PT1198453E - Derivados de n-(indolcarbonil)-piperazina como ligandos do receptor 5-ht2a - Google Patents

Derivados de n-(indolcarbonil)-piperazina como ligandos do receptor 5-ht2a

Info

Publication number
PT1198453E
PT1198453E PT00949288T PT00949288T PT1198453E PT 1198453 E PT1198453 E PT 1198453E PT 00949288 T PT00949288 T PT 00949288T PT 00949288 T PT00949288 T PT 00949288T PT 1198453 E PT1198453 E PT 1198453E
Authority
PT
Portugal
Prior art keywords
indolcarbonyl
pyperazine
derivatives
receptor ligands
ht2a receptor
Prior art date
Application number
PT00949288T
Other languages
English (en)
Inventor
Greiner Dr Hartmut
Gerd Bartoszyk
Christoph Seyfri
Henning Bottcher
Christoph Van Amsterdam
Juergen Harting
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT1198453E publication Critical patent/PT1198453E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
PT00949288T 1999-07-22 2000-07-07 Derivados de n-(indolcarbonil)-piperazina como ligandos do receptor 5-ht2a PT1198453E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19934433A DE19934433A1 (de) 1999-07-22 1999-07-22 N-(Indolcarbonyl-)piperazinderivate

Publications (1)

Publication Number Publication Date
PT1198453E true PT1198453E (pt) 2003-08-29

Family

ID=7915702

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00949288T PT1198453E (pt) 1999-07-22 2000-07-07 Derivados de n-(indolcarbonil)-piperazina como ligandos do receptor 5-ht2a

Country Status (26)

Country Link
US (2) US6838461B1 (pt)
EP (1) EP1198453B9 (pt)
JP (2) JP5242871B2 (pt)
KR (1) KR100779207B1 (pt)
CN (1) CN1229345C (pt)
AR (1) AR024819A1 (pt)
AT (1) ATE236877T1 (pt)
AU (1) AU770411B2 (pt)
BR (1) BR0012607A (pt)
CA (1) CA2383779C (pt)
CZ (1) CZ300510B6 (pt)
DE (2) DE19934433A1 (pt)
DK (1) DK1198453T5 (pt)
ES (1) ES2192535T3 (pt)
HK (1) HK1048636B (pt)
HU (1) HUP0201988A3 (pt)
MX (1) MXPA02000730A (pt)
MY (1) MY122531A (pt)
NO (1) NO322154B1 (pt)
PL (1) PL201893B1 (pt)
PT (1) PT1198453E (pt)
RU (1) RU2251548C2 (pt)
SK (1) SK286066B6 (pt)
UA (1) UA73518C2 (pt)
WO (1) WO2001007435A2 (pt)
ZA (1) ZA200201486B (pt)

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IL146309A (en) 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
DE19934432A1 (de) * 1999-07-22 2001-02-01 Merck Patent Gmbh Indolderivate
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
DE10102053A1 (de) * 2001-01-17 2002-07-18 Merck Patent Gmbh Piperazinylcarbonylchinoline und -isochinoline
BR0210411A (pt) 2001-06-15 2004-08-17 Hoffmann La Roche Derivados 4-piperazinilindol com afinidade para o receptor 5-ht6
BR0210628A (pt) * 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
DE10157673A1 (de) * 2001-11-24 2003-06-05 Merck Patent Gmbh Verwendung von N-(Indolcarbonyl-)piperazinderivaten
GB0203811D0 (en) 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
MXPA05002270A (es) * 2002-08-30 2005-06-08 Becton Dickinson Co Metodo para controlar farmacocineticos de compuestos inmunomoduladores.
DE10246357A1 (de) * 2002-10-04 2004-04-15 Merck Patent Gmbh Verwendung von 5-HT2Rezeptorantagonisten
EP1635876A4 (en) * 2003-06-13 2009-05-06 Becton Dickinson Co IMPROVED INTRADERMAL ADMINISTRATION OF BIOACTIVE AGENTS
MXPA06002159A (es) * 2003-08-26 2006-05-22 Becton Dickinson Co Metodos para la administracion intradermica de agentes terapeuticos.
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
AU2005240991A1 (en) * 2004-04-15 2005-11-17 Georgetown University Use of (4-alkylpiperazinyl) (phenyl) methanones in the treatment of Alzheimer's disease
US20050256182A1 (en) * 2004-05-11 2005-11-17 Sutter Diane E Formulations of anti-pain agents and methods of using the same
DE102004047517A1 (de) * 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
PL1831159T3 (pl) * 2004-12-21 2010-06-30 Hoffmann La Roche Pochodne tetraliny i indanu oraz ich zastosowania
GT200600042A (es) 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
WO2007130814A1 (en) * 2006-05-05 2007-11-15 Merck Patent Gmbh Crystalline (3-cyano-1h-indol-7-yl)-[4-(4-fluorophenethyl)piperazin-1-yl]methanone phosphate
US7514433B2 (en) * 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
CN101679400B (zh) * 2007-05-14 2013-04-17 爱思开生物制药株式会社 氨基甲酰氧基芳基链烷芳基哌嗪化合物，含该化合物的药物组合物以及通过给予该化合物治疗疼痛、焦虑和抑郁的方法
EP2008656A1 (en) * 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
JP5393677B2 (ja) * 2007-08-15 2014-01-22 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体
KR101062376B1 (ko) 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
US9308323B2 (en) 2011-11-15 2016-04-12 Smiths Medical Asd, Inc. Systems and methods for illuminated medical tubing detection and management indicating a characteristic of at least one infusion pump
RU2549963C1 (ru) * 2014-04-08 2015-05-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Дальневосточный государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО "ДВГМУ" Минздрава России) Способ прогнозирования развития критической печеночной недостаточности на основании сывороточного уровня селена
GB2554371B (en) * 2016-09-22 2019-10-09 Resolute Energy Solutions Ltd Well apparatus and associated methods

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US5093341A (en) * 1987-12-17 1992-03-03 Merrell Dow Pharmaceuticals Inc. N-aralkyl piperidine derivatives useful as antithrombolytic agents
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Also Published As

Publication number Publication date
DE50001729D1 (de) 2003-05-15
NO322154B1 (no) 2006-08-21
US20050096330A1 (en) 2005-05-05
US6838461B1 (en) 2005-01-04
HK1048636B (zh) 2006-08-11
HUP0201988A2 (hu) 2002-11-28
JP5242871B2 (ja) 2013-07-24
EP1198453B1 (de) 2003-04-09
SK512002A3 (en) 2002-05-09
US7084143B2 (en) 2006-08-01
PL353446A1 (en) 2003-11-17
WO2001007435A3 (de) 2001-08-16
EP1198453B9 (de) 2004-11-10
SK286066B6 (sk) 2008-02-05
CN1364157A (zh) 2002-08-14
UA73518C2 (en) 2005-08-15
AR024819A1 (es) 2002-10-23
MY122531A (en) 2006-04-29
AU770411B2 (en) 2004-02-19
CZ200268A3 (cs) 2002-04-17
CZ300510B6 (cs) 2009-06-03
ES2192535T3 (es) 2003-10-16
CA2383779A1 (en) 2001-02-01
ZA200201486B (en) 2003-07-30
CN1229345C (zh) 2005-11-30
AU6270400A (en) 2001-02-13
HUP0201988A3 (en) 2003-12-29
DK1198453T5 (da) 2005-01-31
DK1198453T3 (da) 2003-07-21
DE19934433A1 (de) 2001-01-25
BR0012607A (pt) 2002-04-09
ATE236877T1 (de) 2003-04-15
WO2001007435A2 (de) 2001-02-01
KR20020019513A (ko) 2002-03-12
JP2003505458A (ja) 2003-02-12
EP1198453A2 (de) 2002-04-24
PL201893B1 (pl) 2009-05-29
JP2012006940A (ja) 2012-01-12
NO20020307L (no) 2002-03-21
HK1048636A1 (en) 2003-04-11
KR100779207B1 (ko) 2007-11-27
CA2383779C (en) 2011-03-29
NO20020307D0 (no) 2002-01-21
MXPA02000730A (es) 2002-08-20
RU2251548C2 (ru) 2005-05-10

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