ATE199151T1 - Kondensierte heteroaromatische cyclopentenderivate mit endothelin- antagonistischer aktivität - Google Patents
Kondensierte heteroaromatische cyclopentenderivate mit endothelin- antagonistischer aktivitätInfo
- Publication number
- ATE199151T1 ATE199151T1 AT94922382T AT94922382T ATE199151T1 AT E199151 T1 ATE199151 T1 AT E199151T1 AT 94922382 T AT94922382 T AT 94922382T AT 94922382 T AT94922382 T AT 94922382T AT E199151 T1 ATE199151 T1 AT E199151T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopent
- derivatives
- antagonistic activity
- condensed heteroaromatic
- endothelin antagonistic
- Prior art date
Links
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- LMKPHJYTFHAGHK-UHFFFAOYSA-N cyclodrine Chemical class C1CCCC1(O)C(C(=O)OCCN(CC)CC)C1=CC=CC=C1 LMKPHJYTFHAGHK-UHFFFAOYSA-N 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
- -1 2-oxo-3H-1,2,3,5-oxathiadiazol-4-yl Chemical group 0.000 abstract 2
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 125000002433 cyclopentenyl group Chemical class C1(=CCCC1)* 0.000 abstract 1
- 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22510093 | 1993-08-18 | ||
| JP28161393 | 1993-10-15 | ||
| JP28567793 | 1993-10-21 | ||
| US08/165,880 US5389620A (en) | 1993-08-18 | 1993-12-14 | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
| JP8591494 | 1994-03-30 | ||
| PCT/JP1994/001357 WO1995005374A1 (en) | 1993-08-18 | 1994-08-16 | Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199151T1 true ATE199151T1 (de) | 2001-02-15 |
Family
ID=27525184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94922382T ATE199151T1 (de) | 1993-08-18 | 1994-08-16 | Kondensierte heteroaromatische cyclopentenderivate mit endothelin- antagonistischer aktivität |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0714897B1 (de) |
| JP (1) | JP2847969B2 (de) |
| CN (1) | CN1049219C (de) |
| AT (1) | ATE199151T1 (de) |
| AU (1) | AU675870B2 (de) |
| CA (1) | CA2169737C (de) |
| DE (1) | DE69426698T2 (de) |
| DK (1) | DK0714897T3 (de) |
| ES (1) | ES2156157T3 (de) |
| GR (1) | GR3035620T3 (de) |
| PT (1) | PT714897E (de) |
| WO (1) | WO1995005374A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9800975A (es) * | 1995-08-02 | 1998-04-30 | Smithkline Beecham Corp | Antagonistas de receptor de endotelina. |
| US6545031B1 (en) | 1995-08-02 | 2003-04-08 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US6162932A (en) * | 1995-11-08 | 2000-12-19 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
| US6080862A (en) * | 1995-11-08 | 2000-06-27 | Smithkline Beecham Corporation | Stereoselective synthesis of endothelin receptor antagonists |
| EP0915699A4 (de) * | 1995-11-08 | 2008-06-25 | Smithkline Beecham Corp | Sterepselektive synthese von endothelinrezeptor-antagonisten |
| EP0906108B1 (de) * | 1996-04-04 | 2005-06-15 | Banyu Pharmaceutical Co., Ltd. | Endothelin-antagonisten zur behandlung von herzversagen |
| CA2262676A1 (en) * | 1996-08-09 | 1998-02-19 | Merck & Co., Inc. | Stereoselective deoxygenation reaction |
| US6030975A (en) * | 1997-03-14 | 2000-02-29 | Basf Aktiengesellschaft | Carboxylic acid derivatives, their preparation and use in treating cancer |
| HUP0003689A3 (en) * | 1997-09-05 | 2003-05-28 | Warner Lambert Co | Benzothiazine dioxide derivatives with endothelin antagonist activity, pharmaceutical compositions containing them and process for the preparation of known derivatives |
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| WO1999037639A1 (en) * | 1998-01-21 | 1999-07-29 | Banyu Pharmaceutical Co., Ltd. | Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl) cyclopentenopyridine derivative |
| WO1999048530A1 (en) * | 1998-03-23 | 1999-09-30 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US6410554B1 (en) | 1998-03-23 | 2002-06-25 | Merck & Co., Inc. | Combination therapy for the treatment of benign prostatic hyperplasia |
| US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| MXPA04003625A (es) | 2001-10-19 | 2004-12-02 | Sotechnika Inc | Sintesis de analogos de ciclosporina. |
| US20060089503A1 (en) * | 2002-12-27 | 2006-04-27 | Kaneka Corporation | Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor |
| US7148194B2 (en) | 2002-12-30 | 2006-12-12 | Kimberly-Clark Worldwide, Inc. | Method to increase fibronectin |
| GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| NZ549535A (en) | 2004-03-17 | 2010-11-26 | Novartis Ag | Use of aliskiren for treating renal and other disorders |
| AR080683A1 (es) | 2010-03-16 | 2012-05-02 | Novartis Ag | Composiciones farmaceuticas de aliskiren y metodos de administracion |
| JP7714554B2 (ja) * | 2020-02-20 | 2025-07-29 | ダウ グローバル テクノロジーズ エルエルシー | ２－ベンゾイル安息香酸アルキルの合成のための効率的かつ選択的な経路 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59190956A (ja) * | 1983-04-15 | 1984-10-29 | 金 明儒 | ロカグラマイド化合物 |
| US4845129A (en) * | 1988-03-14 | 1989-07-04 | Sandoz Pharm. Corp. | Diaryl substituted cyclopentane and cyclopentene derivatives |
| HUT67665A (en) * | 1991-11-05 | 1995-04-28 | Smithkline Beckman Corp | Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them |
| JP4066571B2 (ja) * | 1999-02-17 | 2008-03-26 | 株式会社デンソー | 携帯型光学情報読取り装置 |
-
1994
- 1994-08-16 AU AU73511/94A patent/AU675870B2/en not_active Ceased
- 1994-08-16 JP JP7506865A patent/JP2847969B2/ja not_active Expired - Fee Related
- 1994-08-16 DK DK94922382T patent/DK0714897T3/da active
- 1994-08-16 CA CA002169737A patent/CA2169737C/en not_active Expired - Fee Related
- 1994-08-16 CN CN94193138A patent/CN1049219C/zh not_active Expired - Fee Related
- 1994-08-16 ES ES94922382T patent/ES2156157T3/es not_active Expired - Lifetime
- 1994-08-16 WO PCT/JP1994/001357 patent/WO1995005374A1/ja not_active Ceased
- 1994-08-16 EP EP94922382A patent/EP0714897B1/de not_active Expired - Lifetime
- 1994-08-16 DE DE69426698T patent/DE69426698T2/de not_active Expired - Lifetime
- 1994-08-16 AT AT94922382T patent/ATE199151T1/de active
- 1994-08-16 PT PT94922382T patent/PT714897E/pt unknown
-
2001
- 2001-03-22 GR GR20010400465T patent/GR3035620T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2156157T3 (es) | 2001-06-16 |
| WO1995005374A1 (en) | 1995-02-23 |
| EP0714897A4 (de) | 1996-11-20 |
| CA2169737C (en) | 2003-04-15 |
| EP0714897B1 (de) | 2001-02-14 |
| DK0714897T3 (da) | 2001-03-19 |
| PT714897E (pt) | 2001-05-31 |
| GR3035620T3 (en) | 2001-06-29 |
| AU675870B2 (en) | 1997-02-20 |
| DE69426698D1 (de) | 2001-03-22 |
| JP2847969B2 (ja) | 1999-01-20 |
| CN1049219C (zh) | 2000-02-09 |
| EP0714897A1 (de) | 1996-06-05 |
| DE69426698T2 (de) | 2001-08-16 |
| CN1129448A (zh) | 1996-08-21 |
| AU7351194A (en) | 1995-03-14 |
| CA2169737A1 (en) | 1995-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner |