HRP20200185T1 - Metode za unaprjeđenje alergen-specifične imunoterapije primjenom inhibitora il-4r - Google Patents
Metode za unaprjeđenje alergen-specifične imunoterapije primjenom inhibitora il-4r Download PDFInfo
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- HRP20200185T1 HRP20200185T1 HRP20200185TT HRP20200185T HRP20200185T1 HR P20200185 T1 HRP20200185 T1 HR P20200185T1 HR P20200185T T HRP20200185T T HR P20200185TT HR P20200185 T HRP20200185 T HR P20200185T HR P20200185 T1 HRP20200185 T1 HR P20200185T1
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- 238000000034 method Methods 0.000 title claims 14
- 239000013566 allergen Substances 0.000 title claims 4
- 238000009169 immunotherapy Methods 0.000 title claims 2
- 230000002708 enhancing effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 17
- 229940123418 Interleukin 4 receptor antagonist Drugs 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000000750 progressive effect Effects 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 244000105624 Arachis hypogaea Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 1
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 241000209140 Triticum Species 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940124581 decongestants Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229950003468 dupilumab Drugs 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 235000019688 fish Nutrition 0.000 claims 1
- 239000013568 food allergen Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 235000014571 nuts Nutrition 0.000 claims 1
- 235000020232 peanut Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000015170 shellfish Nutrition 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Endocrinology (AREA)
Claims (12)
1. Farmaceutski pripravak koji sadrži antagonist receptora interleukina-4 (IL-4R) za primjenu u metodi za unaprjeđenje učinkovitosti i/ili neškodljivosti režima alergen-specifične imunoterapije (engl. specific immunotherapy, SIT), pri čemu se metoda sastoji od primjene terapijski učinkovite količine predmetnog pripravka kod subjekta neposredno prije ili istovremeno sa režimom SIT, naznačeno time, što alergen predstavlja alergen koji se nalazi u prehrambenom proizvodu, naznačeno time, što antagonist IL-4R predstavlja antitijelo IL-4Rα ili njegov fragment koji se vezuje za antigen, naznačeno time, što HCVR antitijela ili njegovog fragmenta koji se vezuje za antigen sadrži aminokiselinsku sekvencu SEQ ID NO: 1, a LCVR sadrži aminokiselinsku sekvencu SEQ ID NO: 2.
2. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 1, naznačen time, što režim SIT obuhvaća fazu progresivnog doziranja nakon koje slijedi faza održavanja.
3. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što režim SIT predstavlja ubrzani režim SIT, koji se sastoji od faze progresivnog doziranja kraće od 5 dana.
4. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta jednom tjedno, jednom svaka dva tjedna, jednom svaka tri tjedna ili jednom mjesečno, prije ili tijekom faze progresivnog doziranja.
5. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta jednom tjedno, jednom svaka dva tjedna, jednom svaka tri tjedna ili jednom mjesečno, tijekom ili nakon faze održavanja.
6. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 2, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta jednom tjedno, jednom svaka dva tjedna, jednom svaka tri tjedna ili jednom mjesečno, za cijelo vrijeme trajanja režima SIT.
7. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 6, naznačen time, što se režim SIT sastoji od primjene alergena iz hrane dobivenog iz prehrambenog proizvoda odabranog iz skupine koja se sastoji od mliječnih proizvoda, jaja, pšenice, soje, ribe, školjkaša, kikirikija i orašastih plodova.
8. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 7, naznačen time, što farmaceutski pripravak sadrži od 0,05 do 600 mg antagonista IL-4R.
9. Farmaceutski pripravak za primjenu u metodi prema patentnom zahtjevu 8, naznačen time, što farmaceutski pripravak sadrži 300 mg antagonista IL-4R.
10. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 9, naznačen time, što se farmaceutski pripravak primjenjuje kod subjekta u kombinaciji s drugim terapijskim sredstvom odabranim iz skupine koja se sastoji od kortikosteroida, antihistaminika, sredstava za dekongestiju i sredstava protiv IgE.
11. Farmaceutski pripravak za primjenu u metodi prema bilo kojem patentnom zahtjevu od 1 do 10, naznačen time, što se antitijelo ili njegov fragment koji se vezuje za antigen vezuje za IL-4Rα i sprječava interakciju između IL-4 i/ili IL-13 s receptorom IL-4 tipa 1 ili tipa 2.
12. Farmaceutski pripravak za primjenu u metodi prema bilo kojem od prethodnih patentnim zahtjeva, naznačen time što je antitijelo IL-4Rα dupilumab.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830919P | 2013-06-04 | 2013-06-04 | |
| PCT/US2014/040695 WO2014197470A1 (en) | 2013-06-04 | 2014-06-03 | Mehods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
| EP14733922.0A EP3004166B1 (en) | 2013-06-04 | 2014-06-03 | Methods for enhancing allergen-specific immunotherapy by administering an il-4r inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200185T1 true HRP20200185T1 (hr) | 2020-05-01 |
Family
ID=51023185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200185TT HRP20200185T1 (hr) | 2013-06-04 | 2020-02-05 | Metode za unaprjeđenje alergen-specifične imunoterapije primjenom inhibitora il-4r |
Country Status (26)
| Country | Link |
|---|---|
| US (5) | US10392439B2 (hr) |
| EP (2) | EP3617233A1 (hr) |
| JP (5) | JP6499167B2 (hr) |
| KR (3) | KR102355114B1 (hr) |
| CN (3) | CN105377894A (hr) |
| AU (3) | AU2014275094C1 (hr) |
| CA (1) | CA2914203C (hr) |
| CY (1) | CY1124095T1 (hr) |
| DK (1) | DK3004166T3 (hr) |
| ES (1) | ES2767080T3 (hr) |
| HK (1) | HK1216898A1 (hr) |
| HR (1) | HRP20200185T1 (hr) |
| HU (1) | HUE048655T2 (hr) |
| IL (2) | IL242456B (hr) |
| LT (1) | LT3004166T (hr) |
| MX (2) | MX2015016473A (hr) |
| NZ (1) | NZ630183A (hr) |
| PL (1) | PL3004166T3 (hr) |
| PT (1) | PT3004166T (hr) |
| RS (1) | RS59883B1 (hr) |
| RU (1) | RU2679920C2 (hr) |
| SG (3) | SG10201913835XA (hr) |
| SI (1) | SI3004166T1 (hr) |
| TW (3) | TWI755763B (hr) |
| WO (1) | WO2014197470A1 (hr) |
| ZA (1) | ZA201508174B (hr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| HUE064945T2 (hu) | 2012-08-21 | 2024-04-28 | Sanofi Biotechnology | Eljárások asztma kezelésére vagy megelõzésére IL-4R antagonista beadásával |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| CN111437387A (zh) | 2013-06-21 | 2020-07-24 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗鼻息肉症的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| RU2704999C2 (ru) | 2014-02-28 | 2019-11-01 | Ридженерон Фармасьютикалз, Инк. | Способ лечения кожной инфекции путем введения антагониста il-4r |
| KR20230158131A (ko) | 2014-11-14 | 2023-11-17 | 사노피 바이오테크놀로지 | Ｉｌ-4ｒ 길항제의 투여에 의한, 비용종을 동반한 만성 부비동염의 치료 방법 |
| CA3232651A1 (en) * | 2015-04-02 | 2016-10-06 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| WO2017102920A1 (en) * | 2015-12-18 | 2017-06-22 | Intervet International B.V. | Caninized human antibodies to human and canine il-4r alpha |
| JP2019505554A (ja) * | 2016-02-19 | 2019-02-28 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｉｌ−４ｒアンタゴニストを投与することによるワクチンの有効性を増強する方法 |
| EP3500297A1 (en) | 2016-08-16 | 2019-06-26 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| MX2019002344A (es) * | 2016-09-01 | 2019-09-06 | Regeneron Pharma | Metodos de prevenir o tratar la alergia administrando un antagonista de il-4r. |
| WO2018053244A1 (en) * | 2016-09-16 | 2018-03-22 | Dyax Corp. | Protein biomarkers for diseases associated with the contact activation system |
| WO2018057776A1 (en) | 2016-09-22 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
| PL3532838T3 (pl) | 2016-10-25 | 2022-10-03 | Regeneron Pharmaceuticals, Inc. | Metody i systemy analizy danych chromatograficznych |
| TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| EP3703818B1 (en) | 2017-10-30 | 2023-11-01 | Sanofi Biotechnology | Il-4r antagonist for use in a method for treating or preventing asthma |
| MX2020005699A (es) | 2017-12-13 | 2020-10-16 | Regeneron Pharma | Dispositivos y sistemas para manipulacion de soportes de lecho de columna para cromatografia y metodos relacionados. |
| WO2019148405A1 (zh) * | 2018-02-01 | 2019-08-08 | 北京凯因科技股份有限公司 | IL-4Rα抗体及其用途 |
| CN108373505B (zh) * | 2018-04-20 | 2019-08-20 | 北京智仁美博生物科技有限公司 | 抗il-4r抗体及其用途 |
| CA3096582A1 (en) * | 2018-04-25 | 2019-12-05 | Kiniksa Pharmaceuticals, Ltd. | Treatment of skin diseases or disorders by delivery of anti-osmr.beta. antibodies |
| TWI814812B (zh) | 2018-05-02 | 2023-09-11 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
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| US20230295312A1 (en) * | 2018-12-27 | 2023-09-21 | Akeso Biopharma, Inc | Antibody against human il-4ra and use thereof |
| RU2700788C1 (ru) * | 2019-01-17 | 2019-09-23 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Способ оценки эффективности проведения аллерген-специфической иммунотерапии при аллергическом рините |
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| BR112022011098A2 (pt) | 2019-12-09 | 2022-09-20 | Sanofi Biotechnology | Métodos para tratamento de distúrbios relacionados a il-4/il-13 digitalmente identificados |
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