PT3004166T - Métodos para melhorar a imunoterapia específica de alergénios administrando um inibidor de il-4r - Google Patents
Métodos para melhorar a imunoterapia específica de alergénios administrando um inibidor de il-4rInfo
- Publication number
- PT3004166T PT3004166T PT147339220T PT14733922T PT3004166T PT 3004166 T PT3004166 T PT 3004166T PT 147339220 T PT147339220 T PT 147339220T PT 14733922 T PT14733922 T PT 14733922T PT 3004166 T PT3004166 T PT 3004166T
- Authority
- PT
- Portugal
- Prior art keywords
- administering
- inhibitor
- methods
- specific immunotherapy
- treating allergy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830919P | 2013-06-04 | 2013-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3004166T true PT3004166T (pt) | 2020-01-14 |
Family
ID=51023185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT147339220T PT3004166T (pt) | 2013-06-04 | 2014-06-03 | Métodos para melhorar a imunoterapia específica de alergénios administrando um inibidor de il-4r |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US10392439B2 (enExample) |
| EP (2) | EP3617233A1 (enExample) |
| JP (6) | JP6499167B2 (enExample) |
| KR (3) | KR102355114B1 (enExample) |
| CN (3) | CN117982639A (enExample) |
| AU (3) | AU2014275094C1 (enExample) |
| CA (1) | CA2914203C (enExample) |
| CY (1) | CY1124095T1 (enExample) |
| DK (1) | DK3004166T3 (enExample) |
| ES (1) | ES2767080T3 (enExample) |
| HR (1) | HRP20200185T1 (enExample) |
| HU (1) | HUE048655T2 (enExample) |
| IL (3) | IL273678B2 (enExample) |
| LT (1) | LT3004166T (enExample) |
| MX (2) | MX384112B (enExample) |
| NZ (1) | NZ630183A (enExample) |
| PL (1) | PL3004166T3 (enExample) |
| PT (1) | PT3004166T (enExample) |
| RS (1) | RS59883B1 (enExample) |
| RU (1) | RU2679920C2 (enExample) |
| SG (3) | SG10201913835XA (enExample) |
| SI (1) | SI3004166T1 (enExample) |
| TW (3) | TWI755763B (enExample) |
| WO (1) | WO2014197470A1 (enExample) |
| ZA (1) | ZA201508174B (enExample) |
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| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| KR102502640B1 (ko) | 2012-08-21 | 2023-02-23 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| CN118286417A (zh) | 2012-09-07 | 2024-07-05 | 瑞泽恩制药公司 | 以il-4r拮抗剂治疗特应性皮炎的方法 |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| RS59354B1 (sr) | 2013-06-21 | 2019-10-31 | Sanofi Biotechnology | Postupci lečenja nosne polipoze davanjem il-4r antagonista |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| PT3110848T (pt) | 2014-09-24 | 2024-03-05 | Regeneron Pharma | Métodos para tratamento de infeção cutânea por administração de um antagonista do il-4r |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| CA3246946A1 (en) | 2014-11-14 | 2025-11-29 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| EP3954710A3 (en) | 2015-04-02 | 2022-07-20 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| ES3014160T3 (en) * | 2015-12-18 | 2025-04-21 | Intervet Int Bv | Caninized human antibodies to human and canine il-4r alpha |
| EP3416685B1 (en) | 2016-02-19 | 2024-06-26 | Regeneron Pharmaceuticals, Inc. | Methods for enhancing efficacy of a vaccine by administering an il-4r antagonist |
| AU2017228329B2 (en) * | 2016-03-01 | 2021-03-11 | Corcept Therapeutics, Inc. | The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors |
| AU2017312785B2 (en) | 2016-08-16 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| KR102872485B1 (ko) * | 2016-09-01 | 2025-10-20 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 알레르기를 예방하거나 치료하기 위한 방법 |
| WO2018053244A1 (en) * | 2016-09-16 | 2018-03-22 | Dyax Corp. | Protein biomarkers for diseases associated with the contact activation system |
| KR102759512B1 (ko) | 2016-10-25 | 2025-02-03 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피 데이터 분석을 위한 방법 및 시스템 |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| WO2019060062A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals Inc. | METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM |
| US11034768B2 (en) | 2017-10-30 | 2021-06-15 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| CN117405806A (zh) * | 2017-12-13 | 2024-01-16 | 里珍纳龙药品有限公司 | 管理层析柱床支架的装置和系统及相关方法 |
| WO2019148405A1 (zh) * | 2018-02-01 | 2019-08-08 | 北京凯因科技股份有限公司 | IL-4Rα抗体及其用途 |
| CN108373505B (zh) * | 2018-04-20 | 2019-08-20 | 北京智仁美博生物科技有限公司 | 抗il-4r抗体及其用途 |
| CN112533675A (zh) * | 2018-04-25 | 2021-03-19 | 基尼克萨制药有限公司 | 通过递送抗OSMRβ抗体治疗皮肤疾病或病症 |
| TWI903214B (zh) | 2018-05-02 | 2025-11-01 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
| MX2020012064A (es) | 2018-05-13 | 2021-04-13 | Regeneron Pharma | Metodos para tratar la dermatitis atopica administrando un inhibidor de il-4r. |
| TWI919355B (zh) | 2018-07-02 | 2026-03-21 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| MX2021000239A (es) * | 2018-07-10 | 2021-03-25 | Regeneron Pharma | Modificacion de moleculas de union para minimizar interacciones preexistentes. |
| JP2022500037A (ja) * | 2018-09-14 | 2022-01-04 | キンドレッド バイオサイエンシズ インコーポレイテッド | 獣医学的使用のための抗il4受容体抗体 |
| KR102330596B1 (ko) * | 2018-11-09 | 2021-11-26 | 아주대학교산학협력단 | 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도 |
| CN111494626B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| SG11202107007VA (en) * | 2018-12-27 | 2021-07-29 | Akeso Biopharma Inc | Antibody against human il-4ra and use thereof |
| RU2700788C1 (ru) * | 2019-01-17 | 2019-09-23 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ оценки эффективности проведения аллерген-специфической иммунотерапии при аллергическом рините |
| EA202192422A1 (ru) | 2019-03-05 | 2021-12-09 | Ридженерон Фармасьютикалз, Инк. | Человеческий сывороточный альбумин в составах |
| KR20210143246A (ko) * | 2019-03-21 | 2021-11-26 | 리제너론 파아마슈티컬스, 인크. | 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용 |
| KR20220034878A (ko) | 2019-07-16 | 2022-03-18 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| JP7736667B2 (ja) | 2019-08-05 | 2025-09-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Il-4rアンタゴニストを投与することによるアトピー性皮膚炎の治療方法 |
| US11504426B2 (en) * | 2019-08-05 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| CN111825766B (zh) * | 2019-10-31 | 2021-05-11 | 上海洛启生物医药技术有限公司 | 抗il-4r单域抗体及其应用 |
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| CA3161037A1 (en) | 2019-12-09 | 2021-06-17 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
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| BR112022011797A2 (pt) | 2019-12-20 | 2022-08-30 | Intervet Int Bv | Anticorpos contra receptor alfa de interleucina-4 canino |
| AU2021214938B2 (en) | 2020-01-29 | 2024-02-08 | Corcept Therapeutics Incorporated | Treatment of adrenocortical carcinoma with selective glucocorticoid receptor modulators (SGRMs) and antibody checkpoint inhibitors |
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| CN115960236B (zh) * | 2023-01-05 | 2024-08-06 | 江苏荃信生物医药股份有限公司 | 一种定量检测血清中抗人白介素4受体α单克隆抗体含量的酶联免疫分析方法 |
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| KR20260105275A (ko) * | 2024-12-26 | 2026-07-06 | 주식회사 종근당 | 항-hIL-4Rα 항체를 위한 안정화된 액상 조성물 |
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