KR830009069A - 알카놀아민 유도체의 제조방법 - Google Patents
알카놀아민 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830009069A KR830009069A KR1019820000429A KR820000429A KR830009069A KR 830009069 A KR830009069 A KR 830009069A KR 1019820000429 A KR1019820000429 A KR 1019820000429A KR 820000429 A KR820000429 A KR 820000429A KR 830009069 A KR830009069 A KR 830009069A
- Authority
- KR
- South Korea
- Prior art keywords
- carbon atoms
- formula
- alkenyl
- carbamoyl
- benzo
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- -1 hydroxy, amino, nitro, carbamoyl Chemical group 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000004593 Epoxy Substances 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 239000002160 alpha blocker Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 239000002327 cardiovascular agent Substances 0.000 claims 1
- 229940125692 cardiovascular agent Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229940097271 other diuretics in atc Drugs 0.000 claims 1
- 210000003516 pericardium Anatomy 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 229940125723 sedative agent Drugs 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- (a) 하기 구조식(I)의 화합물을 하기 구조식(II)의 산 또는 그의 반응유도체와 반응시키거나, 또는 (b) 하기 구조식(III)의 에폭시화합물을 하기 구조식(IV)의 아민과 반응시킴으로서 알카놀아민 유도체 또는 그의 산부가염을 제조하는 방법.Ar-OCH2ㆍCHOHㆍCH2-NH-A1-NH2(I)상기 식에서, Ar은 할로겐, 트리플루오로메틸, 하이드록시, 아미노, 니트로, 카바모일, 카바모일, 메틸 및 시아노, 각각 탄소수가 6인 알킬, 알케닐, 알콕시, 알케닐옥시, 알킬티오, 알카노일 및 알카노일 아미노로 부터 선정된 1 또는 2의 치환체를 제공하거나 또는 치환되지 않은 페닐 또는 나프틸이거나, 또는 Ar이 4-인돌일, 4-벤조 [b]-티에닐, 5-벤조 [1,4] 디옥사닐, 4- 또는 5-인다닐, 5-또는 6-(1,2,3,4-테트라하이드로나프틸), 2,3-디하이드록시-1,2,3,4-테트라하이드로나프트-5-일 또는 4-모르포리노-1,2,5-티아디아졸-3-일이며, R은 할로겐이고, A1은 탄소수가 2-6인 알케닐이며, 그리고 A2는 페닐, 하이드록시 또는 카바모일 치환체를 제공하거나 치환되지 않은 탄소수 1-7의 알케닐, 또는 탄소수 3-6인 시클로 알킬렌이다.
- 약리적으로 허용할 수 있는 희석제 또는 담체와 함께활성성분으로서 적어도 하나의 알카놀아민 유도체 또는 그의 산부가염으로 구성되어 있는 제약 조성물.
- 제2항에 있어서, 진정제, 혈관확장제, 기타 이뇨제, 혈압강하제, 심장막 안정제, 파킨스병 및 진전 치료에 사용되는 약품, 강심제와 α-아드레날린 차단제로 부터 선정되는 하나 또는 그 이상의 약품을 함유하는 제약 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8103131 | 1981-02-02 | ||
| GB8103131 | 1981-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830009069A true KR830009069A (ko) | 1983-12-17 |
Family
ID=10519390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820000429A KR830009069A (ko) | 1981-02-02 | 1982-02-02 | 알카놀아민 유도체의 제조방법 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4399138A (ko) |
| EP (1) | EP0057572B1 (ko) |
| JP (1) | JPS57163370A (ko) |
| KR (1) | KR830009069A (ko) |
| AT (1) | ATE14576T1 (ko) |
| AU (1) | AU550763B2 (ko) |
| CA (1) | CA1198110A (ko) |
| DE (1) | DE3264964D1 (ko) |
| DK (1) | DK43382A (ko) |
| ES (1) | ES509250A0 (ko) |
| FI (1) | FI820266L (ko) |
| GR (1) | GR75872B (ko) |
| HU (1) | HU187634B (ko) |
| IE (1) | IE52345B1 (ko) |
| IL (1) | IL64890A (ko) |
| NO (1) | NO820291L (ko) |
| NZ (1) | NZ199627A (ko) |
| PH (1) | PH18070A (ko) |
| PT (1) | PT74373B (ko) |
| YU (1) | YU22082A (ko) |
| ZA (1) | ZA82562B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3361244D1 (de) * | 1982-01-29 | 1986-01-02 | Ici Plc | Alkanolamine derivatives |
| US4604394A (en) * | 1984-10-01 | 1986-08-05 | Merck & Co., Inc. | Antiarrhythmic compositions and method |
| GB8810933D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Heterocyclic compounds |
| GB8810934D0 (en) * | 1987-05-26 | 1988-06-15 | Ici America Inc | Amides |
| US4803206A (en) * | 1988-03-07 | 1989-02-07 | Schering Corporation | Antihypertensive acylpyrazines |
| GB8812342D0 (en) * | 1988-05-25 | 1988-06-29 | Ici America Inc | Bicyclic compounds |
| GB8812343D0 (en) * | 1988-05-25 | 1988-06-29 | Ici America Inc | Amino compounds |
| UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3472847A (en) * | 1966-08-25 | 1969-10-14 | Merck & Co Inc | Conversion of pyrazinoylcyanamides to pyrazinoylguanidines |
| US3577418A (en) * | 1969-02-12 | 1971-05-04 | Merck & Co Inc | Pyrazinamide derivatives and processes for their preparation |
| US3573306A (en) * | 1969-03-05 | 1971-03-30 | Merck & Co Inc | Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides |
| US3544568A (en) * | 1969-03-18 | 1970-12-01 | Merck & Co Inc | 3-amino-5,6-substituted pyrazinamides |
| US3655663A (en) * | 1969-04-21 | 1972-04-11 | Burton K Wasson | 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles |
| US3948895A (en) * | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
| GB1509527A (en) * | 1974-06-05 | 1978-05-04 | Ici Ltd | 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them |
| US4139623A (en) * | 1974-05-14 | 1979-02-13 | C-G Corp. | Cyclic-substituted derivatives of 1-amino-2-propanol |
| US4115409A (en) * | 1975-12-05 | 1978-09-19 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
| US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
| GB1540463A (en) * | 1976-10-07 | 1979-02-14 | Ici Ltd | Alkanolamine derivatives |
| US4219561A (en) * | 1977-09-22 | 1980-08-26 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
-
1982
- 1982-01-27 FI FI820266A patent/FI820266L/fi not_active Application Discontinuation
- 1982-01-27 IE IE175/82A patent/IE52345B1/en unknown
- 1982-01-28 DE DE8282300443T patent/DE3264964D1/de not_active Expired
- 1982-01-28 EP EP82300443A patent/EP0057572B1/en not_active Expired
- 1982-01-28 AU AU79946/82A patent/AU550763B2/en not_active Ceased
- 1982-01-28 ZA ZA82562A patent/ZA82562B/xx unknown
- 1982-01-28 IL IL64890A patent/IL64890A/xx unknown
- 1982-01-28 AT AT82300443T patent/ATE14576T1/de not_active IP Right Cessation
- 1982-01-29 HU HU82270A patent/HU187634B/hu unknown
- 1982-01-29 PH PH26799A patent/PH18070A/en unknown
- 1982-02-01 NZ NZ199627A patent/NZ199627A/en unknown
- 1982-02-01 DK DK43382A patent/DK43382A/da not_active Application Discontinuation
- 1982-02-01 CA CA000395265A patent/CA1198110A/en not_active Expired
- 1982-02-01 NO NO820291A patent/NO820291L/no unknown
- 1982-02-01 YU YU00220/82A patent/YU22082A/xx unknown
- 1982-02-02 KR KR1019820000429A patent/KR830009069A/ko unknown
- 1982-02-02 GR GR67181A patent/GR75872B/el unknown
- 1982-02-02 US US06/344,969 patent/US4399138A/en not_active Expired - Fee Related
- 1982-02-02 ES ES509250A patent/ES509250A0/es active Granted
- 1982-02-02 JP JP57014428A patent/JPS57163370A/ja active Pending
- 1982-02-02 PT PT74373A patent/PT74373B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU550763B2 (en) | 1986-04-10 |
| CA1198110A (en) | 1985-12-17 |
| YU22082A (en) | 1985-04-30 |
| US4399138A (en) | 1983-08-16 |
| AU7994682A (en) | 1982-08-12 |
| EP0057572A1 (en) | 1982-08-11 |
| IE820175L (en) | 1982-08-02 |
| EP0057572B1 (en) | 1985-07-31 |
| IE52345B1 (en) | 1987-09-16 |
| ZA82562B (en) | 1982-12-29 |
| NO820291L (no) | 1982-08-03 |
| IL64890A (en) | 1986-09-30 |
| DK43382A (da) | 1982-08-03 |
| FI820266L (fi) | 1982-08-03 |
| GR75872B (ko) | 1984-08-02 |
| PT74373B (en) | 1983-07-14 |
| ATE14576T1 (de) | 1985-08-15 |
| ES8304952A1 (es) | 1983-03-16 |
| ES509250A0 (es) | 1983-03-16 |
| IL64890A0 (en) | 1982-03-31 |
| HU187634B (en) | 1986-02-28 |
| NZ199627A (en) | 1984-11-09 |
| JPS57163370A (en) | 1982-10-07 |
| DE3264964D1 (de) | 1985-09-05 |
| PH18070A (en) | 1985-03-18 |
| PT74373A (en) | 1982-03-01 |
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