PT1345594E - Composição farmacêutica sólida termomoldável para libertação controlada de ivabradina - Google Patents

Composição farmacêutica sólida termomoldável para libertação controlada de ivabradina Download PDF

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Publication number
PT1345594E
PT1345594E PT01989654T PT01989654T PT1345594E PT 1345594 E PT1345594 E PT 1345594E PT 01989654 T PT01989654 T PT 01989654T PT 01989654 T PT01989654 T PT 01989654T PT 1345594 E PT1345594 E PT 1345594E
Authority
PT
Portugal
Prior art keywords
pharmaceutical composition
mixture
controlled release
solid pharmaceutical
ivabradine
Prior art date
Application number
PT01989654T
Other languages
English (en)
Portuguese (pt)
Inventor
Gerald Pichon
Patrick Wuthrich
Herve Rolland
Gilles Briault
Francois Tharrault
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT1345594E publication Critical patent/PT1345594E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT01989654T 2000-12-26 2001-12-21 Composição farmacêutica sólida termomoldável para libertação controlada de ivabradina PT1345594E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0017015A FR2818552B1 (fr) 2000-12-26 2000-12-26 Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine

Publications (1)

Publication Number Publication Date
PT1345594E true PT1345594E (pt) 2007-04-30

Family

ID=8858190

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01989654T PT1345594E (pt) 2000-12-26 2001-12-21 Composição farmacêutica sólida termomoldável para libertação controlada de ivabradina

Country Status (26)

Country Link
US (1) US20040028743A1 (enExample)
EP (1) EP1345594B1 (enExample)
JP (2) JP2004518665A (enExample)
KR (1) KR100542472B1 (enExample)
CN (1) CN1203844C (enExample)
AT (1) ATE352290T1 (enExample)
AU (1) AU2002228119B2 (enExample)
BR (1) BR0116548A (enExample)
CA (1) CA2432645A1 (enExample)
CY (1) CY1106390T1 (enExample)
CZ (1) CZ304587B6 (enExample)
DE (1) DE60126332T2 (enExample)
DK (1) DK1345594T3 (enExample)
EA (1) EA005814B1 (enExample)
ES (1) ES2280420T3 (enExample)
FR (1) FR2818552B1 (enExample)
HU (1) HU229410B1 (enExample)
MX (1) MXPA03005840A (enExample)
NO (1) NO333776B1 (enExample)
NZ (1) NZ526406A (enExample)
PL (1) PL203835B1 (enExample)
PT (1) PT1345594E (enExample)
SI (1) SI1345594T1 (enExample)
SK (1) SK286413B6 (enExample)
WO (1) WO2002051387A1 (enExample)
ZA (1) ZA200304441B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2818552B1 (fr) * 2000-12-26 2003-02-07 Servier Lab Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine
FR2834896B1 (fr) * 2002-01-23 2004-02-27 Servier Lab Composition pharmaceutique orodispersible d'ivabradine
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
US20060165790A1 (en) * 2003-06-27 2006-07-27 Malcolm Walden Multiparticulates
GB2418854B (en) 2004-08-31 2009-12-23 Euro Celtique Sa Multiparticulates
FR2882556B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
WO2010128525A2 (en) * 2009-05-04 2010-11-11 Dinesh Shantilal Patel A formulation of ivabradine for treating the cardiovascular disease
US8900605B2 (en) 2010-06-14 2014-12-02 Ratiopharm Gmbh Solid ivabradine-containing composition
CN101897682B (zh) * 2010-07-13 2012-02-15 石药集团欧意药业有限公司 一种伊伐布雷定或其可药用盐固体制剂及其制备方法
CN102908327B (zh) * 2011-08-05 2015-03-11 江苏恒瑞医药股份有限公司 伊伐布雷定或其可药用盐的缓释制剂
WO2015091992A1 (en) * 2013-12-20 2015-06-25 Synthon B.V. Pharmaceutical composition comprising amorphous ivabradine
EP3025705B8 (en) 2014-11-25 2018-11-28 Sanofi Ilaç Sanayi ve Ticaret Anonim Sirketi Stable ivabradine formulations
CN104398486B (zh) * 2014-12-08 2018-01-12 武汉武药科技有限公司 一种盐酸伊伐布雷定渗透泵控释片及其制备方法
EP3366282B1 (en) 2017-02-28 2025-10-01 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
KR20190001340A (ko) * 2017-06-27 2019-01-04 에리슨제약(주) 이바브라딘을 포함하는 서방성 약제학적 조성물 및 이의 제조방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
DE4138513A1 (de) * 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
EP0952770A4 (en) * 1995-09-07 1999-12-22 Fuisz Technologies Ltd SYSTEM FOR MAKING SUBSTANTIALLY NON-SOLUBLE BIOALTERANT AGENTS BIOAVAILABLE
EP0998272B1 (en) * 1997-08-26 2003-05-02 Aventis Pharmaceuticals Inc. Pharmaceutical composition for combination of piperidinoalkanol-decongestant
US6673367B1 (en) * 1998-12-17 2004-01-06 Euro-Celtique, S.A. Controlled/modified release oral methylphenidate formulations
DE19901040A1 (de) * 1999-01-14 2000-07-20 Knoll Ag Arzneiformen mit gesteuerter Freisetzung, enthaltend gut wasserlösliche Wirkstoffe
FR2795326B1 (fr) * 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
FR2818552B1 (fr) * 2000-12-26 2003-02-07 Servier Lab Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine

Also Published As

Publication number Publication date
WO2002051387A8 (fr) 2004-05-13
EP1345594B1 (fr) 2007-01-24
ZA200304441B (en) 2004-06-25
SI1345594T1 (sl) 2007-04-30
CZ20032020A3 (cs) 2003-11-12
JP2004518665A (ja) 2004-06-24
FR2818552B1 (fr) 2003-02-07
KR20030064876A (ko) 2003-08-02
ES2280420T3 (es) 2007-09-16
DE60126332D1 (de) 2007-03-15
HUP0302522A3 (en) 2007-09-28
EA200300667A1 (ru) 2003-12-25
BR0116548A (pt) 2003-12-23
PL203835B1 (pl) 2009-11-30
HU229410B1 (en) 2013-12-30
NO20032737L (no) 2003-06-16
PL361662A1 (en) 2004-10-04
CN1482901A (zh) 2004-03-17
HK1060514A1 (en) 2004-08-13
WO2002051387A1 (fr) 2002-07-04
CA2432645A1 (fr) 2002-07-04
NO20032737D0 (no) 2003-06-16
NZ526406A (en) 2005-08-26
CY1106390T1 (el) 2011-10-12
EP1345594A1 (fr) 2003-09-24
SK286413B6 (sk) 2008-09-05
SK9422003A3 (en) 2003-12-02
EA005814B1 (ru) 2005-06-30
MXPA03005840A (es) 2003-09-10
KR100542472B1 (ko) 2006-01-11
CN1203844C (zh) 2005-06-01
DK1345594T3 (da) 2007-05-21
US20040028743A1 (en) 2004-02-12
HUP0302522A2 (hu) 2003-12-29
CZ304587B6 (cs) 2014-07-23
DE60126332T2 (de) 2007-08-30
NO333776B1 (no) 2013-09-16
AU2002228119B2 (en) 2006-04-27
ATE352290T1 (de) 2007-02-15
JP2010100641A (ja) 2010-05-06
FR2818552A1 (fr) 2002-06-28

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