ES2163896T3 - Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos. - Google Patents
Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos.Info
- Publication number
- ES2163896T3 ES2163896T3 ES98955907T ES98955907T ES2163896T3 ES 2163896 T3 ES2163896 T3 ES 2163896T3 ES 98955907 T ES98955907 T ES 98955907T ES 98955907 T ES98955907 T ES 98955907T ES 2163896 T3 ES2163896 T3 ES 2163896T3
- Authority
- ES
- Spain
- Prior art keywords
- motility
- concentration
- spermatozes
- humans
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004899 motility Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una combinación de L-carnitina y acetil L-carnitina envasadas juntas mezcladas o separadas, capaz de aumentar la concentración o la motilidad de los espermatozoos en un humano, estando dicha combinación en una forma adecuada para la administración oral o parenteral.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/980,821 US5863940A (en) | 1997-12-01 | 1997-12-01 | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
US09/122,897 US6090848A (en) | 1997-12-01 | 1998-07-28 | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2163896T3 true ES2163896T3 (es) | 2002-02-01 |
Family
ID=26820998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98955907T Expired - Lifetime ES2163896T3 (es) | 1997-12-01 | 1998-11-18 | Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos. |
Country Status (23)
Country | Link |
---|---|
US (1) | US6090848A (es) |
EP (1) | EP1039894B1 (es) |
JP (1) | JP2001524520A (es) |
KR (1) | KR20010032702A (es) |
CN (1) | CN1184966C (es) |
AT (1) | ATE206916T1 (es) |
AU (1) | AU749754B2 (es) |
BR (1) | BR9814711A (es) |
CA (1) | CA2314942C (es) |
DE (1) | DE69802113T2 (es) |
DK (1) | DK1039894T3 (es) |
EE (1) | EE200000309A (es) |
ES (1) | ES2163896T3 (es) |
HK (1) | HK1033280A1 (es) |
HU (1) | HU228989B1 (es) |
IL (1) | IL136299A0 (es) |
IS (1) | IS5501A (es) |
NO (1) | NO20002798L (es) |
PL (1) | PL192438B1 (es) |
PT (1) | PT1039894E (es) |
SK (1) | SK7572000A3 (es) |
TR (1) | TR200001519T2 (es) |
WO (1) | WO1999027925A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003508488A (ja) * | 1999-09-03 | 2003-03-04 | シグマ−タウ・ヘルスサイエンス・ソシエタ・ペル・アチオニ | 超微細l−カルニチン、その調製方法、それを含む組成物、及びその使用方法 |
ITRM20010029A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per |
LV12978B (en) * | 2001-09-07 | 2003-05-20 | Ivars Kalvins | Pharmaceutical composition |
EA009279B1 (ru) * | 2001-09-12 | 2007-12-28 | Апплайд Резеч Системз Арс Холдинг Н.В. | Применение лютеинизирующего гормона человека, в том числе в сочетании с фолликулостимулирующим гормоном, для содействия имплантации и/или снижения частоты выкидышей |
AR036592A1 (es) * | 2001-09-12 | 2004-09-22 | Applied Research Systems | Uso de gch en la hiperestimulacion ovarica controlada |
ITRM20010621A1 (it) * | 2001-10-18 | 2003-04-18 | Aldo Fassi | Sali metallici non igroscopici e idrosolubili di alcanoil l-carnitine, integratori dietetici che li contengono e kit dietetici, per contrast |
ITRM20020194A1 (it) * | 2002-04-09 | 2003-10-09 | Sigma Tau Healthscience Spa | Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo. |
US7776913B2 (en) | 2002-12-13 | 2010-08-17 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Carnitines for treating or preventing disorders caused by andropause |
AT503219B1 (de) | 2006-02-03 | 2008-07-15 | Annerl Brigitte | Kombinationspräparat auf basis von antioxidanzien zur verbesserung der samenqualität |
AU2007311444B2 (en) * | 2006-10-18 | 2012-11-29 | Periness Ltd. | Method and pharmacological composition for the diagnosis and treatment of male sub-fertility |
DE102007053369A1 (de) | 2007-11-09 | 2009-07-02 | Alzchem Trostberg Gmbh | Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit |
WO2009068278A2 (en) * | 2007-11-30 | 2009-06-04 | Bayer Consumer Care Ag | A pharmaceutical composition |
US20110015154A1 (en) * | 2009-07-20 | 2011-01-20 | Kellermann Gottfried H | Supporting acetylcholine function |
US20110098265A1 (en) * | 2009-10-28 | 2011-04-28 | Neuroscience, Inc. | Methods for reducing cravings and impulses associated with addictive and compulsive behaviors |
CA2931109C (en) * | 2013-12-05 | 2021-08-24 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composition useful for promoting female fertility |
CN105695398A (zh) * | 2016-04-25 | 2016-06-22 | 广西大学 | 含o-乙酰基-l-肉碱盐酸盐的水牛卵母细胞体外成熟液及培养方法 |
ES2813573T3 (es) * | 2016-07-11 | 2021-03-24 | Laboratoire Des Granions | Composición que comprende L-carnitina para el tratamiento de la infertilidad masculina |
CN107375346A (zh) * | 2017-07-25 | 2017-11-24 | 昭远制药(上海)有限公司 | 提高人类精子浓度和运动性的组合物及其制备方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1235153B (it) * | 1988-11-15 | 1992-06-22 | Sigma Tau Ind Farmaceuti | Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento |
IT1224795B (it) * | 1988-12-01 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento |
IT1224842B (it) * | 1988-12-27 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso |
IT1240760B (it) * | 1990-02-12 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
IT1240799B (it) * | 1990-03-15 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare. |
IT1244636B (it) * | 1991-01-04 | 1994-08-08 | Sigma Tau Ind Farmaceuti | Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. |
IT1248323B (it) * | 1991-05-16 | 1995-01-05 | Sigma Tau Ind Farmaceuti | Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti |
IT1245699B (it) * | 1991-05-29 | 1994-10-14 | Sigma Tau Ind Farmaceuti | Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi |
IT1249462B (it) * | 1991-10-21 | 1995-02-23 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e acil l-carnitine nel trattamento delle oligoastenospermie idiopatiche. |
IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
IT1263013B (it) * | 1992-10-20 | 1996-07-23 | Avantgarde Spa | Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee. |
IT1261688B (it) * | 1993-05-28 | 1996-05-29 | Avantgarde Spa | Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
IT1261696B (it) * | 1993-06-02 | 1996-05-29 | Avantgarde Spa | Uso di esteri sull'ossidrile della l-carnitina con acidi aromatici perprodurre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
IT1261984B (it) * | 1993-06-22 | 1996-06-11 | Avantgarde Spa | Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee. |
IT1272290B (it) * | 1994-06-20 | 1997-06-16 | Avantgarde Spa | Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee |
IT1274156B (it) * | 1994-09-08 | 1997-07-15 | Avantgarde Spa | "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee" |
IT1274157B (it) * | 1994-09-08 | 1997-07-15 | Avantgarde Spa | "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee" |
IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
IT1277953B1 (it) * | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per |
US5889055A (en) * | 1997-04-04 | 1999-03-30 | Howard; James R. | L-carnitine and acetyl-L-carnitine combined for prevention and treatment of syndromes related to diseases of energy metabolism |
IT1295408B1 (it) * | 1997-10-03 | 1999-05-12 | Sigma Tau Ind Farmaceuti | Associazione di l-carnitina e alcanoil l-carnitine per il trattamento dell'alcoolismo |
-
1998
- 1998-07-28 US US09/122,897 patent/US6090848A/en not_active Expired - Lifetime
- 1998-11-18 PL PL342115A patent/PL192438B1/pl unknown
- 1998-11-18 AU AU12591/99A patent/AU749754B2/en not_active Expired
- 1998-11-18 PT PT98955907T patent/PT1039894E/pt unknown
- 1998-11-18 EE EEP200000309A patent/EE200000309A/xx unknown
- 1998-11-18 BR BR9814711-0A patent/BR9814711A/pt not_active IP Right Cessation
- 1998-11-18 KR KR1020007005989A patent/KR20010032702A/ko not_active Application Discontinuation
- 1998-11-18 IL IL13629998A patent/IL136299A0/xx unknown
- 1998-11-18 HU HU0004562A patent/HU228989B1/hu unknown
- 1998-11-18 SK SK757-2000A patent/SK7572000A3/sk unknown
- 1998-11-18 AT AT98955907T patent/ATE206916T1/de active
- 1998-11-18 DK DK98955907T patent/DK1039894T3/da active
- 1998-11-18 CA CA002314942A patent/CA2314942C/en not_active Expired - Lifetime
- 1998-11-18 TR TR2000/01519T patent/TR200001519T2/xx unknown
- 1998-11-18 WO PCT/IT1998/000324 patent/WO1999027925A1/en not_active Application Discontinuation
- 1998-11-18 EP EP98955907A patent/EP1039894B1/en not_active Expired - Lifetime
- 1998-11-18 DE DE69802113T patent/DE69802113T2/de not_active Expired - Lifetime
- 1998-11-18 JP JP2000522911A patent/JP2001524520A/ja active Pending
- 1998-11-18 ES ES98955907T patent/ES2163896T3/es not_active Expired - Lifetime
- 1998-11-18 CN CNB98813635XA patent/CN1184966C/zh not_active Expired - Lifetime
-
2000
- 2000-05-19 IS IS5501A patent/IS5501A/is unknown
- 2000-05-31 NO NO20002798A patent/NO20002798L/no not_active Application Discontinuation
-
2001
- 2001-06-14 HK HK01104092A patent/HK1033280A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE206916T1 (de) | 2001-11-15 |
JP2001524520A (ja) | 2001-12-04 |
HUP0004562A3 (en) | 2003-05-28 |
BR9814711A (pt) | 2000-10-03 |
IL136299A0 (en) | 2001-05-20 |
NO20002798L (no) | 2000-06-27 |
HU228989B1 (en) | 2013-07-29 |
IS5501A (is) | 2000-05-19 |
DE69802113T2 (de) | 2002-06-06 |
PL342115A1 (en) | 2001-05-21 |
TR200001519T2 (tr) | 2000-11-21 |
DE69802113D1 (de) | 2001-11-22 |
HK1033280A1 (en) | 2001-08-24 |
US6090848A (en) | 2000-07-18 |
EP1039894B1 (en) | 2001-10-17 |
EE200000309A (et) | 2001-08-15 |
CN1184966C (zh) | 2005-01-19 |
NO20002798D0 (no) | 2000-05-31 |
HUP0004562A2 (hu) | 2001-05-28 |
WO1999027925A1 (en) | 1999-06-10 |
EP1039894A1 (en) | 2000-10-04 |
DK1039894T3 (da) | 2002-02-11 |
KR20010032702A (ko) | 2001-04-25 |
CA2314942A1 (en) | 1999-06-10 |
AU749754B2 (en) | 2002-07-04 |
AU1259199A (en) | 1999-06-16 |
PL192438B1 (pl) | 2006-10-31 |
SK7572000A3 (en) | 2000-11-07 |
CA2314942C (en) | 2009-05-05 |
PT1039894E (pt) | 2002-04-29 |
CN1284871A (zh) | 2001-02-21 |
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Legal Events
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