ZA878917B (en) 1989-07-26
IL84633A0 (en) 1988-04-29
PL269047A1 (en) 1988-09-15
NO874958D0 (no) 1987-11-27
FI875212A0 (fi) 1987-11-26
YU213887A (en) 1988-12-31
CS850787A2 (en) 1989-11-14
US4948812A (en) 1990-08-14
DK625287A (da) 1988-05-29

Similar Documents

Publication Publication Date Title
US5859246A (en) 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
AT398201B (de) Neue chinolinsulfonaminoderivate und verfahren zu deren herstellung sowie pharmazeutische zusammensetzung
DD205904A5 (de) Verfahren zur herstellung von imidazo (4,5-c) pyridin-derivaten
EP0159566A1 (en) Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
RU2091379C1 (ru) Дифенилметилпиперазиновые производные или их фармацевтически приемлемая соль
US3974158A (en) 2-(Substituted anilino)methylmorpholines
EP0047923A1 (de) Isochinolinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE69127976T2 (de) Tropolonderivate und pharmazeutische zubereitungen davon zur vorbeugung und behandlung von ischämischen krankheiten
US4067904A (en) Alkylsulfonylphenoxypropanolamine derivatives
EP0104614B1 (en) Phenylpiperazine derivatives and process for producing the same
FI80448C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara piperazinkarboxamidderivat.
EP1021415A1 (en) Tricyclic aminoalkylcarboxamides; novel dopamine d 3? receptor subtype specific ligands
IE852285L (en) Piperazinylindanes
FI70708C (fi) Foerfarande foer framstaellning av nya farmaceutiskt anvaendbara 2-imidazolin-1-yl-urinaemne- och -amidofoereningar
PT86226B (pt) Processo para a preparacao de novos 1-ariloxi-3-amino-2-propanois e de composicoes farmaceuticas que os contem
US3721739A (en) Imidazolidinone derivatives in a composition and method for producing c.n.s.depressant effects
US5244895A (en) Anti-ulcer agent
DE3723648A1 (de) Indol-derivate, ihre herstellung und sie enthaltende arzneimittel
US4031216A (en) 3-(3,4-Dialkoxy-benzyl)-3-methyl-piperazines
PT96315B (pt) Processo para a preparacao de derivados de diamina e de composicoes farmaceuticas que os contem
EP0167245B1 (en) Anti-arrhythmic agents
DE69024385T2 (de) Verbindung zur Behandlung von Störungen des Neurotransmittersystems im Gehirn
US3996360A (en) Piperazine compounds
DE2905637C3 (de) 1,5-Benzothiazepin-Derivate
DE1795060C3 (de) Morpholin- und N-Methyl-piperazinderivate und Arzneimittel

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19910907