PT2011799E - Processo de obtenção de monossialogangliosídeo gm1 puro para utilização médica - Google Patents

Processo de obtenção de monossialogangliosídeo gm1 puro para utilização médica Download PDF

Info

Publication number
PT2011799E
PT2011799E PT80105588T PT08010558T PT2011799E PT 2011799 E PT2011799 E PT 2011799E PT 80105588 T PT80105588 T PT 80105588T PT 08010558 T PT08010558 T PT 08010558T PT 2011799 E PT2011799 E PT 2011799E
Authority
PT
Portugal
Prior art keywords
medical use
obtaining pure
monosialoganglioside
pure monosialoganglioside
obtaining
Prior art date
Application number
PT80105588T
Other languages
English (en)
Inventor
Stefano Carlino
René-Pierre Bunter
Original Assignee
Medidom Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medidom Lab filed Critical Medidom Lab
Publication of PT2011799E publication Critical patent/PT2011799E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G3/00—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
PT80105588T 2007-06-18 2008-06-06 Processo de obtenção de monossialogangliosídeo gm1 puro para utilização médica PT2011799E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/812,331 US7943750B2 (en) 2007-06-18 2007-06-18 Process for obtaining pure monosialoganglioside GM1 for medical use

Publications (1)

Publication Number Publication Date
PT2011799E true PT2011799E (pt) 2015-08-27

Family

ID=39670910

Family Applications (2)

Application Number Title Priority Date Filing Date
PT111683710T PT2377872T (pt) 2007-06-18 2008-06-06 Monossialogangliosídeo gm1 puro para utilização médica
PT80105588T PT2011799E (pt) 2007-06-18 2008-06-06 Processo de obtenção de monossialogangliosídeo gm1 puro para utilização médica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT111683710T PT2377872T (pt) 2007-06-18 2008-06-06 Monossialogangliosídeo gm1 puro para utilização médica

Country Status (13)

Country Link
US (4) US7943750B2 (pt)
EP (2) EP2011799B1 (pt)
KR (2) KR101503882B1 (pt)
CN (2) CN103951715A (pt)
CH (1) CH704106B1 (pt)
DK (2) DK2377872T3 (pt)
ES (2) ES2844301T3 (pt)
HK (1) HK1123559A1 (pt)
MY (1) MY157713A (pt)
PL (2) PL2011799T3 (pt)
PT (2) PT2377872T (pt)
RU (1) RU2483736C2 (pt)
TW (2) TWI530291B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2567661C2 (ru) 2009-09-01 2015-11-10 Лз Терапьютикс, Инк. Способы выделения и очистки ганглиозидов
KR102039204B1 (ko) 2012-01-20 2019-10-31 가넷 바이오쎄라퓨틱스 인크. 강글리오시드 생산의 방법
CN103191196B (zh) * 2013-04-03 2015-04-01 中国科学院过程工程研究所 肉苁蓉功能成分的集成化超声循环提取及分离工艺
CN104195200A (zh) * 2014-09-01 2014-12-10 华东理工大学 一种运用重组唾液酸酶转化多唾液酸神经节苷脂制备单唾液四己糖神经节苷脂的方法
WO2017046172A1 (en) 2015-09-16 2017-03-23 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
RU2632710C2 (ru) * 2016-03-31 2017-10-09 Лонг Шенг Фарма Лимитед Способ получения натрий моносиалового ганглиозида и нейропротекторное средство на его основе
RU2632709C1 (ru) * 2016-07-27 2017-10-09 Лонг Шенг Фарма Лимитед Нейропротекторный агент из свиного мозга на основе натрий моносиалового ганглиозида
CN106905387A (zh) * 2017-03-20 2017-06-30 泸州瑞兴生物工程有限公司 一种单唾液酸四己糖神经节苷脂钠的制备方法
CN106986902A (zh) * 2017-03-20 2017-07-28 泸州瑞兴生物工程有限公司 提高单唾液酸四己糖神经节苷脂钠成品纯度的精制方法
CN107688093B (zh) * 2017-08-25 2020-04-07 李红俊 肺癌检测试纸条、试剂盒及其使用方法
CN109721632B (zh) * 2017-10-27 2023-10-31 齐鲁制药有限公司 一种高纯度神经节苷脂gm1及其制备方法
CN110075817A (zh) * 2019-03-15 2019-08-02 无锡加莱克色谱科技有限公司 一种用于分离总神经节苷脂的疏水色谱填料及其制备方法
CN112961202A (zh) * 2021-03-15 2021-06-15 武汉糖智药业有限公司 一种单唾液酸四己糖神经节苷脂的制备及纯化方法
KR102586733B1 (ko) * 2021-03-30 2023-10-16 경성대학교 산학협력단 강글리오사이드 GM3, GM4, GD1b, GD1a 및 GM1을 포함하는 비경구용 제제의 제조 방법
CN113866310B (zh) * 2021-09-28 2023-01-17 吉林天成制药有限公司 含猪脑神经节苷脂成分药物制剂的指纹图谱检测方法及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5877894A (ja) 1981-11-05 1983-05-11 Mitsui Toatsu Chem Inc 蛋白質の除去方法
ES8506323A1 (es) 1984-01-04 1985-07-01 Bioiberica Procedimiento para la obtencion de un complejo glicoesfingolipidico
IT1199116B (it) 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
JP2724588B2 (ja) 1988-05-02 1998-03-09 丸金醤油株式会社 ノイラミニダーゼ・アイソザイムｓ及びガングリオシド類の製造法
JP2726898B2 (ja) 1988-05-02 1998-03-11 丸金醤油株式会社 ノイラミニダーゼ・アイソザイムｌ及びガングリオシド類の製造法
IN170630B (pt) 1988-11-04 1992-04-25 Council Scient Ind Res
AU5160590A (en) * 1989-02-16 1990-09-05 Angio-Medical Corporation Composition and method for treatment of gastric and duodenal ulcers and mucosal erosions
IT1243340B (it) * 1990-07-13 1994-06-10 Crinos Industria Farmaco Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio
IT1241332B (it) 1990-12-04 1994-01-10 Firestone Int Dev Spa Metodo per la realizzazione di un componente armato di una carcassa di pneumatico di veicolo
DE69132362T2 (de) 1991-05-16 2001-04-05 Fidia Spa Verfahren zur herstellung und reinigung von einer glykosphingolipidmischung frei von verunreinigungen durch ungewöhnliche viren
DE69122105T2 (de) * 1991-11-05 1997-02-06 Technochemical Corp S A Verfahren zur Erlangen von Monosialogangliosiden
IT1254706B (it) * 1991-12-23 1995-10-09 Fidia Spa Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale
IT1254280B (it) * 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
US5532141A (en) * 1995-06-13 1996-07-02 Holler; Larry D. Process for obtaining ganglioside lipids
JP3703199B2 (ja) * 1996-03-01 2005-10-05 タカラバイオ株式会社 モノシアロガングリオシドｇｍ１の製造方法
JP3929085B2 (ja) 1996-04-26 2007-06-13 雪印乳業株式会社 ガングリオシド高含有組成物の製造法
CN1193035C (zh) 1996-07-19 2005-03-16 宝生物工程公司 生产鞘脂类和鞘脂类衍生物的方法
RU2195296C2 (ru) * 2000-04-12 2002-12-27 Ставропольский научно-исследовательский противочумный институт Способ получения ганглиозидов
CN1189488C (zh) 2000-11-03 2005-02-16 中国石油天然气股份有限公司 高反应活性聚异丁烯的制备方法
CN1353112A (zh) * 2000-11-09 2002-06-12 重庆富进生物医药有限公司 单唾液酸四己糖神经节苷脂的高纯度制备工艺
CN1182253C (zh) 2001-10-30 2004-12-29 齐鲁制药厂 单唾液酸四己糖神经节苷脂gm1的制备方法
CN1158295C (zh) 2002-04-16 2004-07-21 广州市力拓发展有限公司 一种制备单唾液酸四己糖神经节苷脂制剂的方法
CN1814610A (zh) 2005-02-02 2006-08-09 商宗一 大批量高纯度神经节苷脂化合物的制备方法

Also Published As

Publication number Publication date
DK2377872T3 (da) 2021-01-18
RU2483736C2 (ru) 2013-06-10
PL2011799T3 (pl) 2015-09-30
EP2011799A1 (en) 2009-01-07
PT2377872T (pt) 2021-01-14
TW201350123A (zh) 2013-12-16
EP2377872A1 (en) 2011-10-19
US20160375046A1 (en) 2016-12-29
CN103951715A (zh) 2014-07-30
EP2011799B1 (en) 2015-04-22
US20140107045A1 (en) 2014-04-17
CN101328196A (zh) 2008-12-24
US7943750B2 (en) 2011-05-17
MY157713A (en) 2016-07-15
KR20080111398A (ko) 2008-12-23
TWI530291B (zh) 2016-04-21
KR101503882B1 (ko) 2015-03-18
DK2011799T3 (en) 2015-07-06
ES2844301T3 (es) 2021-07-21
TW200906420A (en) 2009-02-16
TWI415615B (zh) 2013-11-21
EP2377872B1 (en) 2020-10-21
US20110178035A1 (en) 2011-07-21
KR20140130404A (ko) 2014-11-10
ES2542347T3 (es) 2015-08-04
RU2008124890A (ru) 2009-12-27
US20080312165A1 (en) 2008-12-18
CH704106B1 (fr) 2012-05-31
US9498490B2 (en) 2016-11-22
CN101328196B (zh) 2014-05-14
PL2377872T3 (pl) 2021-04-06
HK1123559A1 (en) 2009-06-19

Similar Documents

Publication Publication Date Title
PL2011799T3 (pl) Sposób otrzymywania czystego monosialogangliozydu GM1 do zastosowania leczniczego
HK1223262A1 (zh) 醫療器械
HK1168749A1 (en) Medical apparatus
EP2189100A4 (en) MEDICAL DEVICE
GB0719608D0 (en) Medical Apparatus
GB2455238B (en) Patient monitor
EP2026738A4 (en) PATIENT AUSCULTATION SYSTEM
EP2005806A4 (en) SETTING PATIENTS BY TOMOSYNTHESIS TECHNIQUES
GB0511847D0 (en) Medical apparatus
EP2078536A4 (en) MEDICAL DEVICE
EP2194374A4 (en) EXAMINING APPARATUS
EP2196137A4 (en) MEDICAL DIAGNOSTIC SUPPORT SYSTEM
EP2119444A4 (en) THERAPEUTIC AGENT FOR PAIN
GB0512413D0 (en) Patient monitor
HK1143728A1 (en) Medical instrument
EP2187198A4 (en) BLOOD EXAMINATION APPARATUS
EP2178440A4 (en) ANALYSIS BY OPTICAL COHERENCE TOMOGRAPHY
PL2001670T3 (pl) Rurka do celów medycznych
GB0725263D0 (en) Instrument for removing tissue
EP2186466A4 (en) MEDICAL INSTRUMENT SYSTEM
ZA201005306B (en) 5-o-substituted 3-n-phenyl-1,3,4-oxadiazolones for medical use
AP3142A (en) Process for preparing human G-CSF
GB0701456D0 (en) Treatment for respiratory disease
GB2447884B (en) Treatment for skin disease
EP2210878A4 (en) THERAPEUTIC AGENT AGAINST TRPV1-MEDIATED DISEASES