PT1015444E - Derivados de pirimidina e processos para a sua preparacao - Google Patents

Derivados de pirimidina e processos para a sua preparacao

Info

Publication number
PT1015444E
PT1015444E PT98911242T PT98911242T PT1015444E PT 1015444 E PT1015444 E PT 1015444E PT 98911242 T PT98911242 T PT 98911242T PT 98911242 T PT98911242 T PT 98911242T PT 1015444 E PT1015444 E PT 1015444E
Authority
PT
Portugal
Prior art keywords
processes
preparation
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
PT98911242T
Other languages
English (en)
Portuguese (pt)
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Original Assignee
Yuhan Corp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp Ltd filed Critical Yuhan Corp Ltd
Publication of PT1015444E publication Critical patent/PT1015444E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT98911242T 1997-03-27 1998-03-24 Derivados de pirimidina e processos para a sua preparacao PT1015444E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970010863 1997-03-27
KR19970010862 1997-03-27

Publications (1)

Publication Number Publication Date
PT1015444E true PT1015444E (pt) 2003-10-31

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98911242T PT1015444E (pt) 1997-03-27 1998-03-24 Derivados de pirimidina e processos para a sua preparacao

Country Status (21)

Country Link
US (1) US6352993B1 (ref)
EP (1) EP1015444B1 (ref)
JP (1) JP3176379B2 (ref)
KR (1) KR100278857B1 (ref)
CN (1) CN1118464C (ref)
AR (1) AR012181A1 (ref)
AT (1) ATE241613T1 (ref)
AU (1) AU720385B2 (ref)
BR (1) BR9808070A (ref)
CA (1) CA2284795C (ref)
DE (1) DE69815126T2 (ref)
DK (1) DK1015444T3 (ref)
ES (1) ES2200324T3 (ref)
HU (1) HUP0000851A3 (ref)
IN (1) IN188411B (ref)
PT (1) PT1015444E (ref)
RU (1) RU2203894C2 (ref)
TR (1) TR199902383T2 (ref)
TW (1) TW542831B (ref)
UY (1) UY24938A1 (ref)
WO (1) WO1998043968A1 (ref)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
AU2003254282A1 (en) 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US20070161637A1 (en) * 2003-07-22 2007-07-12 Neurogen Corporation Substituted pyridin-2-ylamine analogues
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
WO2005041961A1 (en) 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
WO2007042571A1 (en) * 2005-10-14 2007-04-19 Neurosearch A/S Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
NZ590688A (en) 2008-08-05 2012-09-28 Daiichi Sankyo Co Ltd imidazo[4,5-b]pyridin-2-one derivatives
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
BR112013011737A2 (pt) 2010-11-15 2016-08-09 Univ Leuven Kath composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
CN103402997B (zh) 2011-02-25 2015-08-26 柳韩洋行 二氨基嘧啶衍生物及其制备方法
MX2014009933A (es) * 2012-02-17 2015-12-16 Abbvie Inc Diaminopirimidinas utiles como inhibidores del virus sincitial respiratorio humano (rsv).
WO2013181136A1 (en) 2012-05-29 2013-12-05 Momentive Performance Materials Gmbh Preparation of isocyanato silanes
JP6412503B2 (ja) 2012-11-21 2018-10-24 ピーティーシー セラピューティクス， インコーポレイテッド 置換逆ピリミジンＢｍｉ−１阻害剤
RU2015143517A (ru) 2013-03-13 2017-04-19 Дженентек, Инк. Пиразолсодержащие соединения и их применения
KR102232595B1 (ko) 2013-08-30 2021-03-26 피티씨 테라퓨틱스, 인크. 치환된 피리미딘 bmi-1 저해제
CN104903312B (zh) * 2013-10-07 2019-01-29 卡德门企业有限公司 Rho激酶抑制剂
EP3071553A4 (en) 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
EP3209299A4 (en) * 2014-10-22 2018-04-04 The Board of Regents of The University of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
ES2915948T3 (es) * 2016-01-04 2022-06-27 ObsEva SA Administración conjunta de alfa-aminoéster de derivado de hidroxipropiltiazolidin-carboxamida y un agente tocolítico
EP3606915A1 (de) * 2017-04-05 2020-02-12 Bayer CropScience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
JP2021535198A (ja) 2018-08-17 2021-12-16 ピーティーシー セラピューティクス， インコーポレイテッド 膵臓癌を治療する方法
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
ES2081863T3 (es) 1989-03-22 1996-03-16 Ciba Geigy Ag Plaguicidas.
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
DK0556310T3 (da) 1990-11-06 1995-08-21 Pfizer Quinazolinderivater til forhøjelse af antitumoraktivitet
BR9205906A (pt) 1991-04-17 1994-07-05 Pfizer Derivados de pirimidina para aumento da atividade antitumoral
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
US5807885A (en) * 1993-08-12 1998-09-15 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
ATE163647T1 (de) 1993-08-26 1998-03-15 Ono Pharmaceutical Co 4-aminopyrimidin derivate
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
AU688087B2 (en) * 1994-08-13 1998-03-05 Yuhan Corporation Novel pyrimidine derivatives and processes for the preparation thereof
EP0900214B1 (en) 1996-05-04 2001-09-26 Yuhan Corporation Process for preparation of pyrimidine derivatives

Also Published As

Publication number Publication date
CN1251586A (zh) 2000-04-26
JP3176379B2 (ja) 2001-06-18
CA2284795C (en) 2004-01-20
BR9808070A (pt) 2000-03-08
JP2000513014A (ja) 2000-10-03
TR199902383T2 (xx) 2000-06-21
ES2200324T3 (es) 2004-03-01
DE69815126D1 (de) 2003-07-03
HUP0000851A1 (hu) 2001-04-28
RU2203894C2 (ru) 2003-05-10
HK1026418A1 (en) 2000-12-15
WO1998043968A1 (en) 1998-10-08
KR19980080789A (ko) 1998-11-25
US6352993B1 (en) 2002-03-05
AR012181A1 (es) 2000-09-27
AU6523998A (en) 1998-10-22
DK1015444T3 (da) 2003-08-18
DE69815126T2 (de) 2004-04-08
IN188411B (ref) 2002-09-21
TW542831B (en) 2003-07-21
EP1015444A1 (en) 2000-07-05
CA2284795A1 (en) 1998-10-08
CN1118464C (zh) 2003-08-20
HUP0000851A3 (en) 2002-04-29
ATE241613T1 (de) 2003-06-15
EP1015444B1 (en) 2003-05-28
KR100278857B1 (ko) 2001-01-15
UY24938A1 (es) 2001-01-31
AU720385B2 (en) 2000-06-01

Similar Documents

Publication Publication Date Title
PT874846E (pt) Derivados de purina e processos para a sua preparacao
BR9605919A (pt) Catalisadores e processos para sua preparação
NO20001776L (no) Medikamenter
PT994956E (pt) Regiao reguladora preferida por tecido masculino e metodo para a sua utilizacao
DK0864799T3 (da) Ekspanderbar stiftprop
DK1015444T3 (da) Pyrimidinderivater og fremgangsmåder til fremstilling deraf
PT1005446E (pt) Derivados de n-aroilfenilalanina
PT1032524E (pt) Painel afastador saliente soldado e metodo para a sua construcao
NO980546D0 (no) Farmasöytiske midler
PT1113965E (pt) Acessorio para gargalo de garrafa
DE69805807D1 (de) Mikrobiozide n-sulfonylglycin-alkynyloxyphenethylamid-derivate
PT1027362E (pt) Derivados de cetolidos 2-halogeno-6-o-substituidos
PT9493U (pt) Cabeca para esfregona
PT903339E (pt) Bifenilsulfonilcianamidas processos para a sua preparacao e sua utilizacao como medicamentos
DE69524611D1 (de) Pyrimidon-derivate
DE69801856D1 (de) Befestigungselement
DE59805315D1 (de) Wasserlösliche chinacridone
PT966437E (pt) Derivados de 5-aroilnaftaleno
FI972795L (fi) Pyrimidiinijohdannaisia
PT939083E (pt) Complexos de ferro-succinilcaseina procedimento para sua preparacao e suas composicoes farmaceuticas
NO970503L (no) Hudpreparat
DE59813712D1 (de) Transponder
PT102095B (pt) Composicao de accao prolongada de granulos contendo 4-nitro-2-fenoximetanosulfonilida e processo para a sua preparacao
DE59805373D1 (de) Nephroprotektive Arzneimittel
KR970059635U (ko) 장구줄 조임구