CN107375346A - 提高人类精子浓度和运动性的组合物及其制备方法 - Google Patents
提高人类精子浓度和运动性的组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种提高人类精子浓度和运动性的组合物,采用左旋肉碱、乙酰左旋肉碱、氨基酸、牛磺酸、果糖、硒源、锌源、叶酸、维生素B12、维生素E、虾青素、N‑乙酰神经氨酸作为原料并适当配比,各种组分间协同作用,能有效调节男性生殖系统中的氧化与抗氧化动态平衡,促进精子生成,使精子免于聚积导致运动受阻,提高精子的成活率,增强精子的活动力,最终有效提高人类精子浓度和运动性;本发明所述药物能够适应复杂病情的治疗要求,无不良反应,疗效显著持久,安全可靠,服用方便,是治疗各种原因引起的精子前向运动能力差、精子浓度低、精子活率低下的有效药物。数据显示,本发明所述的提高人类精子浓度和运动性的组合物,治疗有效率高达96%。
Description
技术领域
本发明属于药物技术领域,具体涉及一种提高人类精子浓度和运动性的组合物及其制备方法。
背景技术
随着环境污染的日益加重,工作生活压力的不断增大,加之不良的生活习惯,近年来我国不育症的发病率呈不断上升的趋势,给患者本人和家属带来了沉重的精神和经济负担,成为影响家庭和睦的重要因素之一。不育不仅是家庭问题,也逐渐成为一个全球性的公共社会问题,成为许多国家生殖健康服务的重要内容之一。在不育病例中,男性不育约占到30-40%男性不育的原因很多,例如睾丸发育异常、精索静脉曲张、性功能障碍以及各种内科疾病并发的不育等,但是高达60-75%的患者找不到原因,他们一般表现为精子前向运动能力差、精子浓度低、精子活率低下等精子质量异常症状。
目前,对于男性不育症的治疗,西医的诸多疗法中往往只能针对单一病变组织施治,而无法达到全面治疗、全面调理之效;并且对于精子前向运动能力差、精子浓度低、精子活率低下,主要是采用各种激素治疗,虽有一定的疗效,但都存在不同程度的副作用;中医对本病的认识基本都是肾精不足,治疗有偏于温补益肾和滋阴补肾两大类;中成药也有很多,但长期服用后,治疗效果并不明显。
发明内容
为了解决现有技术存在的上述问题,本发明提供了一种配方科学、疗效显著、安全可靠能有效促进精子生成、提高精子成活率、增强精子活动力的提高人类精子浓度和运动性的组合物及其制备方法。
本发明所采用的技术方案为:
一种提高人类精子浓度和运动性的组合物,原料组分包括:左旋肉碱4-10重量份、乙酰左旋肉碱2-8重量份、氨基酸2-5重量份、牛磺酸0.1-0.2重量份、果糖5-15重量份、硒源0.01-0.1重量份、锌源0.01-0.1重量份、叶酸0.001-0.01重量份、维生素B12 0.1-1重量份、维生素E 0.1-1重量份、虾青素0.01-0.1重量份、N-乙酰神经氨酸0.001-0.01重量份。
进一步优选所述的提高人类精子浓度和运动性的组合物的原料组分包括:左旋肉碱6-8重量份、乙酰左旋肉碱4-6重量份、氨基酸3-4重量份、牛磺酸0.12-0.18重量份、果糖8-12重量份、硒源0.04-0.08重量份、锌源0.04-0.08重量份、叶酸0.004-0.008重量份、维生素B12 0.4-0.6重量份、维生素E 0.4-0.6重量份、虾青素0.04-0.06重量份、N-乙酰神经氨酸0.004-0.006重量份。
进一步优选所述的提高人类精子浓度和运动性的组合物的原料组分包括:左旋肉碱7重量份、乙酰左旋肉碱5重量份、氨基酸3.5重量份、牛磺酸0.15重量份、果糖10重量份、硒源0.05重量份、锌源0.05重量份、叶酸0.005重量份、维生素B12 0.5重量份、维生素E 0.5重量份、虾青素0.05重量份、N-乙酰神经氨酸0.005重量份。
所述氨基酸为L-精氨酸。
所述硒源为硒酵母。
所述锌源为甘氨酸锌。
所述果糖为低聚果糖。
所述原料组分还包括1-5重量份的调味剂。
所述调味剂为蜂蜜冻干粉、木糖醇、D-甘露糖醇、三氯蔗糖中的一种或几种的混合物。
一种制备所述的提高人类精子浓度和运动性的组合物的方法,包括如下步骤:
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
本发明的有益效果为:
本发明所述的提高人类精子浓度和运动性的组合物,采用左旋肉碱、乙酰左旋肉碱、氨基酸、牛磺酸、果糖、硒源、锌源、叶酸、维生素B12、维生素E、虾青素、N-乙酰神经氨酸作为原料并进行适合配比,利用各种组分相互间的协同作用,能有效调节男性生殖系统中的氧化与抗氧化动态平衡,促进精子生成,使精子免于聚积导致运动受阻,提高精子的成活率,增强精子的活动力,最终有效提高人类精子浓度和运动性;本发明所述药物能够适应复杂病情的治疗要求,无不良反应,疗效显著持久,安全可靠,服用方便,是治疗各种原因引起的精子前向运动能力差、精子浓度低、精子活率低下的有效药物。数据显示,本发明所述的提高人类精子浓度和运动性的组合物,治疗有效率高达97%。
具体实施方式
下面实施例中以1重量份代表1g。
实施例1
本实施例提供一种提高人类精子浓度和运动性的组合物,其原料组分包括:左旋肉碱4重量份、乙酰左旋肉碱8重量份、L-精氨酸2重量份、牛磺酸0.2重量份、低聚果糖5重量份、硒酵母0.1重量份、甘氨酸锌0.01重量份、叶酸0.01重量份、维生素B12 0.1重量份、维生素E 1重量份、虾青素0.01重量份、N-乙酰神经氨酸0.01重量份、蜂蜜冻干粉1重量份。
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
实施例2
本实施例提供一种提高人类精子浓度和运动性的组合物,其原料组分包括:左旋肉碱10重量份、乙酰左旋肉碱2重量份、L-精氨酸5重量份、牛磺酸0.1重量份、低聚果糖15重量份、硒酵母0.01重量份、甘氨酸锌0.1重量份、叶酸0.001重量份、维生素B12 1重量份、维生素E 0.1重量份、虾青素0.1重量份、N-乙酰神经氨酸0.001重量份、木糖醇5重量份。
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
实施例3
本实施例提供一种提高人类精子浓度和运动性的组合物,其原料组分包括:左旋肉碱6重量份、乙酰左旋肉碱6重量份、氨基酸3重量份、牛磺酸0.18重量份、果糖8重量份、硒源0.08重量份、锌源0.04重量份、叶酸0.008重量份、维生素B12 0.4重量份、维生素E0.6重量份、虾青素0.04重量份、N-乙酰神经氨酸0.006重量份、D-甘露糖醇3重量份。
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
实施例4
本实施例提供一种提高人类精子浓度和运动性的组合物,其原料组分包括:左旋肉碱8重量份、乙酰左旋肉碱4重量份、氨基酸4重量份、牛磺酸0.12重量份、果糖12重量份、硒源0.04重量份、锌源0.08重量份、叶酸0.004重量份、维生素B12 0.6重量份、维生素E 0.4重量份、虾青素0.06重量份、N-乙酰神经氨酸0.004重量份、三氯蔗糖4重量份。
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
实施例5
本实施例提供一种提高人类精子浓度和运动性的组合物,其原料组分包括:左旋肉碱7重量份、乙酰左旋肉碱5重量份、氨基酸3.5重量份、牛磺酸0.15重量份、果糖10重量份、硒源0.05重量份、锌源0.05重量份、叶酸0.005重量份、维生素B12 0.5重量份、维生素E0.5重量份、虾青素0.05重量份、N-乙酰神经氨酸0.005重量份、木糖醇2.5重量份。
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
实验例
本发明人通过对就诊的300例少精弱精症患者进行临床验证,年龄23-40岁,病程2-9年,其中少精症100,弱精症100例,少精弱精症100例。
(1)诊断标准:夫妻同居一年以上,性生活正常,未采取任何避孕措施而不育,经检查排除女方因素者。精液检查异常指:(a)精子密度<60×109/L;(b)精子活力a+b级<30%或者a级<10%;(c)精子活率<60%,以上三项具备一项即可确诊。
(2)治疗方法:口服,用水冲服,每次15克,每日2次。
治疗期间患者停止服用其他药物,禁烟酒、勿劳累、忌高温作业及热水泡浴,避免工业污染、放射线及电磁波,穿棉质宽松衣裤,注意营养平衡,并嘱患者配偶倍加关心、鼓励,以减轻患者压力、增强信心。随访患者妻子受孕情况。
(3)疗效评定标准:
疗效标准根据世界卫生组织《不育夫妇标准检查与诊断手册》,并参照《中药新药临床研究指导原则》中有关疗效标准进行评定。
临床治愈:少精症治疗后精子密度≧20×109/L,弱精症精子活动力a级≧25%或a+b级≧50%,或治疗后女方怀孕。
显效:少精症治疗后精子密度提升≧50%,弱精症精子活动力a+b级提升≧25%或a级提升≧12.5%,但未达到正常指标。
有效:少精症治疗后精子密度提升≧15%,弱精症精子活动力a+b级或a级提升≧5%。
无效:治疗后精子密度提升<15%及精子活力提升<5%或无变化。
(4)治疗前后各组疗效见表1,治疗前后各组的精液参数比较见表2。
表1-治疗前后各组疗效
组别 | 治愈 | 显效 | 有效 | 无效 | 总有效率 |
少精症组 | 56 | 29 | 11 | 4 | 96% |
弱精症组 | 65 | 20 | 12 | 3 | 96% |
少精弱精症组 | 33 | 28 | 30 | 9 | 90% |
表2-治疗前后各组的精液参数比较
本发明不局限于上述最佳实施方式,任何人在本发明的启示下都可得出其他各种形式的产品,但不论在其形状或结构上作任何变化,凡是具有与本申请相同或相近似的技术方案,均落在本发明的保护范围之内。
Claims (10)
1.一种提高人类精子浓度和运动性的组合物,其特征在于,原料组分包括:左旋肉碱4-10重量份、乙酰左旋肉碱2-8重量份、氨基酸2-5重量份、牛磺酸0.1-0.2重量份、果糖5-15重量份、硒源0.01-0.1重量份、锌源0.01-0.1重量份、叶酸0.001-0.01重量份、维生素B120.1-1重量份、维生素E 0.1-1重量份、虾青素0.01-0.1重量份、N-乙酰神经氨酸0.001-0.01重量份。
2.根据权利要求1所述的提高人类精子浓度和运动性的组合物,其特征在于,原料组分包括:左旋肉碱6-8重量份、乙酰左旋肉碱4-6重量份、氨基酸3-4重量份、牛磺酸0.12-0.18重量份、果糖8-12重量份、硒源0.04-0.08重量份、锌源0.04-0.08重量份、叶酸0.004-0.008重量份、维生素B12 0.4-0.6重量份、维生素E 0.4-0.6重量份、虾青素0.04-0.06重量份、N-乙酰神经氨酸0.004-0.006重量份。
3.根据权利要求1所述的提高人类精子浓度和运动性的组合物,其特征在于,原料组分包括:左旋肉碱7重量份、乙酰左旋肉碱5重量份、氨基酸3.5重量份、牛磺酸0.15重量份、果糖10重量份、硒源0.05重量份、锌源0.05重量份、叶酸0.005重量份、维生素B12 0.5重量份、维生素E 0.5重量份、虾青素0.05重量份、N-乙酰神经氨酸0.005重量份。
4.根据权利要求1-3任一项所述的提高人类精子浓度和运动性的组合物,其特征在于,所述氨基酸为L-精氨酸。
5.根据权利要求1-3任一项所述的提高人类精子浓度和运动性的组合物,其特征在于,所述硒源为硒酵母。
6.根据权利要求1-3任一项所述的提高人类精子浓度和运动性的组合物,其特征在于,所述锌源为甘氨酸锌。
7.根据权利要求1-3任一项所述的提高人类精子浓度和运动性的组合物,其特征在于,所述果糖为低聚果糖。
8.根据权利要求1-3任一项所述的提高人类精子浓度和运动性的组合物,其特征在于,所述原料组分还包括1-5重量份的调味剂。
9.根据权利要求1-3任一项所述的提高人类精子浓度和运动性的组合物,其特征在于,所述调味剂为蜂蜜冻干粉、木糖醇、D-甘露糖醇、三氯蔗糖中的一种或几种的混合物。
10.一种制备权利要求1-9任一项所述的提高人类精子浓度和运动性的组合物的方法,其特征在于,包括如下步骤:
分别称取各原料并进行充分混合,即得所述提高人类精子浓度和运动性的组合物。
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CN110613124A (zh) * | 2019-09-18 | 2019-12-27 | 孙启城 | 一种含有左旋肉碱和虾青素的保健食品 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1284871A (zh) * | 1997-12-01 | 2001-02-21 | 希格马托保健科学股份公司 | 增加人类精子的浓度和运动性的组合物及方法 |
CN102846673A (zh) * | 2012-03-21 | 2013-01-02 | 陈浩 | 改善人类精子活动力与质量的组合物 |
CN105596885A (zh) * | 2016-01-14 | 2016-05-25 | 梁晓会 | 治疗男性少精弱精、提高精子质量的药物及其制备方法 |
CN106668507A (zh) * | 2016-12-29 | 2017-05-17 | 昭远制药(上海)有限公司 | 一种用于治疗男性不孕不育的药物及其制备方法 |
-
2017
- 2017-07-25 CN CN201710611843.9A patent/CN107375346A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1284871A (zh) * | 1997-12-01 | 2001-02-21 | 希格马托保健科学股份公司 | 增加人类精子的浓度和运动性的组合物及方法 |
CN102846673A (zh) * | 2012-03-21 | 2013-01-02 | 陈浩 | 改善人类精子活动力与质量的组合物 |
CN105596885A (zh) * | 2016-01-14 | 2016-05-25 | 梁晓会 | 治疗男性少精弱精、提高精子质量的药物及其制备方法 |
CN106668507A (zh) * | 2016-12-29 | 2017-05-17 | 昭远制药(上海)有限公司 | 一种用于治疗男性不孕不育的药物及其制备方法 |
Non-Patent Citations (2)
Title |
---|
冯颖等: "唾液酸在精子成熟、获能及精卵结合中作用研究进展", 《中华男科学杂志》 * |
黎娜等: "唾液酸对精子的作用", 《中国细胞生物学学报》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110613124A (zh) * | 2019-09-18 | 2019-12-27 | 孙启城 | 一种含有左旋肉碱和虾青素的保健食品 |
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