ES8601685A1 - Un procedimiento para preparar un unguento oleoso a base de butirato-propionato de hidrocortisona - Google Patents
Un procedimiento para preparar un unguento oleoso a base de butirato-propionato de hidrocortisonaInfo
- Publication number
- ES8601685A1 ES8601685A1 ES529181A ES529181A ES8601685A1 ES 8601685 A1 ES8601685 A1 ES 8601685A1 ES 529181 A ES529181 A ES 529181A ES 529181 A ES529181 A ES 529181A ES 8601685 A1 ES8601685 A1 ES 8601685A1
- Authority
- ES
- Spain
- Prior art keywords
- pref
- mixt
- paraffin
- surfactant
- compsns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002674 ointment Substances 0.000 title abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 6
- 239000012188 paraffin wax Substances 0.000 abstract 4
- 239000004094 surface-active agent Substances 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 2
- FOGXJPFPZOHSQS-AYVLZSQQSA-N Hydrocortisone butyrate propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)CC)(OC(=O)CCC)[C@@]1(C)C[C@@H]2O FOGXJPFPZOHSQS-AYVLZSQQSA-N 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 239000003871 white petrolatum Substances 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UN UNGUENTO OLEOSO A BASE DE BUTIRATO-PROPIONATO DE HIDROCORTISONA. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE DISUELVE EL BUTIRATO-PROPIONATO DE HIDROCORTISONA EN EL PROPILENGLICOL SOLO O EN LA MEZCLA DE PROPILENGLICOL Y AGUA PURIFICADA, A UNA TEMPERATURA DE APROXIMADAMENTE 50 GRADOS; SEGUNDA, SE AÑADE LA SOLUCION RESULTANTE,UNA SOLUCION MIXTA FUNDIDA POR CALOR DEL AGENTE TENSIOACTIVO Y EL HIDROCARBURO PARAFINICO SUPERIOR; TERCERA, SE AGITA LA MEZCLA FORMADA Y SE LE AÑADE EL AGUA PURIFICADA NECESARIA; Y POR ULTIMO, SE ENFRIA LA MEZCLA RESULTANTE AL MISMO TIEMPO QUE SE AGITA A FONDO, HASTA QUE SE FORME UN UNGUENTO OLEOSO Y UNIFORME.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58011638A JPS59137408A (ja) | 1983-01-27 | 1983-01-27 | 軟膏 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529181A0 ES529181A0 (es) | 1985-11-01 |
| ES8601685A1 true ES8601685A1 (es) | 1985-11-01 |
Family
ID=11783480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529181A Expired ES8601685A1 (es) | 1983-01-27 | 1984-01-26 | Un procedimiento para preparar un unguento oleoso a base de butirato-propionato de hidrocortisona |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4794107A (es) |
| JP (1) | JPS59137408A (es) |
| BE (1) | BE898773A (es) |
| CA (1) | CA1207667A (es) |
| CH (1) | CH658187A5 (es) |
| DE (1) | DE3402877A1 (es) |
| ES (1) | ES8601685A1 (es) |
| FR (1) | FR2539991B1 (es) |
| GB (1) | GB2135577B (es) |
| IT (1) | IT1174477B (es) |
| PT (1) | PT78030B (es) |
| ZA (1) | ZA84526B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3534742A1 (de) * | 1985-09-28 | 1987-04-09 | Beiersdorf Ag | Hydrocortisondiester enthaltende w/o-creme |
| DE3534743A1 (de) * | 1985-09-28 | 1987-04-02 | Beiersdorf Ag | Hydrocortisondiester enthaltende o/w-creme |
| US4808610A (en) * | 1986-10-02 | 1989-02-28 | Schering Corporation | Mometasone furoate anti-inflammatory cream composition using hexylene glycol |
| JP2557657B2 (ja) * | 1987-08-28 | 1996-11-27 | エスエス製薬株式会社 | 経皮吸収促進基剤組成物 |
| JPH03129294U (es) * | 1990-04-12 | 1991-12-25 | ||
| JP4729149B2 (ja) * | 1997-06-25 | 2011-07-20 | 帝國製薬株式会社 | 安定なアスピリン軟膏製剤 |
| US20030017181A1 (en) | 2001-05-31 | 2003-01-23 | Rood Gloria A. | Dermatological compositions and methods |
| CA2544599A1 (en) * | 2003-11-06 | 2005-05-26 | Maria Emanuel Ryan | Methods of treating eczema |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1543907A (en) * | 1975-02-19 | 1979-04-11 | Dermal Labor Ltd | Steroid compositions |
| DE2514873C2 (de) * | 1975-04-05 | 1983-12-29 | Merck Patent Gmbh, 6100 Darmstadt | Salbengrundlage |
| US4070462A (en) * | 1976-10-26 | 1978-01-24 | Schering Corporation | Steroid ointment |
| FR2403798A1 (fr) * | 1977-09-22 | 1979-04-20 | Rorer Inc William H | Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire |
| EP0001421B1 (de) * | 1977-09-30 | 1982-06-30 | Ciba-Geigy Ag | Verwendung von Mercaptanen zur Wärmestabilisierung chlorhaltiger Thermoplaste |
| JPS6040439B2 (ja) * | 1978-03-29 | 1985-09-11 | 大正製薬株式会社 | ヒドロコルチゾン誘導体 |
| DE2826257C3 (de) * | 1978-06-15 | 1980-12-04 | Beiersdorf Ag, 2000 Hamburg | Hydrocortison-17,21-diester und Verfahren zu deren Herstellung, diese enthaltende Arzneimittel sowie Hydrocortison -17-propionat als Zwischenprodukt |
| US4289764A (en) * | 1979-12-04 | 1981-09-15 | Drythanol Ltd. | Steroid compositions |
| US4305936A (en) * | 1980-10-09 | 1981-12-15 | Dermik Laboratories | Topical corticosteroid formulations |
| AT370721B (de) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der |
| NZ200918A (en) * | 1981-07-02 | 1985-07-31 | Gist Brocades Nv | Stable fatty oil-in-water emulsion cream for topical application |
| CA1206415A (en) * | 1982-06-30 | 1986-06-24 | John L. Cantrell | Pyridine soluble extract of a microorganism |
| DE3225849A1 (de) * | 1982-07-07 | 1984-01-19 | Schering Ag | Kortikoidhaltige zubereitung zur topischen applikation |
| DE3225848A1 (de) * | 1982-07-07 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Kortikoidhaltige zubereitung zur topischen applikation |
-
1983
- 1983-01-27 JP JP58011638A patent/JPS59137408A/ja active Granted
-
1984
- 1984-01-20 CA CA000445745A patent/CA1207667A/en not_active Expired
- 1984-01-24 ZA ZA84526A patent/ZA84526B/xx unknown
- 1984-01-26 IT IT19329/84A patent/IT1174477B/it active
- 1984-01-26 GB GB08402026A patent/GB2135577B/en not_active Expired
- 1984-01-26 ES ES529181A patent/ES8601685A1/es not_active Expired
- 1984-01-27 CH CH390/84A patent/CH658187A5/de not_active IP Right Cessation
- 1984-01-27 PT PT78030A patent/PT78030B/pt unknown
- 1984-01-27 FR FR8401266A patent/FR2539991B1/fr not_active Expired
- 1984-01-27 BE BE0/212289A patent/BE898773A/fr not_active IP Right Cessation
- 1984-01-27 DE DE19843402877 patent/DE3402877A1/de active Granted
-
1986
- 1986-09-12 US US06/906,653 patent/US4794107A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT8419329A0 (it) | 1984-01-26 |
| DE3402877A1 (de) | 1984-08-02 |
| PT78030B (en) | 1986-07-11 |
| GB8402026D0 (en) | 1984-02-29 |
| JPH0237892B2 (es) | 1990-08-28 |
| ES529181A0 (es) | 1985-11-01 |
| CA1207667A (en) | 1986-07-15 |
| CH658187A5 (de) | 1986-10-31 |
| PT78030A (en) | 1984-02-01 |
| US4794107A (en) | 1988-12-27 |
| FR2539991B1 (fr) | 1987-06-19 |
| ZA84526B (en) | 1984-09-26 |
| DE3402877C2 (es) | 1991-08-29 |
| BE898773A (fr) | 1984-05-16 |
| IT1174477B (it) | 1987-07-01 |
| FR2539991A1 (fr) | 1984-08-03 |
| IT8419329A1 (it) | 1985-07-26 |
| GB2135577A (en) | 1984-09-05 |
| JPS59137408A (ja) | 1984-08-07 |
| GB2135577B (en) | 1986-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20050712 |