PL3354747T3 - Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza - Google Patents

Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza

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Publication number
PL3354747T3
PL3354747T3 PL17202149T PL17202149T PL3354747T3 PL 3354747 T3 PL3354747 T3 PL 3354747T3 PL 17202149 T PL17202149 T PL 17202149T PL 17202149 T PL17202149 T PL 17202149T PL 3354747 T3 PL3354747 T3 PL 3354747T3
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PL
Poland
Prior art keywords
plasma
invasive determination
tumor methylome
methylome
tumor
Prior art date
Application number
PL17202149T
Other languages
English (en)
Polish (pl)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee Chan
Yuk-Ming Dennis Lo
Miu Fan Lun
Peiyong Jiang
Wai Man Chan
Original Assignee
The Chinese University Of Hong Kong
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3354747(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by The Chinese University Of Hong Kong filed Critical The Chinese University Of Hong Kong
Publication of PL3354747T3 publication Critical patent/PL3354747T3/pl

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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12Q2523/00Reactions characterised by treatment of reaction samples
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    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122Massive parallel sequencing
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    • C12Q2600/00Oligonucleotides characterized by their use
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

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  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
PL17202149T 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza PL3354747T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma
EP17202149.5A EP3354747B1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of tumor from plasma
EP13838770.9A EP2898100B9 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (1)

Publication Number Publication Date
PL3354747T3 true PL3354747T3 (pl) 2021-07-26

Family

ID=50340462

Family Applications (4)

Application Number Title Priority Date Filing Date
PL17202149T PL3354747T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza
PL13838770.9T PL2898100T5 (pl) 2012-09-20 2013-09-20 Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza
PL19171630.7T PL3536807T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza
PL22171427.2T PL4056712T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza w osoczu

Family Applications After (3)

Application Number Title Priority Date Filing Date
PL13838770.9T PL2898100T5 (pl) 2012-09-20 2013-09-20 Nieinwazyjny sposób określania metylomu płodu lub guza z wykorzystaniem osocza
PL19171630.7T PL3536807T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza z wykorzystaniem osocza
PL22171427.2T PL4056712T3 (pl) 2012-09-20 2013-09-20 Nieinwazyjne określanie metylomu guza w osoczu

Country Status (28)

Country Link
EP (6) EP4056712B1 (enExample)
JP (6) JP6317354B2 (enExample)
KR (5) KR102587176B1 (enExample)
CN (2) CN117757932A (enExample)
AU (5) AU2013317708C1 (enExample)
BR (3) BR112015006183B1 (enExample)
CA (2) CA2884066C (enExample)
CY (1) CY1124139T1 (enExample)
DK (4) DK4056712T3 (enExample)
EA (1) EA201500327A1 (enExample)
ES (4) ES2969567T3 (enExample)
FI (2) FI4056712T3 (enExample)
HR (3) HRP20241142T1 (enExample)
HU (3) HUE053822T2 (enExample)
IL (4) IL313451A (enExample)
LT (2) LT4056712T (enExample)
MX (1) MX360034B (enExample)
MY (2) MY173356A (enExample)
NZ (2) NZ717423A (enExample)
PH (2) PH12015500547B1 (enExample)
PL (4) PL3354747T3 (enExample)
PT (4) PT3354747T (enExample)
SG (2) SG11201501927VA (enExample)
SI (1) SI4056712T1 (enExample)
SM (1) SMT202100256T1 (enExample)
TW (4) TWI707953B (enExample)
WO (1) WO2014043763A1 (enExample)
ZA (1) ZA201501772B (enExample)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
FI4056712T3 (fi) 2012-09-20 2024-08-29 Univ Hong Kong Chinese Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2685893T3 (es) * 2013-07-30 2018-10-15 Bgi Genomics Co., Limited Método para determinar la composición de ácidos nucleicos de una mezcla de ácidos nucleicos
US10174375B2 (en) * 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
CN106029909B (zh) * 2014-02-18 2021-02-02 生物纳米基因公司 测定核酸结构信息的改进方法
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3134541B1 (en) * 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP3521454A1 (en) 2014-05-09 2019-08-07 LifeCodexx AG Detection of dna that originates from a specific cell-type and related methods
WO2016010401A1 (ko) * 2014-07-18 2016-01-21 에스케이텔레콘 주식회사 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법
US11062789B2 (en) * 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
US20170211143A1 (en) 2014-07-25 2017-07-27 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
ES2923602T3 (es) * 2014-12-31 2022-09-28 Guardant Health Inc Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
EP4012715B1 (en) 2015-02-10 2025-09-24 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
EP3739061B1 (en) 2015-07-20 2022-03-23 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
CN108026572B (zh) 2015-07-23 2022-07-01 香港中文大学 游离dna的片段化模式的分析
CN115433769A (zh) 2015-08-12 2022-12-06 香港中文大学 血浆dna的单分子测序
SG10202107693TA (en) 2015-09-22 2021-09-29 Univ Hong Kong Chinese Accurate quantification of fetal dna fraction by shallow-depth sequencing of maternal plasma dna
US10260088B2 (en) * 2015-10-30 2019-04-16 New England Biolabs, Inc. Compositions and methods for analyzing modified nucleotides
EP4180532A1 (en) * 2015-11-09 2023-05-17 Roche Molecular Systems, Inc. Methods for determining the origin of dna molecules
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
EP3798321B1 (en) * 2015-12-17 2025-08-27 Illumina, Inc. Distinguishing methylation levels in complex biological samples
WO2017136603A1 (en) * 2016-02-02 2017-08-10 Guardant Health, Inc. Cancer evolution detection and diagnostic
US11514289B1 (en) 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
CA3022606A1 (en) 2016-05-03 2017-11-09 University Health Network Methods of capturing cell-free methylated dna and uses of same
EP3452620B1 (en) * 2016-05-04 2025-11-05 Queen's University at Kingston Cell-free detection of methylated tumour dna
US10781490B2 (en) * 2016-05-30 2020-09-22 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free DNA in blood
WO2017218908A2 (en) * 2016-06-16 2017-12-21 The Johns Hopkins University Methods and system for epigenetic analysis
US11999998B2 (en) 2016-08-24 2024-06-04 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof
IL265769B2 (en) * 2016-10-19 2023-12-01 Univ Hong Kong Chinese Estimation of gestational age using methylation and size profile of maternal plasma DNA
SG11201903509QA (en) 2016-10-24 2019-05-30 Univ Hong Kong Chinese Methods and systems for tumor detection
WO2018099418A1 (en) * 2016-11-30 2018-06-07 The Chinese University Of Hong Kong Analysis of cell-free dna in urine and other samples
EP3555311B1 (en) * 2016-12-13 2024-06-26 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
MX2019008320A (es) * 2017-01-11 2019-09-09 Quest Diagnostics Invest Llc Metodo para la deteccion prenatal no invasiva de aneuploidia.
HUE067465T2 (hu) * 2017-01-24 2024-10-28 Bgi Genomics Co Ltd Eljárás elõre meghatározott forrásból származó sejtmentes nukleinsavak arányának meghatározására biológiai mintában
MY197535A (en) 2017-01-25 2023-06-21 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
CN107247873B (zh) * 2017-03-29 2020-04-14 电子科技大学 一种差异甲基化位点识别方法
AU2018266964B2 (en) * 2017-05-12 2024-10-31 Dana-Farber Cancer Institute, Inc. Universal early cancer diagnostics
US12227737B2 (en) 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
CN118782138A (zh) * 2017-07-12 2024-10-15 安德股份有限公司 模式识别系统
EP3652741A4 (en) * 2017-07-12 2021-04-21 University Health Network DETECTION AND CLASSIFICATION OF CANCER USING METHYLOMA ANALYSIS
DK3658684T3 (da) * 2017-07-26 2023-10-09 Univ Hong Kong Chinese Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
EP4269583A3 (en) 2017-09-28 2024-01-17 Grail, LLC Enrichment of short nucleic acid fragments in sequencing library preparation
US11168356B2 (en) 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
US12027237B2 (en) 2018-03-13 2024-07-02 Grail, Llc Anomalous fragment detection and classification
EP3766076A4 (en) * 2018-03-15 2021-12-29 Grail, Inc. Tissue-specific methylation marker
WO2019195268A2 (en) * 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
JP7455757B2 (ja) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装
WO2019204360A1 (en) * 2018-04-16 2019-10-24 Grail, Inc. Systems and methods for determining tumor fraction in cell-free nucleic acid
WO2019209884A1 (en) 2018-04-23 2019-10-31 Grail, Inc. Methods and systems for screening for conditions
US11932899B2 (en) * 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
CN109448789A (zh) * 2018-09-17 2019-03-08 上海派森诺生物科技股份有限公司 一种基于perl语言的种群特异SNP位点的自动化分析方法
AU2019351130B2 (en) 2018-09-27 2025-10-23 GRAIL, Inc Methylation markers and targeted methylation probe panel
CN109295230A (zh) * 2018-10-24 2019-02-01 福建翊善生物科技有限公司 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法
GB2595076B8 (en) 2018-11-21 2023-08-23 Agilent Technologies Inc Methods for targeted nucleic acid library formation
ES2968457T3 (es) * 2018-12-19 2024-05-09 Univ Hong Kong Chinese Características de los extremos del ADN extracelular circulante
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
EP4485464A3 (en) 2019-02-05 2025-02-19 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
WO2020163410A1 (en) 2019-02-05 2020-08-13 Grail, Inc. Detecting cancer, cancer tissue of origin, and/or a cancer cell type
EP3947717A4 (en) 2019-03-25 2022-12-28 The Chinese University Of Hong Kong DETERMINATION OF LINEAR AND ROUND SHAPES OF CIRCULATION NUCLEIC ACIDS
US11773450B2 (en) 2019-04-03 2023-10-03 Grail, Llc Methylation-based false positive duplicate marking reduction
BR112021022084A2 (pt) * 2019-05-03 2022-02-08 Univ Cornell Marcadores para identificar e quantificar a mutação da sequência de ácido nucleico, expressão, variante de splice, translocação, número de cópias ou alterações de metilação
EP4020484A4 (en) * 2019-08-19 2023-08-30 Green Cross Genome Corporation METHOD FOR DETECTING A CHROMOSOME ABNORMALITY USING INFORMATION CONCERNING THE DISTANCE BETWEEN NUCLEIC ACID FRAGMENTS
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
GB201915469D0 (en) 2019-10-24 2019-12-11 Univ London Cancer detection methods
AU2020391488A1 (en) * 2019-11-27 2022-06-09 GRAIL, Inc Systems and methods for evaluating longitudinal biological feature data
EP4097231B1 (en) 2020-01-31 2025-03-19 Agilent Technologies, Inc. Systems and methods for targeted nucleic acid capture
WO2021163163A1 (en) * 2020-02-10 2021-08-19 Palogen, Inc. Nanopore device and methods of detecting and classifying charged particles using same
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
AU2021228737A1 (en) * 2020-02-28 2022-09-22 Grail, LLC. Identifying methylation patterns that discriminate or indicate a cancer condition
CN112662764A (zh) * 2020-03-17 2021-04-16 博尔诚(北京)科技有限公司 一种检测11种癌症的探针组合物
RU2738675C1 (ru) * 2020-07-28 2020-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов
WO2022107145A1 (en) * 2020-11-19 2022-05-27 Nucleix Ltd. Detecting methylation changes in dna samples using restriction enzymes and high throughput sequencing
US20240327922A1 (en) * 2020-12-17 2024-10-03 Jiantao Shi Methods of cancer detection using extraembryonically methylated cpg islands
CN112813148A (zh) * 2021-02-02 2021-05-18 博淼生物科技(北京)有限公司 飞行时间质谱检测5-羟甲基胞嘧啶的方法
EP4409468A4 (en) * 2021-09-28 2025-08-13 Act Genomics Ip Ltd APPARATUS AND METHODS FOR SELECTING METHYLATION BIOMARKERS
KR20230059423A (ko) * 2021-10-26 2023-05-03 주식회사 지씨지놈 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법
EP4384633A1 (en) * 2021-11-04 2024-06-19 Universal Diagnostics, S.A. Systems and methods for preparing biological samples for genetic sequencing
EP4530356A3 (en) 2022-02-07 2025-07-09 Centre for Novostics Fragmentation for measuring methylation and disease
EP4482985A2 (en) * 2022-02-22 2025-01-01 Flagship Pioneering Innovations VI, LLC Intra-individual analysis for presence of health conditions
CN115064211B (zh) * 2022-08-15 2023-01-24 臻和(北京)生物科技有限公司 一种基于全基因组甲基化测序的ctDNA预测方法及装置
CN115612723B (zh) * 2022-09-26 2023-07-14 广州女娲生命科技有限公司 植入前胚胎的筛选方法
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
CN118737268A (zh) * 2023-05-04 2024-10-01 杭州圣庭医疗科技有限公司 一种鉴定肿瘤组织来源的试剂盒的数据分析方法
CN117025753A (zh) * 2023-08-15 2023-11-10 广州女娲生命科技有限公司 检测染色体变异的方法和装置
CN117079822B (zh) * 2023-10-17 2024-01-02 北京大学第三医院(北京大学第三临床医学院) 一种妊娠早中期四因子预测胎儿脑损伤的系统

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
ATE312946T1 (de) 2002-03-05 2005-12-15 Epigenomics Ag Verfahren und vorrichtung zur bestimmung der gewebespezifität von freier dna in körperflüssigkeiten
US20040171037A1 (en) * 2002-11-19 2004-09-02 Jing Li Amplified genes involved in cancer
US20060183128A1 (en) 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
EP1725682B1 (en) 2004-03-08 2015-09-09 Rubicon Genomics, Inc. Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation
US20090280479A1 (en) 2005-05-27 2009-11-12 John Wayne Cancer Institute Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
CN101153336B (zh) * 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
EP2173897A2 (en) 2007-06-19 2010-04-14 Oncomethylome Sciences SA Improved urine sample collecting and processing
EP3892736A1 (en) 2007-07-23 2021-10-13 The Chinese University of Hong Kong Determining a nucleic acid sequence imbalance
JP4347372B2 (ja) 2007-08-10 2009-10-21 トヨタ自動車株式会社 静電塗装装置
US20110028333A1 (en) 2009-05-01 2011-02-03 Brown University Diagnosing, prognosing, and early detection of cancers by dna methylation profiling
US8563242B2 (en) * 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
WO2011038507A1 (en) 2009-10-02 2011-04-07 Centre For Addiction And Mental Health Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids
HUE061110T2 (hu) * 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
MX357692B (es) 2009-11-06 2018-07-19 Univ Hong Kong Chinese Analisis genomico a base de tamaño.
US10662474B2 (en) * 2010-01-19 2020-05-26 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
NZ601079A (en) 2010-01-26 2014-08-29 Nipd Genetics Ltd Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
CA3007805C (en) 2010-04-29 2019-11-26 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)
GB201007944D0 (en) * 2010-05-12 2010-06-30 Univ Aberystwyth Methods
EP2576832B1 (en) 2010-05-25 2016-05-04 The Johns Hopkins University Compositions and methods for detecting a neoplasia
KR20130041961A (ko) * 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
WO2012012703A2 (en) * 2010-07-23 2012-01-26 Esoterix Genetic Laboratories, Llc Identification of differentially represented fetal or maternal genomic regions and uses thereof
WO2012031329A1 (en) 2010-09-10 2012-03-15 Murdoch Childrens Research Institute Assay for detection and monitoring of cancer
SG190344A1 (en) 2010-11-30 2013-06-28 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer
FI4056712T3 (fi) * 2012-09-20 2024-08-29 Univ Hong Kong Chinese Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta

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