PT78030B - Process for the preparation of an ointment based in 17-alpha-propyloxi-11beta-hydroxi-4-pregnene-3,20-dione - Google Patents
Process for the preparation of an ointment based in 17-alpha-propyloxi-11beta-hydroxi-4-pregnene-3,20-dione Download PDFInfo
- Publication number
- PT78030B PT78030B PT78030A PT7803084A PT78030B PT 78030 B PT78030 B PT 78030B PT 78030 A PT78030 A PT 78030A PT 7803084 A PT7803084 A PT 7803084A PT 78030 B PT78030 B PT 78030B
- Authority
- PT
- Portugal
- Prior art keywords
- weight
- ointment
- mixture
- process according
- preparation process
- Prior art date
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000000203 mixture Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- FOGXJPFPZOHSQS-AYVLZSQQSA-N Hydrocortisone butyrate propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)CC)(OC(=O)CCC)[C@@]1(C)C[C@@H]2O FOGXJPFPZOHSQS-AYVLZSQQSA-N 0.000 claims abstract description 16
- 239000008213 purified water Substances 0.000 claims abstract description 16
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 15
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 15
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 12
- 239000004094 surface-active agent Substances 0.000 claims abstract description 12
- 239000003871 white petrolatum Substances 0.000 claims description 8
- 229940057995 liquid paraffin Drugs 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 6
- -1 sorbitan fatty acids Chemical class 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 3
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 2
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- PXGPQCBSBQOPLZ-UHFFFAOYSA-N butanoic acid;propanoic acid Chemical compound CCC(O)=O.CCCC(O)=O PXGPQCBSBQOPLZ-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 229940093625 propylene glycol monostearate Drugs 0.000 description 2
- 239000001593 sorbitan monooleate Substances 0.000 description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 description 2
- 229940035049 sorbitan monooleate Drugs 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005526 vasoconstrictor agent Substances 0.000 description 2
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 1
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000037374 absorbed through the skin Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- QOGCLPPHDLAOIE-UHFFFAOYSA-N butanoic acid;propane-1,2-diol;propanoic acid Chemical compound CCC(O)=O.CC(O)CO.CCCC(O)=O QOGCLPPHDLAOIE-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 229960003338 crotamiton Drugs 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- OIXVKQDWLFHVGR-WQDIDPJDSA-N neomycin B sulfate Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO OIXVKQDWLFHVGR-WQDIDPJDSA-N 0.000 description 1
- YDCVUQVGJSAAKA-UHFFFAOYSA-N octadecanoic acid;prop-1-ene Chemical compound CC=C.CCCCCCCCCCCCCCCCCC(O)=O YDCVUQVGJSAAKA-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58011638A JPS59137408A (ja) | 1983-01-27 | 1983-01-27 | 軟膏 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT78030A PT78030A (en) | 1984-02-01 |
| PT78030B true PT78030B (en) | 1986-07-11 |
Family
ID=11783480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT78030A PT78030B (en) | 1983-01-27 | 1984-01-27 | Process for the preparation of an ointment based in 17-alpha-propyloxi-11beta-hydroxi-4-pregnene-3,20-dione |
Country Status (12)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3534742A1 (de) * | 1985-09-28 | 1987-04-09 | Beiersdorf Ag | Hydrocortisondiester enthaltende w/o-creme |
| DE3534743A1 (de) * | 1985-09-28 | 1987-04-02 | Beiersdorf Ag | Hydrocortisondiester enthaltende o/w-creme |
| US4808610A (en) * | 1986-10-02 | 1989-02-28 | Schering Corporation | Mometasone furoate anti-inflammatory cream composition using hexylene glycol |
| JP2557657B2 (ja) * | 1987-08-28 | 1996-11-27 | エスエス製薬株式会社 | 経皮吸収促進基剤組成物 |
| JPH03129294U (US06272168-20010807-M00014.png) * | 1990-04-12 | 1991-12-25 | ||
| JP4729149B2 (ja) * | 1997-06-25 | 2011-07-20 | 帝國製薬株式会社 | 安定なアスピリン軟膏製剤 |
| AU2002314847A1 (en) | 2001-05-31 | 2002-12-09 | Upsher-Smith Laboratories, Inc. | Dermatological compositions and methods comprising alpha-hydroxy acids or derivatives |
| CA2544599A1 (en) * | 2003-11-06 | 2005-05-26 | Maria Emanuel Ryan | Methods of treating eczema |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1543907A (en) * | 1975-02-19 | 1979-04-11 | Dermal Labor Ltd | Steroid compositions |
| DE2514873C2 (de) * | 1975-04-05 | 1983-12-29 | Merck Patent Gmbh, 6100 Darmstadt | Salbengrundlage |
| US4070462A (en) * | 1976-10-26 | 1978-01-24 | Schering Corporation | Steroid ointment |
| FR2403798A1 (fr) * | 1977-09-22 | 1979-04-20 | Rorer Inc William H | Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire |
| EP0001421B1 (de) * | 1977-09-30 | 1982-06-30 | Ciba-Geigy Ag | Verwendung von Mercaptanen zur Wärmestabilisierung chlorhaltiger Thermoplaste |
| JPS6040439B2 (ja) * | 1978-03-29 | 1985-09-11 | 大正製薬株式会社 | ヒドロコルチゾン誘導体 |
| DE2826257C3 (de) * | 1978-06-15 | 1980-12-04 | Beiersdorf Ag, 2000 Hamburg | Hydrocortison-17,21-diester und Verfahren zu deren Herstellung, diese enthaltende Arzneimittel sowie Hydrocortison -17-propionat als Zwischenprodukt |
| US4289764A (en) * | 1979-12-04 | 1981-09-15 | Drythanol Ltd. | Steroid compositions |
| US4305936A (en) * | 1980-10-09 | 1981-12-15 | Dermik Laboratories | Topical corticosteroid formulations |
| AT370721B (de) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der |
| NZ200918A (en) * | 1981-07-02 | 1985-07-31 | Gist Brocades Nv | Stable fatty oil-in-water emulsion cream for topical application |
| CA1206415A (en) * | 1982-06-30 | 1986-06-24 | John L. Cantrell | Pyridine soluble extract of a microorganism |
| DE3225848A1 (de) * | 1982-07-07 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Kortikoidhaltige zubereitung zur topischen applikation |
| DE3225849A1 (de) * | 1982-07-07 | 1984-01-19 | Schering Ag | Kortikoidhaltige zubereitung zur topischen applikation |
-
1983
- 1983-01-27 JP JP58011638A patent/JPS59137408A/ja active Granted
-
1984
- 1984-01-20 CA CA000445745A patent/CA1207667A/en not_active Expired
- 1984-01-24 ZA ZA84526A patent/ZA84526B/xx unknown
- 1984-01-26 ES ES529181A patent/ES529181A0/es active Granted
- 1984-01-26 GB GB08402026A patent/GB2135577B/en not_active Expired
- 1984-01-26 IT IT19329/84A patent/IT1174477B/it active
- 1984-01-27 PT PT78030A patent/PT78030B/pt unknown
- 1984-01-27 BE BE0/212289A patent/BE898773A/fr not_active IP Right Cessation
- 1984-01-27 FR FR8401266A patent/FR2539991B1/fr not_active Expired
- 1984-01-27 DE DE19843402877 patent/DE3402877A1/de active Granted
- 1984-01-27 CH CH390/84A patent/CH658187A5/de not_active IP Right Cessation
-
1986
- 1986-09-12 US US06/906,653 patent/US4794107A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT1174477B (it) | 1987-07-01 |
| CH658187A5 (de) | 1986-10-31 |
| GB8402026D0 (en) | 1984-02-29 |
| PT78030A (en) | 1984-02-01 |
| FR2539991B1 (fr) | 1987-06-19 |
| ZA84526B (en) | 1984-09-26 |
| JPH0237892B2 (US06272168-20010807-M00014.png) | 1990-08-28 |
| GB2135577A (en) | 1984-09-05 |
| BE898773A (fr) | 1984-05-16 |
| GB2135577B (en) | 1986-08-13 |
| DE3402877C2 (US06272168-20010807-M00014.png) | 1991-08-29 |
| ES8601685A1 (es) | 1985-11-01 |
| ES529181A0 (es) | 1985-11-01 |
| DE3402877A1 (de) | 1984-08-02 |
| JPS59137408A (ja) | 1984-08-07 |
| IT8419329A0 (it) | 1984-01-26 |
| FR2539991A1 (fr) | 1984-08-03 |
| US4794107A (en) | 1988-12-27 |
| CA1207667A (en) | 1986-07-15 |
| IT8419329A1 (it) | 1985-07-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4794106A (en) | Cream | |
| US5061700A (en) | Glyceryl acetate ointment vehicles | |
| US3749773A (en) | Gelled steroid ointment | |
| US4894232A (en) | Base for mucosal and denture adhesive pastes, a process for the preparation thereof, and pastes having this base | |
| KR100449939B1 (ko) | 트라니라스트함유외용제제및그제조방법 | |
| FI95350C (fi) | Menetelmä valmistaa paikallisesti käytettävää lääkenestettä tulehduksen hoitamiseksi | |
| WO1991008733A1 (en) | Stable cream and lotion bases for lipophilic drug compositions | |
| DE2418345A1 (de) | Pharmazeutisches mittel fuer aeusserliche anwendung an menschlicher haut | |
| PT1147778E (pt) | Formulações de gel estáveis para tratamentotópico de problemas de pele. | |
| CS241062B2 (en) | Method of anti-inflammation agent production for local application | |
| PT78030B (en) | Process for the preparation of an ointment based in 17-alpha-propyloxi-11beta-hydroxi-4-pregnene-3,20-dione | |
| PL202852B1 (pl) | Kompozycja farmaceutyczna do stosowania miejscowego zawierająca nimesulid i sposób wytwarzania kompozycji | |
| LU81902A1 (de) | Transdermales medikationssystem fuer isosorbiddinitrat | |
| JPS6061518A (ja) | ゲル状外用組成物 | |
| EP0634170B1 (en) | Compositions containing 8-hydroxy-quinoline for use in the treatment of hyperproliferative skin diseases | |
| BRPI0609126A2 (pt) | composição vesicular inter e intra multilamelar | |
| JPS6218526B2 (US06272168-20010807-M00014.png) | ||
| CA1045974A (en) | Oil-free pharmaceutical cream | |
| GB2279567A (en) | Topical 8-hydroxyquinoline compositions | |
| BRPI0116208B1 (pt) | formulações de cuidados com a pele isentas de água compreendendo uréia micronizada e método de produção das mesmas. | |
| JPS62215528A (ja) | 経皮投与製剤 | |
| BRPI0402223B1 (pt) | composição farmacêutica de cloridrato de diltiazem e seu processo de preparação | |
| JPS62289520A (ja) | エリスロマイシン塩基含有抗アクネ安定組成物 | |
| WO2000041702A1 (fr) | Preparation steroide externe | |
| JP2000264899A (ja) | ステロイド外用剤 |
