PT1828249E - Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r - Google Patents
Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r Download PDFInfo
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- PT1828249E PT1828249E PT05852441T PT05852441T PT1828249E PT 1828249 E PT1828249 E PT 1828249E PT 05852441 T PT05852441 T PT 05852441T PT 05852441 T PT05852441 T PT 05852441T PT 1828249 E PT1828249 E PT 1828249E
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Landscapes
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| US20080193445A1 (en) * | 2002-01-18 | 2008-08-14 | Liliane Goetsch | Novel anti-IGF-IR antibodies and uses thereof |
| KR101086533B1 (ko) * | 2002-05-24 | 2011-11-23 | 쉐링 코포레이션 | 중화 사람 항-ｉｇｆｒ 항체, 이를 제조하는 방법 및 이를 포함하는 조성물 |
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| ES2527871T3 (es) | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
| TW200526684A (en) * | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
| EP3770278A1 (en) | 2005-04-14 | 2021-01-27 | The Trustees of Boston University | Diagnostic for lung disorders using class prediction |
| CA2604393A1 (en) * | 2005-04-15 | 2006-10-26 | Schering Corporation | Methods and compositions for treating or preventing cancer |
| JP2009501141A (ja) | 2005-06-17 | 2009-01-15 | イムクローン システムズ インコーポレイテッド | 転移性骨癌の治療のための受容体アンタゴニスト |
| US8062838B2 (en) * | 2005-09-20 | 2011-11-22 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| WO2007092453A2 (en) | 2006-02-03 | 2007-08-16 | Imclone Systems Incorporated | Igf-ir antagonists as adjuvants for treatment of prostate cancer |
| WO2007093008A1 (en) * | 2006-02-17 | 2007-08-23 | Adelaide Research & Innovation Pty Ltd | Antibodies to insulin-like growth factor i receptor |
| JP2009529329A (ja) | 2006-03-09 | 2009-08-20 | トラスティーズ オブ ボストン ユニバーシティ | 鼻腔上皮細胞の遺伝子発現プロファイルを用いた、肺疾患のための診断および予後診断の方法 |
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| US20100120055A1 (en) * | 2006-09-28 | 2010-05-13 | Cell Signaling Technology, Inc. | Tyrosine phosphorylation sites |
| CA2672828A1 (en) * | 2006-12-13 | 2008-06-26 | Schering Corporation | Methods of treatment |
| WO2008144345A2 (en) * | 2007-05-17 | 2008-11-27 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators |
| WO2009017679A2 (en) * | 2007-07-31 | 2009-02-05 | Merck & Co., Inc. | Igf-1r specific antibodies useful in the detection and diagnosis of cellular proliferative disorders |
| US20090186951A1 (en) * | 2007-09-19 | 2009-07-23 | Brody Jerome S | Identification of novel pathways for drug development for lung disease |
| JP2011501660A (ja) * | 2007-10-03 | 2011-01-13 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | インスリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー |
| CA2694154A1 (en) * | 2007-10-03 | 2009-04-09 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| EP2247757A2 (en) * | 2007-12-18 | 2010-11-10 | Schering Corporation | Biomarkers for sensitivity to anti-igf1r therapy |
| JP2012508563A (ja) * | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | 抗ＩＧＦ１Ｒ発現の増強のためのβＧｌ−ＩＧＧイントロン |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US20110171124A1 (en) * | 2009-02-26 | 2011-07-14 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the EMT status of tumor cells in vivo |
| WO2010129934A2 (en) | 2009-05-07 | 2010-11-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
| WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
| WO2011053779A2 (en) * | 2009-10-30 | 2011-05-05 | Bristol-Myers Squibb Company | Methods for treating cancer in patients having igf-1r inhibitor resistance |
| US8765713B2 (en) | 2009-10-30 | 2014-07-01 | Keio University | Method for determination of sensitivity to anti-cancer agent |
| JP5871816B2 (ja) * | 2009-12-22 | 2016-03-01 | エクスプレッション、パソロジー、インコーポレイテッドＥｘｐｒｅｓｓｉｏｎ Ｐａｔｈｏｌｏｇｙ， Ｉｎｃ． | インスリン受容体基質１（ｉｒｓ１）タンパク質ｓｒｍ／ｍｒｍアッセイ |
| US20110217309A1 (en) * | 2010-03-03 | 2011-09-08 | Buck Elizabeth A | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| EP2519826A2 (en) | 2010-03-03 | 2012-11-07 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| CA2806076A1 (en) | 2010-07-22 | 2012-01-26 | The Regents Of The University Of California | Anti-tumor antigen antibodies and methods of use |
| TW201302793A (zh) * | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| CA2825894C (en) | 2011-02-02 | 2021-11-30 | Amgen Inc. | Prognosis of cancer using a circulating biomarker |
| WO2012116040A1 (en) | 2011-02-22 | 2012-08-30 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma |
| EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2013056069A1 (en) * | 2011-10-13 | 2013-04-18 | Bristol-Myers Squibb Company | Methods for selecting and treating cancer in patients with igf-1r/ir inhibitors |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US20170335396A1 (en) | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| EP3268038B1 (en) | 2015-03-09 | 2021-05-05 | Agensys, Inc. | Antibody drug conjugates (adc) that bind to flt3 proteins |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| MX2022012635A (es) * | 2020-04-08 | 2023-01-11 | Aliada Therapeutics Inc | Composiciones y métodos para distribución de barrera hematoencefálica. |
| CA3195590A1 (en) | 2020-10-14 | 2022-04-21 | Vahe Bedian | Compositions and methods for treatment of thyroid eye disease |
| TW202320850A (zh) * | 2021-08-10 | 2023-06-01 | 美商維里迪恩醫療股份有限公司 | 用於治療甲狀腺眼病之組合物、劑量及方法 |
| US20250099583A1 (en) * | 2023-09-06 | 2025-03-27 | Viridian Therapeutics, Inc. | Pharmaceutical compositions of anti-igf-1r antibodies |
Family Cites Families (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US5534617A (en) | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| CA2025907A1 (en) | 1989-09-21 | 1991-03-22 | Franklin D. Collins | Method of transporting compositions across the blood brain barrier |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| DE69127749T2 (de) | 1990-03-20 | 1998-04-16 | The Trustees Of Columbia University In The City Of New York, New York, N.Y. | Chimäre antikörper mit rezeptor-bindenden liganden anstelle ihrer konstanten region |
| CA2058041A1 (en) | 1990-06-27 | 1991-12-28 | Katsuichi Sakano | Anti-igf-ii monoclonal antibody |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5198340A (en) | 1991-01-17 | 1993-03-30 | Genentech, Inc. | Assay for free igf-i, igf-ii, and gh levels in body fluids |
| US5262308A (en) | 1992-01-28 | 1993-11-16 | Thomas Jefferson University | Cell lines which constitutively express IGF-1 and IGF-1 R |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| WO1994002178A1 (en) | 1992-07-27 | 1994-02-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeting of liposomes to the blood-brain barrier |
| WO1994023034A2 (en) | 1993-04-06 | 1994-10-13 | Cedars-Sinai Medical Center | Variant insulin-like growth factor i receptor subunits and methods for use thereof |
| US20020022023A1 (en) | 1999-01-15 | 2002-02-21 | Axel Ullrich | Treatment of diabetes mellitus and insulin receptor signal transduction |
| AUPM672594A0 (en) | 1994-07-08 | 1994-08-04 | Royal Children's Hospital Research Foundation | A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders |
| EP0861267A4 (en) | 1995-11-14 | 2000-02-02 | Univ Jefferson | INDUCTION AND RESISTANCE TO TUMOR GROWTH BY MEANS OF SOLUBLE IGF-1 |
| US6346390B1 (en) | 1996-03-08 | 2002-02-12 | Receptron, Inc. | Receptor derived peptides involved in modulation of response to ligand binding |
| US5958872A (en) | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
| AUPN999096A0 (en) | 1996-05-22 | 1996-06-13 | Northstar Biologicals Pty Ltd | Peptides, antibodies, vaccines & uses thereof |
| US20020107187A1 (en) | 1996-05-22 | 2002-08-08 | Kingston David J. | Modulating the activity of hormones or their receptors - peptides, antibodies, vaccines and uses thereof |
| US20020155095A1 (en) | 1996-10-18 | 2002-10-24 | Tattanahalli L. Nagabhushan | Methods and compositions for delivery and expression of interferon-a nucleic acids |
| IL129387A0 (en) | 1996-10-18 | 2000-02-17 | Canji Inc | Methods and compositions for delivery and expression of interferon-alpha nucleic acids |
| AU5451598A (en) | 1996-11-22 | 1998-06-10 | Regents Of The University Of California, The | Transport of liposomes across the blood-brain barrier |
| US6294330B1 (en) | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| DE19719001C2 (de) | 1997-05-06 | 2001-05-10 | Schuetzdeller Angelika | Verfahren zum immunologisch-funktionalen Nachweis biologisch aktiver Insulin-Like Growth Factor Binding Proteine oder löslicher Insulin-Like Growth Factor - Rezeptoren im Immunoassay |
| CA2310269A1 (en) | 1997-11-14 | 1999-05-27 | Euro-Celtique, S.A. | Immunoglobulin molecules having a synthetic variable region and modified specificity |
| DE69834828T2 (de) | 1997-11-27 | 2007-01-04 | Commonwealth Scientific And Industrial Research Organisation | Verfahren zur konstruktion von agonisten und antagonisten des igf-rezeptors (1-462) |
| JP2002508160A (ja) | 1998-02-24 | 2002-03-19 | レセプトロン，インコーポレイティド | 受容体活性のモジュレーターとしての受容体由来ペプチド |
| ZA200007412B (en) | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
| CA2332331A1 (en) | 1998-05-15 | 1999-11-25 | Francisco Robert | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases |
| GB9818110D0 (en) | 1998-08-19 | 1998-10-14 | Weston Medical Ltd | Needleless injectors and other devices |
| US6875741B2 (en) | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
| US20030236190A1 (en) | 1998-09-02 | 2003-12-25 | Renuka Pillutla | Isulin and IGF-1 receptor agonists and antagonists |
| US7173005B2 (en) | 1998-09-02 | 2007-02-06 | Antyra Inc. | Insulin and IGF-1 receptor agonists and antagonists |
| WO2000022130A2 (en) | 1998-10-15 | 2000-04-20 | Chiron Corporation | Metastatic breast and colon cancer regulated genes |
| US6096002A (en) | 1998-11-18 | 2000-08-01 | Bioject, Inc. | NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method |
| AU3579200A (en) | 1999-02-26 | 2000-09-14 | Saltech I Goteborg Ab | Method and composition for the regulation of hepatic and extrahepatic productionof insulin-like growth factor-1 |
| US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| WO2000069454A1 (en) | 1999-05-17 | 2000-11-23 | Board Of Regents, The University Of Texas System | Suppression of endogenous igfbp-2 to inhibit cancer |
| AU6607100A (en) | 1999-07-23 | 2001-02-13 | Regents Of The University Of California, The | Anti-growth factor receptor avidin fusion proteins as universal vectors for drugdelivery |
| WO2001030964A2 (en) | 1999-10-22 | 2001-05-03 | Lifespan Biosciences, Inc. | Anti-cancer nucleic acid and protein targets |
| AU1410801A (en) | 1999-11-17 | 2001-05-30 | Compugen Ltd. | Variants of alternative splicing |
| WO2001044464A1 (en) | 1999-12-15 | 2001-06-21 | Mcgill University | Targeting of endosomal growth factor processing as anti-cancer therapy |
| AU2001245888A1 (en) | 2000-03-21 | 2001-10-03 | University Of South Florida | Growth factor binding molecules |
| WO2001070268A1 (en) | 2000-03-22 | 2001-09-27 | Glaxo Group Limited | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
| TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
| ATE529435T1 (de) | 2000-03-29 | 2011-11-15 | Dgi Biotechnologies L L C | Agonisten und antagonisten der rezeptoren des insulin und des igf-1 |
| WO2001075064A2 (en) | 2000-03-31 | 2001-10-11 | Hyseq, Inc. | Method and materials relating to insulin-like growth factor binding protein-like polypeptides and polynucleotides |
| US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
| US20030165502A1 (en) | 2000-06-13 | 2003-09-04 | City Of Hope | Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth |
| US7329745B2 (en) | 2000-06-13 | 2008-02-12 | City Of Hope | Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth |
| CA2414272A1 (en) | 2000-07-10 | 2002-01-17 | Novartis Ag | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
| US20020164333A1 (en) | 2000-07-10 | 2002-11-07 | The Scripps Research Institute | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
| WO2002007783A2 (en) | 2000-07-20 | 2002-01-31 | Regents Of The University Of Minnesota | Radiolabeled immunotoxins |
| US20030162230A1 (en) | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
| US8153121B2 (en) | 2000-10-06 | 2012-04-10 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders |
| DE10050338A1 (de) | 2000-10-11 | 2002-04-25 | Deutsches Krebsforsch | Auf dem Nachweis von IGF-IRbeta und IRS-1 beruhendes Diagnose- bzw. Klassifizierungsverfahren für Carcinome |
| MXPA03003207A (es) | 2000-10-12 | 2004-03-26 | Icos Corp | Materiales y metodos para modular la actividad de union de ligando/enzimatica de proteinas alfa/¦ que contienen un sitio regulador alosterico. |
| WO2002039121A2 (en) | 2000-11-03 | 2002-05-16 | Board Of Regents, The University Of Texas System | Methods for detecting the efficacy of anticancer treatments |
| EP1399184A2 (en) | 2000-12-01 | 2004-03-24 | Schering Corporation | Uses of mammalian genes and related reagents |
| ATE444488T1 (de) | 2000-12-14 | 2009-10-15 | Burnham Inst | Non-apoptotische formen des zelltods und verfahren zur modulation |
| SV2007000775A (es) | 2001-01-05 | 2007-03-15 | Pfizer | Anticuerpos contra el receptor del factor de crecimiento similar a insulina |
| JP4307079B2 (ja) | 2001-01-26 | 2009-08-05 | セレキス エスアー | マトリックス付着領域およびその使用方法 |
| CA2702192A1 (en) | 2001-03-14 | 2002-09-19 | Genentech, Inc. | Igf antagonist peptides |
| WO2002087618A1 (en) | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Preventive/therapeutic method for cancer |
| FR2824076B1 (fr) | 2001-04-27 | 2003-06-13 | Centre Nat Rech Scient | Methode de detection de composes activateurs ou inhibiteurs des recepteurs de la famille du recepteur de l'insuline au moyen d'un recepteur chimere isole |
| CA2445898A1 (en) | 2001-05-01 | 2002-12-19 | The General Hospital Corporation | Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies |
| AR035885A1 (es) * | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| EP1423428B2 (en) | 2001-06-20 | 2012-11-14 | Fibron Ltd. | Antibodies that block fgfr3 activation, methods of screening for and uses thereof |
| CA2489420A1 (en) | 2001-06-25 | 2003-01-03 | Buadbo Aps | Oncology drug innovation |
| US20040253635A1 (en) | 2001-08-06 | 2004-12-16 | Sylvie Luria | Methods of identifying functional analogs of peptide regulators of biological pathways |
| AUPR870501A0 (en) * | 2001-11-07 | 2001-11-29 | Biotech Research Ventures Pte Limited | Composition containing a flavonoid glycone and method for using same as anti-proliferative |
| FR2834900B1 (fr) | 2002-01-18 | 2005-07-01 | Pf Medicament | Nouvelles compositions a activite anti-igf-ir et anti-egfr et leurs applications |
| US7553485B2 (en) | 2002-01-18 | 2009-06-30 | Pierre Fabre Medicament | Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof |
| US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| FR2834991B1 (fr) | 2002-01-18 | 2004-12-31 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| ATE357460T1 (de) | 2002-01-18 | 2007-04-15 | Pf Medicament | Antikörper gegen igf-ir und ihre verwendungen |
| FR2834990A1 (fr) | 2002-01-18 | 2003-07-25 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
| EP1497461A4 (en) | 2002-04-15 | 2007-06-06 | Rigel Pharmaceuticals Inc | METHOD FOR TESTING FOR CELL CYCLE MODULATORS |
| US7655397B2 (en) | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
| US7438911B2 (en) | 2002-04-30 | 2008-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Antibody against human insulin-like growth factor |
| US7485314B2 (en) | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
| KR101086533B1 (ko) * | 2002-05-24 | 2011-11-23 | 쉐링 코포레이션 | 중화 사람 항-ｉｇｆｒ 항체, 이를 제조하는 방법 및 이를 포함하는 조성물 |
| GB0212303D0 (en) * | 2002-05-28 | 2002-07-10 | Isis Innovation | Molecular targetting of IGF-1 receptor |
| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| AU2003249054A1 (en) | 2002-07-12 | 2004-02-02 | The Johns Hopkins University | Neuronal gene expression patterns |
| US20040142381A1 (en) | 2002-07-31 | 2004-07-22 | Hubbard Stevan R. | Methods for designing IGF1 receptor modulators for therapeutics |
| US20040047835A1 (en) | 2002-09-06 | 2004-03-11 | Cell Therapeutics, Inc. | Combinatorial drug therapy using polymer drug conjugates |
| US20030138430A1 (en) | 2002-09-20 | 2003-07-24 | Stimmel Julie Beth | Pharmaceutical comprising an agent that blocks the cell cycle and an antibody |
| TW200501960A (en) * | 2002-10-02 | 2005-01-16 | Bristol Myers Squibb Co | Synergistic kits and compositions for treating cancer |
| US20040102360A1 (en) | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
| US20060281130A1 (en) | 2002-12-20 | 2006-12-14 | Elisabeth Bock | Metod of modulation of interaction between receptor and ligand |
| JP2006517581A (ja) * | 2003-02-13 | 2006-07-27 | ファイザー・プロダクツ・インク | 抗インスリン様増殖因子ｉ受容体抗体の使用 |
| JP2007528201A (ja) | 2003-03-14 | 2007-10-11 | ファルマシア・コーポレーション | 癌治療のためのｉｇｆ−ｉ受容体に対する抗体 |
| WO2004087756A2 (en) | 2003-04-02 | 2004-10-14 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| ES2527871T3 (es) * | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
| US7579157B2 (en) | 2003-07-10 | 2009-08-25 | Hoffmann-La Roche Inc. | Antibody selection method against IGF-IR |
| MXPA06001634A (es) | 2003-08-13 | 2006-04-28 | Pfizer Prod Inc | Anticuerpos humanos modificados igf-1r. |
| DE10348391B3 (de) | 2003-10-17 | 2004-12-23 | Beru Ag | Verfahren zum Glühen einer Glühkerze für einen Dieselmotor |
| CN1938428A (zh) | 2003-11-12 | 2007-03-28 | 先灵公司 | 多基因表达的质粒系统 |
| TW200526684A (en) * | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
| US20050272637A1 (en) | 2004-04-22 | 2005-12-08 | Oregon Health & Science University | Compositions and methods for modulating signaling mediated by IGF-1 receptor and erbB receptors |
| CA2569277A1 (en) | 2004-06-04 | 2005-12-15 | Pfizer Products Inc. | Method for treating abnormal cell growth |
| JP2008506681A (ja) | 2004-07-16 | 2008-03-06 | ファイザー・プロダクツ・インク | 抗ｉｇｆ−１ｒ抗体を用いる非血液性の悪性腫瘍の併用療法 |
| EP1786918A4 (en) | 2004-07-17 | 2009-02-11 | Imclone Systems Inc | NEW BISPECIFIC ANTIBODY TETRAVALENT |
| FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
| US20060205810A1 (en) | 2004-11-24 | 2006-09-14 | Schering Corporation | Platinum therapeutic combinations |
| CA2604393A1 (en) * | 2005-04-15 | 2006-10-26 | Schering Corporation | Methods and compositions for treating or preventing cancer |
| KR20070120156A (ko) | 2005-04-15 | 2007-12-21 | 이뮤노젠 아이엔씨 | 종양에서 이종 또는 혼성 세포 집단의 제거 방법 |
| BRPI0611800A2 (pt) | 2005-06-15 | 2008-12-09 | Schering Corp | formulaÇço estÁvel de anticorpo |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2007093008A1 (en) | 2006-02-17 | 2007-08-23 | Adelaide Research & Innovation Pty Ltd | Antibodies to insulin-like growth factor i receptor |
| EP2405270B1 (en) | 2006-06-30 | 2013-07-17 | Merck Sharp & Dohme Corp. | IGFBP2-Biomarker |
-
2005
- 2005-11-30 JP JP2007544441A patent/JP2008521907A/ja not_active Withdrawn
- 2005-11-30 CA CA002589885A patent/CA2589885A1/en not_active Abandoned
- 2005-11-30 EP EP10185346.3A patent/EP2283831A3/en not_active Withdrawn
- 2005-11-30 US US11/290,687 patent/US7811562B2/en not_active Expired - Fee Related
- 2005-11-30 PT PT05852441T patent/PT1828249E/pt unknown
- 2005-11-30 EP EP05852441A patent/EP1828249B1/en not_active Expired - Lifetime
- 2005-11-30 ES ES05852441T patent/ES2356830T3/es not_active Expired - Lifetime
- 2005-11-30 DE DE602005025685T patent/DE602005025685D1/de not_active Expired - Lifetime
- 2005-11-30 EP EP10184355.5A patent/EP2281841A3/en not_active Withdrawn
- 2005-11-30 MX MX2007006640A patent/MX2007006640A/es active IP Right Grant
- 2005-11-30 AT AT05852441T patent/ATE493442T1/de not_active IP Right Cessation
- 2005-11-30 WO PCT/US2005/043184 patent/WO2006060419A2/en not_active Ceased
- 2005-12-01 TW TW094142319A patent/TWI376233B/zh active
-
2011
- 2011-05-13 JP JP2011108837A patent/JP2011157397A/ja active Pending
- 2011-12-21 JP JP2011280276A patent/JP2012067124A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2281841A2 (en) | 2011-02-09 |
| ES2356830T3 (es) | 2011-04-13 |
| EP1828249A2 (en) | 2007-09-05 |
| WO2006060419A9 (en) | 2006-07-20 |
| TW200626174A (en) | 2006-08-01 |
| ATE493442T1 (de) | 2011-01-15 |
| JP2011157397A (ja) | 2011-08-18 |
| WO2006060419A2 (en) | 2006-06-08 |
| EP1828249B1 (en) | 2010-12-29 |
| EP2281841A3 (en) | 2013-10-23 |
| TWI376233B (en) | 2012-11-11 |
| EP2283831A3 (en) | 2013-10-23 |
| US7811562B2 (en) | 2010-10-12 |
| WO2006060419A3 (en) | 2006-08-24 |
| US20060140960A1 (en) | 2006-06-29 |
| JP2012067124A (ja) | 2012-04-05 |
| JP2008521907A (ja) | 2008-06-26 |
| EP2283831A2 (en) | 2011-02-16 |
| MX2007006640A (es) | 2007-06-19 |
| CA2589885A1 (en) | 2006-06-08 |
| DE602005025685D1 (de) | 2011-02-10 |
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