ES2166442T3 - Procedimiento para la preparacion de 1,1'-(1,4-fenilenobis-(metileno))-bis-1,4,8,11-tetraazaciclotetradecano. - Google Patents

Procedimiento para la preparacion de 1,1'-(1,4-fenilenobis-(metileno))-bis-1,4,8,11-tetraazaciclotetradecano.

Info

Publication number
ES2166442T3
ES2166442T3 ES96912177T ES96912177T ES2166442T3 ES 2166442 T3 ES2166442 T3 ES 2166442T3 ES 96912177 T ES96912177 T ES 96912177T ES 96912177 T ES96912177 T ES 96912177T ES 2166442 T3 ES2166442 T3 ES 2166442T3
Authority
ES
Spain
Prior art keywords
methylene
dimmy
stage
tetraazaciclotetradecano
phenylenobis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96912177T
Other languages
English (en)
Inventor
Mahavir Prashad
Prasad Koteswara Kapa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anormed Inc
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Application granted granted Critical
Publication of ES2166442T3 publication Critical patent/ES2166442T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyamides (AREA)
  • Cephalosporin Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

UN PROCESO MEJORADO PARA PREPARAR 1,1 (METILEN)] LICA LA FUNCIONALIZACION SELECTIVA DE UNA TETRAAMINA ACICLICA PARA OBTENER UN INTERMEDIO DITOSILO ACICLICO Y UN INTERMEDIO TRITOSILO ACICLICO EN UNA PRIMERA ETAPA, LA DIMERIZACION/TOSILACION INDEPENDIENTE DEL INTERMEDIO DITOSILO Y DIMERIZACION DEL INTERMEDIO TRITOSILO PARA OBTENER UN PRECURSOR ACICLICO HEXATOSILO UNIDO A 1,4 CICLACION DE DICHO PRECURSOR QUE PRODUCE UN DIMERO HEXATOSIL CICLAM EN UNA TERCERA ETAPA, Y LA DETOSILACION DEL DIMERO DE CICLAM EN UNA CUARTA ETAPA, SEGUIDA DE BASIFICACION 10, OBTENIENDOSE EL 1,1 TETRAAZACICLOTETRADECANO DESEADO.
ES96912177T 1995-05-02 1996-04-23 Procedimiento para la preparacion de 1,1'-(1,4-fenilenobis-(metileno))-bis-1,4,8,11-tetraazaciclotetradecano. Expired - Lifetime ES2166442T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/434,142 US5606053A (en) 1995-05-02 1995-05-02 Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane

Publications (1)

Publication Number Publication Date
ES2166442T3 true ES2166442T3 (es) 2002-04-16

Family

ID=23722985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96912177T Expired - Lifetime ES2166442T3 (es) 1995-05-02 1996-04-23 Procedimiento para la preparacion de 1,1'-(1,4-fenilenobis-(metileno))-bis-1,4,8,11-tetraazaciclotetradecano.

Country Status (19)

Country Link
US (1) US5606053A (es)
EP (1) EP0823902B1 (es)
JP (1) JPH11504917A (es)
KR (1) KR19990008233A (es)
AT (1) ATE207469T1 (es)
AU (1) AU5511396A (es)
CA (1) CA2219932A1 (es)
DE (1) DE69616305T2 (es)
DK (1) DK0823902T3 (es)
ES (1) ES2166442T3 (es)
HK (1) HK1009128A1 (es)
HU (1) HUP9900745A3 (es)
IL (1) IL118111A (es)
NO (1) NO309567B1 (es)
NZ (1) NZ306534A (es)
PT (1) PT823902E (es)
TW (1) TW328076B (es)
WO (1) WO1996034860A1 (es)
ZA (1) ZA963233B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714604A (en) * 1993-05-06 1998-02-03 The Dow Chemical Company Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives
US6365583B1 (en) 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
CA2371625C (en) * 1999-04-30 2012-04-17 Slil Biomedical Corporation Polyamines and their use in therapy
US6482943B1 (en) * 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
JP2002543163A (ja) * 1999-04-30 2002-12-17 スリル バイオメディカル コーポレイション 癌および前立腺疾患のための治療としての結合体
US20030072715A1 (en) * 2000-08-02 2003-04-17 Benjamin Frydman Cyclic polyamine compounds for cancer therapy
DK2022787T3 (da) 2000-09-29 2013-02-25 Genzyme Corp Fremgangsmåde til fremstilling af nitrogenholdige cykliske polyaminer med N-1-beskyttet N-ring og produkter deraf
AU2001297817A1 (en) * 2000-11-08 2002-11-25 Eli Lilly And Company Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
LT2371361T (lt) * 2001-07-31 2019-09-10 Genzyme Corporation Pirmtakų/kamieninių ląstelių suaktyvinimo būdai
US7169750B2 (en) * 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
WO2003050072A1 (en) 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
ES2497092T3 (es) * 2006-02-24 2014-09-22 Genzyme Corporation Procedimientos para el aumento del flujo sanguíneo y/o la estimulación de la regeneración de tejidos
KR20210094672A (ko) 2011-05-16 2021-07-29 젠자임 코포레이션 Ｃｘｃｒ４ 길항제의 용도
CN103159690B (zh) * 2011-12-14 2015-03-25 朱靖华 对称大环胺化合物的结晶形式
CN104211652B (zh) * 2014-08-27 2016-09-07 吉林大学 一种制备普乐沙福的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3580949A (en) * 1965-03-19 1971-05-25 Hoffmann La Roche N,n'-bis-(aminoalkyl)-benzyl-amines
BR8907277A (pt) * 1988-12-22 1991-03-26 Dow Chemical Co Processo para preparar poliazamacrociclos mono-n-alquilados
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
US5021409A (en) * 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
GB9105489D0 (en) * 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
GB9126677D0 (en) * 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
US5326861A (en) * 1992-10-21 1994-07-05 Lever Brothers Company, Division Of Conopco, Inc. Preparation of organic macrocyclic compounds

Also Published As

Publication number Publication date
NO309567B1 (no) 2001-02-19
IL118111A (en) 2000-06-29
NO975039D0 (no) 1997-10-31
HUP9900745A3 (en) 2000-03-28
JPH11504917A (ja) 1999-05-11
WO1996034860A1 (en) 1996-11-07
KR19990008233A (ko) 1999-01-25
DK0823902T3 (da) 2001-11-19
ZA963233B (en) 1996-07-30
NZ306534A (en) 1999-04-29
CA2219932A1 (en) 1996-11-07
DE69616305T2 (de) 2002-06-27
HK1009128A1 (en) 1999-08-13
ATE207469T1 (de) 2001-11-15
EP0823902B1 (en) 2001-10-24
PT823902E (pt) 2002-04-29
US5606053A (en) 1997-02-25
AU5511396A (en) 1996-11-21
EP0823902A1 (en) 1998-02-18
NO975039L (no) 1997-12-22
TW328076B (en) 1998-03-11
HUP9900745A2 (hu) 1999-06-28
IL118111A0 (en) 1996-09-12
DE69616305D1 (de) 2001-11-29

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