KR880006164A - 1-아릴옥시-3-아미노-2-프로판올, 이의 제조 방법 및 용도 - Google Patents
1-아릴옥시-3-아미노-2-프로판올, 이의 제조 방법 및 용도 Download PDFInfo
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- KR880006164A KR880006164A KR870013326A KR870013326A KR880006164A KR 880006164 A KR880006164 A KR 880006164A KR 870013326 A KR870013326 A KR 870013326A KR 870013326 A KR870013326 A KR 870013326A KR 880006164 A KR880006164 A KR 880006164A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/44—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 라세미체, 순수한 에난티오머 또는 에난티오머의 혼합물 형태인 하기 일반식(I)의 화합물 및 이의 산부가염.상기식에서, R1은 1개 이상의 할로겐원자, 저급 알킬, 알콕시, 알케닐, 알키닐, 알케닐옥시, 알키닐옥시, 사이클로알킬, 아실, 아실옥시, 알콕시카보닐, 하이드록시알킬 또는 알콕시알킬 그룹 또는 설파모일 그룹 또는 유리원자가의 결합이 서로에 대해 오르토-위치에서 이루어지는 환-형성그룹-(CH=CH)2-또는 -O-CH2-O-에 의해 임의로 치환될 수 있는 페닐 그룹을 나타내거나; 1개 이상의 할로겐 원자, 저급 알킬, 알콕시, 알케닐, 알키닐, 알케닐옥시, 알키닐옥시, 하이드록시알킬, 알콕시알킬, 아실, 아실옥시 또는 알콕시카보닐 그룹, 및 유리원자가의 결합이 서로에 대해 오르토-위치에서 이루어지는 환-형성 그룹-(CH=CH)2- 또는 -OCH2-O-에 의해 임의로 치환될 수 있는 아릴옥시알킬 그룹을 나타내거나, 또는 1개 이상의 할로겐원자 또는 저급 알킬 그룹에 의해 치환될 수 있는 아닐리노 그룹, 또는 피리딜 그룹을 나타낼 수 있으며; R2는 수소원자, 할로겐원자, 탄소수 1 내지 4의 알킬 또는 알콕시그룹, 또는 유리원자가의 결합이 서로에 대해 오르토-위치에서 이루어지는 환-형성 그룹-(CH=CH)2-또는 -(CH2)n-(여기에서 n은 3내지 5의 정수이다). 또는 CN그룹을 나타내고; R3는 수소원자, 할로겐 원자, 또는 탄소수 1 내지 4의 알킬그룹을 나타내며; R4는 탄소수 1 내지 10의 직쇄 또는 측쇄 알킬 그룹, 또는 탄소수 2 내지 5의 하이드록시알킬 그룹을 나타내고, R5는 탄소수 1 내지 10의 직쇄 또는 측쇄 알킬 그룹, 탄소수 2 내지 5의 하이드록시알킬 그룹, 페닐알킬 그룹, 또는 페녹시 알킬 그룹을 나타내는데, 여기에서 방향족 부분은 알킬 또는 알콕시그룹에 의해, 또는 염소 또는 브롬원자에 의해 치환될 수 있거나; R4및 R5가 질소원자와 함께는 헤테로사이클릭 그룹을 나타낸다.
- 제1항에 있어서, R1이 치환된 페녹시메틸 그룹이고, R2및 R3가 할로겐, 시아노 또는 메틸을 나타내는데. 이들중의 하나는 또한 수소를 나타낼수 있으며, R4및 R5가 직쇄 또는 측쇄의저급 알킬 그룹을 나타내는 화합물.
- 제1항 또는 2항에 있어서, R1-CO-NH 가 페녹시 그룹의 4-위치에 존재하고, R1이 메틸에 의해 일치환 또는 이치환된 페녹시메틸 그룹을 나타내며, R2및 R3가 염소 또는 메틸을 나타내고, R4및 R5가 메틸, 에틸, n-프로필 또는 이소-프로필을 나타내는데, R2/R3및 R4/R5는 동일하거나 상이할 수 있는 화합물.
- 제1항에 있어서, [1-[2,6-디메틸-4-(2-m-톨릴옥시아세틸아미노)-페녹시]-2-하이드록시-3-디에틸아미노-프로판]하이드로클로라이드 및 이의 산부가염인 화합물.
- 제1항에 있어서, [1-[2,6-디메틸-4-(2-m-톨릴옥시아세틸아미노)-페녹시]-2-하이드록시-3-피페리디노-프로판]하이드로클로라이드 및 이의 산부가염인 화합물.
- 제1항에 있어서, [1-[2,6-디메틸-4-(2-(2,6-디메틸-페녹시)-아세틸아미노)-페녹시]-2-하이드록시-3-디에틸아미노-프로판]하이드로클로라이드 및 이의 산부가염인 화합물.
- 제1항에 있어서, [1-[2,6-디메틸-4-(2-(3-메틸페녹시)-아세틸아미노)-페녹시]-2-하이드록시-3-메틸-n-프로필아미노프로판 및 이의 산부가염인 화합물.
- 통상적인 부형제 및/또는 담체와 함께 1항 내지 7항중 어느 한 항에서 청구된 화합물을 함유함을 특징으로 하는 약제학적 제제.
- 심장 부정맥, 빈맥 또는 고혈압의 치료를 위한 약제학적 제제의 제조시의 제1항 내지 7항중 어느 한항에서 청구된 화합물의 용도.
- 하기 일반식(Ⅱ)의 화합물을 하기 일반식(Ⅲ)의 아민과 반응시킴을 특징으로 하여, 제1항 내지 7항중 어느 한 항에서 청구된 화합물을 제조하는 방법.상기식에서 R1,R2,R3,R4및 R5는 상기에서 정의한 바와동일하며; Z는 그룹또는 -CHOH-CH2-Hal(여기에서 Hal은 할로겐이다)를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863640829 DE3640829A1 (de) | 1986-11-28 | 1986-11-28 | Neue 1-aryloxy-3-amino-2-propanole, ihre herstellung und verwendung |
DEP3640829.8 | 1986-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880006164A true KR880006164A (ko) | 1988-07-21 |
Family
ID=6315091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR870013326A KR880006164A (ko) | 1986-11-28 | 1987-11-26 | 1-아릴옥시-3-아미노-2-프로판올, 이의 제조 방법 및 용도 |
Country Status (20)
Country | Link |
---|---|
US (1) | US4948812A (ko) |
EP (1) | EP0269985A3 (ko) |
JP (1) | JPS63150253A (ko) |
KR (1) | KR880006164A (ko) |
AU (1) | AU594840B2 (ko) |
CS (1) | CS270576B2 (ko) |
DD (1) | DD275241A5 (ko) |
DE (1) | DE3640829A1 (ko) |
DK (1) | DK625287A (ko) |
FI (1) | FI875212A (ko) |
HU (1) | HU200319B (ko) |
IL (1) | IL84633A0 (ko) |
NO (1) | NO874958L (ko) |
NZ (1) | NZ222719A (ko) |
PH (1) | PH24745A (ko) |
PL (1) | PL269047A1 (ko) |
PT (1) | PT86226B (ko) |
SU (1) | SU1574169A3 (ko) |
YU (1) | YU213887A (ko) |
ZA (1) | ZA878917B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994459A (en) * | 1989-12-11 | 1991-02-19 | American Home Products Corporation | Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity |
US5084463A (en) * | 1989-12-11 | 1992-01-28 | American Home Products Corporation | N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity |
US5250570A (en) * | 1990-08-02 | 1993-10-05 | Imperial Chemical Industries Plc | Amidobenzene derivatives, compositions and use |
US7351719B2 (en) * | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1199037A (en) * | 1967-09-27 | 1970-07-15 | Ici Ltd | Alkanolamine Derivatives |
GB1078852A (en) * | 1964-09-30 | 1967-08-09 | Ici Ltd | Alkanolamine derivatives |
US3864398A (en) * | 1972-05-01 | 1975-02-04 | Teikoku Hormone Mfg Co Ltd | Process for the preparation of acylamino alkanol derivatives |
DE2611601A1 (de) * | 1976-03-19 | 1977-09-22 | Basf Ag | Nicotinsaeureanilide |
JPS5988467A (ja) * | 1982-11-09 | 1984-05-22 | Yoshitomi Pharmaceut Ind Ltd | フエノキシアミノプロパノ−ル誘導体 |
-
1986
- 1986-11-28 DE DE19863640829 patent/DE3640829A1/de not_active Withdrawn
-
1987
- 1987-11-20 SU SU874203680A patent/SU1574169A3/ru active
- 1987-11-21 ZA ZA878917A patent/ZA878917B/xx unknown
- 1987-11-25 DD DD87309421A patent/DD275241A5/de not_active IP Right Cessation
- 1987-11-25 CS CS878507A patent/CS270576B2/cs unknown
- 1987-11-25 EP EP87117374A patent/EP0269985A3/de not_active Withdrawn
- 1987-11-25 US US07/125,308 patent/US4948812A/en not_active Expired - Fee Related
- 1987-11-25 YU YU02138/87A patent/YU213887A/xx unknown
- 1987-11-26 KR KR870013326A patent/KR880006164A/ko not_active Application Discontinuation
- 1987-11-26 FI FI875212A patent/FI875212A/fi not_active IP Right Cessation
- 1987-11-26 PT PT86226A patent/PT86226B/pt not_active IP Right Cessation
- 1987-11-26 PL PL26904787A patent/PL269047A1/xx unknown
- 1987-11-27 PH PH36130A patent/PH24745A/en unknown
- 1987-11-27 DK DK625287A patent/DK625287A/da not_active Application Discontinuation
- 1987-11-27 HU HU875356A patent/HU200319B/hu not_active IP Right Cessation
- 1987-11-27 NZ NZ222719A patent/NZ222719A/xx unknown
- 1987-11-27 AU AU81874/87A patent/AU594840B2/en not_active Ceased
- 1987-11-27 JP JP62299614A patent/JPS63150253A/ja active Pending
- 1987-11-27 NO NO874958A patent/NO874958L/no unknown
- 1987-11-27 IL IL84633A patent/IL84633A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CS850787A2 (en) | 1989-11-14 |
DE3640829A1 (de) | 1988-06-09 |
PT86226B (pt) | 1990-11-07 |
NZ222719A (en) | 1990-05-28 |
FI875212A0 (fi) | 1987-11-26 |
DK625287D0 (da) | 1987-11-27 |
EP0269985A3 (de) | 1990-07-04 |
SU1574169A3 (ru) | 1990-06-23 |
IL84633A0 (en) | 1988-04-29 |
HU200319B (en) | 1990-05-28 |
AU8187487A (en) | 1988-06-02 |
US4948812A (en) | 1990-08-14 |
PH24745A (en) | 1990-10-01 |
PL269047A1 (en) | 1988-09-15 |
FI875212A (fi) | 1988-05-29 |
CS270576B2 (en) | 1990-07-12 |
NO874958L (no) | 1988-05-30 |
ZA878917B (en) | 1989-07-26 |
HUT49112A (en) | 1989-08-28 |
NO874958D0 (no) | 1987-11-27 |
DD275241A5 (de) | 1990-01-17 |
YU213887A (en) | 1988-12-31 |
EP0269985A2 (de) | 1988-06-08 |
AU594840B2 (en) | 1990-03-15 |
JPS63150253A (ja) | 1988-06-22 |
DK625287A (da) | 1988-05-29 |
PT86226A (de) | 1987-12-01 |
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