ES2060257T3 - Procedimiento de aislamiento y purificacion de monosialogangliosido a partir de una mezcla lipidica de partida mediante complejificacion con alfa-ciclodextrina y compuesto intermedio relacionado. - Google Patents

Procedimiento de aislamiento y purificacion de monosialogangliosido a partir de una mezcla lipidica de partida mediante complejificacion con alfa-ciclodextrina y compuesto intermedio relacionado.

Info

Publication number
ES2060257T3
ES2060257T3 ES91111469T ES91111469T ES2060257T3 ES 2060257 T3 ES2060257 T3 ES 2060257T3 ES 91111469 T ES91111469 T ES 91111469T ES 91111469 T ES91111469 T ES 91111469T ES 2060257 T3 ES2060257 T3 ES 2060257T3
Authority
ES
Spain
Prior art keywords
cyclodextrin
monosialoganglioside
alpha
complexification
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91111469T
Other languages
English (en)
Inventor
Benito Casu
Ennio Lanzarotti
Giangiacomo Torri
Annamaria Naggi
Armando Cedro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Crinos Industria Farmacobiologica SpA
Original Assignee
Crinos Industria Farmacobiologica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmacobiologica SpA filed Critical Crinos Industria Farmacobiologica SpA
Application granted granted Critical
Publication of ES2060257T3 publication Critical patent/ES2060257T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

MEDIANTE LA ULTRAFILTRACION DE UNA SOLUCION ACUOSA EN LA QUE SE HA DISUELTO ANTERIORMENTE ALFA-CICLODEXTRINA Y UNA MEZCLA LIPIDICA PURA, ESTA ULTIMA CARACTERIZADA PORQUE CONTIENE MONOSIALOGANGLIOSIDA (GM1) BIEN COMO LA GANGLIOSIDA BASE O DE OTRA FORMA EN UNA CANTIDAD DOMINANTE SOBRE LAS OTRAS GANGLIOSIDAS ASOCIADAS, Y DESPUES DE LA ELIMINACION DE CICLODEXTRINA AL FINAL DEL PROCESO, SE OBTIENE GM1 CON UN TITULO DEL 95% COMO MINIMO. LA PRESENTE INVENCION SE REFIERE TAMBIEN AL COMPLEJO INTERMEDIO QUE SE FORMA ENTRE LA MONOSIALOGANGLIOSIDA Y LA ALFA-CICLODEXTRINA MENCIONADAS ANTERIORMENTE.
ES91111469T 1990-07-13 1991-07-10 Procedimiento de aislamiento y purificacion de monosialogangliosido a partir de una mezcla lipidica de partida mediante complejificacion con alfa-ciclodextrina y compuesto intermedio relacionado. Expired - Lifetime ES2060257T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02094290A IT1243340B (it) 1990-07-13 1990-07-13 Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio

Publications (1)

Publication Number Publication Date
ES2060257T3 true ES2060257T3 (es) 1994-11-16

Family

ID=11174397

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91111469T Expired - Lifetime ES2060257T3 (es) 1990-07-13 1991-07-10 Procedimiento de aislamiento y purificacion de monosialogangliosido a partir de una mezcla lipidica de partida mediante complejificacion con alfa-ciclodextrina y compuesto intermedio relacionado.

Country Status (9)

Country Link
US (1) US5108613A (es)
EP (1) EP0469352B1 (es)
JP (1) JPH04230398A (es)
AT (1) ATE96804T1 (es)
DE (1) DE69100588T2 (es)
DK (1) DK0469352T3 (es)
ES (1) ES2060257T3 (es)
IT (1) IT1243340B (es)
PT (1) PT98270A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1747785A1 (en) * 2005-07-28 2007-01-31 Istituto Clinico Humanitas Cyclodextrins for blood detoxification
US7943750B2 (en) * 2007-06-18 2011-05-17 Laboratoire Medidom S.A. Process for obtaining pure monosialoganglioside GM1 for medical use
CN103087120B (zh) * 2013-02-26 2015-12-02 北京四环制药有限公司 单唾液酸四己糖神经节苷脂的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS615024A (ja) * 1984-06-18 1986-01-10 Takeda Chem Ind Ltd 生薬製剤の製造法
US4868291A (en) * 1987-08-20 1989-09-19 Bristol-Myers Company 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
IT1223408B (it) * 1987-12-09 1990-09-19 Crinos Industria Farmaco Procedimento per la preparazione di monosialoganglioside
CH677494A5 (es) * 1988-10-28 1991-05-31 Nestle Sa

Also Published As

Publication number Publication date
IT1243340B (it) 1994-06-10
US5108613A (en) 1992-04-28
EP0469352B1 (en) 1993-11-03
EP0469352A1 (en) 1992-02-05
IT9020942A1 (it) 1992-01-13
PT98270A (pt) 1992-05-29
JPH04230398A (ja) 1992-08-19
DE69100588D1 (de) 1993-12-09
DE69100588T2 (de) 1994-03-31
IT9020942A0 (it) 1990-07-13
DK0469352T3 (da) 1994-01-03
ATE96804T1 (de) 1993-11-15

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