PT2802652T - Enzimas de clostridium histolyticum - Google Patents

Enzimas de clostridium histolyticum

Info

Publication number
PT2802652T
PT2802652T PT13736040T PT13736040T PT2802652T PT 2802652 T PT2802652 T PT 2802652T PT 13736040 T PT13736040 T PT 13736040T PT 13736040 T PT13736040 T PT 13736040T PT 2802652 T PT2802652 T PT 2802652T
Authority
PT
Portugal
Prior art keywords
clostridium histolyticum
enzyme
histolyticum enzyme
clostridium
histolyticum
Prior art date
Application number
PT13736040T
Other languages
English (en)
Inventor
K Herber Wayne
Original Assignee
Endo Global Ventures
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Global Ventures filed Critical Endo Global Ventures
Publication of PT2802652T publication Critical patent/PT2802652T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24003Microbial collagenase (3.4.24.3)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96419Metalloendopeptidases (3.4.24)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
PT13736040T 2012-01-12 2013-01-10 Enzimas de clostridium histolyticum PT2802652T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261585909P 2012-01-12 2012-01-12

Publications (1)

Publication Number Publication Date
PT2802652T true PT2802652T (pt) 2019-09-10

Family

ID=48782075

Family Applications (2)

Application Number Title Priority Date Filing Date
PT13736040T PT2802652T (pt) 2012-01-12 2013-01-10 Enzimas de clostridium histolyticum
PT191741826T PT3584317T (pt) 2012-01-12 2013-01-10 Enzima de clostridium histolyticum

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT191741826T PT3584317T (pt) 2012-01-12 2013-01-10 Enzima de clostridium histolyticum

Country Status (13)

Country Link
US (4) US9757435B2 (pt)
EP (4) EP3584317B1 (pt)
JP (5) JP6263755B2 (pt)
AU (6) AU2013208028B2 (pt)
BR (1) BR112014017229B1 (pt)
CA (2) CA2970639C (pt)
DK (2) DK3584317T5 (pt)
ES (3) ES2904884T3 (pt)
HU (2) HUE046160T2 (pt)
MX (1) MX351448B (pt)
NZ (5) NZ750379A (pt)
PT (2) PT2802652T (pt)
WO (1) WO2013106510A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2790717B1 (en) * 2011-12-14 2018-05-30 The Board of Trustees of the University of Arkansas Delivery of therapeutic agents by a collagen binding protein
NZ750379A (en) 2012-01-12 2022-10-28 Auxilium Int Holdings Inc Clostridium histolyticum enzymes and methods for the use thereof
RU2540919C1 (ru) * 2013-09-27 2015-02-10 Государственное автономное учреждение здравоохранения "Республиканская клиническая больница Министерства здравоохранения Республики Татарстан" Способ безоперационного лечения контрактуры дюпюитрена iii-iv степени тяжести
PT107276B (pt) * 2013-11-07 2018-06-07 Univ Aveiro Método para produção de colagenase recombinante para digestão de colagénios
WO2017074257A1 (en) * 2015-10-26 2017-05-04 Nanyang Technological University Non-viable derivatives of clostridium sporogenes as anti-cancer therapeutic agents
WO2018104540A1 (en) * 2016-12-08 2018-06-14 Curevac Ag Rnas for wound healing
WO2018104538A1 (en) * 2016-12-08 2018-06-14 Curevac Ag Rna for treatment or prophylaxis of a liver disease
JP7397440B2 (ja) 2017-02-10 2023-12-13 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー コラーゲン結合薬剤組成物およびその使用方法
EP3589204A1 (en) 2017-03-01 2020-01-08 Endo Ventures Limited Apparatus and method for assessing and treating cellulite
CA3057982A1 (en) 2017-03-28 2018-10-04 Endo Ventures Limited Improved method of producing collagenase
CZ308157B6 (cs) 2017-09-13 2020-01-29 MB PHARMA s.r.o. Kmen bakterie Clostridium histolyticum, kolagenáza připravená s použitím tohoto kmene a její použití
WO2020021332A2 (en) 2018-07-12 2020-01-30 Endo Global Aesthetics Limited Injection techniques for the treatment of cellulite
WO2020021330A2 (en) 2018-07-12 2020-01-30 Endo Global Aesthetics Limited Injection techniques for the treatment of cellulite
EP3852715A1 (en) 2018-09-18 2021-07-28 Endo Global Aesthetics Limited Compositions and methods for treating cellulite
CN109355222B (zh) * 2018-11-06 2020-06-02 上海交通大学 对水稻白叶枯病菌具有拮抗作用的芽孢杆菌及分离与应用
WO2020142701A1 (en) 2019-01-06 2020-07-09 Endo Global Aesthetics Limited Collagenase formulations and methods of producing the same
CN113474355A (zh) * 2019-02-14 2021-10-01 诺尔玛克制药有限公司 从i型胶原酶、ii型胶原酶、中性蛋白酶和梭菌蛋白酶选出的至少一种酶的色谱纯化
CN112941058B (zh) * 2021-04-02 2023-12-05 重庆科润生物医药研发有限公司 一种重组溶组织梭菌ii型胶原酶及其制备方法和应用
CN113025599B (zh) * 2021-04-02 2023-09-12 重庆科润生物医药研发有限公司 一种重组溶组织梭菌i型胶原酶及其制备方法和应用
WO2023112020A1 (en) * 2021-12-14 2023-06-22 Ramot At Tel Aviv University Ltd. Modified recombinant collagenase, compositions comprising the same and uses thereof in dental related procedures

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821364A (en) * 1966-07-08 1974-06-28 Advance Biofactures Corp Process of producing collagenase
JPS5662229A (en) 1979-10-25 1981-05-28 Asahi Glass Co Ltd Electro-optical dimming panel
US4338300A (en) 1981-02-05 1982-07-06 The Regents Of The University Of California Use of purified clostridial collangenase in the treatment of Peyronie's disease
DE3473827D1 (en) 1983-01-05 1988-10-13 Pasteur Institut Highly active collagenolytic preparation and pharmaceutical compositions containing it
US4645668A (en) 1983-08-04 1987-02-24 Biospecifics, Nv Method for the prevention and treatment of scars with enzymes
US4524065A (en) 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
US4542065A (en) 1984-05-21 1985-09-17 Ppg Industries, Inc. Chemically treated glass fibers and strands and dispersed products thereof
JPS61289885A (ja) 1985-06-14 1986-12-19 Nitta Zerachin Kk コラゲナ−ゼおよびコラゲナ−ゼの製造方法
JP2898022B2 (ja) 1989-09-05 1999-05-31 株式会社ニッピ コラーゲン分解酵素の製造方法
US5252461A (en) 1990-05-01 1993-10-12 The Regents Of The Univ. Of California Mixed immunoglobulins for detection of rheumatoid factors
CA2047306A1 (en) 1990-07-23 1992-01-24 Milan Holjevac Mutant bacterium clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
US5393792A (en) 1991-11-20 1995-02-28 Advance Biofactures Of Curacao, N.V. High dosage topical forms of collagenase
US5462739A (en) 1991-11-21 1995-10-31 Yeda Research And Development Co., Ltd. Microdelivery device and method for enhanced drug administration to the eye
US5256140A (en) 1992-03-27 1993-10-26 Fallien Cosmeceuticals, Ltd. Composition for levelling skin
CA2138948A1 (en) * 1992-06-22 1994-01-06 Hun-Chi Lin Molecular cloning of the genes responsible for collagenase production from clostridium histolyticum
CA2152898C (en) 1992-12-30 2003-04-29 Hans Israelsen Recombinant lactic acid bacterium containing an inserted promoter and method of constructing same
JP3186881B2 (ja) 1993-02-18 2001-07-11 倉敷紡績株式会社 肝細胞の分離方法
US5332503A (en) 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
CA2189646C (en) 1994-06-24 1999-05-25 Francis E. Dwulet A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum
US5589171A (en) 1994-08-22 1996-12-31 Advance Biofactures Of Curacao Treatment of Dupuytren's disease with collagenase
CA2158822C (en) 1994-09-27 2008-12-23 Kusuki Nishioka Therapeutic agent for rheumatic disease
US6958150B2 (en) 1994-12-15 2005-10-25 Advance Biofactures Of Curacao, N.V. Reduction of adipose tissue
EP0815211A1 (de) 1995-03-16 1998-01-07 Knoll Aktiengesellschaft Neue, definierte enzymmischungen zur zellgewinnung und für die wundbehandlung
US5705170A (en) 1995-10-24 1998-01-06 Plantech International, Inc. Herbal cellulite treatments
US5989888A (en) 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
EP0925364B1 (en) 1996-09-06 2002-10-23 Bioteknologisk Institut A lactic acid bacterial regulatable expression system
CA2272244A1 (en) * 1996-11-19 1998-05-28 Roche Diagnostics Gmbh Recombinant collagenase type i from clostridium histolyticum and its use for isolating cells and groups of cells
US5830741A (en) 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US5753785A (en) 1996-12-16 1998-05-19 Fina Technology, Inc. Production of E-B copolymers with a single metallocene catalyst and a single monomer
US6086872A (en) 1997-03-27 2000-07-11 Advance Biofactures Of Curacao, Nv Amelioration of dupuytren's disease
JPH10262658A (ja) 1997-03-28 1998-10-06 Kikkoman Corp ザルコシン・オキシダーゼの結晶、その製造方法及び三次元構造
US6335388B1 (en) 1997-10-03 2002-01-01 Lavipharm Laboratories Inc. Prolamine-plant polar lipid composition, its method of preparation and applications thereof
GB9724802D0 (en) 1997-11-24 1998-01-21 Unilever Plc Antiperspirant or deodorant compoistions
US20020036328A1 (en) 1998-11-16 2002-03-28 William R. Richards, Jr. Offset drain fermi-threshold field effect transistors
FR2788682B1 (fr) 1999-01-26 2001-04-06 Seb Sa Dispositif de thermographie
US6022539A (en) 1999-06-03 2000-02-08 Advance Biofactures Of Curacao Amelioration of peyronie's disease
RU2180002C2 (ru) 1999-08-16 2002-02-27 Пермское научно-производственное объединение "Биомед" Способ получения коллагеназы
AU6918700A (en) 1999-08-20 2001-03-19 Howard Murad Pharmaceutical compositions and methods for reducing the appearance of cellulite
US6280993B1 (en) * 1999-08-24 2001-08-28 Ichiro Yamato Gene encoding class I collagenase
ITMI991894A1 (it) 1999-09-09 2001-03-09 Carlo Ghisalberti Acido linoleico coniugato e trigliceride nuovi metodi di sintesi e d'uso
ES2534938T3 (es) 1999-09-24 2015-04-30 Proteon Therapeutics, Inc. Una elastasa para abrir conductos biológicos obstruidos
US7811250B1 (en) 2000-02-04 2010-10-12 Boston Scientific Scimed, Inc. Fluid injectable single operator exchange catheters and methods of use
US20030026844A1 (en) 2000-04-18 2003-02-06 Hee-Yong Lee Injectable sustained release pharmaceutical composition and processes for preparing the same
DK1356073T3 (da) 2000-10-20 2010-04-06 Bioneer As Fermenteringsfremgangsmåde til fremstilling af heterologe genprodukter i mælkesyrebakterier
CA2432797C (en) 2000-12-18 2014-02-04 David J. Yang Local regional chemotherapy and radiotherapy using in situ hydrogel
US20030022856A1 (en) 2001-01-30 2003-01-30 The Regents Of The University Of Michigan Method for sustained release local delivery of drugs for ablation of unwanted tissue
JP4266817B2 (ja) 2001-07-02 2009-05-20 ノルドマルク・アルツナイミッテル・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト 酵素の精製方法およびその方法で製造された精製済み酵素並びに該酵素の用途
GB0124124D0 (en) 2001-10-08 2001-11-28 Medical Res Council Methods of treatment
JP2003284553A (ja) 2002-03-28 2003-10-07 Seikagaku Kogyo Co Ltd 生理活性タンパク質
KR100923717B1 (ko) 2002-06-25 2009-10-27 울트라세이프 인코포레이티드 신체 미용에 유용한 디바이스 및 방법
EP1433845A1 (en) * 2002-12-23 2004-06-30 Georg-August-Universität Clostridium tetani collagenase and uses thereof
EP1462519A1 (en) 2003-03-24 2004-09-29 Boehringer Ingelheim Austria GmbH Method and devices for producing biomolecules
JP4205496B2 (ja) 2003-06-19 2009-01-07 三菱化学株式会社 新規カルボニル還元酵素及びこれをコードするdna、ならびにこれらを利用した光学活性アルコールの製造方法
EP1709194A4 (en) 2003-12-17 2007-07-25 Univ Columbia ADMINISTRATION OF DNA OR RNA THROUGH LACUNAR JUNCTION OF HOST CELLS TO TARGET CELLS AND CELL-BASED DELIVERY SYSTEM FOR ANTISENSE OR ARNS
NZ576986A (en) 2004-01-30 2010-12-24 Shire Pharmaceuticals Ireland Ltd Production and purification of recombinant arylsulfatase A
CA2562024C (en) 2004-04-07 2014-05-27 Rinat Neuroscience Corp. Methods for treating bone cancer pain by administering a nerve growth factor antagonist
US7622130B2 (en) 2004-05-19 2009-11-24 Los Angeles Biomedical Research Institute at Harbor UCLA-Medical Center Methods and compositions for the non-surgical removal of fat
US7754230B2 (en) 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
US7355027B2 (en) 2004-06-16 2008-04-08 Dynport Vaccine Company Llc Bacillus anthracis protective antigen
CA2572643A1 (en) 2004-07-07 2006-01-12 H. Lundbeck A/S Novel carbamylated epo and method for its production
JP2008505928A (ja) 2004-07-08 2008-02-28 アムジェン インコーポレーテッド 治療用ペプチド
US20060020448A1 (en) 2004-07-21 2006-01-26 Microsoft Corporation Method and apparatus for capitalizing text using maximum entropy
CN101010274B (zh) 2004-08-30 2012-09-05 大赛璐化学工业株式会社 聚甘油单醚及其制造方法
JP4923131B2 (ja) 2004-08-30 2012-04-25 株式会社リコー ログ収集システム、ログ収集装置およびログ収集プログラム
US20150025420A1 (en) 2004-10-06 2015-01-22 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
DE102004060075A1 (de) 2004-12-14 2006-07-06 Merck Patent Gmbh Verfahren zur Herstellung von Onium-Salzen mit Dialkylphosphat-, Dialkylphosphinat oder (O-Alkyl)-alkyl- oder Alkyl-phosphonat-Anionen mit geringem Halogenid-Gehalt
US20070224184A1 (en) 2006-02-22 2007-09-27 The Research Foundation Of The State University Of New York Method for treating cellulite
US7854929B2 (en) 2005-01-21 2010-12-21 The Research Foundation Of State University Of New York Method for treating lateral epicondylitis using collagenase
PT1846022E (pt) 2005-01-21 2015-09-03 Univ New York State Res Found Métodos para o tratamento de capsulite adesiva
JP2006254876A (ja) 2005-03-18 2006-09-28 Hokkaido Univ L−トリプトファン製造法
US20060241673A1 (en) 2005-04-21 2006-10-26 Zadini Filiberto P Subcision device
US20060251581A1 (en) 2005-05-09 2006-11-09 Mcintyre Jon T Method for treatment of uterine fibroid tumors
US20070003541A1 (en) 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for therapeutics
ITPD20050207A1 (it) 2005-07-07 2007-01-08 Fidia Farmaceutici Nuove composizioni farmaceutiche contenenti acido ialuronico e collagenas nel trattamento topico di ferite, ustioni ed ulcere
US20070031482A1 (en) 2005-08-02 2007-02-08 Ceramoptec Industries, Ind. PDT treatment method for cellulites and cosmetic use
US7811560B2 (en) 2006-01-30 2010-10-12 Auxilium Us Holdings, Llc Compositions and methods for treating collagen-mediated diseases
WO2007100590A2 (en) 2006-02-22 2007-09-07 Auxilium Pharmaceuticals, Inc. Methods for treating cellulite
CN102015030A (zh) 2006-03-31 2011-04-13 帝斯曼知识产权资产管理有限公司 化合物和化合物的组合用于改善身体外观的新型用途
US20080233614A1 (en) 2007-02-13 2008-09-25 Cranenburgh Rocky M Production of recombinant collagenases colg and colh in escherichia coli
CN102784387A (zh) 2007-02-14 2012-11-21 友莱尔皮肤产品有限责任公司 修饰的突变体胶原蛋白酶及其在脂肪溶解和疤痕减少中的应用
MX2009012042A (es) 2007-05-11 2009-12-01 Sigma Tau Ind Farmaceuti Gel util para el suministro de ingredientes activos cosmeticos.
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
KR101633612B1 (ko) 2007-10-26 2016-06-27 코닌클리케 필립스 엔.브이. 광각 선택 광 검출기 장치
US20110262508A1 (en) 2007-11-07 2011-10-27 Paul Michael Watt Antimicrobial compositions, formulations and uses thereof
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
ES2388219T3 (es) 2008-06-02 2012-10-10 F. Hoffmann-La Roche Ag Purificación mejorada de colagenasas a partir de un cultivo líquido de Clostridium histolyticum
US8236356B2 (en) 2008-06-11 2012-08-07 Roche Diagnostics Operations, Inc. Growth medium for Clostridium histolyticum
WO2010011605A2 (en) 2008-07-21 2010-01-28 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
US8380531B2 (en) 2008-07-25 2013-02-19 Invivodata, Inc. Clinical trial endpoint development process
CA2741334A1 (en) 2008-10-22 2010-04-29 Allergan, Inc. Clinical assessment scales and methods
US20110217252A1 (en) 2008-11-11 2011-09-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Compound useful for treating cellulite
NZ593239A (en) * 2008-11-19 2013-01-25 Univ Tohoku Fusion Collagenase in which affinity TAG is linked and method for producing the same
IT1397646B1 (it) * 2009-12-15 2013-01-18 Seidita Collagenasi ricombinanti di c. histolyticum e metodo per la loro produzione.
US9132199B2 (en) 2010-03-05 2015-09-15 University of Pittsburgh—of the Commonwealth System of Higher Education Reverse thermal gels and uses therefor
US20130195828A1 (en) 2010-04-14 2013-08-01 Northwestern University Pharmaceutical Compositions and Methods for Digesting Atherosclerotic Plaques
US20130217789A1 (en) 2010-09-03 2013-08-22 North Carolina Central University Biodegradable liquogel and ph sensitive nanocarriers
ES2385239B1 (es) * 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
EP2675460A4 (en) 2011-02-18 2014-07-09 Kythera Biopharmaceuticals Inc TREATMENT OF FAT TISSUE UNDER CHIN
WO2012125948A1 (en) 2011-03-16 2012-09-20 Biospecifics Technologies Corp. Compositions and methods for producing clostridial collagenases
TWI461214B (zh) 2011-06-13 2014-11-21 Univ Chang Gung Biodegradable water-sensitive glue, a drug delivery system as a carrier thereof, and a pharmaceutical composition for the treatment and / or prevention of eye diseases
WO2013059263A1 (en) 2011-10-17 2013-04-25 Sound Surgical Technologies, Llc Ultrasonic probe for treating cellulite
HUE044650T2 (hu) 2011-10-21 2019-11-28 Endo Global Ventures Eljárás EFP kezelésére vagy csökkentésére
NZ750379A (en) 2012-01-12 2022-10-28 Auxilium Int Holdings Inc Clostridium histolyticum enzymes and methods for the use thereof
JP6049862B2 (ja) 2012-09-07 2016-12-21 株式会社 資生堂 フィブリン3及び/又はサルコグリカンγを指標としたセルライトの評価方法及びセルライト効果薬剤の評価方法
US20160000890A1 (en) 2013-03-15 2016-01-07 Biospecifics Technologies Corp. Thermosensitive hydrogel collagenase formulations
CA2907255C (en) 2013-03-15 2021-09-21 Biospecifics Technologies Corporation Treatment method and product for uterine fibroids using purified collagenase
KR102267689B1 (ko) 2013-03-15 2021-06-22 마리 케이 인코포레이티드 화장품 조성물들 및 이의 용도
CN103751102A (zh) 2014-01-15 2014-04-30 上海交通大学 一种胶原酶温敏水凝胶及其制备方法和应用
BR112016030341A8 (pt) 2014-06-27 2021-07-20 Medytox Inc formulação para a remoção não cirúrgica de um depósito de gordura localizada em um indivíduo, método para a remoção não cirúrgica de depósitos de gordura localizada em um indivíduo que tem acúmulo de gordura localizada, e kit
US11355247B2 (en) 2016-02-08 2022-06-07 OutcomeMD, Inc. Systems and methods for determining a wellness score, an improvement score, and/or an effectiveness score with regard to a medical condition and/or treatment
US11344573B2 (en) 2016-10-28 2022-05-31 Merz Pharma Gmbh & Co. Kgaa Treatment of gynoid lipodystrophy
EP3589204A1 (en) 2017-03-01 2020-01-08 Endo Ventures Limited Apparatus and method for assessing and treating cellulite
CA3057982A1 (en) 2017-03-28 2018-10-04 Endo Ventures Limited Improved method of producing collagenase

Also Published As

Publication number Publication date
BR112014017229A2 (pt) 2017-06-13
JP2022023041A (ja) 2022-02-07
CA2970639A1 (en) 2013-07-18
CA2861033C (en) 2017-07-25
AU2013208028B2 (en) 2016-04-28
EP2802652A2 (en) 2014-11-19
BR112014017229A8 (pt) 2017-07-04
JP6752309B2 (ja) 2020-09-09
EP2802652B1 (en) 2019-06-05
WO2013106510A3 (en) 2013-10-03
PT3584317T (pt) 2022-01-26
US20150010532A1 (en) 2015-01-08
JP6947888B2 (ja) 2021-10-13
US11975054B2 (en) 2024-05-07
NZ750379A (en) 2022-10-28
US20180055918A1 (en) 2018-03-01
AU2016208378A1 (en) 2016-08-18
DK2802652T3 (da) 2019-07-15
AU2019200192B2 (en) 2021-07-01
NZ718173A (en) 2017-09-29
AU2016208384B2 (en) 2018-09-13
AU2021221653B2 (en) 2023-10-05
JP2015506176A (ja) 2015-03-02
EP4276180A3 (en) 2024-01-10
US20230416717A1 (en) 2023-12-28
NZ733709A (en) 2022-10-28
EP2802652A4 (en) 2015-10-14
ES2904884T3 (es) 2022-04-06
CA2861033A1 (en) 2013-07-18
ES2968836T3 (es) 2024-05-14
DK3584317T5 (da) 2022-01-17
MX2014008441A (es) 2015-03-13
DK3584317T3 (en) 2022-01-03
EP4276180A2 (en) 2023-11-15
EP3584317B1 (en) 2021-11-24
AU2016208384A1 (en) 2016-08-11
ES2740499T3 (es) 2020-02-05
EP4015627B1 (en) 2023-09-27
US11879141B2 (en) 2024-01-23
AU2016208384C1 (en) 2023-10-05
AU2019200192A1 (en) 2019-04-04
EP3584317A1 (en) 2019-12-25
JP6263755B2 (ja) 2018-01-24
AU2013208028A1 (en) 2014-08-07
US20200206326A1 (en) 2020-07-02
BR112014017229B1 (pt) 2022-05-17
JP2018075011A (ja) 2018-05-17
JP2020188810A (ja) 2020-11-26
WO2013106510A2 (en) 2013-07-18
JP2019103505A (ja) 2019-06-27
US10603365B2 (en) 2020-03-31
NZ627372A (en) 2016-04-29
NZ766918A (en) 2023-03-31
US9757435B2 (en) 2017-09-12
AU2023229488A1 (en) 2023-09-28
CA2970639C (en) 2022-04-26
AU2016208378B2 (en) 2018-10-11
JP6496386B2 (ja) 2019-04-03
HUE046160T2 (hu) 2020-02-28
EP4015627A1 (en) 2022-06-22
MX351448B (es) 2017-10-16
HUE057423T2 (hu) 2022-05-28
AU2021221653A1 (en) 2021-09-23
JP7354197B2 (ja) 2023-10-02

Similar Documents

Publication Publication Date Title
HUE046160T2 (hu) Clostridium histolyticum enzim
ZA201600633B (en) Variant enzymes
HK1207881A1 (en) Improved enzyme variants
EP2866024A4 (en) ENZYMATIC ELECTRODE
EP2751265A4 (en) NEW CELLOBIOHYDROLASES
ZA201500911B (en) Enzymes
GB201219602D0 (en) Recombinant clostridium botulinum neurotoxins
EP2880050A4 (en) NOVEL ENZYMES, ENZYME COMPONENTS AND USES THEREOF
EP2866025C0 (en) ENZYMATIC ELECTRODE
HK1198445A1 (en) On-column enzymatic cleavage
HK1216999A1 (zh) 針對艱難梭菌的抗體
GB201214938D0 (en) Alternative oxidase
IL237172A0 (en) פוליפפטידים של clostridium difficile כתרכיבים
GB201207018D0 (en) Enzymes
EP2995681A4 (en) NOVEL DNA COLUMN ENZYME
ZA201400850B (en) Enzyme system
HK1211323A1 (en) Dual enzymatic amplification
GB201211978D0 (en) Enzyme
EP2818559A4 (en) ENZYME TEST PROCEDURE
GB201223308D0 (en) Enzyme inhibitors
EP2970932A4 (en) ENZYMES WITH PULLULANASE ACTIVITY
GB201207952D0 (en) Restriction enzymes
GB201215883D0 (en) Enzyme inhibition
GB201215856D0 (en) Enzyme inhibition
GB201318464D0 (en) Modified enzymes