PT3551753T - Diagnósticos baseados num sistema efetor de crispr - Google Patents

Diagnósticos baseados num sistema efetor de crispr

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Publication number
PT3551753T
PT3551753T PT178794897T PT17879489T PT3551753T PT 3551753 T PT3551753 T PT 3551753T PT 178794897 T PT178794897 T PT 178794897T PT 17879489 T PT17879489 T PT 17879489T PT 3551753 T PT3551753 T PT 3551753T
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PT
Portugal
Prior art keywords
system based
crispr effector
effector system
based diagnostics
diagnostics
Prior art date
Application number
PT178794897T
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English (en)
Original Assignee
Harvard College
Broad Inst Inc
Massachusetts Inst Technology
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62491388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3551753(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College, Broad Inst Inc, Massachusetts Inst Technology filed Critical Harvard College
Publication of PT3551753T publication Critical patent/PT3551753T/pt

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    • C12N9/14Hydrolases (3)
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • GPHYSICS
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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PT178794897T 2016-12-09 2017-12-08 Diagnósticos baseados num sistema efetor de crispr PT3551753T (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662432553P 2016-12-09 2016-12-09
US201762456645P 2017-02-08 2017-02-08
US201762471930P 2017-03-15 2017-03-15
US201762484869P 2017-04-12 2017-04-12
US201762568268P 2017-10-04 2017-10-04

Publications (1)

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PT3551753T true PT3551753T (pt) 2022-09-02

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PT178794897T PT3551753T (pt) 2016-12-09 2017-12-08 Diagnósticos baseados num sistema efetor de crispr

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US (3) US10266886B2 (pt)
EP (2) EP3551753B1 (pt)
JP (2) JP7228514B2 (pt)
KR (3) KR20190104030A (pt)
CN (1) CN110506128A (pt)
AU (1) AU2017371324B2 (pt)
BR (2) BR122021009064B1 (pt)
CA (1) CA3049961A1 (pt)
DK (1) DK3551753T3 (pt)
ES (1) ES2927463T3 (pt)
HU (1) HUE059759T2 (pt)
PL (1) PL3551753T3 (pt)
PT (1) PT3551753T (pt)
SI (1) SI3551753T1 (pt)
WO (1) WO2018107129A1 (pt)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9068179B1 (en) 2013-12-12 2015-06-30 President And Fellows Of Harvard College Methods for correcting presenilin point mutations
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
IL294014B2 (en) 2015-10-23 2024-07-01 Harvard College Nucleobase editors and their uses
US10337051B2 (en) * 2016-06-16 2019-07-02 The Regents Of The University Of California Methods and compositions for detecting a target RNA
KR20230156150A (ko) * 2016-06-17 2023-11-13 더 브로드 인스티튜트, 인코퍼레이티드 제vi형 crispr 오솔로그 및 시스템
CA3032699A1 (en) 2016-08-03 2018-02-08 President And Fellows Of Harvard College Adenosine nucleobase editors and uses thereof
AU2017308889B2 (en) 2016-08-09 2023-11-09 President And Fellows Of Harvard College Programmable Cas9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
WO2018064352A1 (en) 2016-09-30 2018-04-05 The Regents Of The University Of California Rna-guided nucleic acid modifying enzymes and methods of use thereof
GB2569733B (en) 2016-09-30 2022-09-14 Univ California RNA-guided nucleic acid modifying enzymes and methods of use thereof
WO2018071868A1 (en) 2016-10-14 2018-04-19 President And Fellows Of Harvard College Aav delivery of nucleobase editors
CA3049961A1 (en) * 2016-12-09 2018-06-14 The Broad Institute, Inc. Crispr effector system based diagnostics
US10745677B2 (en) 2016-12-23 2020-08-18 President And Fellows Of Harvard College Editing of CCR5 receptor gene to protect against HIV infection
US10726110B2 (en) * 2017-03-01 2020-07-28 Seven Bridges Genomics, Inc. Watermarking for data security in bioinformatic sequence analysis
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
JP2020513815A (ja) * 2017-03-15 2020-05-21 ザ・ブロード・インスティテュート・インコーポレイテッド クラスター化短鎖反復回文配列エフェクター系に基づくウイルス検出用診断法
US11174515B2 (en) * 2017-03-15 2021-11-16 The Broad Institute, Inc. CRISPR effector system based diagnostics
US11104937B2 (en) * 2017-03-15 2021-08-31 The Broad Institute, Inc. CRISPR effector system based diagnostics
IL269458B2 (en) 2017-03-23 2024-02-01 Harvard College Nucleic base editors that include nucleic acid programmable DNA binding proteins
US11618928B2 (en) 2017-04-12 2023-04-04 The Broad Institute, Inc. CRISPR effector system based diagnostics for malaria detection
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
WO2019005866A1 (en) * 2017-06-26 2019-01-03 The Broad Institute, Inc. NEW TYPE VI CRISPR ORTHOLOGISTS AND ASSOCIATED SYSTEMS
WO2019018694A1 (en) * 2017-07-19 2019-01-24 Dana-Farber Cancer Institute, Inc. DIAGNOSIS AND TREATMENT OF CANCER
JP2020534795A (ja) 2017-07-28 2020-12-03 プレジデント アンド フェローズ オブ ハーバード カレッジ ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
EP3679130A4 (en) * 2017-09-09 2021-06-30 The Broad Institute, Inc. DIAGNOSTIC SYSTEMS BASED ON MULTIEFFECTOR CRISPR
WO2019071051A1 (en) * 2017-10-04 2019-04-11 The Broad Institute, Inc. DIAGNOSTICS BASED ON A CRISPR EFFECTOR SYSTEM
US11795443B2 (en) 2017-10-16 2023-10-24 The Broad Institute, Inc. Uses of adenosine base editors
EP3701042A4 (en) * 2017-10-23 2021-08-11 The Broad Institute, Inc. SYSTEMS, PROCEDURES AND COMPOSITIONS FOR TARGETED NUCLEIC ACID EDITING
SG11202003863VA (en) 2017-11-01 2020-05-28 Univ California Casz compositions and methods of use
WO2019089808A1 (en) 2017-11-01 2019-05-09 The Regents Of The University Of California Class 2 crispr/cas compositions and methods of use
US11661599B1 (en) 2017-12-14 2023-05-30 National Technology & Engineering Solutions Of Sandia, Llc CRISPR-Cas based system for targeting single-stranded sequences
BR112020015093A2 (pt) * 2018-01-29 2020-12-08 The Broad Institute, Inc. Diagnóstico baseado no sistema de efetor crispr
US11807877B1 (en) 2018-03-22 2023-11-07 National Technology & Engineering Solutions Of Sandia, Llc CRISPR/Cas activity assays and compositions thereof
CN108893529A (zh) * 2018-06-25 2018-11-27 武汉博杰生物医学科技有限公司 一种基于CRISPR技术特异性检测人KRAS基因2号及3号外显子突变的crRNA
JP2021528090A (ja) 2018-06-26 2021-10-21 マサチューセッツ インスティテュート オブ テクノロジー Crisprエフェクター系に基づく増幅法、システム、及び診断法
SG11202011240YA (en) 2018-06-26 2020-12-30 Broad Inst Inc Crispr/cas and transposase based amplification compositions, systems and methods
JP2021528091A (ja) 2018-06-26 2021-10-21 ザ・ブロード・インスティテュート・インコーポレイテッド Crisprダブルニッカーゼに基づく増幅の組成物、システム、及び方法
CN108841958A (zh) * 2018-07-03 2018-11-20 武汉博杰生物医学科技有限公司 一种检测EGFR基因外显子21L858突变的crRNA及其检测方法
WO2020014261A1 (en) * 2018-07-09 2020-01-16 The Broad Institute, Inc. Rna programmable epigenetic rna modifiers and uses thereof
US20210348217A1 (en) * 2018-07-16 2021-11-11 Massachusetts Institute Of Technology Rna tickertape for recording transcriptional histories of cells
CN109897852A (zh) * 2018-07-25 2019-06-18 广州普世利华科技有限公司 基于C2c2的肿瘤相关突变基因的gRNA、检测方法、检测试剂盒
US11608519B2 (en) * 2018-07-30 2023-03-21 Tokitae Llc Specific detection of deoxyribonucleic acid sequences using novel CRISPR enzyme-mediated detection strategies
EP3830256A2 (en) * 2018-07-31 2021-06-09 The Broad Institute, Inc. Novel crispr enzymes and systems
WO2020028729A1 (en) 2018-08-01 2020-02-06 Mammoth Biosciences, Inc. Programmable nuclease compositions and methods of use thereof
EP3833761A1 (en) * 2018-08-07 2021-06-16 The Broad Institute, Inc. Novel cas12b enzymes and systems
EP3841205A4 (en) * 2018-08-22 2022-08-17 The Regents of The University of California VARIANT TYPE CRISPR/CAS V EFFECTIVE POLYPEPTIDES AND METHODS OF USE THEREOF
CN109055499B (zh) * 2018-08-30 2021-01-19 杭州杰毅生物技术有限公司 基于CRISPR-Cas的等温核酸检测方法及试剂盒
CN109022621B (zh) * 2018-09-03 2020-12-11 中国科学院武汉病毒研究所 尼帕病毒检测试剂盒及其专用引物
US20210348212A1 (en) * 2018-09-07 2021-11-11 The Regents Of The University Of California Hiv or hcv detection with crispr-cas13a
CN109337994A (zh) * 2018-09-30 2019-02-15 沈阳农业大学 一种检测布鲁氏菌的rpa-lfd检测试剂盒及其使用方法
CN109207615B (zh) * 2018-10-12 2021-06-29 广东省生态环境技术研究所 一种免标记荧光检测金黄色葡萄球菌mecA基因的方法及检测试剂盒
KR102124257B1 (ko) * 2018-10-19 2020-06-26 대한민국(관리부서 질병관리본부장) 신속 면역크로마토그래피법을 이용한 유비저균 진단·탐지 키트 및 이를 위한 특이항체와 항체생산세포주
EP3650553B1 (en) * 2018-11-07 2023-07-12 Siemens Healthcare GmbH Method for detection of specific nucleic acids
CN111154913B (zh) * 2018-11-08 2023-04-18 中山大学 用于EB病毒DNA检测的引物和crRNA及其应用
WO2020097445A1 (en) * 2018-11-09 2020-05-14 Inari Agriculture, Inc. Rna-guided nucleases and dna binding proteins
BR112021009425A2 (pt) * 2018-11-14 2021-11-23 Massachusetts Inst Technology Sistemas e métodos de diagnóstico por gotículas com base no sistema crispr
CN109652508A (zh) * 2018-12-04 2019-04-19 浙江天杭生物科技股份有限公司 一种简便快速检测核酸方法
WO2020124050A1 (en) 2018-12-13 2020-06-18 The Broad Institute, Inc. Tiled assays using crispr-cas based detection
CN109706259A (zh) * 2018-12-29 2019-05-03 博奥生物集团有限公司 引物组及其应用
CN111383713B (zh) * 2018-12-29 2023-08-01 北京安诺优达医学检验实验室有限公司 ctDNA检测分析装置及方法
WO2020142739A1 (en) * 2019-01-04 2020-07-09 Mammoth Biosciences, Inc. COMPOSITIONS AND METHODS FOR DETECTING MODIFIED NUCLEIC ACIDS AND AMPLIFYING ssDNA
EP3931313A2 (en) 2019-01-04 2022-01-05 Mammoth Biosciences, Inc. Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
EP3924514A4 (en) * 2019-02-11 2022-12-28 Tokitae LLC SOLUTION-PHASE TRANSACTIVATED REPORTER SYSTEMS FOR USE IN CRISPR-BASED NUCLEIC ACID SEQUENCE DETECTION
WO2020186231A2 (en) 2019-03-14 2020-09-17 The Broad Institute, Inc. Crispr effector system based multiplex diagnostics
US20220220546A1 (en) * 2019-03-14 2022-07-14 The Broad Institute, Inc. Sherlock assays for tick-borne diseases
DE112020001342T5 (de) 2019-03-19 2022-01-13 President and Fellows of Harvard College Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen
CN113692447A (zh) 2019-03-21 2021-11-23 夏洛克生物公司 系统
EP3972729A4 (en) * 2019-05-22 2022-12-21 Citrogene Inc. APPARATUS AND METHOD FOR RAPID IDENTIFICATION OF MICROORGANISMS
US20220380786A1 (en) * 2019-06-06 2022-12-01 Tata Consultancy Services Limited System and method for combating mycobacterium tuberculosis infections
EP3979829A4 (en) * 2019-06-06 2023-06-28 Tata Consultancy Services Limited System and method for combating pseudomonas aeruginosa and staphylococcus aureus infrctions
EP3979828A4 (en) * 2019-06-06 2023-06-28 Tata Consultancy Services Limited System and method for combating infections due to pathogens belonging to phylum proteobacteria
CN114650883B (zh) * 2019-06-18 2023-10-27 猛犸生物科学公司 用于检测核酸的测定和方法
EP4004197A1 (en) * 2019-07-26 2022-06-01 Mammoth Biosciences, Inc. Compositions for detection of dna and methods of use thereof
WO2021026227A1 (en) * 2019-08-05 2021-02-11 Massachusetts Institute Of Technology Transplant diagnostics using crispr-based technology
CN110551846B (zh) * 2019-08-19 2021-10-08 上海科技大学 一种用于非洲猪瘟病毒核酸快速检测的Cpf1试剂盒及其检测方法
WO2021046257A1 (en) 2019-09-03 2021-03-11 The Broad Institute, Inc. Crispr effector system based multiplex cancer diagnostics
JP2022546592A (ja) 2019-09-03 2022-11-04 マイエロイド・セラピューティクス,インコーポレーテッド ゲノム組込みのための方法および組成物
KR102239459B1 (ko) * 2019-09-16 2021-04-12 한국화학연구원 산화 그래핀, DNAzyme 및 PNA를 포함하는 온도 센서용 조성물 및 이를 이용한 온도 센싱 방법
NL2024019B1 (en) * 2019-10-15 2021-06-17 Univ Delft Tech Detection of a target polynucleotide
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
WO2021111466A1 (en) * 2019-12-02 2021-06-10 Council Of Scientific & Industrial Research Method and kit for detection of polynucleotide
WO2021142109A1 (en) * 2020-01-07 2021-07-15 The Trustees Of Columbia University In The City Of New York Transposition-based diagnostics methods and devices
WO2021143714A1 (en) * 2020-01-14 2021-07-22 Mgi Tech Co., Ltd. Rapid multiplexing crispr-based diagnostics using microfluidic compartmentalization
KR20220131939A (ko) 2020-01-27 2022-09-29 셜록 바이오사이언스, 인크. 개선된 검출 검정
US20230091060A1 (en) * 2020-02-07 2023-03-23 University of Conecticut Dynamic multiphase reaction in one-pot for crispr/cas-derived ultra-sensitive molecular detection
CN111187861B (zh) * 2020-02-26 2023-05-23 中国热带农业科学院热带生物技术研究所 一种对海产品诺如病毒gii.4的检测方法
US12012433B1 (en) * 2020-02-27 2024-06-18 Integrated Dna Technologies Inc. Expression and purification of Cas enzymes
AU2020431316A1 (en) 2020-02-28 2022-10-20 Huigene Therapeutics Co., Ltd. Type VI-E and type VI-F CRISPR-Cas system and uses thereof
US20230184757A1 (en) 2020-02-29 2023-06-15 Nuha Khalid ALEKHMIMI Colorimetric detection system for rapid detection of infectious pulmonary diseases and a face mask with said colorimetric detection system
CN113337488B (zh) * 2020-03-02 2024-04-19 中国科学院分子细胞科学卓越创新中心 一种分离的Cas13蛋白
CN111534514A (zh) * 2020-03-09 2020-08-14 宿迁市第一人民医院 一种基于Crisper的新型冠状病毒的检测试剂盒
CN111254223A (zh) * 2020-03-21 2020-06-09 上海海关动植物与食品检验检疫技术中心 一种用于检测非洲猪瘟病毒核酸的反应体系、试剂盒及其应用
US11639523B2 (en) 2020-03-23 2023-05-02 The Broad Institute, Inc. Type V CRISPR-Cas systems and use thereof
CN111491023B (zh) * 2020-04-10 2021-10-26 西咸新区予果微码生物科技有限公司 一种基于crispr技术的微生物检测系统
CN111363842B (zh) * 2020-04-13 2021-02-02 广州医科大学附属第一医院 用于快速检测烟曲霉的序列、试剂盒、方法及应用
CN111450260B (zh) * 2020-04-17 2021-06-25 西南交通大学 一种两歧双歧杆菌抗肿瘤制剂的制备方法及其产品和应用
KR20230002943A9 (ko) 2020-04-22 2024-04-26 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 검출을 위한 등온 방법, 조성물, 키트, 및 시스템
CN116096878A (zh) 2020-05-01 2023-05-09 合成Dna技术公司 在非经典tttt前间区序列邻近基序处具有增强的切割活性的毛螺菌科菌种cas12a突变体
DE112021002672T5 (de) 2020-05-08 2023-04-13 President And Fellows Of Harvard College Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
EP4165218A1 (en) 2020-06-12 2023-04-19 Sherlock Biosciences, Inc. Crispr-based sars-cov-2 detection
CN112080571B (zh) * 2020-09-22 2022-11-11 扬州大学 基于CRISPR-Cas12b系统的空肠弯曲菌检测试剂盒和方法
CN112813143A (zh) * 2020-12-09 2021-05-18 广州市第一人民医院(广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院) 一种免扩增的rna定量检测方法
CN112779358B (zh) * 2021-01-27 2023-06-09 重庆威斯腾前沿生物研究院有限责任公司 一种非诊断目的的dcas9介导检测HPV16型E6基因的免疫层析方法
CN112779346B (zh) * 2021-01-27 2023-11-03 重庆威斯腾前沿生物研究院有限责任公司 一种非诊断目的的dcas9介导检测结核杆菌的免疫层析方法
EP4291678A1 (en) 2021-02-09 2023-12-20 Sherlock Biosciences, Inc. Nucleic acid amplification using promoter primers
EP4291643A1 (en) * 2021-02-09 2023-12-20 Mammoth Biosciences, Inc. Programmable nucleases and methods of use
CN113088579B (zh) * 2021-03-16 2022-03-22 广州医科大学附属第一医院 一种用于定性检测耶氏肺孢子菌的试剂盒和方法
WO2022210822A1 (ja) * 2021-04-02 2022-10-06 キヤノン株式会社 試薬、及びそれを用いた標的核酸の検出方法
CN113265477B (zh) * 2021-04-09 2022-07-19 宁波大学 一种基于BCA-RPA和CRISPR-Cas12a系统检测鼠伤寒沙门氏菌的方法
CN112852980B (zh) * 2021-04-23 2021-11-26 上海海关动植物与食品检验检疫技术中心 基于crispr荧光法检测大西洋鲑核酸的检测方法及其检测试剂盒
CN113308569B (zh) * 2021-05-07 2023-03-31 杭州杰毅生物技术有限公司 一种新型冠状病毒核酸检测试剂盒
US20220389418A1 (en) 2021-06-01 2022-12-08 Helmholtz-Institut Für Rna-Basierte Nfektionsforschung (Hzi) Rna-guided cas nucleases and uses thereof in diagnostics and therapy
US20230167487A2 (en) 2021-07-12 2023-06-01 Labsimply, Inc. Crispr cascade assay
US11814689B2 (en) 2021-07-21 2023-11-14 Montana State University Nucleic acid detection using type III CRISPR complex
IL312452A (en) 2021-11-01 2024-06-01 Tome Biosciences Inc A transformant has a single structure for the simultaneous transfer of a gene editing mechanism and a nucleic acid cargo
US11820983B2 (en) 2021-12-13 2023-11-21 Labsimply, Inc. Tuning cascade assay kinetics via molecular design
US20230279375A1 (en) 2021-12-13 2023-09-07 Labsimply, Inc. Signal boost cascade assay
AU2022420615A1 (en) 2021-12-22 2024-07-04 Tome Biosciences, Inc. Co-delivery of a gene editor construct and a donor template
WO2023122648A1 (en) * 2021-12-23 2023-06-29 Mammoth Biosciences, Inc. Devices, systems, and methods for detecting target nucleic acids
WO2023130076A2 (en) 2021-12-31 2023-07-06 Empyrean Neuroscience, Inc. Targets and pathways for the production of alkaloidal compounds
WO2023205744A1 (en) 2022-04-20 2023-10-26 Tome Biosciences, Inc. Programmable gene insertion compositions
WO2023215831A1 (en) 2022-05-04 2023-11-09 Tome Biosciences, Inc. Guide rna compositions for programmable gene insertion
WO2023225651A2 (en) * 2022-05-19 2023-11-23 Logicink Corporation Pre-amplification-free target sequence detection with colormetric readout
WO2023225670A2 (en) 2022-05-20 2023-11-23 Tome Biosciences, Inc. Ex vivo programmable gene insertion
CN114921576B (zh) * 2022-06-29 2023-11-10 湖南工程学院 一种检测牛结核分枝杆菌的试剂、试剂盒及检测方法
WO2024020587A2 (en) 2022-07-22 2024-01-25 Tome Biosciences, Inc. Pleiopluripotent stem cell programmable gene insertion
CN115786544B (zh) * 2022-08-19 2023-11-17 湖南工程学院 一种检测牛结核分枝杆菌的试剂、试剂盒及检测方法
WO2024055019A1 (en) * 2022-09-09 2024-03-14 The Forsyth Institute Methods and systems for detection of oral bacteria
WO2024072775A1 (en) * 2022-09-26 2024-04-04 The Johns Hopkins University Devices and systems for dna capture
US12091689B2 (en) 2022-09-30 2024-09-17 Vedabio, Inc. Delivery of therapeutics in vivo via a CRISPR-based cascade system
WO2024076473A1 (en) 2022-10-02 2024-04-11 Vedabio, Inc. Dimerization screening assays
US11965205B1 (en) 2022-10-14 2024-04-23 Vedabio, Inc. Detection of nucleic acid and non-nucleic acid target molecules
WO2024108016A2 (en) * 2022-11-16 2024-05-23 Mammoth Biosciences, Inc. Methods for quantitation of nucleic acid targets
WO2024138194A1 (en) 2022-12-22 2024-06-27 Tome Biosciences, Inc. Platforms, compositions, and methods for in vivo programmable gene insertion
US12091690B2 (en) 2023-01-07 2024-09-17 Vedabio, Inc. Engineered nucleic acid-guided nucleases
WO2024151493A1 (en) 2023-01-10 2024-07-18 Vedabio, Inc. Sample splitting for multiplexed detection of nucleic acids without amplification
EP4414452A1 (en) * 2023-02-13 2024-08-14 Universidad de Granada Dual-guide rna composition for executing a single-guide rna crispr-associated system

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
CN100342008C (zh) 1997-10-24 2007-10-10 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US6465177B1 (en) 1998-10-26 2002-10-15 John Wayne Cancer Institute Detection of loss of heterozygosity in tumor and serum of melanoma patients
JP2003525037A (ja) * 2000-02-11 2003-08-26 リボザイム・ファーマシューティカルズ・インコーポレーテッド Cd20およびnogo遺伝子発現の調節および診断のための方法および試薬
DE60141087D1 (de) 2000-06-26 2010-03-04 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
CN101525660A (zh) 2000-07-07 2009-09-09 维西根生物技术公司 实时序列测定
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
WO2003070894A2 (en) 2002-02-20 2003-08-28 University Of Virginia Patent Foundation A non-invasive diagnostic test utilizing histone modification markers
DK3363809T3 (da) 2002-08-23 2020-05-04 Illumina Cambridge Ltd Modificerede nukleotider til polynukleotidsekvensering
DE10317337B4 (de) 2003-04-15 2020-06-10 Andreas Maier Gmbh & Co. Kg Schnellspannzylinder in Modulbauweise
CA2554007C (en) 2004-01-27 2013-03-26 Altivera L.L.C. Diagnostic radio frequency identification sensors and applications thereof
EP1790202A4 (en) 2004-09-17 2013-02-20 Pacific Biosciences California APPARATUS AND METHOD FOR ANALYZING MOLECULES
ES2347167T3 (es) 2004-12-21 2010-10-26 Academia Sinica Variantes geneticas de vkorc1 que predicen la sensibilidad a warfarina.
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
CA2648149A1 (en) 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
US20070243549A1 (en) 2006-04-12 2007-10-18 Biocept, Inc. Enrichment of circulating fetal dna
EP2089517A4 (en) 2006-10-23 2010-10-20 Pacific Biosciences California POLYMERASEENZYME AND REAGENTS FOR ADVANCED NUCKIC ACID SEQUENCING
WO2008149176A1 (en) 2007-06-06 2008-12-11 Cellectis Meganuclease variants cleaving a dna target sequence from the mouse rosa26 locus and uses thereof
US8921118B2 (en) 2008-03-27 2014-12-30 President And Fellows Of Harvard College Paper-based microfluidic systems
US20100240054A1 (en) 2008-09-22 2010-09-23 Biocept, Inc. Identification and isolation of fetal cells and nucleic acid
US20130059290A1 (en) 2009-09-25 2013-03-07 Alere San Diego, Inc. Detection of nucleic acids in crude matrices
AU2011220736C1 (en) 2010-02-24 2014-12-18 The Broad Institute, Inc Methods of diagnosing infectious disease pathogens and their drug sensitivity
KR20130000396A (ko) 2010-03-04 2013-01-02 메사추세츠 인스티튜트 오브 테크놀로지 세포 검출 및 단리를 위한 마이크로유체 선별기
US8771985B2 (en) 2010-04-26 2014-07-08 Sangamo Biosciences, Inc. Genome editing of a Rosa locus using zinc-finger nucleases
WO2012125781A2 (en) 2011-03-15 2012-09-20 Colorado State University Research Foundation Rapid detection of pathogens using paper devices
GB201115098D0 (en) 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
US20140295472A1 (en) 2011-11-10 2014-10-02 The Administrators Of The Tulane Educational Fund Paper Based Diagnostic Test
EP2898096B1 (en) 2012-09-21 2024-02-14 The Broad Institute, Inc. Methods for labeling of rnas
BR112015013784A2 (pt) 2012-12-12 2017-07-11 Massachusetts Inst Technology aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas
WO2014152281A2 (en) 2013-03-15 2014-09-25 The Broad Institute, Inc. Ribosomal ribonucleic acid hybridization for organism identification
US11414695B2 (en) 2013-05-29 2022-08-16 Agilent Technologies, Inc. Nucleic acid enrichment using Cas9
US20150065821A1 (en) 2013-09-05 2015-03-05 Google Inc. Nanoparticle Phoresis
US20160282354A1 (en) * 2013-11-08 2016-09-29 The Broad Institute, Inc. Compositions and methods for selecting a treatment for b-cell neoplasias
JP6387606B2 (ja) * 2013-11-27 2018-09-12 東ソー株式会社 核酸の検出方法
WO2015085194A1 (en) 2013-12-06 2015-06-11 The Broad Institute, Inc. Enhanced methods of ribonucleic acid hybridization
EP3916007A1 (en) * 2014-03-24 2021-12-01 Immco Diagnostics, Inc. Improved anti-nuclear antibody detection and diagnostics for systemic and non-systemic autoimmune disorders
FR3020160B1 (fr) * 2014-04-16 2017-08-11 Commissariat Energie Atomique Systeme d'execution de code avec mecanisme d'hypervision en aveugle
US9737251B2 (en) 2014-05-28 2017-08-22 Verily Life Sciences Llc Needle-free blood draw
EP3227462B1 (en) * 2014-12-01 2020-04-22 The Broad Institute, Inc. Method for in situ determination of nucleic acid proximity
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
WO2016172598A1 (en) 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
EP3297660A2 (en) 2015-05-20 2018-03-28 The Broad Institute Inc. Shared neoantigens
CA3012631A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
EP3314020A1 (en) 2015-06-29 2018-05-02 The Broad Institute Inc. Tumor and microenvironment gene expression, compositions of matter and methods of use thereof
WO2017040316A1 (en) 2015-08-28 2017-03-09 The Broad Institute, Inc. Sample analysis, presence determination of a target sequence
US20170211142A1 (en) * 2015-10-22 2017-07-27 The Broad Institute, Inc. Novel crispr enzymes and systems
WO2017075292A1 (en) 2015-10-28 2017-05-04 The Broad Institute, Inc. Systems and methods for determining relative abundances of biomolecules
US20180327806A1 (en) 2015-11-04 2018-11-15 The Broad Institute, Inc. Multiplex high-resolution detection of micro-organism strains, related kits, diagnostics methods and screening assays
US10337051B2 (en) 2016-06-16 2019-07-02 The Regents Of The University Of California Methods and compositions for detecting a target RNA
KR20230156150A (ko) * 2016-06-17 2023-11-13 더 브로드 인스티튜트, 인코퍼레이티드 제vi형 crispr 오솔로그 및 시스템
EP3500967A1 (en) 2016-08-17 2019-06-26 The Broad Institute, Inc. Methods for identifying class 2 crispr-cas systems
CA3049961A1 (en) * 2016-12-09 2018-06-14 The Broad Institute, Inc. Crispr effector system based diagnostics
CN107939288B (zh) 2017-11-14 2019-04-02 中国科学院地质与地球物理研究所 一种非旋转套的防转装置以及旋转导向装置

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US20190309357A1 (en) 2019-10-10
US10266886B2 (en) 2019-04-23
BR122021009064B1 (pt) 2022-04-12
PL3551753T3 (pl) 2022-10-31
US20180340218A1 (en) 2018-11-29
US20180340219A1 (en) 2018-11-29
ES2927463T3 (es) 2022-11-07
JP2023011606A (ja) 2023-01-24
EP3551753B1 (en) 2022-06-29

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