HRP20200185T1 - Metode za unaprjeđenje alergen-specifične imunoterapije primjenom inhibitora il-4r - Google Patents
Metode za unaprjeđenje alergen-specifične imunoterapije primjenom inhibitora il-4r Download PDFInfo
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- HRP20200185T1 HRP20200185T1 HRP20200185TT HRP20200185T HRP20200185T1 HR P20200185 T1 HRP20200185 T1 HR P20200185T1 HR P20200185T T HRP20200185T T HR P20200185TT HR P20200185 T HRP20200185 T HR P20200185T HR P20200185 T1 HRP20200185 T1 HR P20200185T1
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- 238000000034 method Methods 0.000 title claims 14
- 239000013566 allergen Substances 0.000 title claims 4
- 238000009169 immunotherapy Methods 0.000 title claims 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 17
- 229940123418 Interleukin 4 receptor antagonist Drugs 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000000750 progressive effect Effects 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 244000105624 Arachis hypogaea Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 1
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940124581 decongestants Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229950003468 dupilumab Drugs 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 235000019688 fish Nutrition 0.000 claims 1
- 239000013568 food allergen Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 235000014571 nuts Nutrition 0.000 claims 1
- 235000020232 peanut Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000015170 shellfish Nutrition 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Endocrinology (AREA)
Claims (12)
1. Farmaceutski pripravak koji sadrži antagonist receptora interleukina-4 (IL-4R) za primjenu u metodi za unaprjeđenje učinkovitosti i/ili neškodljivosti režima alergen-specifične imunoterapije (engl. specific immunotherapy, SIT), pri čemu se metoda sastoji od primjene terapijski učinkovite količine predmetnog pripravka kod subjekta neposredno prije ili istovremeno sa režimom SIT, naznačeno time, što alergen predstavlja alergen koji se nalazi u prehrambenom proizvodu, naznačeno time, što antagonist IL-4R predstavlja antitijelo IL-4Rα ili njegov fragment koji se vezuje za antigen, naznačeno time, što HCVR antitijela ili njegovog fragmenta koji se vezuje za antigen sadrži aminokiselinsku sekvencu SEQ ID NO: 1, a LCVR sadrži aminokiselinsku sekvencu SEQ ID NO: 2.
2. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 1, naznačen time, što režim SIT obuhvaća fazu progresivnog doziranja nakon koje slijedi faza održavanja.
3. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što režim SIT predstavlja ubrzani režim SIT, koji se sastoji od faze progresivnog doziranja kraće od 5 dana.
4. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta jednom tjedno, jednom svaka dva tjedna, jednom svaka tri tjedna ili jednom mjesečno, prije ili tijekom faze progresivnog doziranja.
5. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta jednom tjedno, jednom svaka dva tjedna, jednom svaka tri tjedna ili jednom mjesečno, tijekom ili nakon faze održavanja.
6. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta jednom tjedno, jednom svaka dva tjedna, jednom svaka tri tjedna ili jednom mjesečno, za cijelo vrijeme trajanja režima SIT.
7. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 6, naznačen time, što se režim SIT sastoji od primjene alergena iz hrane dobivenog iz prehrambenog proizvoda odabranog iz skupine koja se sastoji od mliječnih proizvoda, jaja, pšenice, soje, ribe, školjkaša, kikirikija i orašastih plodova.
8. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 7, naznačen time, što farmaceutski pripravak sadrži od 0,05 do 600 mg antagonista IL-4R.
9. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 8, naznačen time, što farmaceutski pripravak sadrži 300 mg antagonista IL-4R.
10. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 9, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta u kombinaciji s drugim terapijskim sredstvom odabranim iz skupine koja se sastoji od kortikosteroida, antihistaminika, sredstava za dekongestiju i sredstava protiv IgE.
11. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 10, naznačen time, što se antitijelo ili njegov fragment koji se vezuje za antigen vezuje za IL-4Rα i sprječava interakciju između IL-4 i/ili IL-13 s receptorom IL-4 tipa 1 ili tipa 2.
12. Farmaceutski pripravak za primjenu u metodi prema bilo kojem od prethodnih patentnim zahtjeva, naznačen time što je antitijelo IL-4Rα dupilumab.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361830919P | 2013-06-04 | 2013-06-04 | |
PCT/US2014/040695 WO2014197470A1 (en) | 2013-06-04 | 2014-06-03 | Mehods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
EP14733922.0A EP3004166B1 (en) | 2013-06-04 | 2014-06-03 | Methods for enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20200185T1 true HRP20200185T1 (hr) | 2020-05-01 |
Family
ID=51023185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20200185TT HRP20200185T1 (hr) | 2013-06-04 | 2020-02-05 | Metode za unaprjeđenje alergen-specifične imunoterapije primjenom inhibitora il-4r |
Country Status (26)
Country | Link |
---|---|
US (5) | US10392439B2 (hr) |
EP (2) | EP3617233A1 (hr) |
JP (5) | JP6499167B2 (hr) |
KR (3) | KR102492826B1 (hr) |
CN (3) | CN117982639A (hr) |
AU (3) | AU2014275094C1 (hr) |
CA (1) | CA2914203C (hr) |
CY (1) | CY1124095T1 (hr) |
DK (1) | DK3004166T3 (hr) |
ES (1) | ES2767080T3 (hr) |
HK (1) | HK1216898A1 (hr) |
HR (1) | HRP20200185T1 (hr) |
HU (1) | HUE048655T2 (hr) |
IL (2) | IL273678B1 (hr) |
LT (1) | LT3004166T (hr) |
MX (2) | MX2015016473A (hr) |
NZ (1) | NZ630183A (hr) |
PL (1) | PL3004166T3 (hr) |
PT (1) | PT3004166T (hr) |
RS (1) | RS59883B1 (hr) |
RU (1) | RU2679920C2 (hr) |
SG (3) | SG10201913835XA (hr) |
SI (1) | SI3004166T1 (hr) |
TW (3) | TWI697334B (hr) |
WO (1) | WO2014197470A1 (hr) |
ZA (1) | ZA201508174B (hr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
EP4324479A3 (en) | 2012-08-21 | 2024-04-24 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
RS59354B1 (sr) | 2013-06-21 | 2019-10-31 | Sanofi Biotechnology | Postupci lečenja nosne polipoze davanjem il-4r antagonista |
TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
ES2973858T3 (es) | 2014-02-28 | 2024-06-24 | Regeneron Pharma | Métodos para tratar infecciones cutáneas mediante la administración de un antagonista de IL-4R |
JP6861630B2 (ja) | 2014-11-14 | 2021-04-21 | サノフィ・バイオテクノロジー | Il−4rアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
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US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
KR20180110089A (ko) * | 2016-02-19 | 2018-10-08 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함으로써 백신의 효능을 향상시키는 방법 |
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MA46098A (fr) * | 2016-09-01 | 2019-07-10 | Regeneron Pharma | Méthodes de prévention ou de traitement de l'allergie par administration d'un antagoniste d'il-4 r |
KR102513485B1 (ko) * | 2016-09-16 | 2023-03-23 | 다케다 파머수티컬 컴패니 리미티드 | 접촉 활성화 시스템과 연관된 질환을 위한 단백질 바이오마커 |
WO2018081203A1 (en) | 2016-10-25 | 2018-05-03 | Regeneron Pharmaceuticals, Inc. | Methods and systems for chromatography data analysis |
TW202332696A (zh) | 2016-12-01 | 2023-08-16 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
MA46269B1 (fr) | 2017-08-18 | 2024-05-31 | Regeneron Pharma | Méthodes de traitement d'une dermatite atopique sévère par administration d'un inhibiteur des il-4r |
CN111526920A (zh) | 2017-10-30 | 2020-08-11 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂来治疗或预防哮喘的方法 |
KR20200097759A (ko) * | 2017-12-13 | 2020-08-19 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피 칼럼 베드 지지체를 관리하기 위한 장치 및 시스템, 및 관련 방법 |
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TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
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RU2700788C1 (ru) * | 2019-01-17 | 2019-09-23 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ оценки эффективности проведения аллерген-специфической иммунотерапии при аллергическом рините |
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