IT1243340B - Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio - Google Patents

Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio

Info

Publication number
IT1243340B
IT1243340B IT02094290A IT2094290A IT1243340B IT 1243340 B IT1243340 B IT 1243340B IT 02094290 A IT02094290 A IT 02094290A IT 2094290 A IT2094290 A IT 2094290A IT 1243340 B IT1243340 B IT 1243340B
Authority
IT
Italy
Prior art keywords
purifying
isolating
mixture containing
intermediate compound
lipid mixture
Prior art date
Application number
IT02094290A
Other languages
English (en)
Other versions
IT9020942A0 (it
IT9020942A1 (it
Inventor
Benito Casu
Ennio Lanzarotti
Giangiacomo Torri
Annamaria Naggi
Armando Cedro
Original Assignee
Crinos Industria Farmaco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco
Publication of IT9020942A0 publication Critical patent/IT9020942A0/it
Priority to IT02094290A priority Critical patent/IT1243340B/it
Priority to DE91111469T priority patent/DE69100588T2/de
Priority to AT91111469T priority patent/ATE96804T1/de
Priority to PT98270A priority patent/PT98270A/pt
Priority to DK91111469.2T priority patent/DK0469352T3/da
Priority to ES91111469T priority patent/ES2060257T3/es
Priority to EP91111469A priority patent/EP0469352B1/en
Priority to JP3174194A priority patent/JPH04230398A/ja
Priority to US07/729,728 priority patent/US5108613A/en
Publication of IT9020942A1 publication Critical patent/IT9020942A1/it
Priority to US07/834,454 priority patent/US5152998A/en
Application granted granted Critical
Publication of IT1243340B publication Critical patent/IT1243340B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
IT02094290A 1990-07-13 1990-07-13 Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio IT1243340B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT02094290A IT1243340B (it) 1990-07-13 1990-07-13 Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio
DK91111469.2T DK0469352T3 (da) 1990-07-13 1991-07-10 Fremgangsmåde til isolering og oprensning af monosialgangliosid fra en udgangslipidblanding ved kompleksering med alfa-cyclodextrin og beslægtet mellemforbindelse
AT91111469T ATE96804T1 (de) 1990-07-13 1991-07-10 Verfahren zur abtrennung und reinigung von monosialogangliosid durch komplexierung mit alpha-cyclodextrin und zwischenprodukte.
PT98270A PT98270A (pt) 1990-07-13 1991-07-10 Metodo para o isolamento e purificacao de monosialogangliosido a partir de uma mistura lipidica de partida por complexacao com alfa-ciclodextrina e processo para a preparacao de um composto intermediario relacionado
DE91111469T DE69100588T2 (de) 1990-07-13 1991-07-10 Verfahren zur Abtrennung und Reinigung von Monosialogangliosid durch Komplexierung mit Alpha-Cyclodextrin und Zwischenprodukte.
ES91111469T ES2060257T3 (es) 1990-07-13 1991-07-10 Procedimiento de aislamiento y purificacion de monosialogangliosido a partir de una mezcla lipidica de partida mediante complejificacion con alfa-ciclodextrina y compuesto intermedio relacionado.
EP91111469A EP0469352B1 (en) 1990-07-13 1991-07-10 Process for the isolation and purification of monosialoganglioside from a starting lipidic mixture by complexation with alpha-cyclodextrin and related intermediate compound
JP3174194A JPH04230398A (ja) 1990-07-13 1991-07-15 α−サイクロデキストリンとの複合化による出発原料の脂質混合物からのモノシアロガングリオシドの単離精製方法および関連の中間体化合物
US07/729,728 US5108613A (en) 1990-07-13 1991-07-15 Process for the isolation and purification of monosialoganglioside from a starting lipidic mixture by complexation with alfa-cyclodextrin and related intermediate compound
US07/834,454 US5152998A (en) 1990-07-13 1992-02-12 Process for the isolation and purification of monosialoganglioside from a starting lipidic mixture by complexation with alpha-cyclodextrin and related intermediate compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02094290A IT1243340B (it) 1990-07-13 1990-07-13 Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio

Publications (3)

Publication Number Publication Date
IT9020942A0 IT9020942A0 (it) 1990-07-13
IT9020942A1 IT9020942A1 (it) 1992-01-13
IT1243340B true IT1243340B (it) 1994-06-10

Family

ID=11174397

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02094290A IT1243340B (it) 1990-07-13 1990-07-13 Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio

Country Status (9)

Country Link
US (1) US5108613A (it)
EP (1) EP0469352B1 (it)
JP (1) JPH04230398A (it)
AT (1) ATE96804T1 (it)
DE (1) DE69100588T2 (it)
DK (1) DK0469352T3 (it)
ES (1) ES2060257T3 (it)
IT (1) IT1243340B (it)
PT (1) PT98270A (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1747785A1 (en) * 2005-07-28 2007-01-31 Istituto Clinico Humanitas Cyclodextrins for blood detoxification
US7943750B2 (en) * 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
CN103087120B (zh) * 2013-02-26 2015-12-02 北京四环制药有限公司 单唾液酸四己糖神经节苷脂的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS615024A (ja) * 1984-06-18 1986-01-10 Takeda Chem Ind Ltd 生薬製剤の製造法
US4868291A (en) * 1987-08-20 1989-09-19 Bristol-Myers Company 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
IT1223408B (it) * 1987-12-09 1990-09-19 Crinos Industria Farmaco Procedimento per la preparazione di monosialoganglioside
CH677494A5 (it) * 1988-10-28 1991-05-31 Nestle Sa

Also Published As

Publication number Publication date
EP0469352A1 (en) 1992-02-05
DE69100588D1 (de) 1993-12-09
EP0469352B1 (en) 1993-11-03
PT98270A (pt) 1992-05-29
ES2060257T3 (es) 1994-11-16
DK0469352T3 (da) 1994-01-03
JPH04230398A (ja) 1992-08-19
US5108613A (en) 1992-04-28
ATE96804T1 (de) 1993-11-15
IT9020942A0 (it) 1990-07-13
DE69100588T2 (de) 1994-03-31
IT9020942A1 (it) 1992-01-13

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940727