ES2163896T3 - Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos. - Google Patents

Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos.

Info

Publication number
ES2163896T3
ES2163896T3 ES98955907T ES98955907T ES2163896T3 ES 2163896 T3 ES2163896 T3 ES 2163896T3 ES 98955907 T ES98955907 T ES 98955907T ES 98955907 T ES98955907 T ES 98955907T ES 2163896 T3 ES2163896 T3 ES 2163896T3
Authority
ES
Spain
Prior art keywords
motility
concentration
spermatozes
humans
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98955907T
Other languages
English (en)
Inventor
Claudio Cavazza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau HealthScience SpA
Original Assignee
Sigma Tau HealthScience SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/980,821 external-priority patent/US5863940A/en
Application filed by Sigma Tau HealthScience SpA filed Critical Sigma Tau HealthScience SpA
Application granted granted Critical
Publication of ES2163896T3 publication Critical patent/ES2163896T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una combinación de L-carnitina y acetil L-carnitina envasadas juntas mezcladas o separadas, capaz de aumentar la concentración o la motilidad de los espermatozoos en un humano, estando dicha combinación en una forma adecuada para la administración oral o parenteral.
ES98955907T 1997-12-01 1998-11-18 Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos. Expired - Lifetime ES2163896T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/980,821 US5863940A (en) 1997-12-01 1997-12-01 Medicament and therapeutical method for treating idiopathic asthenozoospermia
US09/122,897 US6090848A (en) 1997-12-01 1998-07-28 Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans

Publications (1)

Publication Number Publication Date
ES2163896T3 true ES2163896T3 (es) 2002-02-01

Family

ID=26820998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98955907T Expired - Lifetime ES2163896T3 (es) 1997-12-01 1998-11-18 Composiciones para aumentar la concentracion y/o motilidad de los espermatozoos en humanos.

Country Status (23)

Country Link
US (1) US6090848A (es)
EP (1) EP1039894B1 (es)
JP (1) JP2001524520A (es)
KR (1) KR20010032702A (es)
CN (1) CN1184966C (es)
AT (1) ATE206916T1 (es)
AU (1) AU749754B2 (es)
BR (1) BR9814711A (es)
CA (1) CA2314942C (es)
DE (1) DE69802113T2 (es)
DK (1) DK1039894T3 (es)
EE (1) EE200000309A (es)
ES (1) ES2163896T3 (es)
HK (1) HK1033280A1 (es)
HU (1) HU228989B1 (es)
IL (1) IL136299A0 (es)
IS (1) IS5501A (es)
NO (1) NO20002798L (es)
PL (1) PL192438B1 (es)
PT (1) PT1039894E (es)
SK (1) SK7572000A3 (es)
TR (1) TR200001519T2 (es)
WO (1) WO1999027925A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508488A (ja) * 1999-09-03 2003-03-04 シグマ−タウ・ヘルスサイエンス・ソシエタ・ペル・アチオニ 超微細ｌ−カルニチン、その調製方法、それを含む組成物、及びその使用方法
ITRM20010029A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
LV12978B (en) * 2001-09-07 2003-05-20 Ivars Kalvins Pharmaceutical composition
EA009279B1 (ru) * 2001-09-12 2007-12-28 Апплайд Резеч Системз Арс Холдинг Н.В. Применение лютеинизирующего гормона человека, в том числе в сочетании с фолликулостимулирующим гормоном, для содействия имплантации и/или снижения частоты выкидышей
AR036592A1 (es) * 2001-09-12 2004-09-22 Applied Research Systems Uso de gch en la hiperestimulacion ovarica controlada
ITRM20010621A1 (it) * 2001-10-18 2003-04-18 Aldo Fassi Sali metallici non igroscopici e idrosolubili di alcanoil l-carnitine, integratori dietetici che li contengono e kit dietetici, per contrast
ITRM20020194A1 (it) * 2002-04-09 2003-10-09 Sigma Tau Healthscience Spa Composizione utile per aumentare la concentrazione e la motilita' degli spermatozoi e migliorarne la morfologia nell'uomo.
US7776913B2 (en) 2002-12-13 2010-08-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Carnitines for treating or preventing disorders caused by andropause
AT503219B1 (de) 2006-02-03 2008-07-15 Annerl Brigitte Kombinationspräparat auf basis von antioxidanzien zur verbesserung der samenqualität
AU2007311444B2 (en) * 2006-10-18 2012-11-29 Periness Ltd. Method and pharmacological composition for the diagnosis and treatment of male sub-fertility
DE102007053369A1 (de) 2007-11-09 2009-07-02 Alzchem Trostberg Gmbh Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit
WO2009068278A2 (en) * 2007-11-30 2009-06-04 Bayer Consumer Care Ag A pharmaceutical composition
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CA2931109C (en) * 2013-12-05 2021-08-24 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Composition useful for promoting female fertility
CN105695398A (zh) * 2016-04-25 2016-06-22 广西大学 含o-乙酰基-l-肉碱盐酸盐的水牛卵母细胞体外成熟液及培养方法
ES2813573T3 (es) * 2016-07-11 2021-03-24 Laboratoire Des Granions Composición que comprende L-carnitina para el tratamiento de la infertilidad masculina
CN107375346A (zh) * 2017-07-25 2017-11-24 昭远制药(上海)有限公司 提高人类精子浓度和运动性的组合物及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1235153B (it) * 1988-11-15 1992-06-22 Sigma Tau Ind Farmaceuti Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento
IT1224795B (it) * 1988-12-01 1990-10-24 Sigma Tau Ind Farmaceuti Uso dell'acetil d-carnitina nel trattamento terapeutico del glaucoma e composizioni farmaceutiche utili in tale trattamento
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240799B (it) * 1990-03-15 1993-12-17 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare.
IT1244636B (it) * 1991-01-04 1994-08-08 Sigma Tau Ind Farmaceuti Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
IT1248323B (it) * 1991-05-16 1995-01-05 Sigma Tau Ind Farmaceuti Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1249462B (it) * 1991-10-21 1995-02-23 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e acil l-carnitine nel trattamento delle oligoastenospermie idiopatiche.
IT1263004B (it) * 1992-10-08 1996-07-23 Sigma Tau Ind Farmaceuti Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261688B (it) * 1993-05-28 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261696B (it) * 1993-06-02 1996-05-29 Avantgarde Spa Uso di esteri sull'ossidrile della l-carnitina con acidi aromatici perprodurre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1272290B (it) * 1994-06-20 1997-06-16 Avantgarde Spa Sale della l-carnitina e composizioni farmaceutiche che lo contengono per il trattamento di affezioni cutanee
IT1274156B (it) * 1994-09-08 1997-07-15 Avantgarde Spa "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee"
IT1274157B (it) * 1994-09-08 1997-07-15 Avantgarde Spa "sale della l-carnitina e composizioni farmaceutiche che lo contengonoper il trattamento di affezioni cutanee"
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
US5889055A (en) * 1997-04-04 1999-03-30 Howard; James R. L-carnitine and acetyl-L-carnitine combined for prevention and treatment of syndromes related to diseases of energy metabolism
IT1295408B1 (it) * 1997-10-03 1999-05-12 Sigma Tau Ind Farmaceuti Associazione di l-carnitina e alcanoil l-carnitine per il trattamento dell'alcoolismo

Also Published As

Publication number Publication date
ATE206916T1 (de) 2001-11-15
JP2001524520A (ja) 2001-12-04
HUP0004562A3 (en) 2003-05-28
BR9814711A (pt) 2000-10-03
IL136299A0 (en) 2001-05-20
NO20002798L (no) 2000-06-27
HU228989B1 (en) 2013-07-29
IS5501A (is) 2000-05-19
DE69802113T2 (de) 2002-06-06
PL342115A1 (en) 2001-05-21
TR200001519T2 (tr) 2000-11-21
DE69802113D1 (de) 2001-11-22
HK1033280A1 (en) 2001-08-24
US6090848A (en) 2000-07-18
EP1039894B1 (en) 2001-10-17
EE200000309A (et) 2001-08-15
CN1184966C (zh) 2005-01-19
NO20002798D0 (no) 2000-05-31
HUP0004562A2 (hu) 2001-05-28
WO1999027925A1 (en) 1999-06-10
EP1039894A1 (en) 2000-10-04
DK1039894T3 (da) 2002-02-11
KR20010032702A (ko) 2001-04-25
CA2314942A1 (en) 1999-06-10
AU749754B2 (en) 2002-07-04
AU1259199A (en) 1999-06-16
PL192438B1 (pl) 2006-10-31
SK7572000A3 (en) 2000-11-07
CA2314942C (en) 2009-05-05
PT1039894E (pt) 2002-04-29
CN1284871A (zh) 2001-02-21

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