MX9204301A - Acilmercaptoalcanoildipeptidos, metodos de preparacion y su uso terapeutico. - Google Patents

Acilmercaptoalcanoildipeptidos, metodos de preparacion y su uso terapeutico.

Info

Publication number
MX9204301A
MX9204301A MX9204301A MX9204301A MX9204301A MX 9204301 A MX9204301 A MX 9204301A MX 9204301 A MX9204301 A MX 9204301A MX 9204301 A MX9204301 A MX 9204301A MX 9204301 A MX9204301 A MX 9204301A
Authority
MX
Mexico
Prior art keywords
acilmercaptoalcanoildipeptidos
preparation
methods
therapeutic use
therapeutic
Prior art date
Application number
MX9204301A
Other languages
English (en)
Inventor
Fournie-Zaluski
Marie-Claude
Roques
Bernard Pierre
Original Assignee
Inst Nat Sante Rech Med
Rech Medicale Inserm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Rech Medicale Inserm filed Critical Inst Nat Sante Rech Med
Publication of MX9204301A publication Critical patent/MX9204301A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
MX9204301A 1991-07-23 1992-07-22 Acilmercaptoalcanoildipeptidos, metodos de preparacion y su uso terapeutico. MX9204301A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9109306A FR2679564A1 (fr) 1991-07-23 1991-07-23 Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US08/185,563 US5591891A (en) 1991-07-23 1994-01-24 N-[Mercaptoacyl (amino acid or peptide ) ] compounds and S-lipophiIic aliphatic carbonyl derivatives thereof as antihypertensives

Publications (1)

Publication Number Publication Date
MX9204301A true MX9204301A (es) 1993-03-01

Family

ID=26228863

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9204301A MX9204301A (es) 1991-07-23 1992-07-22 Acilmercaptoalcanoildipeptidos, metodos de preparacion y su uso terapeutico.

Country Status (8)

Country Link
US (2) US5591891A (es)
EP (2) EP0595878A1 (es)
JP (1) JPH06509335A (es)
AU (1) AU2326892A (es)
CA (1) CA2113358A1 (es)
FR (1) FR2679564A1 (es)
MX (1) MX9204301A (es)
WO (1) WO1993002099A1 (es)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078758C (en) * 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
US5646276A (en) * 1992-05-13 1997-07-08 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
ES2138622T3 (es) * 1992-05-15 2000-01-16 Merrell Pharma Inc Derivados de mercaptoacetilamido piridazo(1,2-a)(1,2)diazepina utilizados como inhibidores de encefalinasa y eca.
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
ES2155852T3 (es) * 1992-10-30 2001-06-01 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida utiles como inhibidores de encefalinasa y eca.
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5432186A (en) * 1993-11-16 1995-07-11 Ciba-Geigy Corporation Cyclic amino acid derivatives
ATE193706T1 (de) * 1993-11-16 2000-06-15 Novartis Ag Zyklische aminosäure-derivate mit ace und nep inhibierender aktivität
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
CN1046512C (zh) * 1994-02-14 1999-11-17 默里尔药物公司 巯基乙酰胺二硫化物衍生物，其制备方法及含有它们的药物组合物
WO1995021857A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0750631B1 (en) * 1994-02-14 2000-04-05 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
CN1069317C (zh) * 1994-02-14 2001-08-08 默里尔药物公司 用作脑啡肽酶抑制剂的新的1,2－二氢化茚－2－巯基乙酰胺二硫化物衍生物
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
JPH09510476A (ja) * 1994-03-24 1997-10-21 メリル・フアーマシユウテイカルズ・インコーポレイテツド 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のアミノアセチルメルカプト誘導体
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5508266A (en) * 1994-06-22 1996-04-16 Ciba-Geigy Corporation Gem-disubstituted amino acid derivatives
DK0784629T3 (da) 1994-10-05 1999-10-25 Darwin Discovery Ltd Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser
AR002945A1 (es) * 1994-11-15 1998-05-27 Bayer Corp Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
IT1277736B1 (it) * 1995-12-28 1997-11-12 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
WO1997038705A1 (en) * 1996-04-12 1997-10-23 Bristol-Myers Squibb Company N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors
US6777550B1 (en) 1996-04-12 2004-08-17 Bristol-Myers Squibb Company N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors
DE19745151A1 (de) * 1997-10-14 1999-04-15 Basf Ag Neue Verbindungen zur Behandlung von Krankheiten, die mit der biologischen Wirkung von Endothelin assoziiert sind
CA2312913A1 (en) * 1997-12-12 1999-06-24 Jeffrey C. Way Compounds and methods for the inhibition of protein-protein interactions
IT1298267B1 (it) * 1998-02-18 1999-12-20 Zambon Spa Procedimento per la preparazione dell'acido (s)-2-acetiltio-3-fenil- propionico e dei suoi sali
IT1298268B1 (it) * 1998-02-18 1999-12-20 Zambon Spa Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico
DE29810240U1 (de) 1998-06-09 1998-09-24 Scheibler Peltzer GmbH & Co, 47803 Krefeld Reinigungstuch
US6486088B1 (en) 1998-10-23 2002-11-26 Exxonmobil Chemical Patents Inc. High activity carbenium-activated polymerization catalysts
US6352976B1 (en) 1998-12-31 2002-03-05 Aventis Pharmaceuticals Inc. Selective inhibitors of MMP-12
JP2003521476A (ja) * 1999-06-15 2003-07-15 メルク エンド カムパニー インコーポレーテッド チオール誘導体、メタロ−β−ラクタマーゼ阻害剤
US6475946B1 (en) 1999-10-22 2002-11-05 Exxonmobil Chemical Patents Inc. Olefin polymerization catalysis with aryl substituted carbenium cationic complexes
US6476164B1 (en) 1999-10-22 2002-11-05 Exxonmobil Chemical Patents Inc. Carbenium cationic complexes suitable for polymerization catalysts
US6489480B2 (en) 1999-12-09 2002-12-03 Exxonmobil Chemical Patents Inc. Group-15 cationic compounds for olefin polymerization catalysts
US6822057B2 (en) 1999-12-09 2004-11-23 Exxon Mobil Chemical Patents Inc. Olefin polymerization catalysts derived from Group-15 cationic compounds and processes using them
US6509330B2 (en) 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
EP1138671B1 (en) * 2000-03-30 2004-09-01 Ajinomoto Co., Inc. Production method of aromatic acylthiocarboxylic acid derivative
US6809209B2 (en) 2000-04-07 2004-10-26 Exxonmobil Chemical Patents Inc. Nitrogen-containing group-13 anionic compounds for olefin polymerization
CN1227255C (zh) 2000-06-23 2005-11-16 埃克森美孚化学专利公司 用于烯烃聚合反应的甲硅烷氧基取代的助催化剂活化剂
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US6777443B2 (en) 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
AU2003244467A1 (en) 2002-02-04 2003-09-02 Kaneka Corporation Process for production of optically active 2-halogeno- carboxylic acids
US7390789B2 (en) * 2005-09-13 2008-06-24 William H Simmons Thio-containing inhibitors of aminopeptidase P, and compositions thereof
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
WO2022043322A1 (en) * 2020-08-25 2022-03-03 Helmholtz-Zentrum für Infektionsforschung GmbH INHIBITORS OF PSEUDOMONAS AERUGINOSA VIRULENCE FACTOR LasB

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH451186A (de) * 1961-11-02 1968-05-15 Santen Phamarceutical Co Ltd Verfahren zur Herstellung von N-Mercaptopropionylglycin und dessen Derivaten
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
US4684660A (en) * 1979-04-02 1987-08-04 E. R. Squibb & Sons, Inc. Mercaptoacyldepeptides
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4474799A (en) * 1981-10-09 1984-10-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
IT1157268B (it) * 1982-02-12 1987-02-11 Farmatis Srl Derivati dagli acidi alfa o beta mercaptopropionilammidoacetici, processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IL69795A (en) * 1983-09-23 1987-01-30 Univ Ramot Ophthalmic preparations containing as active ingredient 2-mercaptoalkanoyl peptides
US4798904A (en) * 1983-10-03 1989-01-17 E. R. Squibb & Sons, Inc. Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
EP0136883B1 (en) * 1983-10-03 1987-11-25 E.R. Squibb & Sons, Inc. Enkephalinase inhibitors
FR2556721B1 (fr) * 1983-12-14 1986-05-16 Roussel Uclaf Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives

Also Published As

Publication number Publication date
FR2679564A1 (fr) 1993-01-29
CA2113358A1 (en) 1993-02-04
EP0595878A1 (en) 1994-05-11
AU2326892A (en) 1993-02-23
US5591891A (en) 1997-01-07
US5801274A (en) 1998-09-01
JPH06509335A (ja) 1994-10-20
WO1993002099A1 (en) 1993-02-04
EP0524553A1 (en) 1993-01-27

Similar Documents

Publication Publication Date Title
MX9204301A (es) Acilmercaptoalcanoildipeptidos, metodos de preparacion y su uso terapeutico.
NO933434D0 (no) Piperidinderivater, deres fremstilling og anvendelse
NO902658D0 (no) N-fenylpyrazolderivater, preparater og anvendelse derav.
DK374389A (da) Arylbenzenoxazolidinoner, deres fremstilling og anvendelse
ITMI920528A0 (it) 14-beta idrossi-10-de acetil-baccatina iii, suoi derivati, loro preparazione ed impiego terapeutico
ITRM920412A0 (it) Eteroprostanoidi, procedimento per la loro preparazione e loro impiegoterapeutico.
TR24895A (tr) PIRIMIDIN TüREVLERI,BUNLARIN ISTIHSAL EDILMESI VE KULLANILMASI
NO940989D0 (no) Triazolkinoksalin-1,4-dioner og deres fremstilling og anvendelse
MX9201780A (es) Eteres oximicos y procedimiento para su preparacion.
NO903978L (no) Pyridinyl-kinolonforbindelser, deres fremstilling og bruk.
NO933435D0 (no) Piperidinderivater, deres fremstilling og anvendelse
MX9205747A (es) Pirazolinas y procedimiento para su preparacion.
FR2675799B1 (fr) Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
IT8821300A0 (it) Procedimento di preparazione di morniflumato e analoghi.
DK73091D0 (da) Quinoxalinforbindelser, deres fremstilling og anvendelse
MX9205746A (es) Pirazolinas y procedimiento para su preparacion.
DK225089A (da) 2-adamantyl-4-isothiazolin-3-oner, deres fremstilling og anvendelse
MX9200706A (es) Composicion y uso.
IT9019565A0 (it) Agenti addensanti,loro preparazione ed uso
ITMI912290A0 (it) Miscele di n-alchilftalimmidi, loro preparazione e loro impiego
NO179073C (no) Imid-terminerte polynitrogenforbindelser, deres fremstilling og anvendelse
NO905543L (no) Fremgangsmaate for fremstilling og anvendelse av aminopyridinylmetanoler og aminometylpyridinaminer.
IT1217177B (it) Palmitoil-fruttosio-1,6-difosfato,suo uso terapeutico e relativi metodi di preparazione
FR2674853B1 (fr) Derives de piperidinylguanidine, leur preparation et leur application en therapeutique.
MX18585A (es) Compuestos de pirrol y su uso.