FR2403798A1 - Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire - Google Patents

Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire

Info

Publication number
FR2403798A1
FR2403798A1 FR7826729A FR7826729A FR2403798A1 FR 2403798 A1 FR2403798 A1 FR 2403798A1 FR 7826729 A FR7826729 A FR 7826729A FR 7826729 A FR7826729 A FR 7826729A FR 2403798 A1 FR2403798 A1 FR 2403798A1
Authority
FR
France
Prior art keywords
pyridyl
bis
oxide
inflammatory activity
disulphide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826729A
Other languages
English (en)
Other versions
FR2403798B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William H Rorer Inc
Original Assignee
William H Rorer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/835,595 external-priority patent/US4152430A/en
Priority claimed from US05/835,596 external-priority patent/US4137311A/en
Application filed by William H Rorer Inc filed Critical William H Rorer Inc
Publication of FR2403798A1 publication Critical patent/FR2403798A1/fr
Application granted granted Critical
Publication of FR2403798B1 publication Critical patent/FR2403798B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compositions synergiques et leur procédé d'utilisation. Ces compositions renferment une quantité efficace de disulfure de bis-(2-pyridyl-1-oxyde) et/ou d'au moins un produit d'addition de disulfure de bis-(2-pyridyl-1-oxyde) ayant la formule empirique: (C5 H4 NOS)2 MYT où M représente un membre choisi dans le groupe se composant de zinc, de fer, de magnésium, d'étain, de cadmium, de zirconium, de métaux alcalins et alcalino-terreux, Y est l'anion d'un acide organique ou minéral, et t vaut 1 ou 2. La présente invention est particulièrement utile pour fournir des compositions synergiques renforçant l'activité anti-inflammatoire de corticostéroïdes et d'agents anti-inflammatoires non constitués de stéroïdes.
FR7826729A 1977-09-22 1978-09-18 Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire Granted FR2403798A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83559477A 1977-09-22 1977-09-22
US05/835,595 US4152430A (en) 1977-09-22 1977-09-22 Synergistic compositions and method of use
US05/835,596 US4137311A (en) 1977-09-22 1977-09-22 Synergistic compositions and method of use

Publications (2)

Publication Number Publication Date
FR2403798A1 true FR2403798A1 (fr) 1979-04-20
FR2403798B1 FR2403798B1 (fr) 1981-12-11

Family

ID=27420252

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826729A Granted FR2403798A1 (fr) 1977-09-22 1978-09-18 Compositions synergiques a base de disulfure de bis(2-pyridyl-1-oxyde et leur utilisation pour leur activite anti-inflammatoire

Country Status (7)

Country Link
JP (1) JPS5455732A (fr)
CA (1) CA1116082A (fr)
DE (1) DE2840684A1 (fr)
FR (1) FR2403798A1 (fr)
GB (1) GB2004742B (fr)
NL (1) NL7809562A (fr)
SE (1) SE7809906L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194571A1 (fr) * 1985-03-12 1986-09-17 Hoechst Aktiengesellschaft Disulfures hétérocycliques, procédé pour leur préparation et médicaments les contenant

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5636411A (en) * 1979-08-31 1981-04-09 Sumitomo Chem Co Ltd Liquid agent for external use
JPS59137408A (ja) * 1983-01-27 1984-08-07 Taisho Pharmaceut Co Ltd 軟膏
JPS59139315A (ja) * 1983-01-31 1984-08-10 Taisho Pharmaceut Co Ltd クリ−ム剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2248880A1 (de) * 1971-10-18 1973-04-26 Olin Corp Bis-(2-pyridyl-1-oxid)-disulfidaddukte mit erdalkalimetallsalzen, verfahren zu ihrer herstellung und diese addukte enthaltende kosmetische praeparate
JPS5212207A (en) * 1975-07-21 1977-01-29 Kao Corp Shampoo composition having ecxcellent effect for preventing dandruff

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2248880A1 (de) * 1971-10-18 1973-04-26 Olin Corp Bis-(2-pyridyl-1-oxid)-disulfidaddukte mit erdalkalimetallsalzen, verfahren zu ihrer herstellung und diese addukte enthaltende kosmetische praeparate
JPS5212207A (en) * 1975-07-21 1977-01-29 Kao Corp Shampoo composition having ecxcellent effect for preventing dandruff

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1977 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194571A1 (fr) * 1985-03-12 1986-09-17 Hoechst Aktiengesellschaft Disulfures hétérocycliques, procédé pour leur préparation et médicaments les contenant

Also Published As

Publication number Publication date
CA1116082A (fr) 1982-01-12
NL7809562A (nl) 1979-03-26
FR2403798B1 (fr) 1981-12-11
GB2004742B (en) 1982-07-07
DE2840684A1 (de) 1979-04-05
GB2004742A (en) 1979-04-11
JPS5455732A (en) 1979-05-04
SE7809906L (sv) 1979-03-23

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Legal Events

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