PT101038A - Derivados de indano e indeno, seu processo de preparacao, composicoes farmaceuticas e seu uso como antagonistas do receptor de endotelina - Google Patents
Derivados de indano e indeno, seu processo de preparacao, composicoes farmaceuticas e seu uso como antagonistas do receptor de endotelinaInfo
- Publication number
- PT101038A PT101038A PT101038A PT10103892A PT101038A PT 101038 A PT101038 A PT 101038A PT 101038 A PT101038 A PT 101038A PT 10103892 A PT10103892 A PT 10103892A PT 101038 A PT101038 A PT 101038A
- Authority
- PT
- Portugal
- Prior art keywords
- indane
- antagonists
- pharmaceutical compositions
- preparation process
- inden
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78787091A | 1991-11-05 | 1991-11-05 | |
US85419592A | 1992-03-20 | 1992-03-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT101038A true PT101038A (pt) | 1994-02-28 |
PT101038B PT101038B (pt) | 1999-07-30 |
Family
ID=27120702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT101038A PT101038B (pt) | 1991-11-05 | 1992-11-05 | Derivados de indano e indeno, seu processo de preparacao, composicoes farmaceuticas e seu uso como antagonistas do receptor de endotelina |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP0612244B1 (pt) |
JP (1) | JP2667294B2 (pt) |
KR (1) | KR100342960B1 (pt) |
CN (2) | CN1034569C (pt) |
AP (1) | AP433A (pt) |
AT (1) | ATE205711T1 (pt) |
AU (1) | AU669866B2 (pt) |
BG (1) | BG61523B1 (pt) |
BR (1) | BR9206722A (pt) |
CA (1) | CA2122820A1 (pt) |
CZ (1) | CZ287406B6 (pt) |
DE (1) | DE69232072T2 (pt) |
DK (1) | DK0612244T3 (pt) |
ES (1) | ES2164054T3 (pt) |
FI (1) | FI942059A (pt) |
HK (1) | HK1012251A1 (pt) |
HU (1) | HUT67665A (pt) |
IL (1) | IL103621A0 (pt) |
MA (1) | MA22758A1 (pt) |
MX (1) | MX9206348A (pt) |
MY (1) | MY108579A (pt) |
NO (1) | NO304887B1 (pt) |
NZ (1) | NZ245000A (pt) |
OA (1) | OA09921A (pt) |
PL (1) | PL176250B1 (pt) |
PT (1) | PT101038B (pt) |
RO (1) | RO117847B1 (pt) |
RU (1) | RU2125980C1 (pt) |
SI (1) | SI9200297B (pt) |
SK (1) | SK282098B6 (pt) |
TW (1) | TW298590B (pt) |
UA (1) | UA44686C2 (pt) |
WO (1) | WO1993008799A1 (pt) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5736509A (en) * | 1990-12-14 | 1998-04-07 | Texas Biotechnology Corporation | Cyclic peptide surface feature mimics of endothelin |
US5817693A (en) | 1991-11-05 | 1998-10-06 | Cousins; Russell Donovan | Endothelin receptor antagonists |
US5378715A (en) * | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
WO1993023404A1 (en) * | 1992-05-19 | 1993-11-25 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
ES2062927B1 (es) * | 1992-12-17 | 1995-07-01 | Smithkline Beecham Corp | Antagonistas de los receptores de endotelina y procedimiento para su preparacion. |
US5767310A (en) * | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
GB9307694D0 (en) | 1993-04-14 | 1993-06-02 | Smithkine Beecham Corp | Novel compounds |
CA2121724A1 (en) * | 1993-04-21 | 1994-10-22 | Toshifumi Watanabe | Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction |
DZ1773A1 (fr) * | 1993-04-27 | 2002-02-17 | Smithkline Beecham Corp | Antagonistes de récepteurs d'endothéline. |
US6030991A (en) * | 1993-05-20 | 2000-02-29 | Texas Biotechnology Corp. | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6087324A (en) * | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
EP0711157A4 (en) * | 1993-08-06 | 1996-07-31 | Smithkline Beecham Corp | ENDOTHELIN RECEPTOR ANTAGONISTS |
EP0723449A1 (en) * | 1993-08-06 | 1996-07-31 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
ATE199151T1 (de) * | 1993-08-18 | 2001-02-15 | Banyu Pharma Co Ltd | Kondensierte heteroaromatische cyclopentenderivate mit endothelin- antagonistischer aktivität |
US5389620A (en) * | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
US5714479A (en) * | 1993-08-18 | 1998-02-03 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
US6140325A (en) * | 1993-08-19 | 2000-10-31 | Takeda Chemical Industries, Ltd. | Thienopyrimidine derivatives, their production and use |
WO1997007119A1 (en) * | 1994-08-26 | 1997-02-27 | Takeda Chemical Industries, Ltd. | Thienopyrimidine derivatives, their production and use |
US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
AU691201B2 (en) * | 1993-11-01 | 1998-05-14 | Japat Ltd. | Endothelin receptor antagonists |
US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
WO1995033748A1 (en) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
JPH10501812A (ja) * | 1994-06-20 | 1998-02-17 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗薬 |
US7208517B1 (en) | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
US6162927A (en) * | 1994-08-19 | 2000-12-19 | Abbott Laboratories | Endothelin antagonists |
US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
ATE219077T1 (de) * | 1994-08-19 | 2002-06-15 | Abbott Lab | Endothelin antagoniste |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5538991A (en) * | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
US5559135A (en) * | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
US5482960A (en) * | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
WO1996020193A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | Compounds and methods |
US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5599811A (en) * | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
ATE186054T1 (de) * | 1995-06-30 | 1999-11-15 | Cerbios Pharma Sa | Glykoside, deren zuckerfreie abbauprodukte und derivate derselben |
DE19527568A1 (de) * | 1995-07-28 | 1997-01-30 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
DE19530032A1 (de) * | 1995-08-16 | 1997-02-20 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19537548A1 (de) * | 1995-10-09 | 1997-04-10 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
JPH09124620A (ja) | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
ZA969363B (en) | 1995-11-08 | 1997-11-18 | Smithkline Beecham Corp | An improved process for preparing aromatic ring-fused cyclopentane derivatives. |
CA2236924A1 (en) * | 1995-11-08 | 1997-05-15 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
US6162932A (en) * | 1995-11-08 | 2000-12-19 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
CO4761056A1 (es) * | 1995-11-08 | 1999-04-27 | Smithkline Beecham Corp | Procedimiento para preparar derivados de ciclopentano condensados con anillos aromaticos |
AU1054297A (en) * | 1995-11-08 | 1997-05-29 | Smithkline Beecham Corporation | A process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives |
US6080862A (en) * | 1995-11-08 | 2000-06-27 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
DE19543639A1 (de) * | 1995-11-23 | 1997-05-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
US5977117A (en) * | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
CA2245587C (en) * | 1996-02-13 | 2008-12-30 | Abbott Laboratories | Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists |
HUP9902316A3 (en) * | 1996-02-13 | 2001-12-28 | Abbott Lab | 4-(benzo-1,3-dioxolyl)-pyrrolidine-3-carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing them |
US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
CN1211183A (zh) | 1996-02-20 | 1999-03-17 | 布里斯托尔-迈尔斯斯奎布公司 | 联苯基异噁唑磺酰胺的制备方法 |
US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
ES2179353T3 (es) * | 1996-07-01 | 2003-01-16 | Schering Corp | Antagonistas muscarinicos. |
US5935958A (en) * | 1996-07-01 | 1999-08-10 | Schering Corporation | Muscarinic antagonists |
US6172235B1 (en) | 1996-08-09 | 2001-01-09 | Merck & Co., Inc. | Asymmetric conjugate addition reaction |
ATE251611T1 (de) * | 1996-08-09 | 2003-10-15 | Merck & Co Inc | Additionsreaktion mit asymmetrischem konjugat |
CA2262676A1 (en) * | 1996-08-09 | 1998-02-19 | Merck & Co., Inc. | Stereoselective deoxygenation reaction |
AU3867997A (en) | 1996-08-27 | 1998-03-19 | Shionogi & Co., Ltd. | Chromene-3-carboxylate derivatives |
DE19653024A1 (de) * | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
HRP980001A2 (en) * | 1997-01-14 | 1998-10-31 | Feng Xu | Asymmetric conjugate addition reaction using a chiral additive |
US5998625A (en) * | 1997-01-14 | 1999-12-07 | Merck & Co., Inc. | Asymmetric conjugate addition reaction using a chiral additive |
TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
WO1998033781A1 (en) * | 1997-01-30 | 1998-08-06 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
US6013674A (en) * | 1997-06-02 | 2000-01-11 | Eli Lilly And Company | Cell adhesion inhibitors |
JP4058507B2 (ja) | 1997-07-10 | 2008-03-12 | 国立大学法人 東京医科歯科大学 | 4,5−ジヒドロ−[1H]−ベンズ[g]インダゾール−3−カルボン酸誘導体 |
US6022972A (en) | 1997-08-08 | 2000-02-08 | Merck & Co., Inc. | Pyridine propanoic acid derivatives |
US5929106A (en) * | 1997-10-27 | 1999-07-27 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
AU742423B2 (en) * | 1998-01-21 | 2002-01-03 | Msd K.K. | Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative |
TWI274750B (en) | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
KR20020004974A (ko) | 1999-03-19 | 2002-01-16 | 스티븐 비. 데이비스 | 비페닐 이속사졸 술폰아미드의 제조방법 |
US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
ATE272048T1 (de) * | 1999-05-26 | 2004-08-15 | Warner Lambert Co | Aminosäuren mit polycyclischer struktur als pharmaka |
MXPA02000242A (es) | 1999-06-30 | 2004-09-10 | Prescient Neuropharma Inc | Analogos de 2-aminoindano. |
ES2236028T3 (es) | 1999-12-31 | 2005-07-16 | Encysive Pharmaceuticals, Inc | Sulfonamidas y sus derivados que modulan la actividad de la endotelina. |
KR101009472B1 (ko) | 2001-06-12 | 2011-01-19 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
US7772240B2 (en) | 2003-08-18 | 2010-08-10 | H. Lundbeck A/S | Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
KR100595963B1 (ko) * | 2004-04-13 | 2006-07-05 | 한국화학연구원 | 인덴 유도체 및 이의 제조방법 |
RU2388748C2 (ru) | 2004-12-21 | 2010-05-10 | Ф. Хоффманн-Ля Рош Аг | Производные тетралина и индана и их применения в качестве антагонистов 5-нт |
TWI376373B (en) | 2005-02-16 | 2012-11-11 | Lundbeck & Co As H | Crystalline base of a pharmaceutical compound |
TWI453198B (zh) | 2005-02-16 | 2014-09-21 | Lundbeck & Co As H | 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s)-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法 |
EP3000487B8 (en) | 2007-02-19 | 2022-06-15 | Marine Polymer Technologies, Inc. | Hemostatic compositions and therapeutic regimens |
JP2013523898A (ja) | 2010-04-15 | 2013-06-17 | マリン ポリマー テクノロジーズ,インコーポレーテッド | ポリ−n−アセチルグルコサミンナノファイバーの抗菌性の適用 |
EP2696680B1 (en) | 2011-04-15 | 2018-11-28 | Marine Polymer Technologies, Inc. | Treatment of hsv infections with poly-n-acetyl glucosamine nanofibers |
CN110343038B (zh) * | 2018-04-02 | 2022-03-15 | 暨南大学 | 一种宝乐果单体、提取物及其制备方法和应用 |
IL309666A (en) | 2021-07-09 | 2024-02-01 | Plexium Inc | Aryl compounds and pharmaceutical preparations that modulate IKZF2 |
WO2024005578A1 (ko) * | 2022-06-29 | 2024-01-04 | 아밀로이드솔루션 주식회사 | 신규 인덴온 유도체 및 이의 용도 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3642785A (en) * | 1969-08-11 | 1972-02-15 | Merck & Co Inc | Indenyl-3-aliphatic amines |
US3737455A (en) * | 1971-01-21 | 1973-06-05 | Merck & Co Inc | Substituted 1-(loweralkyl-sulfinylbenzylidene)-3-indenyloxyacetic acid and esters thereof |
US4224341A (en) * | 1976-01-12 | 1980-09-23 | Lipha, Lyonnaise Industrielle Pharmaceutique | 5-Substituted indan-2 carboxylic acid and functional derivatives |
GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
JPS61197557A (ja) * | 1985-02-27 | 1986-09-01 | Sankyo Co Ltd | インダン誘導体およびその製法 |
IT1190371B (it) * | 1985-06-19 | 1988-02-16 | Zambon Spa | Processo per la preparazione dell'acido cis-5-fluoro-2-metil-1-(4-metiltiobenziliden)-indenil-3-acetico |
-
1992
- 1992-10-29 RU RU94027696A patent/RU2125980C1/ru active
- 1992-10-29 PL PL92303507A patent/PL176250B1/pl not_active IP Right Cessation
- 1992-10-29 RO RO94-00750A patent/RO117847B1/ro unknown
- 1992-10-29 AU AU31259/93A patent/AU669866B2/en not_active Ceased
- 1992-10-29 DE DE69232072T patent/DE69232072T2/de not_active Expired - Fee Related
- 1992-10-29 CZ CZ19941109A patent/CZ287406B6/cs not_active IP Right Cessation
- 1992-10-29 EP EP92925061A patent/EP0612244B1/en not_active Expired - Lifetime
- 1992-10-29 CA CA002122820A patent/CA2122820A1/en not_active Abandoned
- 1992-10-29 UA UA94061677A patent/UA44686C2/uk unknown
- 1992-10-29 JP JP5508672A patent/JP2667294B2/ja not_active Expired - Fee Related
- 1992-10-29 BR BR9206722A patent/BR9206722A/pt not_active Application Discontinuation
- 1992-10-29 AT AT92925061T patent/ATE205711T1/de not_active IP Right Cessation
- 1992-10-29 WO PCT/US1992/009427 patent/WO1993008799A1/en active IP Right Grant
- 1992-10-29 ES ES92925061T patent/ES2164054T3/es not_active Expired - Lifetime
- 1992-10-29 DK DK92925061T patent/DK0612244T3/da active
- 1992-10-29 SK SK521-94A patent/SK282098B6/sk unknown
- 1992-10-29 HU HU9401319A patent/HUT67665A/hu unknown
- 1992-11-02 TW TW081108697A patent/TW298590B/zh active
- 1992-11-02 MA MA22989A patent/MA22758A1/fr unknown
- 1992-11-03 MY MYPI92001994A patent/MY108579A/en unknown
- 1992-11-03 SI SI9200297A patent/SI9200297B/sl not_active IP Right Cessation
- 1992-11-03 NZ NZ245000A patent/NZ245000A/en not_active IP Right Cessation
- 1992-11-03 IL IL103621A patent/IL103621A0/xx unknown
- 1992-11-04 AP APAP/P/1992/000440A patent/AP433A/en active
- 1992-11-04 MX MX9206348A patent/MX9206348A/es unknown
- 1992-11-05 CN CN92114447A patent/CN1034569C/zh not_active Expired - Fee Related
- 1992-11-05 PT PT101038A patent/PT101038B/pt not_active IP Right Cessation
-
1994
- 1994-05-04 BG BG98752A patent/BG61523B1/bg unknown
- 1994-05-04 OA OA60504A patent/OA09921A/en unknown
- 1994-05-04 FI FI942059A patent/FI942059A/fi unknown
- 1994-05-04 NO NO941650A patent/NO304887B1/no not_active IP Right Cessation
- 1994-05-06 KR KR10-1994-0701528A patent/KR100342960B1/ko not_active IP Right Cessation
-
1996
- 1996-01-10 CN CN96101622A patent/CN1145223A/zh active Pending
-
1998
- 1998-12-15 HK HK98113509A patent/HK1012251A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT101038A (pt) | Derivados de indano e indeno, seu processo de preparacao, composicoes farmaceuticas e seu uso como antagonistas do receptor de endotelina | |
IT1219811B (it) | Derivati peptidici,loro preparazione e loro impiego come medicamenti | |
ITMI920528A0 (it) | 14-beta idrossi-10-de acetil-baccatina iii, suoi derivati, loro preparazione ed impiego terapeutico | |
BR9912495B1 (pt) | "agonistas do receptor orl-1 de nociceptina, composições farmacêuticas compreendendo os mesmos e seus usos na fabricação de medicamentos" | |
FI972583A0 (fi) | Tetrasyklisiä spiroyhdisteitä, menetelmä niiden valmistamiseksi ja niiden käyttö 5HT1D-reseptoriantagonisteina | |
FI99016B (fi) | Plastoelastisia polypropyleenikoostumuksia, niiden valmistus ja käyttö | |
BR9206237A (pt) | Uso de derivados de tetrahidrocarbazole como receptores agonistas 5-HT1. | |
MX9204301A (es) | Acilmercaptoalcanoildipeptidos, metodos de preparacion y su uso terapeutico. | |
PT832082E (pt) | Derivados de n-heteroaril-piridinossulfonamidas e sua utilizacao como antagonistas de endotelina | |
IT8947823A0 (it) | Derivati peptidici, loro preparazione e loro impiego come medicamenti | |
KR880701244A (ko) | 위치 17에 스피로 고리가 있는 스테로이드, 이들의 제조 방법 및 중간체 약제로서 이들의 사용, 및 이들을 함유하는 약제학적 조성물 | |
PT100928A (pt) | Derivados de ciclopentano e ciclopenteno, composicoes farmaceuticas contendo estes compostos e seu uso | |
BR9401617A (pt) | Derivados de oxazabiciclo e seu uso como agonistas receptores de 5-ht4 e processo para sua preparação | |
IT1229523B (it) | Derivati isochinolinici, procedimento per la loro preparazione ed impiego | |
NO930709D0 (no) | Nye cholecystokinin-antagonister, deres fremstilling og terapeutiske anvendelse | |
ITMI911520A0 (it) | Derivati di piperidina, loro preparazione e uso | |
DE69428620T2 (de) | Benzoxazule Derivate und ihre Anwendung als Serotonin 5HT3 Rezeptor Antagonisten | |
ITMI911470A1 (it) | N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico | |
IT1229491B (it) | Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali | |
IT1297205B1 (it) | Composizioni farmaceutiche di somatostatina con assorbimento migliorato, loro preparazione e loro impiego | |
IT1227436B (it) | Derivati di 1-azabicicloalcani, loro procedimento di preparazione e loro applicazione come farmaci | |
IT1227362B (it) | Derivati indolici, processo per la loro preparazione e loro uso comefarmaci antitrombotici | |
EE9700230A (et) | Bitsüklilised tahhükiniini antagonistid, nende valmistamine ja kasutamine ravimsegus | |
ITFI920089A0 (it) | Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche. | |
DE69003466D1 (de) | Substituierte Thienopyrimidin-Derivate, deren Herstellung, pharmazeutische Zusammensetzungen und medizinische Verwendung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19930713 |
|
FG3A | Patent granted, date of granting |
Effective date: 19990420 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20091020 |