EA200300667A1 - Твердая термоформируемая фармацевтическая композиция для контролируемого высвобождения ивабрадина - Google Patents

Твердая термоформируемая фармацевтическая композиция для контролируемого высвобождения ивабрадина

Info

Publication number
EA200300667A1
EA200300667A1 EA200300667A EA200300667A EA200300667A1 EA 200300667 A1 EA200300667 A1 EA 200300667A1 EA 200300667 A EA200300667 A EA 200300667A EA 200300667 A EA200300667 A EA 200300667A EA 200300667 A1 EA200300667 A1 EA 200300667A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical composition
release
ivrabradine
controlled
thermoformable
Prior art date
Application number
EA200300667A
Other languages
English (en)
Other versions
EA005814B1 (ru
Inventor
Патрик Вютриш
Эрве Роллан
Жилль Брио
Жеральд Пишо
Франсуа Тарро
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200300667A1 publication Critical patent/EA200300667A1/ru
Publication of EA005814B1 publication Critical patent/EA005814B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение касается новой твёрдой фармацевтической композиции контролируемого высвобождения, полученной термоформированием, в горячем состоянии, смеси, основанной на полимерах, принадлежащих к группе полиметакрилата, и ивабрадине или его фармацевтически приемлемой соли.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300667A 2000-12-26 2001-12-21 Твердая термоформируемая фармацевтическая композиция для контролируемого высвобождения ивабрадина EA005814B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0017015A FR2818552B1 (fr) 2000-12-26 2000-12-26 Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine
PCT/FR2001/004134 WO2002051387A1 (fr) 2000-12-26 2001-12-21 Composition pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine

Publications (2)

Publication Number Publication Date
EA200300667A1 true EA200300667A1 (ru) 2003-12-25
EA005814B1 EA005814B1 (ru) 2005-06-30

Family

ID=8858190

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300667A EA005814B1 (ru) 2000-12-26 2001-12-21 Твердая термоформируемая фармацевтическая композиция для контролируемого высвобождения ивабрадина

Country Status (27)

Country Link
US (1) US20040028743A1 (ru)
EP (1) EP1345594B1 (ru)
JP (2) JP2004518665A (ru)
KR (1) KR100542472B1 (ru)
CN (1) CN1203844C (ru)
AT (1) ATE352290T1 (ru)
AU (1) AU2002228119B2 (ru)
BR (1) BR0116548A (ru)
CA (1) CA2432645A1 (ru)
CY (1) CY1106390T1 (ru)
CZ (1) CZ304587B6 (ru)
DE (1) DE60126332T2 (ru)
DK (1) DK1345594T3 (ru)
EA (1) EA005814B1 (ru)
ES (1) ES2280420T3 (ru)
FR (1) FR2818552B1 (ru)
HK (1) HK1060514A1 (ru)
HU (1) HU229410B1 (ru)
MX (1) MXPA03005840A (ru)
NO (1) NO333776B1 (ru)
NZ (1) NZ526406A (ru)
PL (1) PL203835B1 (ru)
PT (1) PT1345594E (ru)
SI (1) SI1345594T1 (ru)
SK (1) SK286413B6 (ru)
WO (1) WO2002051387A1 (ru)
ZA (1) ZA200304441B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2818552B1 (fr) * 2000-12-26 2003-02-07 Servier Lab Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine
FR2834896B1 (fr) * 2002-01-23 2004-02-27 Servier Lab Composition pharmaceutique orodispersible d'ivabradine
US20060165790A1 (en) * 2003-06-27 2006-07-27 Malcolm Walden Multiparticulates
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
GB2418854B (en) 2004-08-31 2009-12-23 Euro Celtique Sa Multiparticulates
FR2882553B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
WO2010128525A2 (en) 2009-05-04 2010-11-11 Dinesh Shantilal Patel A formulation of ivabradine for treating the cardiovascular disease
PT2579860E (pt) 2010-06-14 2014-05-30 Ratiopharm Gmbh Composição farmacêutica que contém ivabradina com libertação modificada
CN101897682B (zh) * 2010-07-13 2012-02-15 石药集团欧意药业有限公司 一种伊伐布雷定或其可药用盐固体制剂及其制备方法
CN102908327B (zh) * 2011-08-05 2015-03-11 江苏恒瑞医药股份有限公司 伊伐布雷定或其可药用盐的缓释制剂
WO2015091992A1 (en) * 2013-12-20 2015-06-25 Synthon B.V. Pharmaceutical composition comprising amorphous ivabradine
EP3025705B8 (en) 2014-11-25 2018-11-28 Sanofi Ilaç Sanayi ve Ticaret Anonim Sirketi Stable ivabradine formulations
CN104398486B (zh) * 2014-12-08 2018-01-12 武汉武药科技有限公司 一种盐酸伊伐布雷定渗透泵控释片及其制备方法
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
KR20190001340A (ko) * 2017-06-27 2019-01-04 에리슨제약(주) 이바브라딘을 포함하는 서방성 약제학적 조성물 및 이의 제조방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
DE4138513A1 (de) * 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
WO1997008950A1 (en) * 1995-09-07 1997-03-13 Fuisz Technologies, Ltd. System for rendering substantially non-dissoluble bio-affecting agents bio-available
IL133420A (en) * 1997-08-26 2004-07-25 Aventis Pharma Inc Tablet-shaped pharmaceutical preparation containing a combination of piperidinoalkanol and antihistamines and reduces symptomatic congestion
US6673367B1 (en) * 1998-12-17 2004-01-06 Euro-Celtique, S.A. Controlled/modified release oral methylphenidate formulations
DE19901040A1 (de) * 1999-01-14 2000-07-20 Knoll Ag Arzneiformen mit gesteuerter Freisetzung, enthaltend gut wasserlösliche Wirkstoffe
FR2795326B1 (fr) * 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
UA80393C2 (ru) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтическая композиция, которая содержит ингибитор фдэ 4, диспергированный в матрице
FR2818552B1 (fr) * 2000-12-26 2003-02-07 Servier Lab Compositions pharmaceutique solide thermoformable pour la liberation controlee d'ivabradine

Also Published As

Publication number Publication date
ZA200304441B (en) 2004-06-25
MXPA03005840A (es) 2003-09-10
CZ304587B6 (cs) 2014-07-23
ES2280420T3 (es) 2007-09-16
HU229410B1 (en) 2013-12-30
HK1060514A1 (en) 2004-08-13
NO333776B1 (no) 2013-09-16
KR20030064876A (ko) 2003-08-02
EP1345594B1 (fr) 2007-01-24
NO20032737L (no) 2003-06-16
JP2004518665A (ja) 2004-06-24
HUP0302522A3 (en) 2007-09-28
PL361662A1 (en) 2004-10-04
DE60126332D1 (de) 2007-03-15
HUP0302522A2 (hu) 2003-12-29
SI1345594T1 (sl) 2007-04-30
NO20032737D0 (no) 2003-06-16
EP1345594A1 (fr) 2003-09-24
WO2002051387A8 (fr) 2004-05-13
US20040028743A1 (en) 2004-02-12
SK286413B6 (sk) 2008-09-05
CN1482901A (zh) 2004-03-17
DK1345594T3 (da) 2007-05-21
CA2432645A1 (fr) 2002-07-04
FR2818552B1 (fr) 2003-02-07
ATE352290T1 (de) 2007-02-15
PL203835B1 (pl) 2009-11-30
CY1106390T1 (el) 2011-10-12
SK9422003A3 (en) 2003-12-02
JP2010100641A (ja) 2010-05-06
PT1345594E (pt) 2007-04-30
EA005814B1 (ru) 2005-06-30
CZ20032020A3 (cs) 2003-11-12
AU2002228119B2 (en) 2006-04-27
NZ526406A (en) 2005-08-26
CN1203844C (zh) 2005-06-01
FR2818552A1 (fr) 2002-06-28
BR0116548A (pt) 2003-12-23
DE60126332T2 (de) 2007-08-30
WO2002051387A1 (fr) 2002-07-04
KR100542472B1 (ko) 2006-01-11

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU