GB2004742A - Anti-inflammatory Pharmaceutical Compositions - Google Patents

Anti-inflammatory Pharmaceutical Compositions

Info

Publication number
GB2004742A
GB2004742A GB7837779A GB7837779A GB2004742A GB 2004742 A GB2004742 A GB 2004742A GB 7837779 A GB7837779 A GB 7837779A GB 7837779 A GB7837779 A GB 7837779A GB 2004742 A GB2004742 A GB 2004742A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical compositions
disulphide
adducts
pyridyl
oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7837779A
Other versions
GB2004742B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William H Rorer Inc
Original Assignee
William H Rorer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/835,595 external-priority patent/US4152430A/en
Priority claimed from US05/835,596 external-priority patent/US4137311A/en
Application filed by William H Rorer Inc filed Critical William H Rorer Inc
Publication of GB2004742A publication Critical patent/GB2004742A/en
Application granted granted Critical
Publication of GB2004742B publication Critical patent/GB2004742B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pharmaceutical compositions for use in treating inflammation in warm blooded animals by topical administration contain bis-(2-pyridyl-1-oxide)- disulphide and/or one or more adducts thereof, preferably of the general formula: (C5H4NOS)2MYt (I> wherein M represents zinc, iron, magnesium, tin, cadmium, zirconium, an alkali metal or an alkaline earth metal; Y is the anion of an inorganic or organic acid and t is either 1 or 2. Bis-(2- pyridyl-1-oxide)-disulphide or its adducts enhance the anti-inflammatory activity of corticosteroids and non- steroidal anti-inflammatory agents.
GB7837779A 1977-09-22 1978-09-22 Anti-inflammatory pharmaceutical compositions Expired GB2004742B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83559477A 1977-09-22 1977-09-22
US05/835,595 US4152430A (en) 1977-09-22 1977-09-22 Synergistic compositions and method of use
US05/835,596 US4137311A (en) 1977-09-22 1977-09-22 Synergistic compositions and method of use

Publications (2)

Publication Number Publication Date
GB2004742A true GB2004742A (en) 1979-04-11
GB2004742B GB2004742B (en) 1982-07-07

Family

ID=27420252

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7837779A Expired GB2004742B (en) 1977-09-22 1978-09-22 Anti-inflammatory pharmaceutical compositions

Country Status (7)

Country Link
JP (1) JPS5455732A (en)
CA (1) CA1116082A (en)
DE (1) DE2840684A1 (en)
FR (1) FR2403798A1 (en)
GB (1) GB2004742B (en)
NL (1) NL7809562A (en)
SE (1) SE7809906L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2135577A (en) * 1983-01-27 1984-09-05 Taisho Pharmaceutical Co Ltd Hydrocortisone butyrate propionate ointments
GB2135576A (en) * 1983-01-31 1984-09-05 Taisho Pharmaceutical Co Ltd Hydrocortisone butyrate propionate creams

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5636411A (en) * 1979-08-31 1981-04-09 Sumitomo Chem Co Ltd Liquid agent for external use
DE3508666A1 (en) * 1985-03-12 1986-09-18 Hoechst Ag, 6230 Frankfurt HETEROCYCLIC DISULFIDES AND THEIR USE AS IMMUNO MODULATORS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790244A (en) * 1971-10-18 1973-04-18 Olin Corp BIS- (2-PYRIDYL-1-OXIDE) DISULPHIDE ADDITION PRODUCTS, THEIR PREPARATION AND USES
JPS5212207A (en) * 1975-07-21 1977-01-29 Kao Corp Shampoo composition having ecxcellent effect for preventing dandruff

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2135577A (en) * 1983-01-27 1984-09-05 Taisho Pharmaceutical Co Ltd Hydrocortisone butyrate propionate ointments
GB2135576A (en) * 1983-01-31 1984-09-05 Taisho Pharmaceutical Co Ltd Hydrocortisone butyrate propionate creams

Also Published As

Publication number Publication date
NL7809562A (en) 1979-03-26
DE2840684A1 (en) 1979-04-05
FR2403798B1 (en) 1981-12-11
GB2004742B (en) 1982-07-07
JPS5455732A (en) 1979-05-04
CA1116082A (en) 1982-01-12
FR2403798A1 (en) 1979-04-20
SE7809906L (en) 1979-03-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee